2023
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection
Wei J, Patil A, Collings C, Alfajaro M, Liang Y, Cai W, Strine M, Filler R, DeWeirdt P, Hanna R, Menasche B, Ökten A, Peña-Hernández M, Klein J, McNamara A, Rosales R, McGovern B, Luis Rodriguez M, García-Sastre A, White K, Qin Y, Doench J, Yan Q, Iwasaki A, Zwaka T, Qi J, Kadoch C, Wilen C. Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. Nature Genetics 2023, 55: 471-483. PMID: 36894709, PMCID: PMC10011139, DOI: 10.1038/s41588-023-01307-z.Peer-Reviewed Original ResearchConceptsMSWI/SNF complexesAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionHost-directed therapeutic targetSyndrome coronavirus 2 infectionSARS-CoV-2 infectionSWItch/Sucrose Non-Fermentable (SWI/SNF) chromatinSARS-CoV-2 susceptibilityNon-fermentable (SWI/SNF) chromatinCoronavirus 2 infectionEnzyme 2 (ACE2) expressionSARS-CoV-2 variantsHuman cell typesPrimary human cell typesAirway epithelial cellsDrug-resistant variantsNew drug targetsChromatin accessibilitySNF complexACE2 locusACE2 expressionFactor complexHost determinantsTherapeutic targetConfer resistance
2021
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
D’Antonio M, Nguyen J, Arthur T, Matsui H, Neale B, Daly M, Ganna A, Stevens C, Pathak G, Andrews S, Kanai M, Cordioli M, Ganna A, Karjalainen J, Pathak G, Polimanti R, Andrews S, Cordioli M, Pirinen M, Kanai M, Harerimana N, Veerapen K, Wolford B, Nguyen H, Solomonson M, Stevens C, Liao R, Chwialkowska K, Trankiem A, Balaconis M, Hayward C, Richmond A, Campbell A, Morris M, Fawns-Ritchie C, Glessner J, Shaw D, Chang X, Polikowski H, Lauren E, Chen H, Wanying Z, Hakonarson H, Porteous D, Below J, North K, McCormick J, Timmers P, Wilson J, Tenesa A, D’Mellow K, Kerr S, Niemi M, Cordioli M, Nkambul L, von Hohenstaufen K, Sobh A, Eltoukhy M, Yassen A, Hegazy M, Okasha K, Eid M, Moahmed H, Shahin D, El-Sherbiny Y, Elhadidy T, Elghafar M, El-Jawhari J, Mohamed A, Elnagdy M, Samir A, Abdel-Aziz M, Khafaga W, El-Lawaty W, Torky M, El-shanshory M, Batini C, Lee P, Shrine N, Williams A, Tobin M, Guyatt A, John C, Packer R, Ali A, Free R, Wang X, Wain L, Hollox E, Venn L, Bee C, Adams E, Niemi M, Niavarani A, Cordioli M, Nkambul L, Sharififard B, Aliannejad R, Amirsavadkouhi A, Naderpour Z, Tadi H, Aleagha A, Ahmadi S, Moghaddam S, Adamsara A, Saeedi M, Abdollahi H, Hosseini A, Chariyavilaskul P, Chamnanphon M, Suttichet T, Shotelersuk V, Pongpanich M, Phokaew C, Chetruengchai W, Jantarabenjakul W, Putchareon O, Torvorapanit P, Puthanakit T, Suchartlikitwong P, Hirankarn N, Nilaratanakul V, Sodsai P, Brumpton B, Hveem K, Willer C, Wolford B, Zhou W, Rogne T, Solligard E, Åsvold B, Abedalthagafi M, Alaamery M, Alqahtani S, Baraka D, Al Harthi F, Alsolm E, Abu Safieh L, Alowayn A, Alqubaishi F, Al Mutairi A, Mangul S, Alshareef A, Sawaji M, Almutairi M, Aljawini N, Albesher N, Arabi Y, Mahmoud E, Khattab A, Halawani R, Alahmadey Z, Albakri J, Felemban W, Suliman B, Hasanato R, Al-Awdah L, Alghamdi J, AlZahrani D, AlJohani S, Al-Afghani H, Alrashed M, AlDhawi N, AlBardis H, Alkwai S, Alswailm M, Almalki F, Albeladi M, Almohammed I, Barhoush E, Albader A, Massadeh S, AlMalik A, Alotaibi S, Alghamdi B, Jung J, Fawzy M, Lee Y, Magnus P, Trogstad L, Helgeland Ø, Harris J, Mangino M, Spector T, Emma D, Smieszek S, Przychodzen B, Polymeropoulos C, Polymeropoulos V, Polymeropoulos M, Fernandez-Cadenas I, Perez-Tur J, Llucià-Carol L, Cullell N, Muiño E, Cárcel-Márquez J, DeDiego M, Iglesias L, Planas A, Soriano A, Rico V, Agüero D, Bedini J, Lozano F, Domingo C, Robles V, Ruiz-Jaén F, Márquez L, Gomez J, Coto E, Albaiceta G, García-Clemente M, Dalmau D, Arranz M, Dietl B, Serra-Llovich A, Soler P, Colobrán R, Martín-Nalda A, Martínez A, Bernardo D, Rojo S, Fiz-López A, Arribas E, de la Cal-Sabater P, Segura T, González-Villa E, Serrano-Heras G, Martí-Fàbregas J, Jiménez-Xarrié E, de Felipe Mimbrera A, Masjuan J, García-Madrona S, Domínguez-Mayoral A, Villalonga J, Menéndez-Valladares P, Chasman D, Buring J, Ridker P, Franco G, Sesso H, Manson J, Chang X, Glessner J, Hakonarson H, Hayward C, Richmond A, Porteous D, Campbell A, Fawns-Ritchie C, Medina-Gomez C, Uitterlinden A, Ikram M, Kristiansson K, Koskelainen S, Perola M, Donner K, Kivinen K, Palotie A, Ripatti S, Ruotsalainen S, Kaunisto M, FinnGen, Nakanishi T, Butler-Laporte G, Forgetta V, Morrison D, Ghosh B, Laurent L, Belisle A, Henry D, Abdullah T, Adeleye O, Mamlouk N, Kimchi N, Afrasiabi Z, Vulesevic N, Bouab M, Guzman C, Petitjean L, Tselios C, Xue X, Schurr E, Afilalo J, Afilalo M, Oliveira M, Brenner B, Lepage P, Ragoussis J, Auld D, Brassard N, Durand M, Chassé M, Kaufmann D, Lathrop G, Mooser V, Richards J, Li R, Adra D, Rahmouni S, Georges M, Moutschen M, Misset B, Darcis G, Guiot J, Guntz J, Azarzar S, Gofflot S, Beguin Y, Claassen S, Malaise O, Huynen P, Meuris C, Thys M, Jacques J, Léonard P, Frippiat F, Giot J, Sauvage A, Von Frenckell C, Belhaj Y, Lambermont B, Niemi M, Cordioli M, Pigazzini S, Nkambule L, Daya M, Shortt J, Rafaels N, Wicks S, Crooks K, Barnes K, Gignoux C, Chavan S, Laisk T, Läll K, Lepamets M, Mägi R, Esko T, Reimann E, Milani L, Alavere H, Metsalu K, Puusepp M, Metspalu A, Naaber P, Laane E, Pesukova J, Peterson P, Kisand K, Tabri J, Allos R, Hensen K, Starkopf J, Ringmets I, Tamm A, Kallaste A, Bochud P, Rivolta C, Bibert S, Quinodoz M, Kamdar D, Boillat N, Nussle S, Albrich W, Suh N, Neofytos D, Erard V, Voide C, FHoGID, RegCOVID, P-PredictUs, SeroCOVID, CRiPSI, de Cid R, Galván-Femenía I, Blay N, Carreras A, Cortés B, Farré X, Sumoy L, Moreno V, Mercader J, Guindo-Martinez M, Torrents D, Kogevinas M, Garcia-Aymerich J, Castaño-Vinyals G, Dobaño C, Renieri A, Mari F, Fallerini C, Daga S, Benetti E, Baldassarri M, Fava F, Frullanti E, Valentino F, Doddato G, Giliberti A, Tita R, Amitrano S, Bruttini M, Croci S, Meloni I, Mencarelli M, Rizzo C, Pinto A, Beligni G, Tommasi A, Di Sarno L, Palmieri M, Carriero M, Alaverdian D, Busani S, Bruno R, Vecchia M, Belli M, Picchiotti N, Sanarico M, Gori M, Furini S, Mantovani S, Ludovisi S, Mondelli M, Castelli F, Quiros-Roldan E, Degli Antoni M, Zanella I, Vaghi M, Rusconi S, Siano M, Montagnani F, Emiliozzi A, Fabbiani M, Rossetti B, Bargagli E, Bergantini L, D’Alessandro M, Cameli P, Bennett D, Anedda F, Marcantonio S, Scolletta S, Franchi F, Mazzei M, Guerrini S, Conticini E, Cantarini L, Frediani B, Tacconi D, Spertilli C, Feri M, Donati A, Scala R, Guidelli L, Spargi G, Corridi M, Nencioni C, Croci L, Bandini M, Caldarelli G, Piacentini P, Desanctis E, Cappelli S, Canaccini A, Verzuri A, Anemoli V, Ognibene A, Pancrazzi A, Lorubbio M, Monforte A, Miraglia F, Girardis M, Venturelli S, Cossarizza A, Antinori A, Vergori A, Gabrieli A, Riva A, Francisci D, Schiaroli E, Paciosi F, Scotton P, Andretta F, Panese S, Scaggiante R, Gatti F, Parisi S, Baratti S, Della Monica M, Piscopo C, Capasso M, Russo R, Andolfo I, Iolascon A, Fiorentino G, Carella M, Castori M, Merla G, Squeo G, Aucella F, Raggi P, Marciano C, Perna R, Bassetti M, Di Biagio A, Sanguinetti M, Masucci L, Valente S, Mandalà M, Giorli A, Salerni L, Zucchi P, Parravicini P, Menatti E, Trotta T, Giannattasio F, Coiro G, Lena F, Coviello D, Mussini C, Martinelli E, Mancarella S, Tavecchia L, Crotti L, Gabbi C, Rizzi M, Maggiolo F, Ripamonti D, Bachetti T, La Rovere M, Sarzi-Braga S, Bussotti M, Ceri S, Pinoli P, Raimondi F, Biscarini F, Stella A, Zguro K, Capitani K, Suardi C, Niemi M, Cordioli M, Pigazzini S, Dei S, Parati G, Ravaglia S, Artuso R, Cordioli M, Pigazzini S, Nkambule L, Bottà G, Di Domenico P, Rancan I, Bianchi A, Romani D, Bergomi P, Catena E, Colombo R, Tanfoni M, Vincenti A, Ferri C, Grassi D, Pessina G, Tumbarello M, Di Pietro M, Sabrina R, Luchi S, Barbieri C, Acquilini D, Andreucci E, Paciosi F, Segala F, Tiseo G, Falcone M, Lista M, Poscente M, De Vivo O, Petrocelli P, Guarnaccia A, Baroni S, Smith A, Boughton A, Li K, LeFaive J, Annis A, Justice A, Mirshahi T, Chittoor G, Josyula N, Kosmicki J, Ferreira M, Leader J, Carey D, Gass M, Horowitz J, Cantor M, Yadav A, Baras A, Abecasis G, van Heel D, Hunt K, Mason D, Huang Q, Finer S, Team G, Trivedi B, Griffiths C, Martin H, Wright J, Trembath R, Soranzo N, Zhao J, Butterworth A, Danesh J, Di Angelantonio E, Boezen L, Deelen P, Claringbould A, Lopera E, Warmerdam R, Vonk J, van Blokland I, Lanting P, Ori A, Zöllner B, Wang J, Beck A, Peloso G, Ho Y, Sun Y, Huffman J, O’Donnell C, Cho K, Tsao P, Gaziano J, Nivard M, de geus E, Bartels M, Hottenga J, Weiss S, Karlson E, Smoller J, Green R, Feng Y, Mercader J, Murphy S, Meigs J, Woolley A, Perez E, Rader D, Verma A, Ritchie M, Li B, Verma S, Lucas A, Bradford Y, Zeberg H, Frithiof R, Hultström M, Niemi M, Cordioli M, Pigazzini S, Lipcsey M, Nkambul L, Tardif N, Rooyackers O, Grip J, Maricic T, Nakanishi T, Butler-Laporte G, Forgetta V, Richards J, Karczewski K, Atkinson E, Kanai M, Tsuo K, Baya N, Turley P, Gupta R, Callier S, Walters R, Palmer D, Sarma G, Solomonson M, Cheng N, Lu W, Bryant S, Churchhouse C, Cusick C, Goldstein J, King D, Zhou W, Seed C, Finucane H, Martin A, Bryant S, Satterstrom F, Wilson D, Armstrong J, Rudkin J, Band G, Earle S, Lin S, Arning N, Crook D, Wyllie D, O’Connell A, Spencer C, Koelling N, Caulfield M, Scott R, Fowler T, Moutsianas L, Kousathanas A, Pasko D, Walker S, Rendon A, Stuckey A, Odhams C, Rhodes D, Chan G, Arumugam P, Ball C, Hong E, Rand K, Girshick A, Guturu H, Baltzell A, Roberts G, Park D, Coignet M, McCurdy S, Knight S, Partha R, Rhead B, Zhang M, Berkowitz N, Gaddis M, Noto K, Ruiz L, Pavlovic M, Sloofman L, Andrews S, Charney A, Beckmann N, Schadt E, Jordan D, Thompson R, Gettler K, Abul-Husn N, Ascolillo S, Buxbaum J, Chaudhary K, Cho J, Itan Y, Kenny E, Belbin G, Sealfon S, Sebra R, Salib I, Collins B, Levy T, Britvan B, Keller K, Tang L, Peruggia M, Hiester L, Niblo K, Aksentijevich A, Labkowsky A, Karp A, Zlatopolsky M, Preuss M, Loos R, Nadkarni G, Do R, Hoggart C, Choi S, Underwood S, O’Reilly P, Huckins L, Zyndorf M, D’Antonio-Chronowska A, Frazer K. SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues. Cell Reports 2021, 37: 110020. PMID: 34762851, PMCID: PMC8563343, DOI: 10.1016/j.celrep.2021.110020.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingComputational BiologyCOVID-19Databases, GeneticEthnicityGene ExpressionGene Expression ProfilingGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansOrgan SpecificityPolymorphism, Single NucleotideQuantitative Trait LociSARS-CoV-2Severity of Illness IndexTranscriptomeConceptsExpression quantitative trait lociGenome-wide association study signalsTissue/cell typesQuantitative trait lociGenetic fine mappingGene expression levelsLoci colocalizeGenomic lociGWAS lociTrait lociFine mappingVariety of tissuesCausal SNPsGene expressionSNP setsStudy signalsLociCell typesSARS-CoV-2 susceptibilityGenetic variantsSuggestive associationExpression levelsTissue typesSNPsCredible sets
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply