2024
Severe Clinical Outcomes Due to Human Adenoviral Respiratory Infections in Hospitalized Immunocompetent Adults
Legakis L, Nguyen D, Bandaranayake T. Severe Clinical Outcomes Due to Human Adenoviral Respiratory Infections in Hospitalized Immunocompetent Adults. Infectious Diseases In Clinical Practice 2024, 32: e1412. DOI: 10.1097/ipc.0000000000001412.Peer-Reviewed Original ResearchSevere adenoviral infectionAdenoviral infectionImmunocompetent patientsClinical outcomesSmoking historyPulmonary diseaseRisk factorsSevere diseaseAdenoviral respiratory infectionUpper respiratory tract infectionRespiratory viral panelAbsence of feverAdult immunocompetent patientsExtracorporeal membrane oxygenationRespiratory tract infectionsSevere clinical outcomesChronic obstructive pulmonary diseasePresence of coinfectionObstructive pulmonary diseasePotential risk factorsCritical careImmunocompetent adultsImmunocompromised patientsImmunocompetent hostsTract infections
2023
Acute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case report
Oyeyemi D, Chan E, Montano M, Belzer A, Ogbuagu O, Zapata H, Tuan J. Acute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case report. Journal Of Medical Case Reports 2023, 17: 489. PMID: 37946248, PMCID: PMC10636986, DOI: 10.1186/s13256-023-04216-1.Peer-Reviewed Original ResearchConceptsCytomegalovirus proctitisCase reportAcute primary cytomegalovirus infectionPrimary cytomegalovirus infectionHealthy Caucasian individualsImmunocompetent personsTesticular painCytomegalovirus infectionImmunocompetent patientsRare causeImmunocompetent hostsSexual transmissionDiagnostic workupRectal pathologyConclusionsThis reportProctitisEpididymitisCaucasian individualsReportPainPatientsBackgroundWeSerologyWorkupInfection
2022
Rapidly enlarging pulmonary mass due to immune reconstitution inflammatory syndrome (IRIS) in an immunocompetent host with pulmonary Cryptococcus neoformans.
Tucker M, Sheikh AM, Villanueva MS. Rapidly enlarging pulmonary mass due to immune reconstitution inflammatory syndrome (IRIS) in an immunocompetent host with pulmonary Cryptococcus neoformans. BMJ Case Reports 2022, 15: e247495. PMID: 35351746, PMCID: PMC8966528, DOI: 10.1136/bcr-2021-247495.Peer-Reviewed Case Reports and Technical NotesConceptsImmune reconstitution inflammatory syndromeReconstitution inflammatory syndromeInflammatory syndromePulmonary massImmunocompetent hostsInitial induction courseLarge pulmonary massWeeks of fluconazoleLiposomal amphotericin BCritical vascular structuresInduction therapyImmunocompetent manInduction courseSecond courseAmphotericin BCryptococcus neoformansVascular structuresSignificant decreaseCryptococcomaSyndromeWeeksPrednisoneTherapyFlucytosineDisease
2021
5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING
Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING. The EMBO Journal 2021, 40: embj2020106065. PMID: 33615517, PMCID: PMC8013832, DOI: 10.15252/embj.2020106065.Peer-Reviewed Original ResearchConceptsAnti-tumor immunityTumor burdenSubsequent type I interferon productionHigh STING expressionIntratumoral T cellsT-cell depletionType I interferon productionI interferon productionLoss of STINGImmunocompetent hostsColorectal specimensT cellsSTING expressionBetter survivalHigh doseTherapeutic effectivenessHuman colorectal specimensMelanoma tumorsInterferon productionChemotherapeutic drugsMurine colonImmunityEfficacyStingsColon
2019
Risk factors of laryngeal cryptococcosis: A case report
Quintero O, Trachuk P, Lerner MZ, Sarungbam J, Pirofski LA, Park SO. Risk factors of laryngeal cryptococcosis: A case report. Medical Mycology Case Reports 2019, 24: 82-85. PMID: 31080714, PMCID: PMC6506557, DOI: 10.1016/j.mmcr.2019.04.009.Peer-Reviewed Original ResearchConvergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo
Codina A, Renauer PA, Wang G, Chow RD, Park JJ, Ye H, Zhang K, Dong MB, Gassaway B, Ye L, Errami Y, Shen L, Chang A, Jain D, Herbst RS, Bosenberg M, Rinehart J, Fan R, Chen S. Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo. Cell Systems 2019, 8: 136-151.e7. PMID: 30797773, PMCID: PMC6592847, DOI: 10.1016/j.cels.2019.01.004.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomic profilingExtracellular protein productionCancer cellsMutant cellsFunctional interrogationGenetic programCRISPR screensTranscriptomic profilingTumor-intrinsic mutationsTranscriptomic alterationsTumor microenvironmentProtein productionPRKAR1A lossGenetic makeupHost myeloid cellsTumor-intrinsic factorsDrastic alterationsCytometry analysisConvergent identificationMyeloid cellsCellsImmunocompetent hostsCancer immunityMutant tumorsHost
2018
Organoid Modeling of the Tumor Immune Microenvironment
Neal JT, Li X, Zhu J, Giangarra V, Grzeskowiak CL, Ju J, Liu IH, Chiou SH, Salahudeen AA, Smith AR, Deutsch BC, Liao L, Zemek AJ, Zhao F, Karlsson K, Schultz LM, Metzner TJ, Nadauld LD, Tseng YY, Alkhairy S, Oh C, Keskula P, Mendoza-Villanueva D, De La Vega FM, Kunz PL, Liao JC, Leppert JT, Sunwoo JB, Sabatti C, Boehm JS, Hahn WC, Zheng GXY, Davis MM, Kuo CJ. Organoid Modeling of the Tumor Immune Microenvironment. Cell 2018, 175: 1972-1988.e16. PMID: 30550791, PMCID: PMC6656687, DOI: 10.1016/j.cell.2018.11.021.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesPatient-derived organoidsImmune checkpoint blockadePrimary tumor epitheliumTumor epitheliumTumor microenvironmentAntigen-specific tumor-infiltrating lymphocytesTumor immune microenvironmentAir-liquid interface methodSyngeneic immunocompetent hostsImmune stromaCheckpoint blockadeImmunocompetent hostsImmune microenvironmentNeoplastic epitheliumImmune cellsTumor TTumor cytotoxicityMouse tumorsHuman biopsiesImmune repertoireCancer culturesEpitheliumThree-dimensional organoidsOrganoid modeling
2017
Cost-Effectiveness Study of Criteria for Screening Cerebrospinal Fluid To Determine the Need for Herpes Simplex Virus PCR Testing
Hauser RG, Campbell SM, Brandt CA, Wang S. Cost-Effectiveness Study of Criteria for Screening Cerebrospinal Fluid To Determine the Need for Herpes Simplex Virus PCR Testing. Journal Of Clinical Microbiology 2017, 55: 1566-1575. PMID: 28298450, PMCID: PMC5405275, DOI: 10.1128/jcm.00119-17.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidHerpes simplex virus (HSV) central nervous system (CNS) infectionPCR testingCentral nervous system infectionCSF white blood cellsHSV PCR testingNervous system infectionLarge health care systemWhite blood cellsCost-effectiveness studiesHealth care systemDecision analysis modelHSV encephalitisCNS infectionSystem infectionHSV infectionAbsence of markersImmunocompetent hostsNecessary diagnostic testsOrgan transplantsPatient careDiagnostic testsBlood cellsCare systemPCR test
2016
Ocular Syphilis Presenting as Bilateral Acute Retinal Necrosis in an Immunocompetent Host.
Hussnain SA, Ketner S, Coady PA, Kombo N, Nwanyanwu K. Ocular Syphilis Presenting as Bilateral Acute Retinal Necrosis in an Immunocompetent Host. Connecticut Medicine 2016, 80: 533-536. PMID: 29772137.Peer-Reviewed Original ResearchConceptsBilateral acute retinal necrosisAcute retinal necrosisOcular syphilisRetinal necrosisCases of syphilisOphthalmic testingOcular inflammationGreat masqueraderImmunocompetent hostsDiagnostic dilemmaClinical signsHigh indexSyphilisNecrosisSignsInflammationPatientsPresentingOphthalmologistsSymptomsCliniciansSuspicionCytomegalovirus appendicitis in an immunocompetent host
Canterino JE, McCormack M, Gurung A, Passarelli J, Landry ML, Golden M. Cytomegalovirus appendicitis in an immunocompetent host. Journal Of Clinical Virology 2016, 78: 9-11. PMID: 26942831, DOI: 10.1016/j.jcv.2016.02.011.Peer-Reviewed Case Reports and Technical NotesConceptsImmune-compromising conditionsEnd-organ diseaseCommon viral pathogensCMV appendicitisCytomegalovirus appendicitisMononucleosis syndromeImmunocompetent hostsImmunocompetent individualsAsymptomatic infectionCommon manifestationHealthy individualsViral pathogensAppendicitisCytomegalovirusPatientsSyndromeInfectionDiseaseIndividuals
2015
Pulmonary Nocardiosis in the Immunocompetent Host: Case Series
Singh I, West F, Sanders A, Hartman B, Zappetti D. Pulmonary Nocardiosis in the Immunocompetent Host: Case Series. Case Reports In Pulmonology 2015, 2015: 314831. PMID: 26491594, PMCID: PMC4605260, DOI: 10.1155/2015/314831.Peer-Reviewed Original Research
2014
Epstein–Barr Virus: Epidemiology and Clinical Features of Related Cancer
Hudnall S. Epstein–Barr Virus: Epidemiology and Clinical Features of Related Cancer. 2014, 25-50. DOI: 10.1007/978-1-4939-0870-7_3.Peer-Reviewed Original ResearchCell lymphomaEBV latency genesRisk of EBVEBV-positive lymphomasNK-cell lymphomasEpstein-Barr virusEndemic Burkitt lymphomaEBV gene expressionB-cell lymphomaHuman malignant tumorsImmunodeficiency-associated lymphomasApparent immunodeficiencyEBV infectionFalciparum malariaLymphoepithelial carcinomaOrgan failureClinical featuresImmunocompetent hostsLikely multifactorialSeroprevalence ratesImmunodeficient hostsMalignant tumorsSevere diseaseNasopharyngeal carcinomaBurkitt's lymphomaCheating by type 3 secretion system-negative Pseudomonas aeruginosa during pulmonary infection
Czechowska K, McKeithen-Mead S, Al Moussawi K, Kazmierczak BI. Cheating by type 3 secretion system-negative Pseudomonas aeruginosa during pulmonary infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 7801-7806. PMID: 24821799, PMCID: PMC4040582, DOI: 10.1073/pnas.1400782111.Peer-Reviewed Original ResearchConceptsT3SS-inducing conditionsOpportunistic pathogen Pseudomonas aeruginosaType 3 secretion systemPathogen Pseudomonas aeruginosaWT P. aeruginosaPositive bacteriaFitness advantageDefective mutantsRelative fitnessSecretion systemBacterial virulenceSelective advantageMyD88 knockout miceNeutrophil-depleted animalsVitro growth rateMutantsInnate immune cellsPseudomonas aeruginosaP. aeruginosa infectionCompetition experimentsAcute pneumonia modelBacteriaFitnessPulmonary infectionImmunocompetent hosts
2012
Disseminated Mycobacterium intracellulare Infection in an Immunocompetent Host
Kim W, Jang S, Ok T, Kim G, Park H, Leem J, Kang B, Park J, Oh D, Kang B, Lee B, Ji W, Shim T. Disseminated Mycobacterium intracellulare Infection in an Immunocompetent Host. Tuberculosis And Respiratory Diseases 2012, 72: 452-456. PMID: 23101011, PMCID: PMC3475463, DOI: 10.4046/trd.2012.72.5.452.Peer-Reviewed Original ResearchImmunocompetent subjectsDisseminated Mycobacterium avium complex infectionDisseminated Mycobacterium intracellulare infectionFluorodeoxyglucose positron emission tomography (FDG-PET) imagingMycobacterium avium complex infectionMultiple hypermetabolic lesionsEvidence of malignancyMycobacterium intracellulare infectionPositron emission tomography (PET) imagingDisseminated MACImmunocompetent patientsHypermetabolic lesionsLymph nodesClinical presentationImmunocompetent hostsSerial biopsiesDisseminated infectionIntracellulare infectionComplex infectionRespiratory specimensHematogenous metastasisMultiple bonesAccurate diagnosisMalignancyTomography imaging
2009
Unusual presentations of nervous system infection by Cryptococcus neoformans
Searls D, Sico JJ, Omay S, Bannykh S, Kuohung V, Baehring J. Unusual presentations of nervous system infection by Cryptococcus neoformans. Clinical Neurology And Neurosurgery 2009, 111: 638-642. PMID: 19541406, DOI: 10.1016/j.clineuro.2009.05.007.Peer-Reviewed Original ResearchConceptsNervous system infectionHuman immunodeficiency virusSystem infectionCryptococcal meningitisNeurological manifestationsCryptococcus neoformansRecurrent cerebral infarctionSevere neurological disabilityC. neoformans infectionUnusual clinical presentationUnusual neurological manifestationsDetailed clinical descriptionMagnetic resonance imagingOphthalmic zosterCryptococcal infectionCerebral infarctionImmunocompetent patientsNeoformans infectionNeurological disabilityClinical presentationHodgkin's diseaseImmunodeficiency syndromeImmunocompetent hostsImmunodeficiency virusCSF analysisToxoplasma gondii
Kravetz J. Toxoplasma gondii. 2009, 217-228. DOI: 10.1128/9781555815486.ch12.Peer-Reviewed Original ResearchOcular toxoplasmosisToxoplasma encephalitisHuman immunodeficiency virus (HIV)-infected individualsPrimary infectionCongenital toxoplasmosis resultsCases of Toxoplasma encephalitisHigh-dose steroidsPrimary toxoplasmosis infectionCongenital Toxoplasma infectionNewborn health problemsT. gondiiImmunocompetent hostsImmunocompromised hostsPregnant womenCongenital toxoplasmosisOrgan transplantationReactivation of T. gondiiLong-term consequencesToxoplasmosis infectionTransplacental transmissionInfectionObligate intracellular protozoanToxoplasma infectionEncephalitisToxoplasma gondii
2008
Parvovirus
Landry M. Parvovirus. 2008, 183-193. DOI: 10.1128/9781555815455.ch9.Peer-Reviewed Original ResearchParvovirus B19 infectionParvovirus B19B19 infectionChronic fatigue syndromeTreatable causeAcute infectionChronic anemiaFatigue syndromeImmunocompetent hostsHuman bocavirusNeurologic syndromeIgG antibodiesCerebrospinal fluidRenal syndromeImmunoglobulin MBone marrowInfectionSyndromeB19Parvoviridae familyParvovirusHuman diseasesMinute virusVasculitisUveitisFever and Focal Cerebral Dysfunction
Spudich S. Fever and Focal Cerebral Dysfunction. 2008, 233-240. DOI: 10.1017/cbo9780511547454.041.Peer-Reviewed Original ResearchCerebral infectionIntracranial abscessNeurological findingsCerebral diseaseCentral nervous system infectionFocal cerebral dysfunctionFocal neurological findingsFocal neurological deficitsNervous system infectionPresence of feverVisual field cutCongenital heart diseaseHerpes simplex virusOne-sided weaknessCerebral complicationsFocal encephalitisNeurological deficitsSystem infectionGeneralized seizuresValvular diseaseCerebral dysfunctionImmunocompetent hostsMain diagnosisChronic infectionEar infections
2007
Human gammaherpesvirus immune evasion strategies
Means R, Lang S, Jung J. Human gammaherpesvirus immune evasion strategies. 2007, 559-586. DOI: 10.1017/cbo9780511545313.032.Peer-Reviewed Original ResearchEpstein-Barr virusMulticentric Castleman's diseasePrimary effusion lymphomaImmune systemKaposi's sarcoma-associated herpesvirusKaposi's sarcomaImmune responsePersistent infectionNasopharyngeal carcinomaInnate responseSarcoma-associated herpesvirusHemophagocytic lymphohistiocytosis syndromeNatural killer cellsNormal immune systemClearance of infectionImmune evasion strategiesInfectious mononucleosisImmunocompromised hostHodgkin's diseaseKiller cellsImmunocompetent hostsCastleman's diseaseHHV-4HHV-8Gastric cancerKluyvera co‐infection in two solid organ transplant recipients: an emerging pathogen or a colonizer bystander?
Cheruvattath R, Balan V, Stewart R, Heilman RL, Mulligan DC, Kusne S. Kluyvera co‐infection in two solid organ transplant recipients: an emerging pathogen or a colonizer bystander? Transplant Infectious Disease 2007, 9: 83-86. PMID: 17313481, DOI: 10.1111/j.1399-3062.2006.00198.x.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsTransplant recipientsDeceased donor kidney transplantAlpha-1 antitrypsin deficiencyDonor liver transplantationDonor kidney transplantsFocal segmental glomerulosclerosisAntibiotic coverageLiver transplantationTransplant patientsKidney transplantRenal failureUrinary infectionUrine cultureImmunocompetent hostsPatient populationSerious infectionsSegmental glomerulosclerosisAntitrypsin deficiencyNegative bacilliKluyvera infectionsMixed organismsAbscess aspirateCommensal organisms
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