Blood Cells; Hematopoietic System
Yale University: Yale School of Medicine
I am interested in understanding the role of genetics in human development and disease.
Extensive Research Description
Currently, I work on understanding molecular mechanisms that underly stem and progenitor cell fate decisions. I have developed a novel method for time-lapse microscopy of bipotent progenitors dividing and committing to two potential lineages. I also study the function of specific domains within a co-transcriptional activator during megakaryocytopoiesis.
Retroelement demethylation associated with abnormal placentation in Mus musculus x Mus caroli hybrids.
Biol Reprod. 2012 Mar 30;86(3):88. doi: 10.1095/biolreprod.111.095273. Brown JD, Piccuillo V, O'Neill RJ.
Loss of Cbl-PI3K interaction modulates the periosteal response to fracture by enhancing osteogenic commitment and differentiation.
Scanlon V, Walia B, Yu J, Hansen M, Drissi H, Maye P, Sanjay A. Bone. 2017 Feb;95:124-135. doi: 10.1016/j.bone.2016.11.020. Epub 2016 Nov 22.
Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair.
Scanlon V, Soung do Y, Adapala NS, Morgan E, Hansen MF, Drissi H, Sanjay A. PLoS One. 2015 Sep 22;10(9):e0138194. doi: 10.1371/journal.pone.0138194. eCollection 2015.
Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy.
Adapala NS, Holland D, Scanlon V, Barbe MF, Langdon WY, Tsygankov AY, Lorenzo JA, Sanjay A. Bone. 2014 Oct;67:1-9. doi: 10.1016/j.bone.2014.06.013. Epub 2014 Jul 1.
Establishment of human cell type-specific iPS cells with enhanced chondrogenic potential.
Guzzo RM, Scanlon V, Sanjay A, Xu RH, Drissi H. Stem Cell Rev. 2014 Dec;10(6):820-9. doi: 10.1007/s12015-014-9538-8.