2023
SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication
Meseguer S, Rubio M, Lainez B, Pérez-Benavente B, Pérez-Moraga R, Romera-Giner S, García-García F, Martinez-Macias O, Cremades A, Iborra F, Candelas-Rivera O, Almazan F, Esplugues E. SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication. Frontiers In Microbiology 2023, 14: 1066493. PMID: 36876111, PMCID: PMC9978209, DOI: 10.3389/fmicb.2023.1066493.Peer-Reviewed Original ResearchViral infectionSARS-CoV-2 viral infectionSARS-CoV-2 infectionCOVID-19 patientsMitochondrial antiviral signaling proteinInnate immunity factorsInnate immune responseVero E6 cellsSARS-CoV-2Viral proteinsImmune responseE6 cellsTherapeutic potentialViral replicationInfectionVero E6Immunity factorsSmall viral RNAsCertain virusesProtein 5SERINC5 expressionViral RNAHost expressionDifferent virusesVirus
2021
Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting
Sun Y, Abriola L, Niederer RO, Pedersen SF, Alfajaro MM, Silva Monteiro V, Wilen CB, Ho YC, Gilbert WV, Surovtseva YV, Lindenbach BD, Guo JU. Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2023051118. PMID: 34185680, PMCID: PMC8256030, DOI: 10.1073/pnas.2023051118.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 replicationSARS-CoV-2Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Vero E6 cellsHigh-throughput compound screenOpen reading frame 1bEffective antiviral strategiesCoronavirus 2E6 cellsAntiviral strategiesViral gene expressionCompound screenFluoroquinolone antibacterialsFrame 1bGene expression
2020
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB. Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection. Cell 2020, 184: 76-91.e13. PMID: 33147444, PMCID: PMC7574718, DOI: 10.1016/j.cell.2020.10.028.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2AnimalsCell LineChlorocebus aethiopsClustered Regularly Interspaced Short Palindromic RepeatsCoronavirusCoronavirus InfectionsCOVID-19Gene Knockout TechniquesGene Regulatory NetworksGenome-Wide Association StudyHEK293 CellsHMGB1 ProteinHost-Pathogen InteractionsHumansSARS-CoV-2Vero CellsVirus InternalizationConceptsSARS-CoV-2 infectionSARS-CoV-2Vesicular stomatitis virusGenome-wide CRISPR screenSWI/SNF chromatinSARS-CoV-2 host factorsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionTherapeutic targetHost factorsCoronavirus disease 2019 (COVID-19) pathogenesisSyndrome coronavirus 2 infectionCRISPR screensHost genesGene productsMiddle East respiratory syndrome CoVCoronavirus 2 infectionGenetic hitsHuman cellsSARS-CoV-2 spikeNovel therapeutic targetPotential therapeutic targetVero E6 cellsSARS-CoV-1Small molecule antagonists
2004
Persistent Seoul virus infection in Lewis rats
Compton SR, Jacoby RO, Paturzo FX, Smith AL. Persistent Seoul virus infection in Lewis rats. Archives Of Virology 2004, 149: 1325-1339. PMID: 15221534, PMCID: PMC7087218, DOI: 10.1007/s00705-004-0294-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ViralBrainCells, CulturedDisease ReservoirsEndothelial CellsHantavirus InfectionsHemorrhagic Fever with Renal SyndromeHyperglycemiaIn Situ HybridizationIslets of LangerhansKidneyLiverLungMuscle, Smooth, VascularMyocytes, Smooth MusclePancreasRatsRats, Inbred LewReverse Transcriptase Polymerase Chain ReactionRNA, ViralSalivary GlandsSeoul virusSkinSpleenConceptsSeoul virus infectionVirus infectionDays of ageLewis ratsClinical signsPersistent infectionSeoul virusViral RNAEndothelial cellsVascular smooth muscleVero E6 cellsSmooth muscle cellsCultured rat smooth muscle cellsRat smooth muscle cellsCultured endothelial cellsHantavirus persistencePancreatic infectionAssociated hyperglycemiaCommon siteSmooth muscleAnimal modelsHost cell typesE6 cellsExperimental infectionInfectious virus
1995
Isolation of black creek canal virus, a new hantavirus from Sigmodon hispidus in Florida
Rollin P, Ksiazek T, Elliott L, Ravkov E, Martin M, Morzunov S, Livingstone W, Monroe M, Glass G, Ruo S, Khan A, Childs J, Nichol S, Peters C. Isolation of black creek canal virus, a new hantavirus from Sigmodon hispidus in Florida. Journal Of Medical Virology 1995, 46: 35-39. PMID: 7623004, DOI: 10.1002/jmv.1890460108.Peer-Reviewed Original ResearchConceptsBlack Creek Canal virusReverse transcriptase-polymerase chain reaction assaysNew hantavirusCotton ratsTranscriptase-polymerase chain reaction assaysVero E6 cellsHantavirus pulmonary syndrome casesVirologic studiesChain reaction assaysHantavirus antigensHigh seroprevalenceSyndrome casesE6 cellsSpleen homogenatesRT-PCRReaction assaysDirect RT-PCRVirusSerologic relationshipHantavirusesRatsRodentsSigmodon hispidusDade CountySeroprevalence
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