2025
Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates
De Oliveira A, Versteeg L, Briggs N, Adhikari R, Villar M, Redd J, Hotez P, Bottazzi M, Pollet J. Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates. PLOS Neglected Tropical Diseases 2025, 19: e0012809. PMID: 39792959, PMCID: PMC11756802, DOI: 10.1371/journal.pntd.0012809.Peer-Reviewed Original ResearchConceptsAntigen-specific antibodiesMRNA vaccine candidateMRNA vaccinesVaccine candidatesNa-GST-1Plasma membrane-anchoredRobust CD8+ T-cell responsesCD8+ T cell responsesMemory T cell populationsTiters of antigen-specific antibodiesLevels of antigen-specific antibodiesT cell responsesT cell populationsRecombinant Na-GST-1In vivo efficacySubunit vaccine candidateInduce humoral responsesImmunogenicity findingsNeutralizing antibodiesClinical studiesDevelopment of multivalent vaccinesHumoral responseRNA vaccinesImmune responsePeptide presentationDistinct immunogenicity outcomes of DNA vaccines encoding malaria transmission-blocking vaccine target antigens Pfs230D1M and Pvs230D1
Cao Y, da Silva Araujo M, Lorang C, Dos Santos N, Tripathi A, Vinetz J, Kumar N. Distinct immunogenicity outcomes of DNA vaccines encoding malaria transmission-blocking vaccine target antigens Pfs230D1M and Pvs230D1. Vaccine 2025, 47: 126696. PMID: 39787798, PMCID: PMC11781949, DOI: 10.1016/j.vaccine.2024.126696.Peer-Reviewed Original ResearchConceptsTransmission-reducing activityTransmission-blocking vaccinesDirect membrane feeding assaysStandard membrane feeding assayTransmission-blocking vaccine candidateMembrane feeding assaysDNA vaccineP. vivaxSexual-stage antigensSurface of gametocytesEfficacy of DNA vaccinesPreclinical immunogenicity studiesVaccine target antigensComplement-dependent mannerIn vivo electroporationInhibit parasite developmentImmunogenicity outcomesLow antibody avidityMalaria controlP. falciparumPreclinical studiesPlasmodium falciparumClinical trialsImmunogenicity studiesTarget antigen
2024
PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration
Wang J, Shen S, You J, Wang Z, Li Y, Chen Y, Tuo Y, Chen D, Yu H, Zhang J, Wang F, Pang X, Xiao Z, Lan Q, Wang Y. PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration. Cell Death & Disease 2024, 15: 524. PMID: 39043634, PMCID: PMC11266590, DOI: 10.1038/s41419-024-06920-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCell Line, TumorCell MovementEnhancer of Zeste Homolog 2 ProteinFemaleGene Expression Regulation, NeoplasticGlioblastomaHumansMaleMiceMice, Inbred BALB CMice, NudeNeoplasm InvasivenessNuclear ProteinsProtein StabilityProtein-Arginine N-MethyltransferasesProteolysisTNF Receptor-Associated Factor 6UbiquitinationConceptsProtein arginine methyltransferase 6Glioblastoma cell invasionStability of EZH2Protein stabilityCell invasionOverexpression of PRMT6Inhibited glioblastoma cell invasionGlioblastoma cellsEZH2 protein stabilityHistone methylation marksMigration of glioblastoma cellsHallmarks of cancerProliferation of glioblastoma cellsMethylation marksTumor cell invasionEpigenetic regulationGlioblastoma cells in vivoBioinformatics analysisMigration in vitroRegulatory relationshipsEZH2 proteinUbiquitination degradationProteinCells in vivoTRAF6Natural resistance to meglumine antimoniate is associated with treatment failure in cutaneous leishmaniasis caused by Leishmania (Viannia) panamensis
Fernández O, Rosales-Chilama M, Sánchez-Hidalgo A, Gómez P, Rebellón-Sánchez D, Regli I, Díaz-Varela M, Tacchini-Cottier F, Saravia N. Natural resistance to meglumine antimoniate is associated with treatment failure in cutaneous leishmaniasis caused by Leishmania (Viannia) panamensis. PLOS Neglected Tropical Diseases 2024, 18: e0012156. PMID: 38709850, PMCID: PMC11098511, DOI: 10.1371/journal.pntd.0012156.Peer-Reviewed Original ResearchConceptsAssociated with treatment failureTreatment failureHost risk factorsBALB/c miceRisk factorsDrug susceptibilityClinical strainsOutcome of cutaneous leishmaniasisOdds of treatment failureMeglumine antimoniateParasitological response to treatmentLeishmania (Viannia) panamensisSubgroup of patientsAntimicrobial drug susceptibilityResponse to treatmentU937 macrophagesEvaluate drug susceptibilityCutaneous leishmaniasis patientsCutaneous leishmaniasisFailed treatmentPlasma CmaxTherapeutic responseClinical outcomesPatient's lesionsTreatment outcomes
2023
Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice
Tran J, Muench M, Gaillard B, Darst O, Tomayko M, Jackman R. Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice. Frontiers In Immunology 2023, 14: 1281130. PMID: 38146372, PMCID: PMC10749330, DOI: 10.3389/fimmu.2023.1281130.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHistocompatibility AntigensInflammationLipopolysaccharidesMiceMice, Inbred BALB CPlatelet TransfusionPoly CPoly I-CConceptsB cell responsesPlatelet transfusionsMajor histocompatibility complexCell responsesPrior exposurePlatelet alloimmunizationMemory B cell responsesPlatelet transfusion recipientsSubsequent platelet transfusionsAllogeneic platelet transfusionsNegative bacterial infectionsPolyinosinic-polycytidylic acidGerminal center formationPrior inflammationAlloantibody responsesAlloimmune responsePlatelet refractorinessFuture transplantTransfusion recipientsMHC tetramersAdverse reactionsInflammatory environmentAntigen experiencePlatelet antigensTransfusionBacterial production of recombinant contraceptive vaccine antigen from CatSper displayed on a human papilloma virus-like particle
Nand K, Jordan T, Yuan X, Basore D, Zagorevski D, Clarke C, Werner G, Hwang J, Wang H, Chung J, McKenna A, Jarvis M, Singh G, Bystroff C. Bacterial production of recombinant contraceptive vaccine antigen from CatSper displayed on a human papilloma virus-like particle. Vaccine 2023, 41: 6791-6801. PMID: 37833124, DOI: 10.1016/j.vaccine.2023.09.044.Peer-Reviewed Original ResearchConceptsVirus-like particlesSperm hyperactivated motilityHuman papilloma virusInclusion bodiesLong-acting protectionCalcium ion channelsNon-hormonal interventionsContraceptive efficacyHyperactivated motilityPapilloma virusPrincipal pieceSperm tailContraceptive vaccineBALB/c miceHypervariable regionCatSperVaccine antigensBacterial productionVaccine candidatesIon channelsIn vitroVaccinePregnancyRecombinant vaccineExtracellular loopImmune sensing of food allergens promotes avoidance behaviour
Florsheim E, Bachtel N, Cullen J, Lima B, Godazgar M, Carvalho F, Chatain C, Zimmer M, Zhang C, Gautier G, Launay P, Wang A, Dietrich M, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature 2023, 620: 643-650. PMID: 37437602, PMCID: PMC10432274, DOI: 10.1038/s41586-023-06362-4.Peer-Reviewed Original ResearchConceptsMast cellsImmune systemBALB/c miceAllergen-specific IgEDifferentiation factor 15Behavioral modificationAllergen avoidanceAllergic sensitizationAllergic inflammationFood allergyTractus solitariusC miceCysteinyl leukotrienesParabrachial nucleusAllergen ingestionE antibodiesCentral amygdalaFactor 15Mouse modelFood allergensBrain areasImmune sensingAvoidance behaviorAversive stimuliGenetic backgroundTranscriptome Analysis of Retinal and Choroidal Pathologies in Aged BALB/c Mice Following Systemic Neonatal Murine Cytomegalovirus Infection
Zhang X, Xu J, Marshall B, Dong Z, Liu Y, Espinosa-Heidmann D, Zhang M. Transcriptome Analysis of Retinal and Choroidal Pathologies in Aged BALB/c Mice Following Systemic Neonatal Murine Cytomegalovirus Infection. International Journal Of Molecular Sciences 2023, 24: 4322. PMID: 36901754, PMCID: PMC10001583, DOI: 10.3390/ijms24054322.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChoroidCytomegalovirus InfectionsEye Infections, ViralGene Expression ProfilingMiceMice, Inbred BALB CMuromegalovirusConceptsBALB/c miceMurine cytomegalovirus infectionCytomegalovirus infectionC miceInflammatory responseImmune/inflammatory responseChoroid/RPEDegeneration of photoreceptorsQIAGEN Ingenuity Pathway AnalysisMolecular genetic changesIngenuity Pathway AnalysisMCMV latencyOcular latencyChoroidal pathologiesControl eyesInfected eyesChoroidal capillariesCell death signaling pathwaysRNA sequencing analysisDeath signaling pathwaysMiceCell death pathwaysEyesSignaling pathwaysCanonical pathways
2022
Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice
Nakao T, Inomata T, Blanco T, Musayeva A, Tahvildari M, Amouzegar A, Yin J, Chauhan S, Chen Y, Dana R. Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice. Transplantation 2022, 107: 1302-1310. PMID: 36584368, PMCID: PMC10205651, DOI: 10.1097/tp.0000000000004424.Peer-Reviewed Original ResearchConceptsNK cell depletionAllograft survivalNatural killerNK cellsGraft survivalYounger recipientsRejection of corneal allograftsSuppressing NK cell responsesSuppressive function of TregsCell depletionActivity of NK cellsIn vitro suppression assaySecretion of interferon-gammaRegulatory T cell functionFlow cytometryNatural killer cell activityAllogeneic corneal transplantationCorneal allograft survivalCorneal transplant outcomesYoung graft recipientsFrequency of TregsNK cell responsesRegulatory T cellsFunction of TregsActivated natural killerDual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer
Gao D, Asghar S, Ye J, Zhang M, Hu R, Wang Y, Huang L, Yuan C, Chen Z, Xiao Y. Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer. Carbohydrate Polymers 2022, 294: 119785. PMID: 35868795, DOI: 10.1016/j.carbpol.2022.119785.Peer-Reviewed Original ResearchConceptsBreast cancerHyaluronic acid nanogelsTumor-bearing BALB/c miceTherapy of breast cancerTreatment of breast cancerTargeting breast cancerBreast cancer cellsRat pharmacokinetic profilesIn vivo studiesTherapeutic efficacyBALB/c miceEntrapment efficiencyPharmacokinetic profileCancer cellsClearance rateCD44 receptorControl groupCancerPaclitaxelDrug loadingHigher cytotoxicityReceptorsCD44DrugCells
2021
Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease
Aggarwal N, Deerhake ME, DiPalma D, Shahi SK, Gaggioli MR, Mangalam AK, Shinohara ML. Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease. Cell Reports 2021, 37: 110170. PMID: 34965439, PMCID: PMC8759344, DOI: 10.1016/j.celrep.2021.110170.Peer-Reviewed Original ResearchConceptsIntestinal epithelial cellsAcute GVHDHost diseaseMajor target organAcute graftBacteria AkkermansiaGastrointestinal pathologyMouse modelTarget organsFunction of osteopontinCD4Protective rolePotential biomarkersBeneficial effectsEpithelial cellsOPN isoformsMouse mutant modelsGVHDOsteopontinGraftCell deathDiseaseCellsMutant modelsAkkermansiaWEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway
Guo E, Xiao R, Wu Y, Lu F, Liu C, Yang B, Li X, Fu Y, Wang Z, Li Y, Huang Y, Li F, Wu X, You L, Qin T, Lu Y, Huang X, Ma D, Mills G, Sun C, Chen G. WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway. Journal Of Experimental Medicine 2021, 219: e20210789. PMID: 34825915, PMCID: PMC8628262, DOI: 10.1084/jem.20210789.Peer-Reviewed Original ResearchMeSH KeywordsA549 CellsAnimalsAntineoplastic Combined Chemotherapy ProtocolsCD8-Positive T-LymphocytesCell Cycle ProteinsCell Line, TumorEndogenous RetrovirusesEnzyme InhibitorsFemaleGene Expression Regulation, NeoplasticHCT116 CellsHumansImmune Checkpoint InhibitorsMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NODMice, SCIDNeoplasms, ExperimentalProtein-Tyrosine KinasesPyrazolesPyrimidinonesRNA, Double-StrandedSignal TransductionTumor BurdenConceptsImmune checkpoint blockadeAnti-tumor immunityEndogenous retroviral elementsWEE1 inhibitionCheckpoint blockadeCD8+ T cell-dependent mannerSensitivity to immune checkpoint blockadeResponse to immune checkpoint blockadeAnti-tumor T cellsCombination of WEE1 inhibitorT cell-dependent mannerPathway-targeted therapiesMultiple tumor modelsPopulation of patientsEmergence of resistanceDown-regulating FoxM1Viral defense pathwaysPD-L1Tumor regressionCombination therapyTargeted therapyCombination partnerT cellsPatient selectionWEE1 inhibitorA stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Alpert T, Anderson F, Earnest R, Fauver J, Kalinich C, Munyenyembe K, Ott I, Petrone M, Rothman J, Watkins A, Wilen C, Landry M, Grubaugh N, Pyle A, Iwasaki A. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. Journal Of Experimental Medicine 2021, 219: e20211818. PMID: 34757384, PMCID: PMC8590200, DOI: 10.1084/jem.20211818.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntiviral AgentsCOVID-19COVID-19 Drug TreatmentDisease Models, AnimalImmunity, InnateInterferon Type IMiceMice, Inbred BALB CRNASARS-CoV-2ConceptsSARS-CoV-2 infectionChronic SARS-CoV-2 infectionVariants of concernLethal SARS-CoV-2 infectionPost-infection therapyLower respiratory tractPost-exposure treatmentType I interferonSARS-CoV-2Effective medical countermeasuresAdaptive immune systemBroad-spectrum antiviralsContext of infectionSingle doseRespiratory tractViral controlImmunodeficient miceSevere diseaseMouse modelI interferonViral infectionImmune systemInnate immunityDisease preventionConsiderable efficacyMitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology
Fujiwara H, Seike K, Brooks MD, Mathew AV, Kovalenko I, Pal A, Lee HJ, Peltier D, Kim S, Liu C, Oravecz-Wilson K, Li L, Sun Y, Byun J, Maeda Y, Wicha MS, Saunders TL, Rehemtulla A, Lyssiotis CA, Pennathur S, Reddy P. Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology. Nature Immunology 2021, 22: 1440-1451. PMID: 34686860, PMCID: PMC9351914, DOI: 10.1038/s41590-021-01048-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCase-Control StudiesCell CommunicationCells, CulturedColitisColonCytotoxicity, ImmunologicDisease Models, AnimalElectron Transport Complex IIEpithelial CellsFemaleGraft vs Host DiseaseHumansImmunity, MucosalIntestinal MucosaMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicMitochondriaOxidative PhosphorylationSuccinic AcidT-LymphocytesConceptsGenetic experimental approachesCell-intrinsic featuresMetabolic flux studiesIntestinal epithelial cellsOxidative phosphorylationDisease severityT cell-mediated immunopathologyT cell-mediated colitisIntestinal epithelial cell damageProtein analysisSuccinate dehydrogenaseCell-mediated immunopathologyInflammatory bowel diseaseEpithelial cell damageHuman clinical samplesSuccinate levelsEpithelial cellsCritical roleSDHAHost diseaseBowel diseaseComplementary chemicalIntestinal diseaseT cellsMetabolic alterationsVector competence of human-biting ticks Ixodes scapularis, Amblyomma americanum and Dermacentor variabilis for Powassan virus
Sharma R, Cozens D, Armstrong P, Brackney D. Vector competence of human-biting ticks Ixodes scapularis, Amblyomma americanum and Dermacentor variabilis for Powassan virus. Parasites & Vectors 2021, 14: 466. PMID: 34503550, PMCID: PMC8427896, DOI: 10.1186/s13071-021-04974-1.Peer-Reviewed Original ResearchConceptsNaïve miceBALB/c micePublic health threatViremic miceC micePowassan virusIxodes sppIxodes scapularisInfection statusConclusionsOur findingsMiceDermacentor variabilisHealth threatPOWVTransmission fociTick speciesPotential roleInfected nymphsCompetent vectorsVector competenceEpidemiologyHuman riskFuture studiesResultsThe resultsVirusInfluenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses
Mytle N, Leyrer S, Inglefield JR, Harris AM, Hickey TE, Minang J, Lu H, Ma Z, Andersen H, Grubaugh ND, Guina T, Skiadopoulos MH, Lacy MJ. Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses. Viruses 2021, 13: 1708. PMID: 34578289, PMCID: PMC8473317, DOI: 10.3390/v13091708.Peer-Reviewed Original ResearchConceptsBALB/c miceC miceAntigens of influenzaSeasonal influenza vaccineInfluenza virus antigensSerum antibody responseVaccinia virus AnkaraMajor protective antigenMatrix protein 2Influenza A virusesViral burdenInfluenza vaccineAnnual immunizationProtective immunityLethal challengeAntibody responseVirus antigenVirus AnkaraNatural immunityAntigen hemagglutininM2e antigenAntigenic driftA virusAntigenProtective antigenOral Bacteria Combined with an Intranasal Vaccine Protect from Influenza A Virus and SARS-CoV-2 Infection
Nagai M, Moriyama M, Ichinohe T. Oral Bacteria Combined with an Intranasal Vaccine Protect from Influenza A Virus and SARS-CoV-2 Infection. MBio 2021, 12: 10.1128/mbio.01598-21. PMID: 34399617, PMCID: PMC8406166, DOI: 10.1128/mbio.01598-21.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAdjuvants, ImmunologicAdministration, IntranasalAnimalsAntibodies, ViralBacteriaCell LineChlorocebus aethiopsCOVID-19COVID-19 VaccinesDogsHemagglutinin Glycoproteins, Influenza VirusImmunity, MucosalInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesMadin Darby Canine Kidney CellsMiceMice, Inbred BALB CMyeloid Differentiation Factor 88Nasal MucosaOrthomyxoviridae InfectionsPathogen-Associated Molecular Pattern MoleculesSARS-CoV-2VaccinationVero CellsConceptsInfluenza virus infectionVirus-specific adaptive immunityVaccine-specific antibody responseVirus-specific antibody responsesAntibody responseMyD88-dependent mannerVirus infectionHealthy human volunteersPathogen-associated molecular patternsImmune responseNasal bacteriaOral bacteriaCommensal bacteriaIntranasal supplementationHA vaccineVaccine protectsIntranasal vaccineIntranasal administrationIntranasal applicationAdaptive immunityOral cavityAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSevere acute respiratory syndrome coronavirus 2Influenza virus hemagglutinin vaccineThe Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis
Zhang X, Xu J, Marshall B, Dong Z, Smith SB, Zhang M. The Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis. International Journal Of Molecular Sciences 2021, 22: 8135. PMID: 34360899, PMCID: PMC8348425, DOI: 10.3390/ijms22158135.Peer-Reviewed Original ResearchConceptsDay 14 p.MCMV retinitisBystander cell deathWT miceInfected eyesKO miceCaspase-12Innate immune responseTUNEL staining cellsMCMV infected cellsSimilar virus titersCell deathCytomegalovirus retinitisInjected eyeReal-time PCRVirus infectionImmune responseImmunohistochemical stainingSimilar numberInterferon αRetinitisNeural retinaDay 7Innate immunityVirus titers(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
Bagdas D, Sevdar G, Gul Z, Younis R, Cavun S, Tae HS, Ortells MO, Arias HR, Gurun MS. (E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation. Neurological Research 2021, 43: 1056-1068. PMID: 34281483, DOI: 10.1080/01616412.2021.1949684.Peer-Reviewed Original ResearchMeSH KeywordsAcrylamidesalpha7 Nicotinic Acetylcholine ReceptorAnalgesicsAnimalsAnxietyBehavior, AnimalDepressionMaleMiceMice, Inbred BALB CNeuralgiaNociceptionConceptsPositive allosteric modulationΑ7 nAChRsNeuropathic painΑ7-selective antagonist methyllycaconitineΑ7 nicotinic acetylcholine receptorChronic constriction injuryPaw licking behaviorNeuropathic pain modelAcute systemic administrationChronic painful conditionsAntidepressant-like activityAnti-nociceptive activityDepression-like behaviorAnxiogenic-like effectsNicotinic acetylcholine receptorsAffective behaviorHuman α7 nAChRConstriction injuryMechanical allodyniaFormalin testPain modelAntagonist methyllycaconitineChronic painPainful conditionsRat α7 nAChRRetinal and Choroidal Pathologies in Aged BALB/c Mice Following Systemic Neonatal Murine Cytomegalovirus Infection
Xu J, Liu X, Zhang X, Marshall B, Dong Z, Smith SB, Espinosa-Heidmann DG, Zhang M. Retinal and Choroidal Pathologies in Aged BALB/c Mice Following Systemic Neonatal Murine Cytomegalovirus Infection. American Journal Of Pathology 2021, 191: 1787-1804. PMID: 34197777, PMCID: PMC8485058, DOI: 10.1016/j.ajpath.2021.06.008.Peer-Reviewed Original ResearchMeSH KeywordsAgingAngiogenesis Inducing AgentsAnimalsAnimals, NewbornAntigens, ViralChoroidDNA, ViralGene Expression Regulation, ViralHerpesviridae InfectionsHost-Pathogen InteractionsImmunosuppression TherapyInflammationMice, Inbred BALB CMuromegalovirusPhagocytesRetinaRetinal Pigment EpitheliumTomography, Optical CoherenceVirus ActivationConceptsMurine cytomegalovirus infectionCytomegalovirus infectionChoroidal pathologiesVirus infectionSystemic murine cytomegalovirus infectionBALB/c miceAge-related macular degenerationAcute virus infectionRetinal pigment epithelium cellsDissemination of virusLatent virus infectionPigment epithelium cellsOcular latencyNeonatal infectionChoroidal atrophyHuman ocular diseasesOcular infectionsC miceSitu inflammationMacular degenerationOcular pathologyOcular diseasesPhotoreceptor degenerationAngiogenic factorsEpithelium cells
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