2025
Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA (PAX LC): a double-blind, randomised, placebo-controlled, phase 2, decentralised trial
Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li S, Herrin J, Christian D, Coppi A, Warner F, Holub J, Henriquez Y, Johnson M, Goddard T, Rocco E, Hummel A, Mouslmani M, Hooper W, Putrino D, Carr K, Charnas L, De Jesus M, Nepert D, Abreu P, Ziegler F, Spertus J, Iwasaki A, Krumholz H. Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA (PAX LC): a double-blind, randomised, placebo-controlled, phase 2, decentralised trial. The Lancet Infectious Diseases 2025 PMID: 40188838, DOI: 10.1016/s1473-3099(25)00073-8.Peer-Reviewed Original ResearchPhysical health summary scoreBaseline to dayAdverse eventsNirmatrelvir-ritonavirSARS-CoV-2 infectionDouble-blindStudy drug-related treatment-emergent adverse eventsDrug-related treatment-emergent adverse eventsTreatment-emergent adverse eventsIntention-to-treat populationWeek 6Baseline to week 6Documented SARS-CoV-2 infectionActive liver diseaseEffective pharmacological interventionsLong COVIDAcute medical illnessSafety populationPatient-Reported Outcomes Measurement Information SystemEarly treatment terminationRenal impairmentTreat long-COVIDPlacebo-controlledEfficacy endpointRandomised controlled trialsIn the time of COVID-19: challenges, successes and lessons learned from studies in cancer patients
Mack P, Crawford J, Chang A, Yin A, Klein S, Shea P, Hirsch F, Zidar D, Simon V, Gleason C, McBride R, Cordon-Cardo C, VanOudenhove J, Halene S, Lee F, Mantis N, Kushi L, Weiskopf D, Merchant A, Reckamp K, Skarbinski J, Figueiredo J. In the time of COVID-19: challenges, successes and lessons learned from studies in cancer patients. Journal Of The National Cancer Institute 2025, djaf073. PMID: 40127178, DOI: 10.1093/jnci/djaf073.Peer-Reviewed Original ResearchChanging public health landscapePublic health landscapeEnrollment of participantsSARS-CoV-2National Cancer InstituteRisk of SARS-CoV-2 infectionU.S. National Cancer InstituteNational Institute of AllergyOverall healthHealth landscapeSelf-reportCohort studyStudy designBiospecimen collectionInstitute of AllergySARS-CoV-2 infectionCancer InstituteStandard serological testsData elementsStudy immune responsesHematologic malignanciesClinicopathological dataNational InstituteCancer patientsCOVID-19Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative
Mandel H, Shah S, Bailey L, Carton T, Chen Y, Esquenazi-Karonika S, Haendel M, Hornig M, Kaushal R, Oliveira C, Perlowski A, Pfaff E, Rao S, Razzaghi H, Seibert E, Thomas G, Weiner M, Thorpe L, Divers J, Cohort R. Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative. Journal Of Medical Internet Research 2025, 27: e59217. PMID: 40053748, PMCID: PMC11923460, DOI: 10.2196/59217.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record dataPostacute sequelae of SARS-CoV-2 infectionSequelae of SARS-CoV-2 infectionElectronic health record systemsHealth record systemsLong COVIDHealth recordsEHR dataEpidemiological researchRecording systemPostacute sequelaeMultifaceted conditionNational InstituteSARS-CoV-2 infectionData sourcesCOVID researchCOVIDInitiationNationalOpportunitiesData2024 Update of the RECOVER-Adult Long COVID Research Index
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Cheng D, Chibnik L, Ciriello M, Costenbader K, Dimitrov D, Estiri H, Fayad M, Feldman C, Gainer V, Ghosh B, Gollub R, Guan Z, Harris A, Helmer K, Hendrix A, Holzbach A, Huang W, Kaufman D, Keogh D, Kerr J, Klann J, Krishnamoorthy A, Lasky-Su J, Liao K, MacFadden D, Maram A, Martel M, Mendis M, Metta R, Monteiro J, Morales E, Morse R, Nazaire M, Neils G, Nguyen A, Norman J, Paik H, Pant D, Park H, Rabideau D, Reeder H, Rossi-Roh K, Santacroce L, Schlepphorst K, Schulte C, Selvaggi C, Shinnick D, Simons W, Simpson L, St. Jean Flanders M, Strasser Z, Thakrar M, Thaweethai T, Thorn M, Trewett P, Van Fleet D, Wagholikar K, Wang T, Wattanasin N, Weber G, Williams M, Zhang R, Cicek M, Flotte T, Boysen E, Chang N, Ellingworth E, Frisch E, Welch G, Yusuf A, Zahnle N, Cerda M, Clash V, Taylor B, Zissis M, Akintonwa T, Blancero F, Brown H, Carmilani M, Copeland D, Hall Y, kondo K, Lerma L, Lindsay J, Marti H, Maughan C, Minor T, Vincent H, Aragon L, Bander B, Bishof K, Carignan E, Castro Baucom L, Clash V, Coombs K, Corchado C, Davis H, Diggs M, Dunn M, Edwards B, Fisher L, Fitzgerald M, Gage Witvliet M, Gustafson T, Holmes V, Hornig M, Hornig M, Jain N, Kochis N, Lam J, Letts R, Lewis J, Martinez T, McCorkell L, McGrath R, Nguyen K, Nichols L, O'Brien L, Peddie A, Perlowski A, Phillips-Lorenzo E, Prentiss L, Raytselis N, Regino L, Rockwell M, Rutter J, Seibert E, Sekar A, Taylor E, Wallace A, Wilensky R, Williams M, Williams N, Williams-Dawson K, Wylam A. 2024 Update of the RECOVER-Adult Long COVID Research Index. JAMA 2025, 333: 694-700. PMID: 39693079, PMCID: PMC11862971, DOI: 10.1001/jama.2024.24184.Peer-Reviewed Original ResearchConceptsLong COVIDQuality-of-life measuresStudy visitsPost-COVID-19 conditionObservational cohort studyMain OutcomesPatient communityParticipant dataParticipant-reported symptomsCohort studyPostexertional malaiseSymptom listSARS-CoV-2 infectionShortness of breathParticipantsEnhanced recoveryBrain fogAdultsResearch indexVisitsChest painSymptomsPost-COVID-19Symptom subtypesChronic coughTargeting the SARS-CoV-2 reservoir in long COVID
Proal A, Aleman S, Bomsel M, Brodin P, Buggert M, Cherry S, Chertow D, Davies H, Dupont C, Deeks S, Ely E, Fasano A, Freire M, Geng L, Griffin D, Henrich T, Hewitt S, Iwasaki A, Krumholz H, Locci M, Marconi V, Mehandru S, Muller-Trutwin M, Painter M, Pretorius E, Price D, Putrino D, Qian Y, Roan N, Salmon D, Tan G, VanElzakker M, Wherry E, Van Weyenbergh J, Yonker L, Peluso M. Targeting the SARS-CoV-2 reservoir in long COVID. The Lancet Infectious Diseases 2025, 25: e294-e306. PMID: 39947217, DOI: 10.1016/s1473-3099(24)00769-2.Peer-Reviewed Original ResearchSARS-CoV-2Duration of treatmentPotential combination approachSARS-CoV-2 persistenceSARS-CoV-2 infectionPost hoc analysisHIV reservoirHepatitis CMechanism of actionPatient subgroupsInterpretation of trialsDebilitating disease statesPrecision oncologyMonoclonal antibodiesGrowing body of evidenceBody of evidenceLong COVID Incidence Proportion in Adults and Children Between 2020 and 2024: An EHR-Based Study From the RECOVER Initiative
Mandel H, Yoo Y, Allen A, Abedian S, Verzani Z, Karlson E, Kleinman L, Mudumbi P, Oliveira C, Muszynski J, Gross R, Carton T, Kim C, Taylor E, Park H, Divers J, Kelly J, Arnold J, Geary C, Zang C, Tantisira K, Rhee K, Koropsak M, Mohandas S, Vasey A, Mosa A, Haendel M, Chute C, Murphy S, O'Brien L, Szmuszkovicz J, Guthe N, Santana J, De A, Bogie A, Halabi K, Mohanraj L, Kinser P, Packard S, Tuttle K, Hirabayashi K, Kaushal R, Pfaff E, Weiner M, Thorpe L, Moffitt R. Long COVID Incidence Proportion in Adults and Children Between 2020 and 2024: An EHR-Based Study From the RECOVER Initiative. Clinical Infectious Diseases 2025, ciaf046. PMID: 39907495, DOI: 10.1093/cid/ciaf046.Peer-Reviewed Original ResearchElectronic health recordsIncidence proportionIncidence estimatesComputable phenotypeEHR-based studiesLong COVIDPublic health priorityPost-acute sequelae of SARS-CoV-2 infectionHealth recordsSequelae of SARS-CoV-2 infectionHealth priorityProportion of individualsRetrospective cohort studyHarmonized definitionExcess incidenceCohort studyImprove preventionSARS-CoV-2 infectionResearch NetworkRisk factorsAdultsCOVID-19Control groupAcute SARS-CoV-2 infectionPediatric populationEffectiveness of the 2023-to-2024 XBB.1.5 COVID-19 Vaccines Over Long-Term Follow-up : A Target Trial Emulation.
Ioannou G, Berry K, Rajeevan N, Li Y, Yan L, Huang Y, Lin H, Bui D, Hynes D, Rowneki M, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Smith V, Berkowitz T, O'Hare A, Viglianti E, Aslan M, Bajema K. Effectiveness of the 2023-to-2024 XBB.1.5 COVID-19 Vaccines Over Long-Term Follow-up : A Target Trial Emulation. Annals Of Internal Medicine 2025, 178: 348-359. PMID: 39903865, DOI: 10.7326/annals-24-01015.Peer-Reviewed Original ResearchConceptsU.S. Department of Veterans AffairsDepartment of Veterans AffairsMatched index dateVaccine effectivenessTarget trial emulationSARS-CoV-2-associated deathsRandomized controlled trialsCOVID-19 vaccineSARS-CoV-2-related outcomesSARS-CoV-2 testingVeterans AffairsResidual confoundingAbsence of randomized controlled trialsLong-term follow-upDocumented SARS-CoV-2 infectionTrial emulationUnvaccinated personsIndex datePositive resultsControlled trialsCOVID-19SARS-CoV-2 infectionIncomplete captureHospitalDocumented infection427. Underlying Medical Conditions and Vaccination Status among U.S. Children Aged ≤17 Years Hospitalized for COVID-19 in COVID-19-Associated Hospitalization Surveillance Network (COVID-NET), January–December 2023
Free R, Patel K, Sachdev D, Alden N, Meek J, Ryan P, Falkowski A, D’Heilly P, Smelser C, Engesser K, Bushey S, Moran N, Sutton M, Talbot H, Swain A, Campbell A, Havers F, Openo K. 427. Underlying Medical Conditions and Vaccination Status among U.S. Children Aged ≤17 Years Hospitalized for COVID-19 in COVID-19-Associated Hospitalization Surveillance Network (COVID-NET), January–December 2023. Open Forum Infectious Diseases 2025, 12: ofae631.141. PMCID: PMC11777352, DOI: 10.1093/ofid/ofae631.141.Peer-Reviewed Original ResearchCOVID-19-Associated Hospitalization Surveillance NetworkAge-eligible childrenChildren aged 6Medical conditionsCOVID-19 hospitalizationVaccine doseAcute care hospitalsAged 6Random sample of childrenPositive SARS-CoV-2 test resultSARS-CoV-2 test resultsVaccination statusAssessed patient ageSample of childrenNeurological disordersMaster of ScienceSARS-CoV-2 infectionActive surveillance systemCare hospitalProbability of selectionPediatric COVID-19 vaccineCOVID-19U.S. childrenPatient ageMedical recordsIncidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study
Vernon S, Zheng T, Do H, Marconi V, Jason L, Singer N, Natelson B, Sherif Z, Bonilla H, Taylor E, Mullington J, Ashktorab H, Laiyemo A, Brim H, Patterson T, Akintonwa T, Sekar A, Peluso M, Maniar N, Bateman L, Horwitz L, Hess R. Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study. Journal Of General Internal Medicine 2025, 1-10. PMID: 39804551, DOI: 10.1007/s11606-024-09290-9.Peer-Reviewed Original ResearchSARS-CoV-2 infectionLongitudinal observational cohort studyClinical diagnostic criteriaSelf-reported symptomsResultsThe incidence rateBackgroundMyalgic encephalomyelitis/chronic fatigue syndromeTiming of SARS-CoV-2 infectionPost-exertional malaiseObservational cohort studyUninfected participantsPost-acuteSARS-CoV-2Diagnostic criteriaCohort studyHazard ratioStudy visitsFatigue syndromeParticipantsEnhanced recoveryME/CFS symptomsLong COVIDMyalgic encephalomyelitisDays of infectionPrevalenceInfected participants
2024
Cxcl10 is protective during mouse-adapted SARS-CoV-2 infection
Majumdar S, Weaver J, Pontejo S, Minai M, Lu X, Gao J, Holmes G, Johnson R, Zhang H, Kelsall B, Farber J, Alves D, Murphy P. Cxcl10 is protective during mouse-adapted SARS-CoV-2 infection. Journal Of Leukocyte Biology 2024, 117: qiae252. PMID: 39607906, DOI: 10.1093/jleuko/qiae252.Peer-Reviewed Original ResearchSARS-CoV-2 infectionSARS-CoV-2Mouse-adapted strain of SARS-CoV-2Absence of CXCL10Associated with poor outcomesCXCL10-/- miceLungs of male miceInflammatory gene inductionAcute SARS-CoV-2 infectionMouse-adapted strainSevere COVID-19Wild type controlsCXCL10-deficientChemokine CXCL10Lymphocytic infiltrationSevere acute respiratory syndrome coronavirus 2Poor outcomeAcute respiratory syndrome coronavirus 2Circulating levelsMale miceRespiratory syndrome coronavirus 2Infected miceSARS-CoV-2 pathogenesisVirus loadCXCL10SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu
Tabachnikova A, Iwasaki A. SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu. Trends In Immunology 2024, 45: 925-927. PMID: 39580310, DOI: 10.1016/j.it.2024.11.002.Peer-Reviewed Original ResearchDiacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study
Carmo H, Castillo A, Bonilha I, Gomes E, Barreto J, Moura F, Davanzo G, de Brito Monteiro L, Muraro S, de Souza G, Morari J, Galdino F, Brunetti N, Reis-de-Oliveira G, Carregari V, Nadruz W, Martins-de-Souza D, Farias A, Velloso L, Proenca-Modena J, Mori M, Loh W, Bhatt D, Yellon D, Davidson S, De Oliveira P, Moraes-Vieira P, Sposito A. Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study. Frontiers In Pharmacology 2024, 15: 1402032. PMID: 39434905, PMCID: PMC11491754, DOI: 10.3389/fphar.2024.1402032.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsSARS-CoV-2 infectionSARS-CoV-2Viral replicationInflammatory responseInflammasome activationMarkers of inflammasome activationPlacebo-controlled studySuppress viral replicationBlood mononuclear cellsInfection in vitroPrimary metabolitesCOVID-19 patientsDouble-blindPrimary endpointHealthy volunteersSevere acute respiratory syndrome coronavirus 2Plasma markersAcute respiratory syndrome coronavirus 2Mononuclear cellsClinical trialsRespiratory syndrome coronavirus 2Day 2Syndrome coronavirus 2A Cross-Sectional Study Revealed a Low Prevalence of SARS-CoV-2 Infection among Asymptomatic University Students in Tripoli, North Lebanon
Rafei R, Tajer L, Nour D, Abboud K, Ankoud D, Osman M, Bedotto M, Ismail M, Dabboussi F, Colson P, Hamze M. A Cross-Sectional Study Revealed a Low Prevalence of SARS-CoV-2 Infection among Asymptomatic University Students in Tripoli, North Lebanon. Pathogens 2024, 13: 872. PMID: 39452743, PMCID: PMC11510414, DOI: 10.3390/pathogens13100872.Peer-Reviewed Original ResearchThe metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Leitner B, Joseph P, Quast A, Ramirez M, Heerdt P, Villalobos J, Singh I. The metabolic and physiologic impairments underlying long COVID associated exercise intolerance. Pulmonary Circulation 2024, 14: e70009. PMID: 39544193, PMCID: PMC11560803, DOI: 10.1002/pul2.70009.Peer-Reviewed Original ResearchPeak VO<sub>2</sub>Long COVID patientsCOVID patientsReduced peak VOSeverity of SARS-CoV-2 infectionSystemic oxygen extractionSARS-CoV-2 infectionLong COVIDArterial blood samplesQuantitative metabolomicsPeak VOVenous lactateCardiac outputImpaired mitochondrial ATP productionMild infectionExercise capacityPatientsMitochondrial ATP productionExercise intoleranceArteriovenous gradientBlood samplesOxygen extractionDependent mannerMetabolomicsPhysiological impairmentA Randomized Placebo-Controlled Trial of Leronlimab in Mild-To-Moderate COVID-19
Seethamraju H, Yang O, Loftus R, Ogbuagu O, Sammartino D, Mansour A, Sacha J, Ojha S, Hansen S, Arman A, Lalezari J. A Randomized Placebo-Controlled Trial of Leronlimab in Mild-To-Moderate COVID-19. Clinical Therapeutics 2024, 46: 891-899. PMID: 39353749, DOI: 10.1016/j.clinthera.2024.08.019.Peer-Reviewed Original ResearchMild to moderate COVID-19National Early Warning Score 2SARS-CoV-2 infectionPost hoc analysisSARS-CoV-2Randomized placebo-controlled trialHoc analysisHuman IgG4 monoclonal antibodyModerate-to-severe diseaseViral replicationHIV-1 infectionPlacebo-controlled studyProduction of pro-inflammatory cytokinesExcessive production of pro-inflammatory cytokinesMild-to-moderateAdverse event ratesExploratory post hoc analysisTotal symptom scorePathophysiology of SARS-CoV-2 infectionPro-inflammatory cytokinesHeightened immune responsePathophysiology of COVID-19IgG4 monoclonal antibodyPlacebo groupDouble-blindPostacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review
Miller C, Borre C, Green A, Funaro M, Oliveira C, Iwasaki A. Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review. American Journal Of Medicine Open 2024, 12: 100078. PMID: 39639960, PMCID: PMC11617896, DOI: 10.1016/j.ajmo.2024.100078.Peer-Reviewed Original ResearchClinical epidemiologyPost-acute sequelae of COVID-19High risk of biasLack of standardized definitionsPost-acute sequelaeRisk of biasSequelae of COVID-19United StatesScoping reviewComprehensive literature searchUS childrenShort follow-up durationFollow-up durationInclusion criteriaFemale sexOlder ageRisk factorsSARS-CoV-2 infectionLiterature searchChest painHigh riskOptimal preventionPediatric patientsPersistent symptomsCOVID-19Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections
Li K, Chaguza C, Stamp J, Chew Y, Chen N, Ferguson D, Pandya S, Kerantzas N, Schulz W, Initiative Y, Hahn A, Ogbunugafor C, Pitzer V, Crawford L, Weinberger D, Grubaugh N. Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections. PLOS Computational Biology 2024, 20: e1012469. PMID: 39288189, PMCID: PMC11432881, DOI: 10.1371/journal.pcbi.1012469.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle-nucleotide polymorphismsAssociation studiesWhole-genome sequencingAmino acid changesSingle nucleotide polymorphismsPairs of substitutionsViral copiesEpistasis testsGenome sequenceGenetic variationSpike geneAcid changesViral genomeNucleotide polymorphismsSARS-CoV-2Detect interactionsHost factorsVirus copiesCopyInfection dynamicsRT-qPCRPolymorphismOmicron BASARS-CoV-2 infectionPositive Autism Screening Rates in Toddlers Born During the COVID-19 Pandemic
Firestein M, Manessis A, Warmingham J, Xu R, Hu Y, Finkel M, Kyle M, Hussain M, Ahmed I, Lavallée A, Solis A, Chaves V, Rodriguez C, Goldman S, Muhle R, Lee S, Austin J, Silver W, O’Reilly K, Bain J, Penn A, Veenstra-VanderWeele J, Stockwell M, Fifer W, Marsh R, Monk C, Shuffrey L, Dumitriu D. Positive Autism Screening Rates in Toddlers Born During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2435005. PMID: 39312236, PMCID: PMC11420691, DOI: 10.1001/jamanetworkopen.2024.35005.Peer-Reviewed Original ResearchConceptsElectronic health recordsCOVID-19 Mother Baby OutcomesM-CHAT-RScreening ratesPandemic exposureMaternal SARS-CoV-2 infectionCohort studyColumbia University Irving Medical CenterMaternal SARS-CoV-2 statusLogistic regression modelsPrenatal exposureSARS-CoV-2 infectionHealth recordsProspective longitudinal studyModified checklistMain OutcomesClinical careBaby outcomeSARS-CoV-2 statusNew York CityPrimary outcomeScreen-positiveMedical CenterPrimary analysisGroup of childrenThe COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management
Becker R, Tantry U, Khan M, Gurbel P. The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management. Journal Of Thrombosis And Thrombolysis 2024, 58: 15-49. PMID: 39179952, PMCID: PMC11762605, DOI: 10.1007/s11239-024-03028-4.Peer-Reviewed Original ResearchNeutrophil extracellular trapsMild to moderate illnessHost immunoinflammatory responseOptimal patient managementSARS-CoV-2SARS-CoV-2 infectionEndothelial cell inflammationVascular endothelial cellsSurveillance modalitiesClinical featuresOrgan injuryImmunoinflammatory responseMicrovascular thrombosisInflammatory signatureAtherothrombotic phenotypeCirculating monocytesChronic phasePatient managementVascular eventsAcute phaseExtracellular trapsCritical illnessThrombosisEndothelial cellsMedical literatureCharacterizing Long COVID in Children and Adolescents
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Characterizing Long COVID in Children and Adolescents. JAMA 2024, 332: 1174-1188. PMID: 39196964, PMCID: PMC11339705, DOI: 10.1001/jama.2024.12747.Peer-Reviewed Original ResearchPostacute sequelae of SARS-CoV-2 infectionSchool-aged childrenPoorer overall healthLongitudinal observational cohort studyProlonged symptomsUS health careSARS-CoV-2 infectionQuality of lifeInfection historyLong COVIDSARS-CoV-2 infection historyObservational cohort studySequelae of SARS-CoV-2 infectionCommunity settingsHealth careMain OutcomesSARS-CoV-2Symptom surveyOverall healthCohort studyCombination of symptomsAge groupsPostacute sequelaeSymptom patternsSymptom domains
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