2025
Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID
Grady C, Bhattacharjee B, Silva J, Jaycox J, Lee L, Silva Monteiro V, Sawano M, Massey D, Caraballo C, Gehlhausen J, Tabachnikova A, Mao T, Lucas C, Peña-Hernandez M, Xu L, Tzeng T, Takahashi T, Herrin J, Güthe D, Akrami A, Assaf G, Davis H, Harris K, McCorkell L, Schulz W, Griffin D, Wei H, Ring A, Guan L, Dela Cruz C, Krumholz H, Iwasaki A. Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID. Communications Medicine 2025, 5: 163. PMID: 40346201, PMCID: PMC12064684, DOI: 10.1038/s43856-025-00829-3.Peer-Reviewed Original ResearchSpike protein-specific IgGProtein-specific IgGSelf-antigensImmune response to COVID-19 vaccinationCOVID-19 vaccineAntibody responseResponse to COVID-19 vaccinationT cell expansionSARS-CoV-2-specific antibody responsesAssociated with no improvementLong COVIDAssociated with symptom improvementChest painCirculating cytokinesImmune phenotypeProspective studyImmune featuresTransient improvementPrimary seriesVaccine doseHerpes virusImmune responseSymptom improvementSignificant elevationImpact of COVID-19 vaccinationAdding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Baker M, Cantley L. Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury. Journal Of Clinical Investigation 2025, 135: e188358. PMID: 40091836, PMCID: PMC11910233, DOI: 10.1172/jci188358.Peer-Reviewed Original ResearchConceptsAcute kidney injuryTubular epithelial cellsKidney injuryTubular cellsCases of acute kidney injuryImmune-mediated processPersistence of inflammationBiphasic immune responseChronic kidney diseaseCell deathTubular cell injuryLymphocyte subsetsTubular repairCell cycle arrestOutflow obstructionTEC differentiationPreclinical findingsLymphocytic infiltrationProinflammatory macrophagesKidney diseaseModulate inflammationImmune responseActivated macrophagesMetabolic reprogrammingTubular castsTranscriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review
Valizadeh A, Veenhuis R, Bradley B, Xu K. Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review. International Journal Of Molecular Sciences 2025, 26: 2598. PMID: 40141240, PMCID: PMC11942185, DOI: 10.3390/ijms26062598.Peer-Reviewed Original ResearchConceptsSimian immunodeficiency virus (SIV)-infected macaquesPrevalence of cannabis useSIV-infected macaquesChronic immune activationHIV-infected human cellsEpithelial cell proliferationModulate immune responsesSystematic reviewSIV/HIV infectionHIV infectionPreclinical evidencePathways related to inflammationImmune activationCannabis useMicro-RNA expressionImmunomodulatory roleImmunomodulatory effectsReduce inflammationImmune responseTetrahydrocannabinolComprehensive searchCell proliferationTranscriptomic alterationsMethodological qualityPWHTNFRSF1A and NCF1 May Act as Hub Genes in Mastitis
Ekhtiyari M, Yousefi M, Samadian F, Ghaderi‐Zefrehei M, Neysi S, Shamsabadi J, Javanmard A, Shahriarpour H, Lesch B. TNFRSF1A and NCF1 May Act as Hub Genes in Mastitis. Veterinary Medicine And Science 2025, 11: e70278. PMID: 40028770, PMCID: PMC11875065, DOI: 10.1002/vms3.70278.Peer-Reviewed Original ResearchConceptsBovine mastitisHub genesMastitis susceptibilityExpression datasetsMolecular mechanismsMultiple expression datasetsProtein-protein interactionsCo-expression network analysisSusceptibility to bovine mastitisRegulatory networksTarget key genesKey genesDairy industryMolecular playersNetwork analysisMRNA-miRNACo-expressionGenesNCF1MastitisBacterial infectionsTherapeutic targetTNFRSF1AImmune responseSusceptibilityProceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation
Morris Z, Demaria S, Monjazeb A, Formenti S, Weichselbaum R, Welsh J, Enderling H, Schoenfeld J, Brody J, McGee H, Mondini M, Kent M, Young K, Galluzzi L, Karam S, Theelen W, Chang J, Huynh M, Daib A, Pitroda S, Chung C, Serre R, Grassberger C, Deng J, Sodji Q, Nguyen A, Patel R, Krebs S, Kalbasi A, Kerr C, Vanpouille-Box C, Vick L, Aguilera T, Ong I, Herrera F, Menon H, Smart D, Ahmed J, Gartrell R, Roland C, Fekrmandi F, Chakraborty B, Bent E, Berg T, Hutson A, Khleif S, Sikora A, Fong L. Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation. The Lancet Oncology 2025, 26: e152-e170. PMID: 40049206, DOI: 10.1016/s1470-2045(24)00656-9.Peer-Reviewed Original ResearchConceptsAnti-tumor immune responseDelivery of radiotherapyTumor immune recognitionSelection of immunotherapyBiomarker-guided approachesNational Cancer Institute workshopClinical trial dataImmunotherapy combinationsClinical responseImprove patient outcomesPreclinical modelsPatient selectionRadiotherapyImmunotherapyClinical endpointsClinical dataClinical studiesImmune recognitionImmune responseImmune effectsAnimal studiesClinical translationPatient outcomesTrial dataNegative trialsEngineering Mice to Study Human Immunity.
Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell R. Engineering Mice to Study Human Immunity. Annual Review Of Immunology 2025 PMID: 40020225, DOI: 10.1146/annurev-immunol-082523-124415.Peer-Reviewed Original ResearchHumanized miceHuman hematopoiesisImmune responseImmune systemHumanized mouse modelHuman hematopoietic stemImmunocompromised murine hostsResident immune cellsHuman immune responseStudy human immunityHuman immune systemIntegration of multi-omicsHematopoietic stemImmune cell growthImmune cellsEngineered miceProgenitor cellsMouse modelImmunological diseasesMurine hostCancer treatmentPreclinical drugsHuman immunityMiceModel diseaseEstimating the Serotype-Specific Association Between the Concentration of Vaccine-Induced Serum Antibodies and Protection Against Pneumococcal Colonization
Wong A, Warren J, Fitch L, Perniciaro S, Dagan R, Weinberger D. Estimating the Serotype-Specific Association Between the Concentration of Vaccine-Induced Serum Antibodies and Protection Against Pneumococcal Colonization. The Journal Of Infectious Diseases 2025, jiaf106. PMID: 40036886, DOI: 10.1093/infdis/jiaf106.Peer-Reviewed Original ResearchHigher-valent PCVsPneumococcal conjugate vaccinePneumococcal colonizationVaccine-induced serum antibodiesRisk of colonizationSerum immunoglobulin GRandomized controlled trialsConjugate vaccinePCV13Clinical trialsSerum IgGImmune responseVaccinated childrenSevere diseaseVaccine effectivenessSerum antibodiesPCV20Serotype-specificImmunoglobulin GSerotypesColonIndirect protectionIgGVaccineTrialsElevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection
Dylla L, Reisz J, Poisson S, Herson P, Sansing L, Monte A. Elevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108268. PMID: 40015349, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108268.Peer-Reviewed Original ResearchConceptsPost-stroke infectionsAssociated with increased oddsTryptophan metabolitesHistory of diabetes mellitusEnd stage renal diseaseNIH Stroke Scale scoreConcentrations of kynurenineAcute ischemic stroke patientsMultivariate logistic regressionStage renal diseaseStroke Scale scoreCirculating kynurenineIschemic stroke onsetIschemic stroke patientsKynurenine concentrationsConcentrations of tryptophanEmergency department admissionsKynurenic acidDiabetes mellitusMortality of ischemic strokeRenal diseaseTryptophan metabolismOdds ratioQuinolinic acidImmune responseKLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
Fagerberg E, Attanasio J, Dien C, Singh J, Kessler E, Abdullah L, Shen J, Hunt B, Connolly K, De Brouwer E, He J, Iyer N, Buck J, Borr E, Damo M, Foster G, Giles J, Huang Y, Tsang J, Krishnaswamy S, Cui W, Joshi N. KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection. Science 2025, 387: eadn2337. PMID: 39946463, DOI: 10.1126/science.adn2337.Peer-Reviewed Original ResearchConceptsCD8 T cellsT cellsCD8 T cell exhaustionNaive CD8 T cellsAcute LCMV infectionT cell exhaustionT cell fate decisionsLineage fidelityLCMV infectionEffector differentiationAcute infectionExhaustion programTranscription factorsImmune responseEpigenetic modulationSuppress differentiationProgenitor stateKLF2InfectionFunctional stateFate decisionsCD8Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody Drug Conjugate TAK-500.
Appleman V, Matsuda A, Ganno M, Zhang D, Rosentrater E, Maldonado Lopez A, Porciuncula A, Hatten T, Christensen C, Merrigan S, Lee H, Lee M, Wang C, Dong L, Huang J, Iartchouk N, Wang J, Xu H, Yoneyama T, Piatkov K, Haridas S, Harbison C, Gregory R, Parent A, Lineberry N, Arendt C, Schalper K, Abu-Yousif A. Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody Drug Conjugate TAK-500. Cancer Immunology Research 2025 PMID: 39918395, DOI: 10.1158/2326-6066.cir-24-0103.Peer-Reviewed Original ResearchIntratumoral myeloid cellsMyeloid cellsTumor microenvironmentImmune responseCCR2+ cellsI interferonImmunosuppressive myeloid populationsImmune activation in vitroImmune cell markersLocal immune activationMurine tumor modelsAdaptive immune responsesAntibody drug conjugatesType I interferonAntitumor immunityInnate immune responseMyeloid populationsSTING agonistsSolid tumorsCCR2 proteinImmune activationTumor modelCell markersHuman tumorsAdaptive immunityTranslocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human
Gronke K, Nguyen M, Fuhrmann H, Santamaria de Souza N, Schumacher J, Pereira M, Löschberger U, Brinkhege A, Becker N, Yang Y, Sonnert N, Leopold S, Martin A, von Münchow-Klein L, Pessoa Rodrigues C, Cansever D, Hallet R, Richter K, Schubert D, Daniel G, Dylus D, Forkel M, Schwinge D, Schramm C, Redanz S, Lassen K, Manfredo Vieira S, Piali L, Palm N, Bieniossek C, Kriegel M. Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human. Science Translational Medicine 2025, 17: eadj6294. PMID: 39908347, DOI: 10.1126/scitranslmed.adj6294.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune diseasesToll-like receptor 8Gut pathobiontsHuman adaptive immune responseLong-term sequelaeAdaptive immune responsesHuman T cellsChronic autoimmune diseaseHuman monocyte activationContribution to autoimmunityAutoimmune hepatitisAutoantibody titersAnti-<i>E.Autoimmune pathophysiologyLupus modelT-helperLifelong immunosuppressionTargeted therapyT cellsDisease activityLupus erythematosusAutoantibody responseMonocyte activationImmune responseA neoantigen vaccine generates antitumour immunity in renal cell carcinoma
Braun D, Moranzoni G, Chea V, McGregor B, Blass E, Tu C, Vanasse A, Forman C, Forman J, Afeyan A, Schindler N, Liu Y, Li S, Southard J, Chang S, Hirsch M, LeBoeuf N, Olive O, Mehndiratta A, Greenslade H, Shetty K, Klaeger S, Sarkizova S, Pedersen C, Mossanen M, Carulli I, Tarren A, Duke-Cohan J, Howard A, Iorgulescu J, Shim B, Simon J, Signoretti S, Aster J, Elagina L, Carr S, Leshchiner I, Getz G, Gabriel S, Hacohen N, Olsen L, Oliveira G, Neuberg D, Livak K, Shukla S, Fritsch E, Wu C, Keskin D, Ott P, Choueiri T. A neoantigen vaccine generates antitumour immunity in renal cell carcinoma. Nature 2025, 639: 474-482. PMID: 39910301, PMCID: PMC11903305, DOI: 10.1038/s41586-024-08507-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntigens, NeoplasmCancer VaccinesCarcinoma, Renal CellClass I Phosphatidylinositol 3-KinasesDNA-Binding ProteinsFemaleHumansIpilimumabKidney NeoplasmsMaleMiddle AgedMutationPrecision MedicineT-LymphocytesTranscription FactorsTumor Suppressor ProteinsUbiquitin ThiolesteraseVon Hippel-Lindau Tumor Suppressor ProteinConceptsPersonalized cancer vaccinesRenal cell carcinomaDriver mutationsAntitumour immunityCell carcinomaI trialResected clear cell renal cell carcinomaImmune responseT cell immune responsesClear cell renal cell carcinomaHigh-risk RCCDose-limiting toxicityLow mutational burdenCell renal cell carcinomaEffective adjuvant therapyPhase I trialT cell reactivityAbsence of recurrenceCirculating immune responsesCell immune responseAutologous tumorNeoantigen vaccinesCancer vaccinesAdjuvant therapyMutational burdenAcute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis.
Hu X, He Y, Li S, Jiang Y, Yu R, Wu Y, Fu X, Song Y, Lin C, Shi J, Li H, Gao Y. Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis. Development 2025, 152 PMID: 39817838, DOI: 10.1242/dev.204226.Peer-Reviewed Original ResearchFetal hematopoiesisMegakaryocyte-erythroid progenitorsAcute inflammationInterferon-stimulated genesDouble-stranded RNAMegakaryocyte maturationPlatelet productionImpaired platelet productionFormation of double-stranded RNADownstream interferon-stimulated genesCell fate determinationRNA m6A modificationPhosphorylation of STAT1Hematopoietic progenitorsMegakaryocyte progenitorsHematopoietic cellsM6A methyltransferase METTL3Hematopoietic developmentGene expression analysisImmune responseMegakaryopoiesisHematopoiesisInflammationFate determinationIGF1 expressionPMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression
Xu Z, Qiao S, Wang Z, Peng C, Hou Y, Liu B, Cao G, Wang T. PMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression. Gut Microbes 2025, 17: 2455508. PMID: 39886799, PMCID: PMC11792855, DOI: 10.1080/19490976.2025.2455508.Peer-Reviewed Original ResearchConceptsPMA1 expressionExtracellular vesiclesCell differentiationAdaptor protein CARD9Th17 cell differentiationCARD9 deficiencyActivity of GAPDHVirulence factorsDecreased enzyme activityPma1Immune responseProteomic analysisCARD9Decreased glycolysisIL-17A productionMucosal immune responsesInduce Th17 cell differentiationMesenteric lymph nodesEditing systemAggravated colitisIL-17ALymph nodesColitis progressionAberrant changesGAPDHCAR-T Entering a New "Phase": Improving CAR-T Function by Harnessing Phase Separation.
Su X. CAR-T Entering a New "Phase": Improving CAR-T Function by Harnessing Phase Separation. Cancer Research 2025, 85: 1011-1012. PMID: 39879116, PMCID: PMC11910263, DOI: 10.1158/0008-5472.can-25-0357.Peer-Reviewed Original ResearchConceptsChimeric antigen receptorFunction of CAR T cellsCAR-T cellsNext-generation cell therapyT cell receptor complexCAR-T functionMouse xenograft modelCytotoxicity in vitroCAR-TT cellsAntigen receptorAntitumor effectCell therapyXenograft modelCoreceptor signalingImmune responseImmunological synapseReceptor complexBiomolecular condensatesCytoplasmic tailCoreceptorTherapyCD3ELiquid-liquid phase separationThe Complex Landscape of Updated Pneumococcal Conjugate Vaccines
Thindwa D, Shapiro E, Weinberger D. The Complex Landscape of Updated Pneumococcal Conjugate Vaccines. Open Forum Infectious Diseases 2025, 12: ofaf050. PMID: 39968305, PMCID: PMC11834978, DOI: 10.1093/ofid/ofaf050.Peer-Reviewed Original ResearchAltering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates
De Oliveira A, Versteeg L, Briggs N, Adhikari R, Villar M, Redd J, Hotez P, Bottazzi M, Pollet J. Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates. PLOS Neglected Tropical Diseases 2025, 19: e0012809. PMID: 39792959, PMCID: PMC11756802, DOI: 10.1371/journal.pntd.0012809.Peer-Reviewed Original ResearchConceptsAntigen-specific antibodiesMRNA vaccine candidateMRNA vaccinesVaccine candidatesNa-GST-1Plasma membrane-anchoredRobust CD8+ T-cell responsesCD8+ T cell responsesMemory T cell populationsTiters of antigen-specific antibodiesLevels of antigen-specific antibodiesT cell responsesT cell populationsRecombinant Na-GST-1In vivo efficacySubunit vaccine candidateInduce humoral responsesImmunogenicity findingsNeutralizing antibodiesClinical studiesDevelopment of multivalent vaccinesHumoral responseRNA vaccinesImmune responsePeptide presentationPhase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas
Sahebjam S, Raval R, Forsyth P, Enderling H, Tran N, Arrington J, Macaulay R, Perlow H, Palmer J, Ghose J, Rajappa P, Giglio P, Li Z, Etame A, Mokhtari S, Cruz-Chamorro R, Bhandari M, Thapa R, Robinson T, Chen D, Yu H. Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas. Neuro-Oncology Advances 2025, 7: vdaf033. PMID: 40134851, PMCID: PMC11934552, DOI: 10.1093/noajnl/vdaf033.Peer-Reviewed Original ResearchTreatment-related adverse eventsStereotactic re-irradiationRecurrent high-grade gliomaHigh-grade gliomasRe-irradiationPD-1PD-1 blockadeProgression-free survivalPhase I studySecondary end pointsPhase 1 trialRecurrent HGGCheckpoint immunotherapyOverall survivalRecurrent glioblastomaAnaplastic astrocytomaBevacizumabNivolumabIpilimumabGrade 3Adverse eventsClinical investigationImmune responseEnd pointsPatientsSystem vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans
Cortese M, Hagan T, Rouphael N, Wu S, Xie X, Kazmin D, Wimmers F, Gupta S, van der Most R, Coccia M, Aranuchalam P, Nakaya H, Wang Y, Coyle E, Horiuchi S, Wu H, Bower M, Mehta A, Gunthel C, Bosinger S, Kotliarov Y, Cheung F, Schwartzberg P, Germain R, Tsang J, Li S, Albrecht R, Ueno H, Subramaniam S, Mulligan M, Khurana S, Golding H, Pulendran B. System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans. Nature Immunology 2025, 26: 116-130. PMID: 39747435, DOI: 10.1038/s41590-024-02036-z.Peer-Reviewed Original ResearchConceptsHuman bone marrow plasma cellsResponse longevityBone marrow plasma cellsAntibody responseVaccine-induced antibody responsesAntibody response magnitudesH5N1 influenza vaccineMIF-CD74 axisInvestigate immune responsesBlood transcriptional signaturesAS03-adjuvantedInfluenza vaccineMegakaryocyte activityResponse durabilityAnalysis of predictorsPlasma cellsVaccine durabilityImmune responseDay 7Transcriptional signaturePromote survivalCell-cell interactionsAntibodiesPlateletVaccine
2024
Role of Toll-like receptor 2 during infection of Leptospira spp: A systematic review
Kappagoda C, Senavirathna I, Agampodi T, Agampodi S. Role of Toll-like receptor 2 during infection of Leptospira spp: A systematic review. PLOS ONE 2024, 19: e0312466. PMID: 39729468, PMCID: PMC11676585, DOI: 10.1371/journal.pone.0312466.Peer-Reviewed Original ResearchConceptsToll-like receptor 2Toll-like receptor 2 expressionReceptor 2TLR2 responsesSystematic reviewIn vivoImmune effectorsIn vitroEx vivoHuman studiesInvolvement of Toll-like receptor 2Systematic Review Centre for Laboratory Animal Experimentation riskInvolvement of TLR4Increased TLR2 expressionNational Institutes of Health Quality Assessment ToolEffective immune responseIn vitro studiesHuman leptospirosisTLR2 involvementRisk of biasIn vivo studiesTLR2 expressionOffice of Health AssessmentWeb of ScienceImmune response
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