2023
High-Dose Targeted Radiation with 131I-Apamistamab Prior to HCT Demonstrated a Dose-Response for Durable Complete Remission in Patients with R/R AML
Litzow M, Chen G, Gyurkocza B, Nath R, Seropian S, Choe H, Abboud C, Koshy N, Tomlinson B, Abhyankar S, Foran J, Abedin S, Al-Kadhimi Z, Kebriaei P, Sabloff M, Orozco J, Jamieson K, Magalhaes-Silverman M, Van Besien K, Schuster M, Law A, Mayer S, Lazarus H, Leung E, Chen M, Natwa M, Spross J, Li K, Nagl N, Haeuber E, Vusirikala M, Nahar A, Sandmaier B, Pagel J, Giralt S, Desai A, Wahl R, Pandit-Taskar N, Brodin P, Stiff P. High-Dose Targeted Radiation with 131I-Apamistamab Prior to HCT Demonstrated a Dose-Response for Durable Complete Remission in Patients with R/R AML. Blood 2023, 142: 3529. DOI: 10.1182/blood-2023-189040.Peer-Reviewed Original ResearchDurable complete remissionConventional careLiver dosePrimary endpointBone marrowR AMLComplete remissionLiver ratioHigh doseLeukemic cellsRadiation doseAllogeneic hematopoietic cell transplantRadiation dose-response relationshipHematopoietic cell transplantMost older patientsPhase 3 studyTotal body irradiationFavorable biodistributionRadiation dose toleranceYears of ageDose toleranceDose-response relationshipDiseased bone marrowMedian doseRefractory AML
2022
Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers
Ralevski E, Horvath T, Shanabrough M, Newcomb J, Pisani E, Petrakis I. Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers. Alcohol And Alcoholism 2022, 58: 100-106. PMID: 36382470, PMCID: PMC9830489, DOI: 10.1093/alcalc/agac058.Peer-Reviewed Original ResearchImplementation opportunities for scaling up methadone maintenance treatment in Kyrgyzstan: Methadone dosage and retention on treatment over two years
Ivasiy R, Madden LM, Farnum SO, Shumskaya N, de Leon S, Bromberg DJ, Kurmanalieva A, Duishenaliev A, Tokubaev R, Altice FL. Implementation opportunities for scaling up methadone maintenance treatment in Kyrgyzstan: Methadone dosage and retention on treatment over two years. Drug And Alcohol Dependence Reports 2022, 4: 100075. PMID: 36267100, PMCID: PMC9581459, DOI: 10.1016/j.dadr.2022.100075.Peer-Reviewed Original ResearchMethadone maintenance treatmentDosage levelsMaintenance treatmentCox multivariate regression modelMethadone dosage levelsProspective observational databaseNational treatment guidelinesProportion of patientsHigher dosage levelsOptimal dosageMMT retentionMMT patientsMethadone dosageTreatment guidelinesHIV statusMultivariate regression modelHigh doseSurvival analysisTreatment dropoutClinical settingCost-effective strategySignificant predictorsMonthsHIVObservational databaseFactors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community
Biondi BE, Vander Wyk B, Schlossberg EF, Shaw A, Springer SA. Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community. Addiction Science & Clinical Practice 2022, 17: 15. PMID: 35255967, PMCID: PMC8899775, DOI: 10.1186/s13722-022-00299-1.Peer-Reviewed Original ResearchConceptsOpioid use disorderHigher pain interferenceMOUD retentionPain interferenceUse disordersOngoing prospective cohort studySevere opioid use disorderProspective cohort studyMultivariable logistic regressionCohort of adultsMethadone doseAnalgesic effectBuprenorphine doseCohort studyOpioid useResultsA totalHigher oddsMOUDAdjusted modelHigh doseLogistic regressionBuprenorphineMethadoneDoseDiscontinuation
2021
Distinct renin/aldosterone activity profiles correlate with renal function, natriuretic response, decongestive ability and prognosis in acute heart failure
Biegus J, Nawrocka-Millward S, Zymliński R, Fudim M, Testani J, Marciniak D, Rosiek-Biegus M, Ponikowska B, Guzik M, Garus M, Ponikowski P. Distinct renin/aldosterone activity profiles correlate with renal function, natriuretic response, decongestive ability and prognosis in acute heart failure. International Journal Of Cardiology 2021, 345: 54-60. PMID: 34728260, DOI: 10.1016/j.ijcard.2021.10.149.Peer-Reviewed Original ResearchConceptsAcute heart failureHeart failureRenal functionDay 1Development of AHFAldosterone system activationSingle cardiology centreAdverse clinical outcomesLower blood pressureAldosterone changesHF rehospitalizationLow natriuresisRAAS overactivitySerum reninNatriuretic responseBlood pressureClinical courseCardiology centersClinical outcomesSerum sodiumYear mortalityStudy populationHigh doseSystem activationClinical relevanceCorrelation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy
Bertolet A, Abolfath R, Carlson DJ, Lustig RA, Hill-Kayser C, Alonso-Basanta M, Carabe A. Correlation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy. International Journal Of Radiation Oncology • Biology • Physics 2021, 112: 237-246. PMID: 34425196, DOI: 10.1016/j.ijrobp.2021.08.027.Peer-Reviewed Original ResearchConceptsT2/fluidNormal tissue complication probabilityComplication probabilityCohort of patientsGroup of patientsPencil beam scanning proton therapyPlanning computed tomography (CT) imagesMost patientsMRI changesProton radiation therapySame doseRadiation therapyHigh doseLow dosePatientsBrain normal tissuesSuperficial lesionsHigh linear energy transferNormal tissuesMagnetic resonance imagesComputed tomography imagesDoseMeningiomasInversion recoveryTherapyOptimal Radiation Dose for Stage III Lung Cancer—Should “Definitive” Radiation Doses Be Used in the Preoperative Setting?
Saffarzadeh AG, Canavan M, Resio BJ, Walters SL, Flores KM, Decker RH, Boffa DJ. Optimal Radiation Dose for Stage III Lung Cancer—Should “Definitive” Radiation Doses Be Used in the Preoperative Setting? JTO Clinical And Research Reports 2021, 2: 100201. PMID: 34590044, PMCID: PMC8474436, DOI: 10.1016/j.jtocrr.2021.100201.Peer-Reviewed Original ResearchLong-term mortality riskStage III NSCLCLow dosePreoperative settingMortality riskHigh doseRadiation doseClinical stage III patientsNational Cancer Database dataStage III lung cancerStage III patientsUse of surgeryLength of stayGy of radiationCox proportional hazardsComparative effectiveness analysisOptimal radiation doseSingle-dose strategyLong-term survivalRadiation dosesLogistic regression modelsDefinitive chemoradiotherapyN2 patientsNonsurgical patientsPerioperative outcomesThreshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDose5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING
Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING. The EMBO Journal 2021, 40: embj2020106065. PMID: 33615517, PMCID: PMC8013832, DOI: 10.15252/embj.2020106065.Peer-Reviewed Original ResearchConceptsAnti-tumor immunityTumor burdenSubsequent type I interferon productionHigh STING expressionIntratumoral T cellsT-cell depletionType I interferon productionI interferon productionLoss of STINGImmunocompetent hostsColorectal specimensT cellsSTING expressionBetter survivalHigh doseTherapeutic effectivenessHuman colorectal specimensMelanoma tumorsInterferon productionChemotherapeutic drugsMurine colonImmunityEfficacyStingsColonLongitudinal Effects of Acute Cannabis Exposure on Automobile Driving Behavior in a Naturalistic Simulated Environment
Meda S, Boer E, Ward N, Book G, Stevens M, Boyle C, Mubeen M, Pearlson G. Longitudinal Effects of Acute Cannabis Exposure on Automobile Driving Behavior in a Naturalistic Simulated Environment. 2021 DOI: 10.26828/cannabis.2021.01.000.21.Peer-Reviewed Original ResearchAcute cannabis exposureHigh-dose subjectsDrug dose levelsSignificant public health riskCannabis exposureDose studyDrug exposureSimulated environmentInfluence of cannabisSafe overtakingSingle acuteHigh doseSPSS v24Psychomotor functionComplex dayDriving functionsDose levelsHigh dosesSeparate daysPublic health riskOverall riskIntoxicated subjectsDoseThree timesNumerous metrics
2020
Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme: Translation from rat to human
Shcherbinin S, Kielbasa W, Dubois S, Lowe S, Phipps K, Tseng J, Kevin D, Natanegara F, Warner S, Dreyfus N, Lindsay‐Scott P, Hawk M, McDonald N, Zhang X, Gilmore J, Biglan K, Mergott D, Russell D, Gunn R, Constantinescu C, Nuthall H, Collins E. Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme: Translation from rat to human. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.040558.Peer-Reviewed Original ResearchPET scansEnzyme occupancyHealthy volunteersPlasma concentration-dependent increaseSingle oral dose studyOral dose studyBaseline PET scanSingle oral doseTau-related diseasesDose-dependent changesConcentration-dependent increaseHuman PET studiesDose cohortsOral doseSingle dosesDose studyClinical studiesEfficacy trialsPharmacokinetic samplesFrontal cortexInitial cohortDose selectionHigh doseNumber of subjectsEnzyme inhibitorsThe Impact of Radiation Energy on Dose Homogeneity and Organ Dose in the Gttingen Minipig Total-Body Irradiation Model
Poirier Y, Becker S, Decesaris C, Culberson W, Draeger E, Gerry AJ, Johnstone CD, Gibbs A, Vujaskovic Z, Jackson IL. The Impact of Radiation Energy on Dose Homogeneity and Organ Dose in the Gttingen Minipig Total-Body Irradiation Model. Radiation Research 2020, 194: 544-556. PMID: 33045066, DOI: 10.1667/rade-20-00135.1.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAbsorption, RadiationAnimalsBody SizeBody WeightCobalt RadioisotopesDose-Response Relationship, RadiationGamma RaysMaleModels, AnimalOrgan SpecificityParticle AcceleratorsPelvisPhotonsProne PositionRadiation DosageRadiation ToleranceRadioisotope TeletherapyRadiotherapy Planning, Computer-AssistedRadiotherapy, High-EnergyShoulderSwineSwine, MiniatureTomography, X-Ray ComputedWhole-Body IrradiationConceptsTotal body irradiationDose-volume histogramsGöttingen minipigsThoracic organsMedical countermeasuresRadiation dose-response relationshipDose-response relationshipNormal tissue damageDose distributionExperienced radiation oncologistsAdditional confounding factorsTBI modelPelvic organsHigh doseIndividual organsAnimal modelsAverage doseConfounding factorsRadiation oncologistsTissue damageLess doseOrgan doseAverage dosesDose homogeneityDoseAll-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors
Gordon K, Manhapra A, Crystal S, Dziura J, Edelman E, Skanderson M, Kerns R, Justice A, Tate J, Becker W. All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors. Drug And Alcohol Dependence 2020, 216: 108291. PMID: 33011662, PMCID: PMC7644145, DOI: 10.1016/j.drugalcdep.2020.108291.Peer-Reviewed Original ResearchConceptsMorphine equivalent daily doseCause mortalityLong-term opioid therapyTime-updated Cox regressionStrong dose-response relationshipUnnatural deathsEquivalent daily doseDose-response relationshipOpioid doseOpioid therapyUninfected patientsOpioid useDaily doseCox regressionMortality outcomesTherapy doseHigh doseMale veteransOverdose fatalitiesOverdose mortalityPLWHMortalityHIVPatientsDoseEffect of Afrezza on Glucose Dynamics During HCL Treatment
Galderisi A, Cohen N, Calhoun P, Kraemer K, Breton M, Weinzimer S, Cengiz E. Effect of Afrezza on Glucose Dynamics During HCL Treatment. Diabetes Care 2020, 43: 2146-2152. PMID: 32661108, PMCID: PMC7440894, DOI: 10.2337/dc20-0091.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAdolescentAdultBlood GlucoseBlood Glucose Self-MonitoringCross-Over StudiesDiabetes Mellitus, Type 1Dose-Response Relationship, DrugEquipment and SuppliesFemaleGlycemic ControlHumansHypoglycemic AgentsInsulin Infusion SystemsInsulin, Regular, HumanMaleMealsPostprandial PeriodYoung AdultConceptsControl armPremeal bolusesPostprandial plasma glucose levelsPostprandial blood glucose controlPrimary efficacy outcomeRapid-acting insulinBlood glucose controlPlasma glucose levelsType 1 diabetesLater time pointsSequential mealsEfficacy outcomesPPG levelsSecondary outcomesGlycemic excursionsMeal studyGlucose controlSubcutaneous routeInsulin delivery systemsGlucose levelsGlucose metricsHigh doseStudy daysInsulin absorptionInsulin bolusProof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteers
Kantrowitz JT, Grinband J, Goff DC, Lahti AC, Marder SR, Kegeles LS, Girgis RR, Sobeih T, Wall MM, Choo TH, Green MF, Yang YS, Lee J, Horga G, Krystal JH, Potter WZ, Javitt DC, Lieberman JA. Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteers. Neuropsychopharmacology 2020, 45: 1842-1850. PMID: 32403118, PMCID: PMC7608251, DOI: 10.1038/s41386-020-0706-z.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexBrief Psychiatric Rating ScaleTS-134Target engagementHealthy volunteersMetabotropic glutamate receptor 2/3 agonistKetamine-induced psychotic symptomsBPRS positive symptomsDouble-blind conditionsProof of mechanismKetamine-induced changesAntipsychotic drug developmentTreatment of schizophreniaPsychiatric Rating ScaleAnterior cingulate cortexPrimary outcomeClinical symptomsGlutamatergic drugsGlutamate neurotransmissionTotal symptomsClinical assessmentLow dosePsychotic symptomsHigh dosePlacebo data
2019
1066O Polo-like kinase 1 (PLK1) inhibitor, onvansertib, in combination with low-dose cytarabine or decitabine in patients with relapsed/refractory acute myeloid leukaemia in phase Ib
Zeidan A, Becker P, Patel P, Schiller G, Tsai M, Lin T, Wang E, Erlander M, Cortes J. 1066O Polo-like kinase 1 (PLK1) inhibitor, onvansertib, in combination with low-dose cytarabine or decitabine in patients with relapsed/refractory acute myeloid leukaemia in phase Ib. Annals Of Oncology 2019, 30: v435. DOI: 10.1093/annonc/mdz251.001.Peer-Reviewed Original ResearchTarget engagementEvaluable ptsHigh dosesRefractory acute myeloid leukemiaInhibition of PLK1CR/CRiLow-dose cytarabinePreclinical AML modelsR AML patientsDose-escalation phasePolo-like kinase 1Anti-leukaemic activityAcute myeloid leukemiaEvaluable patientsLDAC armBM blastsDose escalationAML patientsPolo-like kinase 1 inhibitorsEscalation phaseBiomarker statusMyeloid leukemiaSelective PLK1 inhibitorBlood samplesHigh dosePellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India
Narasimha V, Ganesh S, Reddy S, Shukla L, Mukherjee D, Kandasamy A, Chand P, Benegal V, Murthy P. Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India. Alcohol And Alcoholism 2019, 54: 148-151. PMID: 30721993, DOI: 10.1093/alcalc/agz004.Peer-Reviewed Original ResearchConceptsAlcohol dependence syndromeAddiction treatment centersInpatient careHigh doseTreatment centersDependence syndromeLife-threatening comorbiditiesAcute medical conditionsDeficiency of niacinMulti-systemic diseaseMinority of casesTwo-thirdsPeripheral neuropathyClinical presentationParenteral vitaminDelirium tremensMultivitamin supplementsClassical triadComplete resolutionAssociated conditionMedical conditionsPrompt identificationHigh indexAlcohol dependenceComplete recoveryTofacitinib benefit‐risk profile in chronic plaque psoriasis
Strober B, Gottlieb A, Kerkhof P, Puig L, Bachelez H, Chouela E, Imafuku S, Thaçi D, Tan H, Valdez H, Gupta P, Kaur M, Frajzyngier V, Wolk R. Tofacitinib benefit‐risk profile in chronic plaque psoriasis. British Journal Of Dermatology 2019, 180: e19-e19. DOI: 10.1111/bjd.17373.Peer-Reviewed Original ResearchBiologic treatmentSevere psoriasisPlaque psoriasisHigh doseChronic plaque psoriasisHerpes zoster infectionSevere plaque psoriasisAcceptable safety profileBenefit-risk profileNew oral drugsZoster infectionPatient yearsTofacitinib treatmentUlcerative colitisPatients' qualityRheumatoid arthritisSafety profileAppearance of skinClinical trialsOral drugsEffective treatmentSide effectsPsoriasisPatientsDrugs
2018
Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study
Barsuglia J, Davis A, Palmer R, Lancelotta R, Windham-Herman A, Peterson K, Polanco M, Grant R, Griffiths R. Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study. Frontiers In Psychology 2018, 09: 2459. PMID: 30574112, PMCID: PMC6292276, DOI: 10.3389/fpsyg.2018.02459.Peer-Reviewed Original ResearchHigh doseNew insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice
Bagdas D, Alkhlaif Y, Jackson A, Carroll FI, Ditre JW, Damaj MI. New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice. Neuropharmacology 2018, 138: 72-79. PMID: 29860196, PMCID: PMC6054891, DOI: 10.1016/j.neuropharm.2018.05.025.Peer-Reviewed Original ResearchConceptsEffects of vareniclineNicotine withdrawal signsNicotine rewardΑ5 nAChRWithdrawal signsHigh doseKnockout miceΒ2-nAChRsNicotine withdrawal-induced hyperalgesiaAdministration of vareniclineWithdrawal-induced hyperalgesiaΑ7 knockout miceDose-related mannerNicotinic acetylcholine receptorsΑ5 knockout micePlace preference testVarenicline doseCessation treatmentNicotine withdrawalSomatic signsVareniclineΑ7 nAChRsMouse modelCPP testNicotinic subtypes
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