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American Society for Clinical Investigation Inducts Four School of Medicine Faculty

April 17, 2020
by Robert Forman

The American Society for Clinical Investigation has inducted 80 new members who come from 41 different institutions and represent excellence across the breadth of academic medicine. Four are faculty members at Yale School of Medicine.

Stephanie C. Eisenbarth, MD, PhD, associate professor of laboratory medicine, of immunobiology, and of medicine (immunology), who focuses her research on how dendritic cells, B cells and T cells interact to induce tailored adaptive immune responses. This work spans how this triad is operational in the spleen to transfused red blood cells (RBCs), in the lung to aeroallergens and the gut to food allergens. She also practices clinical pathology at Yale New Haven Hospital with a focus on immune-mediated disorders including autoimmunity, immunodeficiency syndromes and allergic disease.

Shuta Ishibe, MD, associate professor of medicine (nephrology), whose laboratory focuses on the filter lining cells, the podocytes, which are defective in almost all forms of proteinuric kidney diseases. Ishibe and his team have opened a new area of podocyte investigation by examining the relevance of endocytosis in podocyte biology. They also are working toward identifying therapeutic targets.

Lauren H. Sansing, MD, MS, associate professor of neurology, whose research program focuses on inflammatory mechanisms of secondary brain injury after stroke and other cerebrovascular diseases. Her laboratory investigates the role of innate immune responses after intracerebral hemorrhage (ICH) and ischemic stroke in experimental murine in vivo and in vitro models, as well as ex vivo models using patient leukocytes and surgical specimens. Sansing's goal as a physician-scientist is to identify the pathological processes that lead to brain injury in her patients, as well as the processes that aid in recovery and repair.

Kevin N. Sheth, MD, Professor of Neurology and Neurosurgery, who works toward the advancement of therapies for acute brain injury such as stroke, especially those complicated by brain ischemia, swelling and hemorrhage. In pioneering the development of new strategies to treat brain swelling, his work has changed the fundamental approach to brain injury in the ICU and catalyzed the creation of new technologies in drug delivery and neuroimaging. His group uses novel approaches to personalized medicine that also aid in identifying successful treatments. Under his leadership, Yale has served as a national model for academic critical care neurology units.

The American Society for Clinical Investigation seeks to support the scientific efforts, educational needs, and clinical aspirations of physician-scientists to improve the health of all people.

Submitted by Robert Forman on April 17, 2020