Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment.
Antin JH, Ginsburg D, Smith BR, Nathan DG, Orkin SH, Rappeport JM. Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. Blood 1985, 66: 1247-50. PMID: 3904867, DOI: 10.1182/blood.v66.6.1247.bloodjournal6661247.Peer-Reviewed Original ResearchConceptsParoxysmal nocturnal hemoglobinuriaBone marrow transplantationConditioning regimenMarrow transplantationMarrow aplasiaPNH cloneNocturnal hemoglobinuriaPretransplant conditioning regimenCurative therapyAntithymocyte serumComplete engraftmentMarrow graftingSuccessful treatmentAbnormal clonePatientsHematopoietic stem cellsRBC typingTransplantationRegimenCell linesAplasiaDNA sequence polymorphism analysisEngraftmentHemoglobinuriaStem cellsBone Marrow Transplantation for Paroxysmal Nocturnal Hemoglobinuria: Eradication of the PNH Clone and Documentation of Complete Lymphohematopoietic Engraftment
Antin J, Ginsburg D, Smith B, Nathan D, Orkin S, Rappeport J. Bone Marrow Transplantation for Paroxysmal Nocturnal Hemoglobinuria: Eradication of the PNH Clone and Documentation of Complete Lymphohematopoietic Engraftment. Blood 1985, 66: 1247-1250. DOI: 10.1182/blood.v66.6.1247.1247.Peer-Reviewed Original ResearchParoxysmal nocturnal hemoglobinuriaBone marrow transplantationConditioning regimenMarrow transplantationMarrow aplasiaPNH cloneNocturnal hemoglobinuriaPretransplant conditioning regimenCurative therapyAntithymocyte serumComplete engraftmentMarrow graftingSuccessful treatmentAbnormal clonePatientsHematopoietic stem cellsRBC typingTransplantationRegimenCell linesAplasiaDNA sequence polymorphism analysisEngraftmentHemoglobinuriaStem cellsDiscordance between transferrin receptor expression and susceptibility to lysis by natural killer cells.
Bridges K, Smith B. Discordance between transferrin receptor expression and susceptibility to lysis by natural killer cells. Journal Of Clinical Investigation 1985, 76: 913-918. PMID: 2995450, PMCID: PMC423953, DOI: 10.1172/jci112089.Peer-Reviewed Original ResearchConceptsTransferrin receptor expressionSusceptibility to NK cytolysisReceptor expressionNK susceptibilityNK cytolysisK562 cellsSusceptibility to NK lysisNK-sensitive target cellsNatural killer (NKMonoclonal anti-transferrin receptor antibodyHeLa cellsHuman NK cellsNatural killer cellsAnti-transferrin receptor antibodyCell linesReceptors per seTarget recognition structureSusceptible to cytolysisSusceptible to lysisTarget cell linesNK lysisNK cellsReceptor antibodiesTarget antigen(sKiller cellsNatural killer lymphocytes in hairy cell leukemia: presence of phenotypically identifiable cells with defective functional activity.
Smith BR, Rosenthal DS, Ault KA. Natural killer lymphocytes in hairy cell leukemia: presence of phenotypically identifiable cells with defective functional activity. Experimental Hematology 1985, 13: 189-93. PMID: 3884356.Peer-Reviewed Original ResearchConceptsHairy cell leukemiaNK cellsNatural killerFluorescence-activated cell sorterNK activityNK functionCell leukemiaFunctional deficiencyNormal numbersPhenotypic NK cellsMajority of patientsStandard 51Cr releaseSevere functional deficiencyDefective functional activityK562 targetsNK populationPatientsSurface markersK562 cell lineFunctional activityCell populationsCell sorterCell linesLeukemiaIdentifiable cells
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