2022
Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats
Bagdas D, Harris L, Addy N. Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats. Neuroscience Letters 2022, 793: 137008. PMID: 36476758, PMCID: PMC9948648, DOI: 10.1016/j.neulet.2022.137008.Peer-Reviewed Original ResearchConceptsTaste responsesNicotine concentrationsNicotine exposureNicotine withdrawalNicotine effectsAdolescent ratsChronic exposureOral nicotine exposureTaste reactivityAversive tasteChronic nicotine exposureDevelopment of toleranceLow nicotine concentrationsE-cigarette useE-cigarette flavoringsHigher nicotine concentrationsNicotine abstinenceNicotine useNaïve animalsChronic effectsNicotineRatsAversive responsesDifferent nicotine concentrationsWithdrawalNicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure.
Peng G, Xi Y, Bellini C, Pham K, Zhuang ZW, Yan Q, Jia M, Wang G, Lu L, Tang MS, Zhao H, Wang H. Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure. American Journal Of Cancer Research 2022, 12: 3679-3692. PMID: 36119846, PMCID: PMC9442002.Peer-Reviewed Original ResearchElectronic cigarette exposureCigarette exposureMale ApoE-/- miceApoE-/- miceCytokine mRNA expressionPoor health outcomesWhite blood cellsElectronic cigarette useDose-dependent mannerE-cigarette aerosolAerosol inhalationCigarette smokingActivation of MAPKHigher nicotine concentrationsMAPK pathway activationCell-damaging effectsCpG sitesHealth outcomesCigarette useMRNA expressionNicotine concentrationsPathway activationSignificant CpG sitesBlood cellsSignificant alterations
2016
Nicotine concentration of e-cigarettes used by adolescents
Morean ME, Kong G, Cavallo DA, Camenga DR, Krishnan-Sarin S. Nicotine concentration of e-cigarettes used by adolescents. Drug And Alcohol Dependence 2016, 167: 224-227. PMID: 27592270, PMCID: PMC5158305, DOI: 10.1016/j.drugalcdep.2016.06.031.Peer-Reviewed Original ResearchConceptsNicotine usersNicotine e-liquidE-cigarettesNicotine concentrationsE-cigarette usersNicotine-free e-liquidsHigher nicotine concentrationsE-liquidsOwn e-cigaretteCross-sectional surveyLiquid nicotine concentrationHigher nicotine levelsE-cigarette use frequencySmoking statusCigarette smokingMale sexMore smokersNicotine exposureTobacco shopsNicotine levelsSmokersAdolescentsMore malesSexMales
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