2025
Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver
Gursan A, de Graaf R, Thomas M, Prompers J, De Feyter H. Deuterium MRS for In Vivo Measurement of Lipogenesis in the Liver. NMR In Biomedicine 2025, 38: e70014. PMID: 39994887, DOI: 10.1002/nbm.70014.Peer-Reviewed Original ResearchConceptsH-MRSHepatic DNLMRS dataLiver tissueMeasurement of lipogenesisDietary interventionLiver lipidsHepatic de novo lipogenesisLow density lipoproteinDetection of deuteriumGold standard measureMetabolic diseasesIncreased hepatic DNLLiverDensity lipoproteinDrinking waterDeuterium labelingIn vivo measurementsNMR dataExcised liver tissueTissueDeuteriumMRSMethylene resonancesDeuterated waterIntegrated control of leukocyte compartments as a feature of adaptive physiology
Jaschke N, Wang A. Integrated control of leukocyte compartments as a feature of adaptive physiology. Immunity 2025, 58: 279-294. PMID: 39909034, DOI: 10.1016/j.immuni.2025.01.013.Peer-Reviewed Original ResearchAge-invariant genes: multi-tissue identification and characterization of murine reference genes
González J, Thrush-Evensen K, Meer M, Levine M, Higgins-Chen A. Age-invariant genes: multi-tissue identification and characterization of murine reference genes. Aging 2025, 17: 170-202. PMID: 39888841, PMCID: PMC11810059, DOI: 10.18632/aging.206195.Peer-Reviewed Original ResearchRNA-seq datasetsReference genesRNA-seqHallmarks of agingPathway enrichment analysisGenes-thoseCpG islandsShorter transcriptRT-qPCRMolecular functionsExpression studiesGene normalizationTissue-specificEnrichment analysisMouse tissuesGenesMurine tissuesAged tissuesHallmarksYoung organismsLifespanTranscriptionCpGTissuePathwayAge-invariant genes: multi-tissue identification and characterization of murine reference genes
González J, Thrush-Evensen K, Meer M, Levine M, Higgins-Chen A. Age-invariant genes: multi-tissue identification and characterization of murine reference genes. Aging 2025, 17: 170-202. PMID: 39873648, PMCID: PMC11810070, DOI: 10.18632/aging.206192.Peer-Reviewed Original ResearchConceptsRNA-seq datasetsReference genesRNA-seqHallmarks of agingPathway enrichment analysisGenes-thoseCpG islandsShorter transcriptRT-qPCRMolecular functionsExpression studiesGene normalizationTissue-specificEnrichment analysisMouse tissuesGenesMurine tissuesAged tissuesHallmarksYoung organismsLifespanTranscriptionCpGTissuePathwaySpike Ripples: Hidden Clues to the Mystery of the Epileptogenic Zone.
Quraishi I. Spike Ripples: Hidden Clues to the Mystery of the Epileptogenic Zone. Epilepsy Currents 2025, 15357597241306610. PMID: 39780979, PMCID: PMC11705290, DOI: 10.1177/15357597241306610.Peer-Reviewed Original ResearchSpike ripplesFast ripplesInterictal biomarkerSurgical resectionEpileptogenic zoneMulticentre cohortResection volumePersistent seizuresEpileptogenic tissueILA-1Ripple rateImproved biomarkersSubjective outcomesEpileptiform spikesProportion of spikesResectionSubdural electrodesBiomarkersEpileptogenicityHigh-frequency oscillationsOutcomesILASubjectsIntracranial electroencephalogramTissue
2024
Metabolic complementation between cells drives the evolution of tissues and organs
Pavlicev M, DiFrisco J, Love A, Wagner G. Metabolic complementation between cells drives the evolution of tissues and organs. Biology Letters 2024, 20: 20240490. PMID: 39561800, PMCID: PMC11583983, DOI: 10.1098/rsbl.2024.0490.Peer-Reviewed Original ResearchConceptsMetabolic complementationEvolutionary transitionsCell typesSpecialized cell typesConstituent cell typesMetabolic constraintsMetabolic burdenCellular metabolismEvolution of tissuesSpecialized cellsSpecialized tissuesLevels of organizationCellsComplementOrganizationTissueNervous systemTypeMetabolismAchieving Adherence With NCCN Guidelines for Nonmelanoma Skin Cancer Regarding Peripheral and Deep En Face Margin Assessment (PDEMA).
Xu Y, Lim Y, Bordeaux J, Aasi S, Alam M, Chen P, Contreras C, DiMaio D, Donigan J, Farma J, Grekin R, Mark L, Nehal K, Nghiem P, Olino K, Patel T, Scott J, Shaha A, Srivastava D, Schmults C. Achieving Adherence With NCCN Guidelines for Nonmelanoma Skin Cancer Regarding Peripheral and Deep En Face Margin Assessment (PDEMA). Journal Of The National Comprehensive Cancer Network 2024, 22 PMID: 39536442, DOI: 10.6004/jnccn.2024.7037.Peer-Reviewed Original ResearchConceptsMargin assessmentCell carcinomaNCCN GuidelinesHigh-risk basal cell carcinomasCutaneous squamous cell carcinomaDeep margin assessmentMohs micrographic surgerySquamous cell carcinomaBasal cell carcinomaNonmelanoma skin cancerMicrographic surgeryDermatofibrosarcoma protuberansCure rateOptimal patient outcomesUninvolved tissueAccurate resectionSkin cancerPatient outcomesNCCNCarcinomaHistological visualizationMarginal surfacesTissueCCPDMAResectionA brave new framework for glioma drug development
Hotchkiss K, Karschnia P, Schreck K, Geurts M, Cloughesy T, Huse J, Duke E, Lathia J, Ashley D, Nduom E, Long G, Singh K, Chalmers A, Ahluwalia M, Heimberger A, Bagley S, Todo T, Verhaak R, Kelly P, Hervey-Jumper S, de Groot J, Patel A, Fecci P, Parney I, Wykes V, Watts C, Burns T, Sanai N, Preusser M, Tonn J, Drummond K, Platten M, Das S, Tanner K, Vogelbaum M, Weller M, Whittle J, Berger M, Khasraw M. A brave new framework for glioma drug development. The Lancet Oncology 2024, 25: e512-e519. PMID: 39362262, DOI: 10.1016/s1470-2045(24)00190-6.Peer-Reviewed Original ResearchConceptsBrain tumorsBenefits of biopsyBrain tumor therapyLiquid biopsy technologiesTissue samplesPostoperative deficitsBiopsy techniqueBiopsy technologyEffective therapySurgical trialsClinical trialsTumor therapyResistance mechanismsTumorTherapyPatientsDrug developmentTissue analysisBrainTrialsTissueBiopsyGliomaRegulatory agenciesCell signaling and tissue remodeling in the pulmonary autograft after the Ross procedure: A computational study
Maes L, Vervenne T, Hendrickx A, Estrada A, Van Hoof L, Verbrugghe P, Rega F, Jones E, Humphrey J, Famaey N. Cell signaling and tissue remodeling in the pulmonary autograft after the Ross procedure: A computational study. Journal Of Biomechanics 2024, 171: 112180. PMID: 38906711, DOI: 10.1016/j.jbiomech.2024.112180.Peer-Reviewed Original ResearchRoss procedurePulmonary autograftPatient's pulmonary valveTranscription factorsPulmonary valveSmooth muscleActivation of genesAortic positionRelevant transcription factorsTissue remodelingAutograftExcessive dilatationTranscriptome dataGene activationCell signalingSignaling pathwayTarget genesMultiscale modelGenesTissueCellsFailure mechanismCell-scaleMechanical propertiesCell-scale modelSenNet recommendations for detecting senescent cells in different tissues
Suryadevara V, Hudgins A, Rajesh A, Pappalardo A, Karpova A, Dey A, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver C, Aguayo-Mazzucato C, Baker D, Bernlohr D, Jurk D, Mangarova D, Quardokus E, Enninga E, Schmidt E, Chen F, Duncan F, Cambuli F, Kaur G, Kuchel G, Lee G, Daldrup-Link H, Martini H, Phatnani H, Al-Naggar I, Rahman I, Nie J, Passos J, Silverstein J, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer L, Ding L, Wang L, Adams L, Ruiyang L, Doolittle M, Teneche M, Schafer M, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez P, Vasilikos P, Adams P, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery R, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic V, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. SenNet recommendations for detecting senescent cells in different tissues. Nature Reviews Molecular Cell Biology 2024, 25: 1001-1023. PMID: 38831121, PMCID: PMC11578798, DOI: 10.1038/s41580-024-00738-8.Peer-Reviewed Original ResearchSenescent cellsDetect senescent cellsIrreversible cell cycle arrestCellular senescenceCell cycle arrestSenescence markersBiomarker Working GroupCycle arrestCellular senescence markersBiological processesCell biologyPostmitotic cellsSenescent phenotypeCirculating markersTissue culture studiesSenescence signatureSenescenceCellsMorphological featuresDetrimental roleTissueMarkersSeasonal investigationSpatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densities
Janeiro A, Wong E, Jiménez-Sánchez D, de Solorzano C, Lozano M, Teijeira A, Schalper K, Melero I, De Andrea C. Spatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densities. Journal For ImmunoTherapy Of Cancer 2024, 12: e008589. PMID: 38821717, PMCID: PMC11149121, DOI: 10.1136/jitc-2023-008589.Peer-Reviewed Original ResearchPrenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Rivero R, Stitelman D. Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery. Current Stem Cell Reports 2024, 10: 51-57. DOI: 10.1007/s40778-024-00237-8.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaDiaphragmatic herniaAnimal modelsIntra-amniotic injectionLong-term functional outcomeParticle-based deliveryFetal therapyPrenatal therapySpinal defectsTarget specific tissuesCo-morbiditiesCongenital diseaseFunctional outcomesTreatment deliveryStructural diseaseClinical translationMyelomeningoceleTherapyHerniaSpecific tissuesTissueDiseaseDeliveryPrenatallyParticle deliveryAdiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023
Burak M, Stanley T, Lawson E, Campbell S, Lynch L, Hasty A, Domingos A, Dixit V, Hotamışlıgil G, Sheedy F, Dixon A, Brinkley T, Hill J, Donath M, Grinspoon S. Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023. American Journal Of Clinical Nutrition 2024, 120: 257-268. PMID: 38705359, PMCID: PMC11347817, DOI: 10.1016/j.ajcnut.2024.04.029.Peer-Reviewed Original ResearchLow-grade systemic inflammationChronic low-grade inflammationLocal immune environmentAdipose tissueLow-grade inflammationEffect of obesityObesity Research CenterPro-inflammatory pathwaysOutcome of metabolic diseasesImmune environmentSystemic inflammationHealth and DiseaseTreatment therapiesInflammationMultifaceted effectsDisease severityMetabolic diseasesImmunometabolic diseasesImmunityAdiposeDiseaseReduced disease severityObesityTissueDisrupting cellular homeostasis125. The Retention of Significant Vaginal Lengthening with a Novel Vaginal Expansion Device
Colvin J, Meyer H, O'Quin C, Welch V, Solitro G, Shah-Bruce M, Alexander J, Sorrells D. 125. The Retention of Significant Vaginal Lengthening with a Novel Vaginal Expansion Device. Journal Of Pediatric And Adolescent Gynecology 2024, 37: 300. DOI: 10.1016/j.jpag.2024.01.132.Peer-Reviewed Original ResearchVaginal tissueVaginal canalCanal lengthVaginal lengthVaginal dilator therapyPost removalMullerian agenesisResin capVaginal atresiaWeeks of recoveryDilation therapySurgical vaginoplastyCongenital absenceWeeks post-removalChronic inflammationRe-implantationHistological examinationHistological changesHistological analysisTissue contractionWeeksCanalTissueVaginoplastyAgenesisMechanosensing regulates tissue repair program in macrophages
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.Peer-Reviewed Original ResearchConceptsExtracellular matrixRegulate chromatin accessibilityTissue repair programGene expression programsCytoskeletal dynamicsChromatin accessibilityAmoeboid migrationCytoskeletal remodelingBiochemical signalsTissue homeostasisExpression programsColony-stimulating factor-1Tissue-resident macrophagesFactor 1MechanosensingRegulating tissue repairTissue integrityMacrophagesTissueThree-dimensional environmentRepair programHomeostasisCorrelation of telomere length in brain tissue with peripheral tissues in living human subjects
Carver A, Hing B, Elser B, Lussier S, Yamanashi T, Howard M, Kawasaki H, Shinozaki G, Stevens H. Correlation of telomere length in brain tissue with peripheral tissues in living human subjects. Frontiers In Molecular Neuroscience 2024, 17: 1303974. PMID: 38516039, PMCID: PMC10954899, DOI: 10.3389/fnmol.2024.1303974.Peer-Reviewed Original ResearchCorrelation of telomere lengthPeripheral tissuesTissue telomere lengthTelomere lengthDisorder pathophysiologyAssessed telomere lengthBuccal telomere lengthBrain disordersHuman brainBrainIntractable epilepsyLiving human subjectsBrain samplesAverage telomere lengthTime pointsTissue samplesBrain tissueChromosome stabilityTissueHuman subjectsSalivaLiving subjectsSubjectsTransmembrane pH gradient imaging in rodent glioma models
Mishra S, Santana J, Mihailovic J, Hyder F, Coman D. Transmembrane pH gradient imaging in rodent glioma models. NMR In Biomedicine 2024, 37: e5102. PMID: 38263680, PMCID: PMC10987279, DOI: 10.1002/nbm.5102.Peer-Reviewed Original ResearchNormal tissuesRodent glioma modelsGL261 gliomasU87 gliomasTumor microenvironmentPotential therapeutic targetGlioma modelTumor survivalExtracellular acidosisTumorMetabolic reprogrammingRegulate drug deliveryIntracellular pHRat brainExtracellular pHTherapeutic targetGliomaMouse brainDrug deliveryIntracellular milieuTransmembrane pH gradientBrainSubmillimeter resolutionTissueCells
2023
Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection
Torcellan T, Friedrich C, Doucet-Ladevèze R, Ossner T, Solé V, Riedmann S, Ugur M, Imdahl F, Rosshart S, Arnold S, de Agüero M, Gagliani N, Flavell R, Backes S, Kastenmüller W, Gasteiger G. Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection. Immunity 2023, 57: 124-140.e7. PMID: 38157853, PMCID: PMC10783803, DOI: 10.1016/j.immuni.2023.11.018.Peer-Reviewed Original ResearchConceptsNK cellsTrNK cellsAcute infectionTissue residencySecondary infectionTissue-resident NK cellsConventional NK cellsDistinct developmental requirementsNK cell responsesNatural killer cellsTranscriptional regulator Blimp1Effector cellsKiller cellsCNK cellsPrevious infectionEffector responsesEffector functionsBacterial infectionsCell responsesInfectionRestricted expressionTerms of ontogenyTissueCell formationHuman tissuesReframing macrophage diversity with network motifs
Pizzurro G, Miller-Jensen K. Reframing macrophage diversity with network motifs. Trends In Immunology 2023, 44: 965-970. PMID: 37949786, PMCID: PMC11057955, DOI: 10.1016/j.it.2023.10.009.Commentaries, Editorials and LettersConceptsNetwork motifsDistinct biological functionsSystems biology conceptsMacrophage stateMacrophage responseBiological functionsMacrophage diversityExtracellular networkMacrophage activationDisease contextsMotifLocal molecular interactionsMolecular interactionsFunctional modulesBiology conceptsDiversityActivationTissueIntracellularResponseProgress on the Endometrium
Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.Peer-Reviewed Original ResearchConceptsAbsence of pregnancyEvidence-based approachEndometrial assessmentStromal maturationEndometrial proliferationEndometrial pathologyInflammatory mediatorsOvarian steroidsImplantation failureBlastocyst implantationEndometrial sloughingDiagnostic measuresEndometriumOffer hopeDynamic tissueDevelopmental markersSingle testTissueInternal reproductionMaturationEndometriosisPregnancyDecidualizationInfertilityUterus
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