2022
Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure.
Peng G, Xi Y, Bellini C, Pham K, Zhuang ZW, Yan Q, Jia M, Wang G, Lu L, Tang MS, Zhao H, Wang H. Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure. American Journal Of Cancer Research 2022, 12: 3679-3692. PMID: 36119846, PMCID: PMC9442002.Peer-Reviewed Original ResearchElectronic cigarette exposureCigarette exposureMale ApoE-/- miceApoE-/- miceCytokine mRNA expressionPoor health outcomesWhite blood cellsElectronic cigarette useDose-dependent mannerE-cigarette aerosolAerosol inhalationCigarette smokingActivation of MAPKHigher nicotine concentrationsMAPK pathway activationCell-damaging effectsCpG sitesHealth outcomesCigarette useMRNA expressionNicotine concentrationsPathway activationSignificant CpG sitesBlood cellsSignificant alterations
2020
A glioneuronal tumor with CLIP2-MET fusion
Chowdhury T, Lee Y, Kim S, Yu H, Ji S, Bae J, Won J, Shin J, Weinberger D, Choi S, Park C, Kim J, Park S. A glioneuronal tumor with CLIP2-MET fusion. Npj Genomic Medicine 2020, 5: 24. PMID: 32550005, PMCID: PMC7270112, DOI: 10.1038/s41525-020-0131-6.Peer-Reviewed Original ResearchCannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation
Liu C, Sadat S, Ebisumoto K, Sakai A, Panuganti B, Ren S, Goto Y, Haft S, Fukusumi T, Ando M, Saito Y, Guo T, Tamayo P, Yeerna H, Kim W, Hubbard J, Sharabi A, Gutkind J, Califano J. Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation. Clinical Cancer Research 2020, 26: 2693-2703. PMID: 31932491, PMCID: PMC7538010, DOI: 10.1158/1078-0432.ccr-18-3301.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCannabinoidsCell MovementCell ProliferationFemaleHead and Neck NeoplasmsHumansMiceMice, Nudep38 Mitogen-Activated Protein KinasesPapillomaviridaePapillomavirus InfectionsPrognosisReceptors, CannabinoidSquamous Cell Carcinoma of Head and NeckTumor Cells, CulturedXenograft Model Antitumor AssaysConceptsHead and neck squamous cell carcinomaHPV-positive head and neck squamous cell carcinomaHPV-positive HNSCC cell linesNeck squamous cell carcinomaHNSCC cell linesSingle-sample gene set enrichment analysisSquamous cell carcinomaP38 MAPK pathway activationHNSCC cohortCell carcinomaMAPK pathway activationHPV-negative head and neck squamous cell carcinomaHuman papillomavirus (HPV)-related headCell linesAnimal modelsCannabinoid receptor activationHPV- HNSCC patientsHead and neck squamous cell carcinomas dataMarijuana usePathway activationDaily marijuana useWhole-genome expression analysisCannabinoid exposureHNSCC patientsP38 MAPK activation
2017
A FISH assay efficiently screens for BRAF gene rearrangements in pancreatic acinar-type neoplasms
Wang L, Basturk O, Wang J, Benayed R, Middha S, Zehir A, Linkov I, Rao M, Aryeequaye R, Cao L, Chmielecki J, Ross J, Stephens P, Adsay V, Askan G, Balci S, Klimstra D. A FISH assay efficiently screens for BRAF gene rearrangements in pancreatic acinar-type neoplasms. Modern Pathology 2017, 31: 132-140. PMID: 28884748, DOI: 10.1038/modpathol.2017.106.Peer-Reviewed Original ResearchConceptsNext-generation sequencing studiesSequencing studiesNext-generation sequencing-based technologiesFusion partnerNext-generation sequencing-based platformsInhibited MAPK pathway activationFISH assaySequencing-based platformsSequencing-based studiesSequencing-based technologiesNext-generation sequencing-based analysisSequencing-based analysisGene rearrangementsBRAF gene rearrangementsNext-generation sequencingFrequent fusion partnerBRAF fusionsMAPK pathway activationAcinar cell carcinomaBRAF gene fusionsGene fusionsFISH analysisPotential therapeutic targetFISH investigationsCell carcinoma
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