2003
Systemic Tropheryma whippleii infection associated with monoclonal B-cell proliferation: a Helicobacter pylori-type pathogenesis?
Wang S, Ernst LM, Smith BR, Tallini G, Howe JG, Crouch J, Cooper DL. Systemic Tropheryma whippleii infection associated with monoclonal B-cell proliferation: a Helicobacter pylori-type pathogenesis? Archives Of Pathology & Laboratory Medicine 2003, 127: 1619-22. PMID: 14632565, DOI: 10.5858/2003-127-1619-stwiaw.Peer-Reviewed Original ResearchConceptsMonoclonal B-cell proliferationLymph nodesB cell proliferationWhipple's diseasePeripheral bloodPolymerase chain reactionB cellsRight axillary lymph nodeAxillary lymph nodesMesenteric lymph nodesMonoclonal B-cell populationTime of presentationPatients' peripheral bloodPrevious biopsy specimensChain reactionB-cell lymphomaMonoclonal B cellsB cell populationsPeriodic acid-Schiff stainFlow cytometry studiesRoutine cytogenetic studiesEntire followMesenteric lymphBiopsy specimensImmunohistochemical stains
1998
Morphologic, Immunophenotypic, and Molecular Evaluation of Bone Marrow Involvement in Non-Hodgkin's Lymphoma
Crotty P, Smith B, Tallini G. Morphologic, Immunophenotypic, and Molecular Evaluation of Bone Marrow Involvement in Non-Hodgkin's Lymphoma. Applied Immunohistochemistry & Molecular Morphology 1998, 7: 90-95. PMID: 9785007, DOI: 10.1097/00019606-199804000-00005.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDBiomarkers, TumorBone MarrowBone Marrow ExaminationClone CellsFlow CytometryGene Rearrangement, B-LymphocyteGene Rearrangement, T-LymphocyteHumansImmunophenotypingLymphoma, B-CellLymphoma, Non-HodgkinLymphoma, T-CellNeoplasm ProteinsNeoplastic Stem CellsPolymerase Chain ReactionSensitivity and SpecificityConceptsPrimer polymerase chain reactionMarrow involvementT-cell neoplasiaFlow cytometryB-cell neoplasiaObjective evidenceT-cell receptor gene rearrangementsBone marrow involvementConsensus primer polymerase chain reactionNon-Hodgkin lymphomaChronic lymphocytic leukemiaB-cell lymphomaT-cell neoplasmsB-cell neoplasmsReceptor gene rearrangementsDetection of clonalityDetectable diseaseHodgkin's lymphomaPolymerase chain reactionLymphocytic leukemiaApparent diseaseLymphomaPatientsImportant adjunctNeoplasia
1994
B-Cell Precursor Bone Marrow Reconstitution After Bone Marrow Transplantation
Leitenberg D, Rappeport J, Smith B. B-Cell Precursor Bone Marrow Reconstitution After Bone Marrow Transplantation. American Journal Of Clinical Pathology 1994, 102: 231-236. PMID: 8042594, DOI: 10.1093/ajcp/102.2.231.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, CDBlotting, SouthernB-LymphocytesBone MarrowBone Marrow CellsBone Marrow TransplantationChildChild, PreschoolClone CellsFemaleFlow CytometryFluorescent Antibody TechniqueGene Rearrangement, B-Lymphocyte, Heavy ChainHematopoietic Stem CellsHumansImmunophenotypingInfantKineticsMaleMiddle AgedNeprilysinConceptsBone marrow transplantationMarrow transplantationB cell subsetsBone marrow reconstitutionB cell precursorsSurface antigenic phenotypeImmature B cellsImmunoglobulin gene rearrangementsHumoral immunodeficiencyMonoclonal gammapathyMarrow reconstitutionAntigenic phenotypeB cellsTransplantationGene rearrangementsMarked increaseLeukemia lymphoblastsCellsPatientsGammapathyImmunodeficiencyMarrowCD34ReconstitutionMonths
1986
Long-lasting deficit of functional T cell precursors in human bone marrow transplant recipients revealed by limiting dilution methods.
Rozans MK, Smith BR, Burakoff SJ, Miller RA. Long-lasting deficit of functional T cell precursors in human bone marrow transplant recipients revealed by limiting dilution methods. The Journal Of Immunology 1986, 136: 4040-8. PMID: 2939139, DOI: 10.4049/jimmunol.136.11.4040.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBone Marrow TransplantationChildChild, PreschoolClone CellsFlow CytometryHematopoietic Stem CellsHumansImmunologic Deficiency SyndromesInfantInfant, NewbornInterleukin-2Leukocyte CountLymphocyte ActivationLymphocyte Culture Test, MixedTime FactorsT-LymphocytesT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerConceptsBone marrow transplantationBMT patientsHuman bone marrow transplant recipientsAllogeneic bone marrow transplantationBone marrow transplant recipientsNormal levelsResidual immune dysfunctionT cell frequenciesMarrow transplant recipientsDilution methodT cell precursorsNear-normal levelsTransplant recipientsBMT recipientsImmune dysfunctionMarrow transplantationPrecursor frequencyLeu-3Immune functionNormal controlsPatientsLeu-2Cell frequencyDecreased frequencyCell precursors
1984
Circulating Monoclonal B Lymphocytes in Non-Hodgkin's Lymphoma
Smith B, Weinberg D, Robert N, Towle M, Luther E, Pinkus G, Ault K. Circulating Monoclonal B Lymphocytes in Non-Hodgkin's Lymphoma. New England Journal Of Medicine 1984, 311: 1476-1481. PMID: 6438505, DOI: 10.1056/nejm198412063112304.Peer-Reviewed Original ResearchConceptsMonoclonal B lymphocytesMonoclonal lymphocytesLight chain typeB lymphocytesHodgkin's lymphomaSensitive flow cytometric methodBone marrow involvementDiffuse histiocytic lymphomaProlonged clinical remissionNon-Hodgkin lymphomaForms of lymphomaCategory of lymphomaClinical remissionComplete remissionFlow cytometric methodClinical stagingProlonged remissionsHistologic subclassificationPrognostic importanceHistiocytic lymphomaRemissionPatient's diseasePatientsLymphomaClonal excess
1983
In Waldenstrom's macroglobulinemia the quantity of detectable circulating monoclonal B lymphocytes correlates with clinical course.
Smith BR, Robert NJ, Ault KA. In Waldenstrom's macroglobulinemia the quantity of detectable circulating monoclonal B lymphocytes correlates with clinical course. Blood 1983, 61: 911-4. PMID: 6403083, DOI: 10.1182/blood.v61.5.911.bloodjournal615911.Peer-Reviewed Original ResearchConceptsMonoclonal B lymphocytesWaldenstrom's macroglobulinemiaB lymphocytesSerum IgM levelsAbnormal cellsMonoclonal surfaceBlood involvementAsymptomatic presentationClinical responseClinical courseIgM levelsMultiple myelomaClinical activitySerial determinationsSerial studiesPatientsSurface immunoglobulinMacroglobulinemiaFlow cytometryLymphocytesMonoclonal cellsOvernight cultureSuch cellsDiseaseCells