2023
Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics
Ouyang Z, Dong L, Yao F, Wang K, Chen Y, Li S, Zhou R, Zhao Y, Hu W. Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics. International Journal Of Molecular Sciences 2023, 24: 9841. PMID: 37372989, PMCID: PMC10298547, DOI: 10.3390/ijms24129841.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisArticular cartilageCourse of osteoarthritisNew biochemical markersDisease progressionPathogenic factorsCartilage damageDegradation of collagenBiochemical markersProgressive destructionClinical diagnosisMechanical injuryConnective tissueDisease statesRole of collagenCollagen productionLow immunogenicityFacilitate drug developmentArthritisDrug developmentOsteoarthritisBiomechanical propertiesMechanical functionCartilageCollagen
2022
The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy.
Micevic G, Bosenberg M, Yan Q. The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy. Clinical Cancer Research 2022, 29: 1173-1182. PMID: 36449280, PMCID: PMC10073242, DOI: 10.1158/1078-0432.ccr-22-0784.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImmune checkpoint inhibitorsImmune checkpoint therapyT cell exhaustionCheckpoint therapyAntitumor immune responseT cell populationsCell-intrinsic immunityTypes of cancerViral mimicry responseLow response rateCheckpoint inhibitorsCurrent immunotherapiesPancreatic cancerSustained responsePreclinical modelsTreatment outcomesImmune responseEndogenous antigensResponse rateTumor typesMultiple epigenetic regulatorsCritical mediatorLow immunogenicityTherapyCancer
2019
The evolving landscape of immunotherapy in advanced prostate cancer
Patel V, Oh W. The evolving landscape of immunotherapy in advanced prostate cancer. Immunotherapy 2019, 11: 903-912. PMID: 31161846, DOI: 10.2217/imt-2019-0019.Peer-Reviewed Original ResearchConceptsCastration-resistant prostate cancerImmune checkpoint blockadeProstate cancerCheckpoint blockadeAdvent of immune checkpoint blockadeCastration-resistant prostate cancer settingEvolving landscape of immunotherapyImmune resistanceAndrogen synthesis inhibitorsCastration-resistant diseaseCastration-resistant settingLandscape of immunotherapyOvercome immune resistanceImmunosuppressive tumor microenvironmentAdvanced prostate cancerProstate tumor cellsImmunotherapeutic platformImmunogenic tumorsSipuleucel-TTherapeutic vaccinesTumor microenvironmentClinical benefitImmunization modalityTumor cellsLow immunogenicity
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