2025
Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees
Mulligan C, Quinn E, Hamadmad D, Dutton C, Nevell L, Binder A, Panter-Brick C, Dajani R. Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees. Scientific Reports 2025, 15: 5945. PMID: 40016245, PMCID: PMC11868390, DOI: 10.1038/s41598-025-89818-z.Peer-Reviewed Original ResearchConceptsSyrian refugeesExposure to violenceWar-related violenceExposed to violenceExposure to warAdult health outcomesViolenceIntergenerational exposureSurvey dataRefugeesHealth outcomesEpigenome-wide association studiesTrauma effectsInfluence infantsImpact future generationsEpigenetic age accelerationFuture generationsMothersAssociated with germlineMaternal traumaFamilyAssociation studiesPregnant mothersWarDNA methylationCelebrating the Unseen Benefits of Surgical Careers for Mothers in Cardiothoracic Surgery
Cangut B, Sakowitz S, Rajah T, Papageorge M, Boyd R, Lin N, Stanley M, Blackmon S, Molena D, Watkins A, Worrell S, Antonoff M. Celebrating the Unseen Benefits of Surgical Careers for Mothers in Cardiothoracic Surgery. JTCVS Open 2025 DOI: 10.1016/j.xjon.2025.02.009.Peer-Reviewed Original ResearchAdult childrenCo-parentingBenefits to familiesEssential life skillsFamily dynamicsPositive impactInstilling disciplineChild developmentNegative stereotypesHome lifeFinancial foundationsLife skillsParticipants answered questionsPartners/spousesCareerCardiothoracic surgeonsCardiothoracic (CT) surgeryPotential negative impactPersonal growthFamilyMedical guidanceNegative impactChildrenRewarding careerMothers
2024
Enhancing patient representation learning with inferred family pedigrees improves disease risk prediction
Huang X, Arora J, Erzurumluoglu A, Stanhope S, Lam D, Arora J, Erzurumluoglu A, Lam D, Khoueiry P, Jensen J, Cai J, Lawless N, Kriegl J, Ding Z, de Jong J, Zhao H, Ding Z, Wang Z, de Jong J. Enhancing patient representation learning with inferred family pedigrees improves disease risk prediction. Journal Of The American Medical Informatics Association 2024, 32: 435-446. PMID: 39723811, PMCID: PMC11833479, DOI: 10.1093/jamia/ocae297.Peer-Reviewed Original ResearchConceptsElectronic health recordsDisease risk predictionElectronic health record researchFamily health historyGenetic aspects of diseaseRisk predictionInflammatory bowel disease subtypeHealth recordsHealth historyAspects of diseaseFamily relationsHealthcare researchPatient's disease riskInfluence of geneticsDisease riskDiagnosis dataFamily pedigreeEnvironmental exposuresRisk factorsDisease dependencyPatient representation learningClinical profileFamilyDisease subtypesRiskHaven for Hope: A Transformational Campus Model to Address Homelessness
Tsai J, Gonzalez K, Orsinger R, Jefferies K. Haven for Hope: A Transformational Campus Model to Address Homelessness. Community Mental Health Journal 2024, 1-7. PMID: 39641884, DOI: 10.1007/s10597-024-01419-8.Peer-Reviewed Original ResearchChronically homeless individualsCommunity partner organizationsServices on-siteHomeless individualsNonprofit organizationsJob trainingCommunity collaborationHomelessnessPartner organizationsHavensHopeSan AntonioResearch literatureOrganizational levelCommunityChildcareCampusFamilyCampus modelHousingIndividualsOperational activitiesJobAntonioResearchNavigating Gatekeeping Challenges in Pediatric and Young Adult Palliative Oncology and End-of-Life Research
Ananth P, Snaman J. Navigating Gatekeeping Challenges in Pediatric and Young Adult Palliative Oncology and End-of-Life Research. Journal Of Clinical Oncology 2024, 43: 776-779. PMID: 39496096, DOI: 10.1200/jco-24-01944.Peer-Reviewed Original ResearchNeuronal parts list and wiring diagram for a visual system
Matsliah A, Yu S, Kruk K, Bland D, Burke A, Gager J, Hebditch J, Silverman B, Willie K, Willie R, Sorek M, Sterling A, Kind E, Garner D, Sancer G, Wernet M, Kim S, Murthy M, Seung H. Neuronal parts list and wiring diagram for a visual system. Nature 2024, 634: 166-180. PMID: 39358525, PMCID: PMC11446827, DOI: 10.1038/s41586-024-07981-1.Peer-Reviewed Original ResearchCommunication trends over time in new-onset refractory status epilepticus (NORSE): Interim analysis from the NORSE/FIRES Family Registry
Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Farias-Moeller R, Eschbach K, Gofton T. Communication trends over time in new-onset refractory status epilepticus (NORSE): Interim analysis from the NORSE/FIRES Family Registry. Epilepsy & Behavior 2024, 160: 110023. PMID: 39241640, DOI: 10.1016/j.yebeh.2024.110023.Peer-Reviewed Original ResearchPalliative care servicesFamily RegistryCare servicesImprove overall carePrognostic conversationsAcute hospitalsOverall careEpidemiological informationConsensus definitionPhysician-patient-family relationshipRegistryNORSE/FIRESMinority of patientsPrognostic informationSatisfactionFamilySystematic effortRecovery processServicesCarePatientsHospitalPrevalenceQualityEpilepsy syndromesA Secret Shopper Study of Language Accessibility of Community-Based Behavioral Health Services for Children in Families Who Speak Spanish and English
Lomax S, Klusaritz H, Jimenez M, Frausto B, Cahen V, Njoroge W, Yun K. A Secret Shopper Study of Language Accessibility of Community-Based Behavioral Health Services for Children in Families Who Speak Spanish and English. The Journal Of Pediatrics 2024, 276: 114275. PMID: 39218205, PMCID: PMC11645237, DOI: 10.1016/j.jpeds.2024.114275.Peer-Reviewed Original ResearchBehavioral health facilitiesMedicaid-insured childrenHealth facilitiesPreferred languageBehavioral health careSubstance abuse servicesSpanish-speaking familiesModifiable barriersHealth schedulesHealth careAbuse servicesOutpatient facilitiesStandardized scriptPrimary outcomeTelephone numbersAppointmentChildrenEnglishCallersLanguageScripted callsAccess trainingFacilitiesSpanishFamilyPatterns of Family Conflict and Accusations of Abuse in Dementia Family Caregivers: A Latent Class Analysis
Browning W, Yildiz M, Maxwell C, Sullivan T, Yefimova M, Chilatra J, Pickering C. Patterns of Family Conflict and Accusations of Abuse in Dementia Family Caregivers: A Latent Class Analysis. The Gerontologist 2024, 64: gnae108. PMID: 39166288, PMCID: PMC11446213, DOI: 10.1093/geront/gnae108.Peer-Reviewed Original ResearchLatent class analysisFamily conflictNeglectful behaviorsNon-traditional family structuresGroup membershipClass analysisNon-traditional caregiversRelationship typesFamily caregiversAdult childrenFour-class solutionFamily structureMultinomial logistic regressionProbability of abuseAccusations of abuseConflictUnique risk factorsAccusationsAbuseMembershipDementia family caregiversNeglectCaregiversElevated probabilityFamilyRare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes
Olfson E, Farhat L, Liu W, Vitulano L, Zai G, Lima M, Parent J, Polanczyk G, Cappi C, Kennedy J, Fernandez T. Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. Nature Communications 2024, 15: 5870. PMID: 38997333, PMCID: PMC11245598, DOI: 10.1038/s41467-024-50247-7.Peer-Reviewed Original ResearchConceptsDNA sequencesRisk genesHigh-confidence risk genesWhole-exome DNA sequencingSequencing of familiesIdentified de novoLysine demethylase 5BDNA variantsTrio cohortBiological pathwaysGenesSequencing cohortGenetic factorsChildhood neurodevelopmental disordersAttention-deficit/hyperactivity disorderSequenceVariantsADHD riskNeurodevelopmental disordersKDM5BDNAMutationsFamilyLysineDiscoveryOverlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles
Park D, Fujise K, Wu Y, Luján R, Del Olmo-Cabrera S, Wesseling J, De Camilli P. Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2409605121. PMID: 38985768, PMCID: PMC11260120, DOI: 10.1073/pnas.2409605121.Peer-Reviewed Original ResearchConceptsSynaptic vesiclesFamily proteinsBiogenesis of synaptic vesiclesClusters of small vesiclesSize of synaptic vesiclesSynaptogyrin familySynaptogyrin-1Vesicle proteinsSynaptogyrinTransmembrane domainOrganismal levelSmall vesiclesProteinMild defectsVesiclesFamily membersBiogenesisSmall sizeFamilyMiceSynapsinCoexpressionAbundanceSynaptoporinMembersUnraveling the genetic tapestry of pediatric sarcomeric cardiomyopathies and masquerading phenocopies in Jordan
Azab B, Aburizeg D, Shaaban S, Ji W, Mustafa L, Isbeih N, Al-Akily A, Mohammad H, Jeffries L, Khokha M, Lakhani S, Al-Ammouri I. Unraveling the genetic tapestry of pediatric sarcomeric cardiomyopathies and masquerading phenocopies in Jordan. Scientific Reports 2024, 14: 15141. PMID: 38956129, PMCID: PMC11219879, DOI: 10.1038/s41598-024-64921-9.Peer-Reviewed Original ResearchConceptsExome sequencingSarcomere-related genesMitochondrial-related diseasesAt-risk family membersGenetic architectureGenetic landscapePathogenic variantsGene panelPediatric cardiomyopathyMolecular underpinningsGenetic testingPhenocopiesSarcomeric cardiomyopathiesGenesSequenceStorage disorderFamily membersAt-riskVariantsEarly interventionExomeFamilyGlycogen storage disorderHypertrophic cardiomyopathyCardiomyopathyState paid family leave policies and breastfeeding duration: cross-sectional analysis of 2021 national immunization survey-child
Rosenberg J, Nardella D, Shabanova V. State paid family leave policies and breastfeeding duration: cross-sectional analysis of 2021 national immunization survey-child. International Breastfeeding Journal 2024, 19: 37. PMID: 38796467, PMCID: PMC11128124, DOI: 10.1186/s13006-024-00646-9.Peer-Reviewed Original ResearchConceptsFamily leaveParental leave policiesLeave policiesSocial demographic characteristicsPolicyCross-sectional analysisUnited StatesNational Immunization Survey-ChildMedical leaveFamilyBreastfeeding ratesPromote breastfeedingSurveyed childrenStateBreastfeedingWorkforceLong-term health benefitsNationalBreastfeeding durationMixed feedPrevalence ratiosJuvenile Justice-Based Interdisciplinary Collective Care: An Innovative Approach
Brown S, Perez O. Juvenile Justice-Based Interdisciplinary Collective Care: An Innovative Approach. Community Mental Health Journal 2024, 60: 1042-1054. PMID: 38730075, DOI: 10.1007/s10597-024-01285-4.Peer-Reviewed Original ResearchConceptsYouth offendersNegative life outcomesMental health concernsJuvenile justice systemCriminogenic riskJustice systemMental health needsDelinquent behaviorUnited StatesLife outcomesOffendersCollective careHealth needsCollective collaborationYouthCommunity partnersHealth concernCultural responsivenessHealth crisisRecidivismConcernsServicesEffective interventionsFamilyScholarshipPartnering With Parents to Dismantle “Good-Death” Narratives
Broden E, McCarthy S, Snaman J. Partnering With Parents to Dismantle “Good-Death” Narratives. JAMA Pediatrics 2024, 178: 431-432. PMID: 38466276, DOI: 10.1001/jamapediatrics.2024.0103.Peer-Reviewed Original ResearchSupported Privacy: An Essential Principle for End-of-Life Care for Children and Families in the PICU
Butler A, Pasek T, Clark T, Broden E. Supported Privacy: An Essential Principle for End-of-Life Care for Children and Families in the PICU. Pediatric Critical Care Medicine 2024, 25: e258-e262. PMID: 38695704, DOI: 10.1097/pcc.0000000000003440.Peer-Reviewed Original ResearchConceptsEnd-of-lifeEnd-of-life care practicesDelivery of high-quality careEnd-of-life experiencesHigh-quality careProvision of privacyPICU staffCare practicesPICU teamChild deathsFamily feelingsMedicine perspectivePractical needsPICUCareStaffNeedsChildrenFamilyEmotional responsesParadoxical needPediatricCliniciansTeamDeliveryExamining developmental assets of young Black sexual gender minority males in preventing suicidal behaviors
Boyd D, Jones K, Hawthorne D, Quinn C, Mueller-Williams A, Ramos S, Dyer T, Wilton L. Examining developmental assets of young Black sexual gender minority males in preventing suicidal behaviors. Journal Of Psychiatric Research 2024, 171: 256-262. PMID: 38325106, PMCID: PMC11495657, DOI: 10.1016/j.jpsychires.2024.01.035.Peer-Reviewed Original ResearchConceptsFamily supportDevelopmental assetsIntersection of raceCommunity-based organizationsBisexual male adolescentsDepressive symptomsSuicide attemptsSexual orientationStigmatized identitiesMinority malesPolicy implicationsExternal assetsSuicide outcomesAssociated with suicide attemptsAssociated with depressive symptomsPrevent suicidal behaviorAssociated with planningFamily communicationMale adolescentsCross-sectional surveyPrevent depressive symptomsAmazon M-TurkSuicidal behaviorFamilySuicide
2023
Identifying candidate genes underlying isolated congenital anosmia
Kamarck M, Trimmer C, Murphy N, Gregory K, Manoel D, Logan D, Saraiva L, Mainland J. Identifying candidate genes underlying isolated congenital anosmia. Clinical Genetics 2023, 105: 376-385. PMID: 38148624, PMCID: PMC10932857, DOI: 10.1111/cge.14470.Peer-Reviewed Original ResearchConceptsIsolated congenital anosmiaWhole-exome sequencingCongenital anosmiaGene candidate listsLoss-of-function variantsSpectrum of genetic alterationsOlfactory transduction pathwayZinc ion bindingDeleterious variantsExome sequencingTransduction pathwaysGenetic alterationsOlfactory signalsNon-syndromicOlfactory functionAssociated with olfactionQuality of lifeGenesAnosmiaIon bindingEstimated 1VariantsOlfactionFamilyCNGA2Family rejection of non-hetero sexuality–Sexual orientation and behavior anonymity among sexual minority men in slum communities-BSGH 001
Shamrock O, Abu-Ba’are G, Zigah E, Apreku A, Agbemedu G, Boyd D, Adjaka G, Nelson L. Family rejection of non-hetero sexuality–Sexual orientation and behavior anonymity among sexual minority men in slum communities-BSGH 001. PLOS Global Public Health 2023, 3: e0001659. PMID: 38039264, DOI: 10.1371/journal.pgph.0001659.Peer-Reviewed Original ResearchGenomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study
Abdi M, Aliyev E, Trost B, Kohailan M, Aamer W, Syed N, Shaath R, Gandhi G, Engchuan W, Howe J, Thiruvahindrapuram B, Geng M, Whitney J, Syed A, Lakshmi J, Hussein S, Albashir N, Hussein A, Poggiolini I, Elhag S, Palaniswamy S, Kambouris M, de Fatima Janjua M, Tahir M, Nazeer A, Shahwar D, Azeem M, Mokrab Y, Aati N, Akil A, Scherer S, Kamal M, Fakhro K. Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study. Genome Medicine 2023, 15: 81. PMID: 37805537, PMCID: PMC10560429, DOI: 10.1186/s13073-023-01228-w.Peer-Reviewed Original ResearchConceptsTandem repeat expansionsSingle nucleotide variantsGenetic architectureNovel ASD candidate genesWhole-genome sequencing dataMitochondrial DNA variantsASD candidate genesMulti-omics researchGenomic architectureRecessive variationMtDNA variantsCandidate genesDNA variantsSequencing dataRepeat expansionNumber variantsSNVs/indelsDe novoNon-consanguineous familyGenesGenetics guidelinesUnique resourcePathogenic variantsFamilyMedical Genetics guidelines
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply