2023
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression
Wei J, Alfajaro M, Cai W, Graziano V, Strine M, Filler R, Biering S, Sarnik S, Patel S, Menasche B, Compton S, Konermann S, Hsu P, Orchard R, Yan Q, Wilen C. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression. PLOS Pathogens 2023, 19: e1011351. PMID: 37410700, PMCID: PMC10325096, DOI: 10.1371/journal.ppat.1011351.Peer-Reviewed Original ResearchConceptsMouse hepatitis virusReceptor expressionTherapeutic targetMERS-CoVMajor SARS-CoV-2 variantsPrimary human airwaySARS-CoV-2 variantsNovel therapeutic targetViral receptor expressionSARS-CoV-2Histone methyltransferase KMT2DIntestinal epithelial cellsCoronavirus SusceptibilityDiverse coronavirusesHistone demethylase KDM6ADPP4 expressionCoronavirus receptorsHost determinantsHepatitis virusHuman airwaysSARS-CoVSmall molecule inhibitionViral entryPotential drug targetsViral receptors
2016
Is There a Role for Opportunistic Infection Prophylaxis in Pemphigus? An Expert Survey
Leshem Y, Snast I, Friedland R, Atzmony L, Levi A, Hodak E, Mimouni D. Is There a Role for Opportunistic Infection Prophylaxis in Pemphigus? An Expert Survey. American Journal Of Clinical Dermatology 2016, 18: 127-132. PMID: 27826815, DOI: 10.1007/s40257-016-0233-1.Peer-Reviewed Original ResearchConceptsOpportunistic infection prophylaxisImmunosuppressive therapyInfection prophylaxisInitiation of immunosuppressive therapyEffects of immunosuppressive therapyAdverse effects of immunosuppressive therapyEmergence of resistant pathogensCessation of immunosuppressionHistory of OIInfectious disease specialistsDrug of choiceTertiary care settingBackgroundOpportunistic infectionsImmunosuppressive agentsImmunosuppressive conditionsRisk stratificationDisease specialistsFrequent drugsResistant pathogensSide effectsSevere diseaseHepatitis virusObjectiveOur objectivePatientsPemphigus
2015
Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis.
Compton SR, Macy JD. Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis. Journal Of The American Association For Laboratory Animal Science 2015, 54: 745-55. PMID: 26632784, PMCID: PMC4671790.Peer-Reviewed Original ResearchConceptsMouse hepatitis virusMouse parvovirusMyocoptes musculinusInfectious agentsS. obvelataDetection of infectionHepatitis virusPCR analysisHousing micePathogen transmissionFacility levelMiceCages housing miceHelicobacter sppM. pulmonisSyphacia obvelataMycoplasma pulmonisCage washingParvovirusAnimal facilitiesSentinelsVirusAgentsPulmonisPathogen screening
2014
Human Cancer Virology: An Historical Review
Hudnall S. Human Cancer Virology: An Historical Review. 2014, 1-6. DOI: 10.1007/978-1-4939-0870-7_1.Peer-Reviewed Original ResearchMerkel cell carcinomaCell carcinomaHepatocellular carcinomaAdult T-cell leukemia/lymphomaT-cell leukemia/lymphomaCell leukemia/lymphomaBurkitt's lymphoma tissueEpstein-Barr virusHepatitis B virusLeukemia/lymphomaHuman cancer virusesKaposi's sarcoma tissueRetrovirus HTLV-1Tumor-inducing propertiesCervical cancerHuman papillomavirusB virusHepatitis virusLymphoma tissuesHTLV-1CarcinomaSarcoma tissuesWart tissueSophisticated molecular techniquesCancer viruses
2010
Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection
Mason W, Liu C, Aldrich C, Litwin S, Yeh M. Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection. Journal Of Virology 2010, 84: 8308-8315. PMID: 20519397, PMCID: PMC2916518, DOI: 10.1128/jvi.00833-10.Peer-Reviewed Original ResearchConceptsChronic hepatitis B virus infectionHepatitis B virus infectionB virus infectionExtensive clonal expansionClonal expansionHBV DNAInfected hepatocytesNoncirrhotic liverVirus infectionHepatocellular carcinomaImmune killingHuman HBV carriersNormal-appearing hepatocytesHuman hepatocytesWoodchuck hepatitis virusIntegrated HBV DNAHBV carriersSurgical resectionChronic infectionHepatitis virusNoncancerous liverInfectionLiverTissue sectionsHepatocytes
2009
Consequences of Drug Abuse and HIV/AIDS in China: Recommendations for Integrated Care of HIV-Infected Drug Users
Li X, He G, Wang H, Williams AB. Consequences of Drug Abuse and HIV/AIDS in China: Recommendations for Integrated Care of HIV-Infected Drug Users. AIDS Patient Care And STDs 2009, 23: 877-884. PMID: 19799494, DOI: 10.1089/apc.2009.0015.Peer-Reviewed Original ResearchConceptsHIV/AIDSDrug usersDrug abuseHealth care providers' attitudesCare providers' attitudesMethadone maintenance treatmentNeedle syringe programsInjection drug usersHIV/AIDS epidemicUnprotected sexual behaviorMedical care servicesDrug User QualityDrug abuse behaviorHIV infectionMaintenance treatmentNeedle sharingSyringe programsHigh prevalenceHepatitis virusProvider attitudesCare servicesHealth professionalsIntegrated careSevere mental problemsPsychosocial consequences
2004
Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice.
Compton SR, Ball-Goodrich LJ, Johnson LK, Johnson EA, Paturzo FX, Macy JD. Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Comparative Medicine 2004, 54: 681-9. PMID: 15679267.Peer-Reviewed Original ResearchConceptsT cell-deficient miceCell-deficient miceMouse hepatitis virusBALB/cGastrointestinal tractC57BL/6 miceLymphoid tissueViral RNASubclinical infectionHepatitis virusInfected B-cell-deficient miceSmall intestineEnterotropic mouse hepatitis virusB cell-deficient miceImmunocompetent BALB/cMost natural infectionsChronic subclinical infectionMultiple organ systemsTranscriptase-polymerase chain reaction analysisImmunocompetent miceLethal infectionEnterotropic strainsT cellsImmunodeficient miceIntestinal mucosaTransmission of enterotropic mouse hepatitis virus from immunocompetent and immunodeficient mice.
Compton SR, Ball-Goodrich LJ, Paturzo FX, Macy JD. Transmission of enterotropic mouse hepatitis virus from immunocompetent and immunodeficient mice. Comparative Medicine 2004, 54: 29-35. PMID: 15027615.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Outbred StrainsFecesFemaleHepatitis, Viral, AnimalImmunocompetenceImmunocompromised HostInfectious Disease Transmission, VerticalMiceMice, Inbred StrainsMurine hepatitis virusReverse Transcriptase Polymerase Chain ReactionRNA, ViralRodent DiseasesSentinel SurveillanceSpecies SpecificityVirus SheddingConceptsCell-deficient miceEnterotropic mouse hepatitis virusT cell-deficient miceMouse hepatitis virusInfected miceIntestinal infectionsC57BL/6 miceHepatitis virusB cell-deficient miceViral RNABALB/c miceSevere disseminated diseaseNon-infectious RNADisseminated diseaseNaive miceC miceMHV infectionImmunodeficient miceSentinel miceBALB/ cViral transmissionInfectionMiceVirus RNAWeeks
2002
Assessment of static isolator cages with automatic watering when used with conventional husbandry techniques as a factor in the transmission of mouse hepatitis virus.
Macy JD, Cameron GA, Ellis SL, Hill EA, Compton SR. Assessment of static isolator cages with automatic watering when used with conventional husbandry techniques as a factor in the transmission of mouse hepatitis virus. Journal Of The American Association For Laboratory Animal Science 2002, 41: 30-5. PMID: 12109894.Peer-Reviewed Original ResearchConceptsFilter-top cagesMouse hepatitis virusUninoculated miceHepatitis virusCages of miceTransmission of infectionExamination of fecesLong-term useImmunocompetent miceHigh virus concentrationsPolymerase chain reaction amplificationMiceChain reaction amplificationWeeksStandard cagesMHV-A59Fecal samplesRoutine husbandrySerologyTest cageVirusInfected cagesInfectionReaction amplificationRows of cages
1995
Coronavirus Receptors
Holmes K, Compton S. Coronavirus Receptors. The Viruses 1995, 55-71. DOI: 10.1007/978-1-4899-1531-3_4.Peer-Reviewed Original Research
1994
Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors
Compton S. Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors. Virology 1994, 203: 197-201. PMID: 8030279, PMCID: PMC7131022, DOI: 10.1006/viro.1994.1475.Peer-Reviewed Original ResearchConceptsSJL miceLimited tissue tropismMHV-RIEnterotropic mouse hepatitis virusBALB/c miceTissue tropismMonoclonal antibody CC1BALB/cMouse hepatitis virusRole of receptorsMurine carcinoembryonic antigenC miceEnterotropic strainsHepatitis virusCarcinoembryonic antigenBHK cellsInfectionMiceDifferent receptorsReceptorsCell linesGlycoprotein receptorsMurine tissuesMouse coronavirusMHV
1990
Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity?
Holmes K, Williams R, Cardellichio C, Compton S, Stephensen C, Snyder S, Frana M, Jiang G, Smith A, Knobler R. Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity? Advances In Experimental Medicine And Biology 1990, 276: 37-44. PMID: 1966425, DOI: 10.1007/978-1-4684-5823-7_6.Peer-Reviewed Original ResearchConceptsSJL/J miceNormal target tissuesJ miceMHV-A59BALB/c miceTarget tissuesVirus overlay protein blot assaySJL/JMouse hepatitis virusSusceptible miceBinding of virionsC miceHepatitis virusOnly receptorBlot assaysVirus bindingMiceTissue tropismIntestine membranesMurine virusesHepatocyte membraneProtein blot assayVirusInfectionMolecular mechanisms
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