2024
The Incidence of CNS Relapse in Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) and Its Impact on Clinical Outcome: Results from Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND)
Shah K, El Kettani M, Narra R, Mims A, Coltoff A, Medawar G, Hisrich B, Shallis R, Hunter C, Kota V, Othman T, Jonas B, Desai S, Sacchi de Camargo Correia G, Patel A, Duvall A, Palmisiano N, Curran E, Omer Z, Advani A, Atallah E, Litzow M, Badar T. The Incidence of CNS Relapse in Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) and Its Impact on Clinical Outcome: Results from Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND). Blood 2024, 144: 4184-4184. DOI: 10.1182/blood-2024-205812.Peer-Reviewed Original ResearchCNS relapseCentral nervous system involvementPh+ acute lymphoblastic leukemiaRelapse free survivalTyrosine kinase inhibitorsAcute lymphoblastic leukemiaIncidence of CNS relapseMedian relapse free survivalCentral nervous systemCNS diseaseOverall survivalAllo-HCTIntrathecal chemotherapyWhite blood cellsIntensive chemotherapyPost-relapseT315I mutationBaseline characteristicsMedian time to CNS relapseAllogeneic stem cell transplantationAssociated with significant toxicityIncidence of CNS diseaseMedian white blood cellAdequate CNS prophylaxisCentral nervous system penetrationOutcome of an Urban Cohort of North American Adult T-Cell Leukemia/Lymphoma Patients
Qureshi H, Kiwan A, Foss F, Kothari S, Huntington S, Isufi I, Seropian S, Sethi T. Outcome of an Urban Cohort of North American Adult T-Cell Leukemia/Lymphoma Patients. Blood 2024, 144: 6421-6421. DOI: 10.1182/blood-2024-211850.Peer-Reviewed Original ResearchAdult T-cell leukemia/lymphomaWhite blood cellsProgression free survivalWhite blood cell countOverall survivalHuman immunodeficiency virusComplete responseProgressive diseaseATLL patientsHD-MTXInstitutional cohortResponse to first line therapyAdult T-cell leukemia/lymphoma patientsMultivariate analysisMedian progression free survivalMedian time to relapseAllogeneic stem cell transplantationHuman T-cell lymphotropic virus type 1Median age of diagnosisMedian white blood cellMedian overall survivalHigh-dose methotrexateMulti-agent chemotherapyFirst line therapyMedian follow-upIs Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis
Sujijantarat N, Templeton K, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Amllay A, Nowicki K, Huttner A, Giles J, Navaratnam D, Sansing L, Hebert R, King J, Matouk C. Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.124.001426.Peer-Reviewed Original ResearchCause of strokeRed blood cellsWhite blood cellsBlood cellsMechanical thrombectomyCardioembolic groupHistological compositionMeta-analysisLow red blood cellQuantity of red blood cellsRandom-effects meta-analysisAcute ischemic strokeEffects meta-analysisEnglish-language articlesMean percentage differenceAdult patientsMEDLINE databaseCochrane LibraryClinical utilityIschemic strokeLanguage articlesPatientsPercentage differenceArteryCellular compositionPost‐exchange neutrophil count, but not post‐hematocrit, predicts endogenous erythropoiesis in patients with sickle cell disease undergoing chronic red cell exchange
Yurtsever N, Tong N, Geetha S, Nandi V, Shi P. Post‐exchange neutrophil count, but not post‐hematocrit, predicts endogenous erythropoiesis in patients with sickle cell disease undergoing chronic red cell exchange. Transfusion 2024, 64: 2270-2278. PMID: 39404130, DOI: 10.1111/trf.18044.Peer-Reviewed Original ResearchConceptsRed cell exchangeSickle cell diseaseChronic red cell exchangeCell exchangeSickle cell disease morbidityEndogenous erythropoiesisNeutrophil countCell diseaseAbsolute reticulocyte countPost-procedural parametersWhite cell countWhite blood cellsChronic transfusionPre-HCTSustained suppressionReticulocyte countRetrospective analysisWhite cell depletionMale genderCell depletionCell countIsovolemic hemodilutionReticulocytosisBlood cellsPatientsThe human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity
Marin-Lopez A, Huck J, Esterly A, Azcutia V, Rosen C, Garcia-Milian R, Sefik E, Vidal-Pedrola G, Raduwan H, Chen T, Arora G, Halene S, Shaw A, Palm N, Flavell R, Parkos C, Thangamani S, Ring A, Fikrig E. The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity. Science Immunology 2024, 9: eadk9872-eadk9872. PMID: 39121194, PMCID: PMC11924945, DOI: 10.1126/sciimmunol.adk9872.Peer-Reviewed Original ResearchConceptsSuppress antiviral responsesArthropod proteinsPathogen replicationAntiviral responseProtein AVertebrate hostsMosquito salivary proteinsUp-regulatedBlood feedingHuman macrophagesPleomorphic effectsSkin infectionsZika virus disseminationInhibit proinflammatory responsesSalivary proteinsProteinNatural ligandWhite blood cellsHuman skin explantsProinflammatory responseMosquito salivaVirus disseminationHuman CD47Salivary factorsArbovirus infectionModified blood cell GAP model as a prognostic biomarker in idiopathic pulmonary fibrosis
Kreuter M, Lee J, Tzouvelekis A, Oldham J, Molyneaux P, Weycker D, Atwood M, Samara K, Kirchgässler K, Maher T. Modified blood cell GAP model as a prognostic biomarker in idiopathic pulmonary fibrosis. ERJ Open Research 2024, 10: 00666-2023. PMID: 39076530, PMCID: PMC11284599, DOI: 10.1183/23120541.00666-2023.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisWhite blood cellsRed blood cellsNeutrophil countMonocyte countPulmonary fibrosisHemoglobin levelsRandomised phase III trialBaseline white blood cellC-statisticIPF outcomesBlood cellsTrials of pirfenidoneIdiopathic pulmonary fibrosis progressionImprove prediction of outcomeRed blood cell variablesBlood cell countPredictive of outcomeStudy outcomesRed blood cell parametersMortality prediction toolRespiratory-related hospitalisationEosinophil countRetrospective analysisMultivariate analysis
2023
Consensus Recommendations on Peripheral Blood Smear Review: Defining Curricular Standards and Fellow Competency
Chase M, Drews R, Zumberg M, Ellis L, Reid E, Gerds A, Lee A, Hobbs G, Berry J, Freed J. Consensus Recommendations on Peripheral Blood Smear Review: Defining Curricular Standards and Fellow Competency. Blood Advances 2023, 7: 3244-3252. PMID: 36930800, PMCID: PMC10336252, DOI: 10.1182/bloodadvances.2023009843.Peer-Reviewed Original ResearchConceptsPeripheral blood smear reviewPeripheral blood smearAccreditation Council for Graduate Medical EducationConsensus recommendationsDiagnosis of acute leukemiaSignificant patient morbidityBlood smear reviewGraduate Medical EducationGraduate medical education trainingWhite blood cellsThrombotic microangiopathyAcute leukemiaConsensus guidelinesPatient morbiditySmear reviewMedical education trainingMalignant hematologyBlood cellsFellow competencyMedical educationBlood smearsVisuospatial tasksClinical careOne-hour focus groupsStrong consensusFirst-in-human phase 1 dose escalation study of the KAT6 inhibitor PF-07248144 in patients with advanced solid tumors.
Sommerhalder D, Hamilton E, Mukohara T, Yonemori K, Mita M, Yamashita T, Zheng J, Liu L, Maity A, Homji Mishra N, Bogg O, Li M, LoRusso P. First-in-human phase 1 dose escalation study of the KAT6 inhibitor PF-07248144 in patients with advanced solid tumors. Journal Of Clinical Oncology 2023, 41: 1054-1054. DOI: 10.1200/jco.2023.41.16_suppl.1054.Peer-Reviewed Original ResearchWhite blood cellsEndocrine therapyPartial responsePart 1BPhase 1 dose-escalation studyHuman phase 1 studyPreclinical anti-tumor activityDurable partial responseTreatment-related AEsAdvanced solid tumorsDose-escalation studySystemic anticancer therapyPhase 1 studyAnti-tumor activityPart 1AEscalation studyMedian agePrior linesStandard therapyDose escalationCDK4/6 inhibitorsDisease progressionBreast cancerTumor biopsiesG1-2Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity
Hollander M, Malaker S, Riley N, Perez I, Abney N, Gray M, Maxson J, Cochran J, Bertozzi C. Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity. Journal Of Biological Chemistry 2023, 299: 104755. PMID: 37116708, PMCID: PMC10245049, DOI: 10.1016/j.jbc.2023.104755.Peer-Reviewed Original ResearchConceptsProtein domain mappingSingle amino acid mutationLigand-independent activityChronic neutrophilic leukemiaCell surface receptorsAmino acid mutationsColony-stimulating factor 3 receptorSerine residuesPresence of GalNAcHotspot residuesNeutrophilic leukemiaHuman diseasesAcid mutationsReceptor signalingAmino acidsCell growthSurface receptorsReceptor alpha chainMutationsAbundant typeDomain mappingDisease mechanismsUncontrolled activityAlpha chainWhite blood cellsRebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus
Kincer L, Joseph S, Gilleece M, Hauser B, Sizemore S, Zhou S, Di Germanio C, Zetterberg H, Fuchs D, Deeks S, Spudich S, Gisslen M, Price R, Swanstrom R. Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus. Nature Microbiology 2023, 8: 260-271. PMID: 36717718, PMCID: PMC10201410, DOI: 10.1038/s41564-022-01306-6.Peer-Reviewed Original ResearchConceptsCentral nervous systemT cell-tropic virusesInfected T cellsCerebrospinal fluidAntiretroviral therapyHIV-1Rebound virusViral loadT cellsMacrophage-tropic HIV-1CSF viral loadSuppressive antiretroviral therapyHIV-1 reservoirMacrophage-tropic virusesHigh viral loadWhite blood cellsTherapy interruptionLatent reservoirLymphoid systemNervous systemSystemic infectionVirus replicationBlood cellsTransient influxVirus
2022
Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure.
Peng G, Xi Y, Bellini C, Pham K, Zhuang ZW, Yan Q, Jia M, Wang G, Lu L, Tang MS, Zhao H, Wang H. Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure. American Journal Of Cancer Research 2022, 12: 3679-3692. PMID: 36119846, PMCID: PMC9442002.Peer-Reviewed Original ResearchElectronic cigarette exposureCigarette exposureMale ApoE-/- miceApoE-/- miceCytokine mRNA expressionPoor health outcomesWhite blood cellsElectronic cigarette useDose-dependent mannerE-cigarette aerosolAerosol inhalationCigarette smokingActivation of MAPKHigher nicotine concentrationsMAPK pathway activationCell-damaging effectsCpG sitesHealth outcomesCigarette useMRNA expressionNicotine concentrationsPathway activationSignificant CpG sitesBlood cellsSignificant alterationsInfiltrative Disease of the Tubulointerstitium
Aklilu A, Luciano R. Infiltrative Disease of the Tubulointerstitium. 2022, 231-241. DOI: 10.1007/978-3-030-93438-5_18.Peer-Reviewed Original ResearchInfiltrative diseasePlasma cell disordersRenal cell carcinomaRenal tubular cellsWhite blood cellsCancer-targeted therapyKidney injuryPrimary malignancySecondary inflammationTubular damageTubulointerstitial nephritisBronchogenic carcinomaInfiltrative lesionsLymphoproliferative disordersCell carcinomaMetastatic spreadBreast cancerPrimary involvementNormal kidneySolid cancersCell disordersTubular cellsTubular lumenBlood cellsDiseaseCan transfusion-associated graft-versus-host disease (TA-GvHD) be prevented with leukoreduction alone?
Rodriguez JV, Tormey CA. Can transfusion-associated graft-versus-host disease (TA-GvHD) be prevented with leukoreduction alone? Transfusion And Apheresis Science 2022, 61: 103402. PMID: 35288056, DOI: 10.1016/j.transci.2022.103402.Peer-Reviewed Original ResearchConceptsTransfusion-associated graftTA-GVHDHost diseaseCellular blood productsHigh mortality rateWhite blood cellsBlood productsEffective treatmentMortality rateTransfusion communityHigh mortalityMedical literatureBlood cellsDiseaseDevastating diseaseGraftLeukocytesLeukoreductionQuantitative reductionHospitalMortalityEffectiveness of the use of a high-flow nasal cannula to treat COVID-19 patients and risk factors for failure: a meta-analysis
Xu D, Dai B, Tan W, Zhao H, Wang W, Kang J. Effectiveness of the use of a high-flow nasal cannula to treat COVID-19 patients and risk factors for failure: a meta-analysis. Therapeutic Advances In Respiratory Disease 2022, 16: 17534666221091931. PMID: 35467449, PMCID: PMC9047804, DOI: 10.1177/17534666221091931.Peer-Reviewed Original ResearchConceptsHigh-flow nasal cannulaInitiation of high-flow nasal cannulaHigh-flow nasal cannula failureSequential Organ Failure AssessmentRegister of Randomized Controlled TrialsCOVID-19 patientsBody mass indexFailure groupROX indexRisk factorsHigher heart rateWhite blood cellsNasal cannulaChronic Health Evaluation (APACHE) II scoreEfficacy of high-flow nasal cannulaHeart rateDuration of HFNCOdds ratioCochrane Central Register of Randomized Controlled TrialsRisk of HFNC failureHigher white blood cellWhite blood cell countLower ROX indexOrgan Failure AssessmentPooled odds ratio
2021
Relationship of Multiplex Molecular Pneumonia Panel Results With Hospital Outcomes and Clinical Variables
Rand K, Beal S, Cherabuddi K, Houck H, Lessard K, Tremblay E, Couturier B, Lingenfelter B, Rindlisbacher C, Jones J. Relationship of Multiplex Molecular Pneumonia Panel Results With Hospital Outcomes and Clinical Variables. Open Forum Infectious Diseases 2021, 8: ofab368. PMID: 34458392, PMCID: PMC8391091, DOI: 10.1093/ofid/ofab368.Peer-Reviewed Original ResearchPneumonia PanelBronchoalveolar lavageInflammatory responseGroup 1Percent polymorphonuclear leukocytesBioFire FilmArray Pneumonia PanelAntibiotic treatment decisionsConsecutive bronchoalveolar lavagesWhite blood cellsEndotracheal specimensHospital outcomesIll patientsAntimicrobial resistance markersClinical variablesAntibiotic stewardshipMicrobiologic resultsLaboratory turnaround timeTreatment decisionsGroup 2Group 3Drug AdministrationPolymorphonuclear leukocytesPatientsRoutine cultureBlood cellsEstablishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy
Zuo S, Sun L, Wang Y, Chen B, Wang J, Ge X, Lu Y, Yang N, Shen P. Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy. Cell Death & Disease 2021, 12: 208. PMID: 33627636, PMCID: PMC7904926, DOI: 10.1038/s41419-021-03499-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoatesCell LineageCoculture TechniquesGene Expression Regulation, LeukemicHumansHydrazinesJanus KinasesK562 CellsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, NudeMitogen-Activated Protein KinasesPyrazolesReceptors, ThrombopoietinSignal TransductionSTAT Transcription FactorsThrombopoiesisUmbilical CordXenograft Model Antitumor AssaysConceptsChronic myeloid leukemiaTyrosine kinase inhibitorsProgression of CMLCML cellsUC-MSCsDifferentiation therapyCurrent tyrosine kinase inhibitorsTherapeutic potentialMesenchymal stem cell treatmentAcute promyelocytic leukemia (APL) treatmentImmature white blood cellsSevere adverse effectsWhite blood cellsTrans retinoic acidStem cell treatmentStem/progenitor cellsComplete remissionTreatment regimenTumor burdenCML patientsCure rateMAPK signaling pathwaysPeripheral bloodHematopoietic stem/progenitor cellsMyeloid leukemiaClinical, immunophenotypic and genomic findings of NK lymphoblastic leukemia: a study from the Bone Marrow Pathology Group
Weinberg OK, Chisholm KM, Ok CY, Fedoriw Y, Grzywacz B, Kurzer JH, Mason EF, Moser KA, Bhattacharya S, Xu M, Babu D, Foucar K, Tam W, Bagg A, Orazi A, George TI, Wang W, Wang SA, Arber DA, Hasserjian RP. Clinical, immunophenotypic and genomic findings of NK lymphoblastic leukemia: a study from the Bone Marrow Pathology Group. Modern Pathology 2021, 34: 1358-1366. PMID: 33526873, DOI: 10.1038/s41379-021-00739-4.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaAcute undifferentiated leukemiaWhite blood cellsLymphoblastic leukemiaAcute leukemiaBone Marrow Pathology GroupHigher white blood cellEvent-free survivalNatural killer cellsClinical outcome dataNative immune systemMore frequent expressionAUL patientsFree survivalAmbiguous lineageOverall survivalCytoplasmic CD3Leukemia groupClinical presentationHLA-DRKiller cellsPlatelet countProvisional entityCD10 expressionMyeloid leukemia
2020
Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization
Hanson BM, Tao X, Zhan Y, Kim JG, Klimczak AM, Herlihy NS, Scott RT, Seli E. Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization. Fertility And Sterility 2020, 115: 957-965. PMID: 33272640, DOI: 10.1016/j.fertnstert.2020.09.164.Peer-Reviewed Original ResearchConceptsWhite blood cellsPatient ageInfertile womenCumulus cellsBlood cellsEmbryonic aneuploidyPeak estradiol levelsAntimüllerian hormone levelsProspective cohort studyTelomere lengthNumber of oocytesShorter telomere lengthReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHigh rateWarrants further investigationTelomere length assessmentSignificant overlap existsCohort studyOocyte retrievalSingle centerEstradiol levelsInfertile populationMaternal agePolymerase chain reactionPerformance of a Semiquantitative Multiplex Bacterial and Viral PCR Panel Compared With Standard Microbiological Laboratory Results: 396 Patients Studied With the BioFire Pneumonia Panel
Rand K, Beal S, Cherabuddi K, Couturier B, Lingenfelter B, Rindlisbacher C, Jones J, Houck H, Lessard K, Tremblay E. Performance of a Semiquantitative Multiplex Bacterial and Viral PCR Panel Compared With Standard Microbiological Laboratory Results: 396 Patients Studied With the BioFire Pneumonia Panel. Open Forum Infectious Diseases 2020, 8: ofaa560. PMID: 33447631, PMCID: PMC7793460, DOI: 10.1093/ofid/ofaa560.Peer-Reviewed Original ResearchPneumonia PanelLower respiratory tract infectionsRespiratory tract infectionsWhite blood cellsTract infectionsBronchoalveolar lavageAntibiotic stewardshipInflammatory responseMicrobiologic resultsPatient managementCommon bacterial speciesPatientsCulture resultsOptimal managementRapid turnaround timeBlood cellsPCR panelCopy numberClinical laboratoriesAdditional targetsPotential pathogensLaboratory resultsBacterial detectionStandard cultureStainYoung women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model
Hanson BM, Tao X, Zhan Y, Jenkins TG, Morin SJ, Scott RT, Seli EU. Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model. Human Reproduction 2020, 35: 2579-2588. PMID: 33049778, DOI: 10.1093/humrep/deaa206.Peer-Reviewed Original ResearchConceptsPoor ovarian responseWhite blood cellsPolycystic ovary syndromeOvarian responseOvarian stimulationChronologic ageWBC samplesEpigenetic age accelerationCumulus cellsAge accelerationYoung womenSTUDY FUNDING/COMPETINGBlood cellsProspective cohort studyGood responder groupCommon clinical challengePeripheral blood samplesPARTICIPANTS/MATERIALSROLE OF CHANCEYears of agePatient's chronologic ageGeneral health consequencesCC samplesAge-related changesAge prediction model
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