2025
Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis.
Hu X, He Y, Li S, Jiang Y, Yu R, Wu Y, Fu X, Song Y, Lin C, Shi J, Li H, Gao Y. Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis. Development 2025, 152 PMID: 39817838, DOI: 10.1242/dev.204226.Peer-Reviewed Original ResearchFetal hematopoiesisMegakaryocyte-erythroid progenitorsAcute inflammationInterferon-stimulated genesDouble-stranded RNAMegakaryocyte maturationPlatelet productionImpaired platelet productionFormation of double-stranded RNADownstream interferon-stimulated genesCell fate determinationRNA m6A modificationPhosphorylation of STAT1Hematopoietic progenitorsMegakaryocyte progenitorsHematopoietic cellsM6A methyltransferase METTL3Hematopoietic developmentGene expression analysisImmune responseMegakaryopoiesisHematopoiesisInflammationFate determinationIGF1 expression
2024
Neuropeptide signalling orchestrates T cell differentiation
Hou Y, Sun L, LaFleur M, Huang L, Lambden C, Thakore P, Geiger-Schuller K, Kimura K, Yan L, Zang Y, Tang R, Shi J, Barilla R, Deng L, Subramanian A, Wallrapp A, Choi H, Kye Y, Ashenberg O, Schiebinger G, Doench J, Chiu I, Regev A, Sharpe A, Kuchroo V. Neuropeptide signalling orchestrates T cell differentiation. Nature 2024, 635: 444-452. PMID: 39415015, DOI: 10.1038/s41586-024-08049-w.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 3AnimalsCalcitonin Gene-Related PeptideCalcitonin Receptor-Like ProteinCell DifferentiationCyclic AMP Response Element-Binding ProteinFemaleMaleMiceMice, Inbred C57BLReceptor Activity-Modifying Protein 3Signal TransductionSTAT1 Transcription FactorTh1 CellsTh2 CellsConceptsT helper type 1Acute viral infectionActivating transcription factor 3Th1 cell differentiationCAMP response element-binding proteinViral infectionCell differentiationNeuropeptide CGRPFate determinationT cellsCD8+ T cell responsesDifferentiation of Th2 cellsIn vitro polarizationT cell fate determinationT cell responsesTh1 cell responsesCell fate determinationIn vivo CRISPR screeningDownstream cAMP response element-binding proteinT cell differentiationT helper cell differentiationIn vivo differentiationResponse element-binding proteinElement-binding proteinNeuroimmune circuitsThe dishevelled associated activator of morphogenesis protein 2 (Daam2) regulates neural tube closure
Nama K, Su B, Marquez J, Khokha M, Habas R. The dishevelled associated activator of morphogenesis protein 2 (Daam2) regulates neural tube closure. Developmental Dynamics 2024, 253: 1130-1146. PMID: 38877839, PMCID: PMC11611695, DOI: 10.1002/dvdy.720.Peer-Reviewed Original ResearchWnt signaling pathwayActin cytoskeletonSub-cellular localization studiesFormin homology proteinsSignaling pathwayNon-canonical Wnt pathwayCellular actin cytoskeletonActin filament formationActin cytoskeleton modulationMammalian cultured cellsCo-immunoprecipitation assaysNeural tube morphogenesisNon-canonical signalingStem cell homeostasisNon-canonical pathwayNeural tube closure defectsNeural tube closureVertebrate gastrulationCytoskeleton modulationCell polarityFate determinationCellular processesTube morphogenesisCo-immunoprecipitationVertebrate developmentHox Genes
Duraiswamy A, Senkumar L, De Kumar B. Hox Genes. 2024 DOI: 10.1016/b978-0-12-822563-9.00196-7.Peer-Reviewed Original ResearchHox genesAberrant expression of HOX genesCell fate determinationExpression of Hox genesFate determinationTissue homeostasisMetastatic behavior of tumorsCell migrationGenesDevelopmental eventsDevelopmental defectsHoxCancer progressionAberrant expressionMetastatic behaviorBehavior of tumorsCellsDisease progressionDisease prognosisProteinHomeostasisOrganogenesisPrognosis
2023
KDM5 Lysine Demethylases in Pathogenesis, from Basic Science Discovery to the Clinic
Zhang S, Cao J, Yan Q. KDM5 Lysine Demethylases in Pathogenesis, from Basic Science Discovery to the Clinic. Advances In Experimental Medicine And Biology 2023, 1433: 113-137. PMID: 37751138, DOI: 10.1007/978-3-031-38176-8_6.ChaptersConceptsPlant homeodomainFamily proteinsKey epigenetic markCell fate determinationHistone methylation marksCancer type-dependent mannerKetoglutarate-dependent dioxygenasesSelective KDM5 inhibitorsTumor suppressive functionType-dependent mannerEpigenetic marksTumor suppressive roleFate determinationJumonji CLysine 4Active chromatinMethylation marksHistone H3Lysine demethylasesCatalytic coreKDM5 inhibitorsDrug targetsKDM5Cancer metastasisSuppressive role
2021
Multiple Functions of RNA Methylation in T Cells: A Review
Chao Y, Li H, Zhou J. Multiple Functions of RNA Methylation in T Cells: A Review. Frontiers In Immunology 2021, 12: 627455. PMID: 33912158, PMCID: PMC8071866, DOI: 10.3389/fimmu.2021.627455.Peer-Reviewed Original ResearchConceptsRNA methylationRNA modificationsMessenger RNAFate determinationEpigenetic regulationEpigenetic modificationsNoncoding RNAsCell homeostasisUbiquitous mechanismMethylationBiological significanceT cell homeostasisMultiple functionsCell proliferationEssential rolePotential therapeutic strategyRecent findingsRNAImmune responseBiological activityPathological statesT cellsCellsTherapeutic strategiesViral infection
2020
Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration
Morozov YM, Mackie K, Rakic P. Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration. International Journal Of Molecular Sciences 2020, 21: 8657. PMID: 33212822, PMCID: PMC7696736, DOI: 10.3390/ijms21228657.Peer-Reviewed Original ResearchConceptsNeural stem cellsStem cellsCannabinoid type 1 receptorType 1 receptorFate determinationRadial neuronal migrationCell movementEmbryonic developmentIntracellular vesiclesCellular locationMRNA sequencingMolecular mechanismsCortical plateElectron microscopic reconstructionCellular proliferationNeuronal migrationZone cellsSubventricular zone cellsEmbryonic miceMolecular substratesSVZ cellsMicroscopic reconstructionRecreational cannabis useMacaque cerebral cortexPrimate neuronsCurrent understanding of human megakaryocytic-erythroid progenitors and their fate determinants.
Kwon N, Thompson EN, Mayday MY, Scanlon V, Lu YC, Krause DS. Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants. Current Opinion In Hematology 2020, 28: 28-35. PMID: 33186151, PMCID: PMC7737300, DOI: 10.1097/moh.0000000000000625.Peer-Reviewed Original ResearchConceptsMegakaryocyte-erythroid progenitorsFate decisionsCell fate decisionsMegakaryocytic-erythroid progenitorsGene expression patternsProgenitor cell biologyFate determinantsFate determinationCurrent understandingTranscription factorsCell biologyExpression patternsPluripotent progenitorsProgenitorsModel systemExtrinsic factorsBiologyDisease statesFateDevelopment leadEpigeneticsMegakaryocytesUnderstandingDiscoveryIsolation
2018
Flexible fate determination ensures robust differentiation in the hair follicle
Xin T, Gonzalez D, Rompolas P, Greco V. Flexible fate determination ensures robust differentiation in the hair follicle. Nature Cell Biology 2018, 20: 1361-1369. PMID: 30420661, PMCID: PMC6314017, DOI: 10.1038/s41556-018-0232-y.Peer-Reviewed Original ResearchConceptsSingle-cell levelStem cellsStem cell differentiationGerm stem cellsTissue architectureMultiple cell typesFate determinationDetermination mechanismTissue homeostasisSame stem cellsCommon progenitorDifferentiation outcomesDifferentiation stimuliDifferentiation lineageCell differentiationCell typesNormal differentiationWnt activationHair folliclesUnanticipated flexibilityDifferentiationRobust differentiationProgenitorsCellsUninjured condition
2017
New Advances in Human X Chromosome Status from a Developmental and Stem Cell Biology
Patterson B, Tanaka Y, Park IH. New Advances in Human X Chromosome Status from a Developmental and Stem Cell Biology. Tissue Engineering And Regenerative Medicine 2017, 14: 643-652. PMID: 29276809, PMCID: PMC5738034, DOI: 10.1007/s13770-017-0096-4.Peer-Reviewed Original ResearchPluripotent stem cellsX chromosome statusStem cell biologyCell biologyX chromosome dosage compensationStem cellsDosage compensation processX-chromosome regulationChromosome dosage compensationHuman PSCsCell fate determinationActive X chromosomeChromosome statusEmbryonic stem cellsHuman pluripotent stem cellsHuman preimplantation embryosSpecific lincRNAsDosage compensationChromosome architectureChromosome regulationFate determinationImprinting statusEpigenetic dysregulationX chromosomePreimplantation embryosDevelopmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment
Boya R, Yadavalli AD, Nikhat S, Kurukuti S, Palakodeti D, Pongubala JMR. Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment. Nucleic Acids Research 2017, 45: 11070-11087. PMID: 28977418, PMCID: PMC5737614, DOI: 10.1093/nar/gkx722.Peer-Reviewed Original ResearchConceptsChromatin reorganizationHigher-order chromatin interactionsGenome-wide expression profilesCell fate choiceCell fate determinationCell fate commitmentHi-C analysisMulti-potent progenitorsB cell fate determinationGene expression patternsB cell fate choicesChromatin architectureGenome architectureGenome organizationChromatin interactionsTranscription regulationEpigenetic landscapeFate determinationGenomic lociFate commitmentB compartmentsCommitted stateDevelopmental switchInteraction landscapeExpression patternsChapter 15 Comparative Functions of miRNAs in Embryonic Neurogenesis and Neuronal Network Formation
Ristori E, Nicoli S. Chapter 15 Comparative Functions of miRNAs in Embryonic Neurogenesis and Neuronal Network Formation. 2017, 265-282. DOI: 10.1016/b978-0-12-804402-5.00015-7.Peer-Reviewed Original ResearchTarget mRNA degradationCell fate determinationGene regulatory pathwaysDynamic spatiotemporal expressionImportance of miRNAsSmall noncoding RNAsStem cell proliferationMulticellular organismsFate determinationMost miRNAsNeuronal network formationTranslational repressionModel organismsNeural stem cell proliferationMRNA degradationPosttranscriptional regulatorsNoncoding RNAsRegulatory pathwaysDevelopmental processesEmbryonic neurogenesisGene expressionSpatiotemporal expressionNovel roleNeuronal differentiationMiRNAs
2015
Choosing Cell Fate Through a Dynamic Cell Cycle
Chen X, Hartman A, Guo S. Choosing Cell Fate Through a Dynamic Cell Cycle. Current Stem Cell Reports 2015, 1: 129-138. PMID: 28725536, PMCID: PMC5487535, DOI: 10.1007/s40778-015-0018-0.Peer-Reviewed Original ResearchCell fate changesCell fateCell cycle dynamicsFate changesSomatic cellsDifferentiated somatic cell typesCell cycleCell fate specificationCell fate determinationInduction of pluripotencyTranscription factor concentrationsSomatic cell typesFate specificationFate determinationCell cycle accelerationCycle dynamicsTissue homeostasisDevelopmental systemsYamanaka factorsCell typesNormal developmentPluripotencyRecent discoveryReprogrammingFate
2013
Spatial organization within a niche as a determinant of stem-cell fate
Rompolas P, Mesa KR, Greco V. Spatial organization within a niche as a determinant of stem-cell fate. Nature 2013, 502: 513-518. PMID: 24097351, PMCID: PMC3895444, DOI: 10.1038/nature12602.Peer-Reviewed Original ResearchConceptsStem cell fateHair follicle nicheStem cell lineagesStem cellsStem cell nicheHair follicle stem cellsStem cell compartmentFollicle stem cellsFate determinationGenetic lineagesDifferentiated fateAdult tissuesNiche locationsMammalian tissuesNicheHair regenerationLineagesSpatial organizationEpithelial cellsFateCellsHair growthRegenerationLive miceTissuePax6 regulates Tbr1 and Tbr2 expressions in olfactory bulb mitral cells
Imamura F, Greer CA. Pax6 regulates Tbr1 and Tbr2 expressions in olfactory bulb mitral cells. Molecular And Cellular Neuroscience 2013, 54: 58-70. PMID: 23353076, PMCID: PMC3622182, DOI: 10.1016/j.mcn.2013.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA-Binding ProteinsDopaminergic NeuronsEye ProteinsGABAergic NeuronsGene Expression Regulation, DevelopmentalHomeodomain ProteinsInterneuronsMiceMitosisNeural Stem CellsNeurogenesisNeurogliaOlfactory BulbPaired Box Transcription FactorsPAX6 Transcription FactorRepressor ProteinsT-Box Domain ProteinsConceptsExogenous expressionRegulation of Pax6Expression of Tbr1Mitral cell developmentCell precursorsFate determinationCell fateRadial glial cellsMitral cellsCell developmentTbr2 expressionPax6Embryonic olfactory bulbCortical projection neuronsOlfactory bulb mitral cellsPostmitotic precursorsPrecursor cellsUtero electroporationVentricular zoneNumber of cellsDopaminergic interneuronsTbr1Projection neuronsExpressionGlial cells
2011
Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain
Sunmonu N, Li K, Li J. Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain. Journal Of Cellular Physiology 2011, 226: 1722-1726. PMID: 21506104, PMCID: PMC3071877, DOI: 10.1002/jcp.22587.Peer-Reviewed Original ResearchConceptsVertebrate developmentDevelopment of multicellular organismsSplice variantsIsoform proteinsIntegration of cell proliferationRNA alternative splicingMouse Fgf8 geneFibroblast growth factorIn vivo functionMulticellular organismsAlternative splicingFate determinationSoluble growth factorsFgf8 geneN-terminiPolypeptide growth factorsGrowth factorFgf8Ligand-receptor systemSplicingVertebratesCell proliferationFunction of FGF8IsoformsProtein
2010
Neurotransmitter signaling in postnatal neurogenesis: The first leg
Platel JC, Stamboulian S, Nguyen I, Bordey A. Neurotransmitter signaling in postnatal neurogenesis: The first leg. Brain Research Reviews 2010, 63: 60-71. PMID: 20188124, PMCID: PMC2862802, DOI: 10.1016/j.brainresrev.2010.02.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFate determinationSonic hedgehogNeurotransmitter signalingDifferent cell typesSubventricular zoneMultitude of receptorsMaster regulatorGenetic signaturesMosaic natureGamma-aminobutyric acidMicroenvironmental signalsCell typesIntracellular pathwaysAstrocyte-like cellsFunction of neurotransmittersHedgehogSignalingNeurogenesisNeurogenic zonesAdult brainPostnatal neurogenesisPeripheral organsNeurotransmitter functionSynaptic integrationGenes
2009
Decision by division: making cortical maps
Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Decision by division: making cortical maps. Trends In Neurosciences 2009, 32: 291-301. PMID: 19380167, PMCID: PMC3601545, DOI: 10.1016/j.tins.2009.01.007.Peer-Reviewed Original ResearchConceptsNeuronal fate determinationFate determinationFinal mitotic divisionEvolutionary expansionCell determinationMitotic divisionProtomap hypothesisEarly specificationLatest compendiumBiological basisProliferative zoneNeuronal classesNewborn neuronsBroad spectrumDivisionGenesHuman neocortexCortical malformationsNeuronsRadial unitsCompendiumMigrationCerebral wall
2008
GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors
Beuling E, Bosse T, de Kerk D, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Developmental Biology 2008, 322: 179-189. PMID: 18692040, PMCID: PMC3031907, DOI: 10.1016/j.ydbio.2008.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCell DifferentiationCell ProliferationEnterocytesGATA4 Transcription FactorGene Expression RegulationIntestinal AbsorptionIntestinal MucosaIntestine, SmallMiceMice, TransgenicNuclear ProteinsOrgan SpecificityOrganic Anion Transporters, Sodium-DependentRNA, MessengerSymportersTranscription FactorsTranscriptional ActivationConceptsFriend of GATAGene repressionCell fate determinationFamily of cofactorsMammalian small intestineProximal-distal patternRepression functionGata (FOG) cofactorsFate determinationCell lineage markersFOG cofactorsGATA factorsGATA4 mutantsGene activationTranscription factorsGATA4 functionIntestinal epithelial cellsGATA4Multiple tissuesRepressionLineage markersMouse small intestineCofactorEpithelial cellsGenes
2007
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
Breunig JJ, Silbereis J, Vaccarino FM, Šestan N, Rakic P. Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20558-20563. PMID: 18077357, PMCID: PMC2154470, DOI: 10.1073/pnas.0710156104.Peer-Reviewed Original ResearchConceptsAbrogation of NotchCell cycle exitNeuronal fate determinationPrecursor cellsTransit-amplifying cellsFate determinationInducible gainCell fateCycle exitNeural precursor cellsModulates SurvivalMolecular controlPostnatal progenitor cellsLifelong additionHippocampal morphogenesisDifferentiation statePostnatal dentate gyrusNewborn granule cellsMembrane receptorsNeural stemGenetic ablationExpression of Notch1Structural plasticityProgenitor cellsEnvironmental modulators
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