2025
A multi-center study of symptoms in patients with esophageal cancer postoperatively: A networking analysis
Chen F, Shen Z, Xiong Y, Jiang Y, Zhou D, Guo J, Huang H, Knobf M, Ye Z. A multi-center study of symptoms in patients with esophageal cancer postoperatively: A networking analysis. European Journal Of Oncology Nursing 2025, 74: 102784. PMID: 39813978, DOI: 10.1016/j.ejon.2025.102784.Peer-Reviewed Original ResearchConceptsEsophageal cancerSymptom clustersDry mouthEating difficultiesCross-sectional surveyStudy of symptomsExploratory factor analysisSymptom burdenMulti-center studyBridge symptomsWeeks post-surgeryAcid indigestionPost-surgerySentinel symptomPatientsCancerMultiple centersSymptomsFactor analysisHeartburnCore symptomsBileWeeksCluster levelMouth
2024
Ultra-sensitive molecular residual disease detection through whole genome sequencing with single-read error correction
Li X, Liu T, Bacchiocchi A, Li M, Cheng W, Wittkop T, Mendez F, Wang Y, Tang P, Yao Q, Bosenberg M, Sznol M, Yan Q, Faham M, Weng L, Halaban R, Jin H, Hu Z. Ultra-sensitive molecular residual disease detection through whole genome sequencing with single-read error correction. EMBO Molecular Medicine 2024, 16: 2188-2209. PMID: 39164471, PMCID: PMC11393307, DOI: 10.1038/s44321-024-00115-0.Peer-Reviewed Original ResearchMolecular residual diseaseCirculating tumor DNAWhole-genome sequencingCell-free DNAGenome sequenceDetection of molecular residual diseaseCirculating tumor DNA detectionResidual disease detectionConsistent with clinical outcomesVariant allele frequencyResidual diseaseMelanoma patientsMonitoring immunotherapyTumor DNAEsophageal cancerClinical outcomesColorectal cancerWGS technologiesAllele frequenciesCancerDNAAnalytical sensitivitySequenceImmunotherapyRelapseSurgical and endoscopic management of clinical T1b esophageal cancer
Ayoade O, Canavan M, De Santis W, Zhan P, Boffa D. Surgical and endoscopic management of clinical T1b esophageal cancer. Journal Of Thoracic And Cardiovascular Surgery 2024, 169: 279-288.e5. PMID: 38925509, DOI: 10.1016/j.jtcvs.2024.06.011.Peer-Reviewed Original ResearchEsophageal cancerTumor attributesEsophagectomy patientsEndoscopic treatmentAccelerated time failure modelsEndoscopic managementTumor size > 1 cmFactors associated with upstagingOccult lymph node metastasisAssociated with improved survivalAssociated with lymphovascular invasionEffect of esophagectomyT1b esophageal cancerTreatment naive patientsNational Cancer DatabaseWell-differentiated tumorsKaplan Meier analysisLymph node metastasisPoor tumor differentiationTime failure modelsNodal upstagingLymphovascular invasionOverall survivalEndoscopic patientsMeier analysisThe Impact of Food Insecurity on the Management and Survival of Stage I-III Esophageal Cancer
Papageorge M, Potter A, Auchincloss H, Sachdeva U, Yang C, Schumacher L. The Impact of Food Insecurity on the Management and Survival of Stage I-III Esophageal Cancer. Annals Of Thoracic Surgery Short Reports 2024, 2: 524-527. PMID: 39790405, PMCID: PMC11708528, DOI: 10.1016/j.atssr.2024.02.002.Peer-Reviewed Original ResearchCancer careFood insecurityStage I-III esophageal cancerAssociated with poor health outcomesImpact of food insecurityFood insecurity interventionsPoor health outcomesEsophageal cancerEsophageal cancer careFood insecurity ratesReceipt of surgeryCox proportional hazards modelsMultinomial logistic regressionHealth outcomesProportional hazards modelNon-HispanicSurgical interventionMultivariate Cox proportional hazards modelSignificant disparitiesReduce inequalitiesLogistic regressionCancer-specific survivalStage III diseaseCompared to patientsSurvival of patients
2023
Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review
Safarpour D, Jabbari B. Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review. Toxins 2023, 15: 689. PMID: 38133193, PMCID: PMC10748363, DOI: 10.3390/toxins15120689.Peer-Reviewed Original ResearchConceptsBoNT injectionsFacial sweatingCancer-related disordersParotid regionSystematic reviewComplication of parotidectomySevere jaw painBotulinum toxin treatmentParotid gland surgeryBotulinum neurotoxin therapyCessation of painSerious side effectsSite of surgeryBoNT effectsGustatory hyperhidrosisJaw painNeurotoxin therapySteroid injectionLocal resectionEsophageal strictureSurgical approachEsophageal cancerLocal injectionSaline injectionToxin treatmentHistology Shift in Esophageal Cancer Between Biopsies and Resections After Neoadjuvant Therapy: A Pilot Study
Hou T, Yang Z, Zhang Q, Zhang X, Liao X, Lin J. Histology Shift in Esophageal Cancer Between Biopsies and Resections After Neoadjuvant Therapy: A Pilot Study. International Journal Of Surgical Pathology 2023, 32: 920-925. PMID: 37899731, DOI: 10.1177/10668969231208029.Peer-Reviewed Original ResearchNeoadjuvant therapyEsophageal adenocarcinomaNeuroendocrine neoplasmsNeuroendocrine carcinomaSurvival rateOverall median survival timeEsophageal neuroendocrine carcinomaPreoperative neoadjuvant therapyAdvanced esophageal adenocarcinomaMedian survival timeObserved survival ratesMainstay treatmentResidual adenocarcinomaConventional adenocarcinomaEsophageal cancerNeuroendocrine morphologyFocal positivitySurvival timeNeuroendocrine componentAdenocarcinomaBiopsyResectionSmall seriesPatientsNeoplasmsF101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISK
Zhou H, Yang B, Kranzler H, Gelernter J. F101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISK. European Neuropsychopharmacology 2023, 75: s274. DOI: 10.1016/j.euroneuro.2023.08.480.Peer-Reviewed Original ResearchInverse variance weightingAlcohol useCancer riskOral/pharyngeal cancerOral cancer riskMendelian randomizationMendelian randomization analysisCumulative epidemiological evidenceSpecific cancer typesDevelopment of cancerPharyngeal cancerEsophageal cancerEpidemiological evidenceProblematic alcohol useAlcohol consumptionUnderreported populationCancerCancer typesMR studiesMR-PRESSOAlcohol-related phenotypesDifferent cancersRandomization analysisBreastMR-EggerS603 Do Bariatric Procedures Impact Barrett’s Esophagus and Esophageal Cancers? Systematic Review and Meta-Analysis
Chhoda A, Woodbine M, Abdalla M, Hariri S, Zapata T, Grimshaw A, Pleskow D, Popov V, Holzwanger E. S603 Do Bariatric Procedures Impact Barrett’s Esophagus and Esophageal Cancers? Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2023, 118: s443-s444. DOI: 10.14309/01.ajg.0000952052.84376.f9.Peer-Reviewed Original ResearchAssessment of a collaborative treatment model for trimodal management of esophageal cancer
Udelsman B, Ermer T, Ely S, Canavan M, Zhan P, Boffa D, Blasberg J. Assessment of a collaborative treatment model for trimodal management of esophageal cancer. Journal Of Thoracic Disease 2023, 15: 4668-4680. PMID: 37868899, PMCID: PMC10586936, DOI: 10.21037/jtd-23-346.Peer-Reviewed Original ResearchPathologic complete responseNational Cancer DatabaseGy of radiationEsophageal cancerCollaborative treatmentCollaborative treatment modelMultiagent chemotherapySingle institutionRate of pCRPatient travel burdenR0 resection rateTreatment modelTrimodality therapyTrimodality treatmentNeoadjuvant chemoradiotherapyNeoadjuvant therapyR0 resectionResection rateComplete responseMultivariable analysisTumor characteristicsCancer DatabaseMedian travel distancePatientsCollaborative CohortPre-operative chemoradiotherapy with or without induction chemotherapy for operable locally-advanced esophageal cancer
Peters G, Talcott W, Peters N, Dhanasopan A, Lacy J, Cecchini M, Kortmansky J, Stein S, Lattanzi S, Park H, Boffa D, Johung K, Jethwa K. Pre-operative chemoradiotherapy with or without induction chemotherapy for operable locally-advanced esophageal cancer. Journal Of Gastrointestinal Oncology 2023, 14: 1181-1192. PMID: 37435226, PMCID: PMC10331751, DOI: 10.21037/jgo-22-1005.Peer-Reviewed Original ResearchProgression-free survivalMedian progression-free survivalOverall survivalIC-CRTInduction chemotherapySingle-institution retrospective cohort studyPre-operative chemoradiotherapyAdvanced esophageal cancerAdvanced esophageal carcinomaPathologic complete responseRetrospective cohort studyKaplan-Meier methodSubset of patientsProportional hazards regressionCycles of inductionAdenocarcinoma histologyCRT cohortCohort studyComplete responsePathologic responseTreatment cohortsDistant metastasisHazards regressionEsophageal cancerEsophageal carcinomaSpecific Intratumor Bacteria Genera and TRG Recombinations Associated with Greater Survival Probability in Alimentary Tract Cancers
Zaman S, Chobrutskiy B, Quach J, Blanck G. Specific Intratumor Bacteria Genera and TRG Recombinations Associated with Greater Survival Probability in Alimentary Tract Cancers. Journal Of Gastrointestinal Cancer 2023, 54: 1300-1307. PMID: 37103748, DOI: 10.1007/s12029-023-00935-2.Peer-Reviewed Original ResearchConceptsT-cell infiltratesStomach adenocarcinomaGamma delta T cellsCox proportional hazards modelAlimentary tract cancersTumor immune milieuProportional hazards modelPrimary tumor samplesImmune milieuOS probabilityCancer Genome AtlasCell infiltrateTract cancerPatient survivalEsophageal cancerPrimary tumorCancer DatabaseT cellsHazards modelTumor samplesExome filesAlimentary tractGenome AtlasBacterial infiltrationInfiltratesEsophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Ajani J, D'Amico T, Bentrem D, Cooke D, Corvera C, Das P, Enzinger P, Enzler T, Farjah F, Gerdes H, Gibson M, Grierson P, Hofstetter W, Ilson D, Jalal S, Keswani R, Kim S, Kleinberg L, Klempner S, Lacy J, Licciardi F, Ly Q, Matkowskyj K, McNamara M, Miller A, Mukherjee S, Mulcahy M, Outlaw D, Perry K, Pimiento J, Poultsides G, Reznik S, Roses R, Strong V, Su S, Wang H, Wiesner G, Willett C, Yakoub D, Yoon H, McMillian N, Pluchino L. Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2023, 21: 393-422. PMID: 37015332, DOI: 10.6004/jnccn.2023.0019.Peer-Reviewed Original ResearchConceptsEsophagogastric junction cancerSquamous cell carcinomaJunction cancerMetastatic diseaseSystemic therapyNCCN Clinical Practice GuidelinesEsophageal squamous cell carcinomaMajor global health problemBest supportive careManagement of recurrentMultidisciplinary team managementClinical practice guidelinesTreatment of patientsGlobal health problemMicrosatellite instability statusNCCN guidelinesPalliative managementSupportive careEsophagogastric junctionCell carcinomaLower esophagusEsophageal cancerHER2 statusTumor locationBiomarker testing
2022
Utilization and Outcomes of Radiation in Stage IV Esophageal Cancer
Zhan P, Canavan M, Ermer T, Pichert M, Li A, Maduka R, Kaminski M, Johung K, Boffa D. Utilization and Outcomes of Radiation in Stage IV Esophageal Cancer. JTO Clinical And Research Reports 2022, 3: 100429. PMID: 36483656, PMCID: PMC9722471, DOI: 10.1016/j.jtocrr.2022.100429.Peer-Reviewed Original ResearchStage IV esophageal cancerNational Cancer DatabaseEsophageal cancerCancer DatabaseRadiation doseSurvival advantageMedian total radiation dosePropensity score-matched pairsOutcome of radiationRetrospective cohort studyKaplan-Meier analysisTotal radiation doseAppropriate radiation dosePalliative regimensCohort studyMedian ageRadiation administrationSurvival associationsBetter survivalPatientsLocal controlCancerDosePalliationFurther studiesNonregional Lymph Nodes as the Only Metastatic Site in Stage IV Esophageal Cancer
Zhan P, Canavan M, Ermer T, Pichert M, Li A, Maduka R, Kaminski M, Boffa D. Nonregional Lymph Nodes as the Only Metastatic Site in Stage IV Esophageal Cancer. JTO Clinical And Research Reports 2022, 3: 100426. PMID: 36444359, PMCID: PMC9700291, DOI: 10.1016/j.jtocrr.2022.100426.Peer-Reviewed Original ResearchStage IV esophageal cancerNonregional lymph nodesEsophageal cancerSystemic metastasesLymph nodesMultiorgan metastasesOrgan metastasisSuperior survivalAcademic facility typesOnly metastatic siteNational Cancer DatabaseOutcomes of patientsPatients 18 yearsRetrospective cohort studyStage IV diseaseKaplan-Meier analysisSquamous cell carcinomaPropensity-matched sampleNonregional lymphCohort studyMetastatic involvementMetastatic sitesCell carcinomaCancer DatabaseCox modelIn-hospital prognosis of malignancy-related pulmonary embolism: an analysis of the national inpatient sample 2016–2018
Park D, An S, Kashoor I, Ezegwu O, Gupta S. In-hospital prognosis of malignancy-related pulmonary embolism: an analysis of the national inpatient sample 2016–2018. Journal Of Thrombosis And Thrombolysis 2022, 54: 630-638. PMID: 35876942, DOI: 10.1007/s11239-022-02684-8.Peer-Reviewed Original ResearchConceptsOdds of in-hospital mortalityIn-hospital mortalityAssociated with higher oddsPulmonary embolismNational Inpatient SamplePropensity score matchingEsophageal cancerLung cancerHigher oddsInpatient SamplePrognosis of PEScore matchingDiagnosis of PEClinically relevant covariatesPrimary diagnosis of PEMalignant groupOvarian cancerRetrospective studyMalignancyPrimary diagnosisRelevant covariatesCancerOddsPatientsMortality
2021
LBA-5 Phase Ib study of the anti-TIGIT antibody tiragolumab in combination with atezolizumab in patients with metastatic esophageal cancer
Wainberg Z, Matos I, Delord J, Cassier P, Gil-Martin M, Kim T, LoRusso P, Bahleda R, Italiano A, Mendus D, Hoang T, Xue C, Wen X, Carvalho O, Pham T, Patil N, Meng R, Bendell J, Cervantes A, Cho B. LBA-5 Phase Ib study of the anti-TIGIT antibody tiragolumab in combination with atezolizumab in patients with metastatic esophageal cancer. Annals Of Oncology 2021, 32: s227-s228. DOI: 10.1016/j.annonc.2021.06.012.Peer-Reviewed Original ResearchChemoradiation as a nonsurgical treatment option for early-stage esophageal cancers: a retrospective cohort study
Pathak R, Canavan ME, Walters S, Salazar MC, Boffa DJ. Chemoradiation as a nonsurgical treatment option for early-stage esophageal cancers: a retrospective cohort study. Journal Of Thoracic Disease 2021, 13: 140-148. PMID: 33569194, PMCID: PMC7867841, DOI: 10.21037/jtd-20-1187.Peer-Reviewed Original ResearchEarly-stage esophageal cancerEsophageal cancerOverall survivalDefinitive non-surgical treatmentComorbidity-free patientsCT1/T2National Cancer DatabaseRetrospective cohort studyNon-surgical treatmentSubset of patientsGoals of careKaplan-Meier curvesNonsurgical treatment optionsKaplan-Meier estimatesInoperable patientsCohort studyNonsurgical approachCure rateTreatment optionsCancer patientsEndoscopic excisionCancer DatabaseTumor removalChemoradiationPatients
2020
Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy
Zhang X, Jain D. Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy. Annals Of The New York Academy Of Sciences 2020, 1482: 163-176. PMID: 32892349, DOI: 10.1111/nyas.14462.Peer-Reviewed Original ResearchConceptsNeoadjuvant therapyEsophageal cancerEsophageal carcinomaRecent American Joint CommitteePreoperative neoadjuvant therapyThorough pathologic assessmentTumor regression gradingAdvanced esophageal carcinomaAmerican Joint CommitteeCancer (AJCC) staging systemTumor regression gradeAccurate tumor stagingValuable prognostic informationRegression gradingSurgical resectionLymph nodesPathologic assessmentRegression gradeHistologic typePathologic evaluationResidual tumorPoor prognosisCell carcinomaGastrointestinal carcinomasStaging systemSurgically Managed Signet Ring Cell Esophageal Carcinomas in the National Cancer Database
Sathe TS, Resio BJ, Hoag JR, Monsalve AF, Pathak R, Blasberg JD, Mase V, Dhanasopon A, Boffa DJ. Surgically Managed Signet Ring Cell Esophageal Carcinomas in the National Cancer Database. The Annals Of Thoracic Surgery 2020, 109: 1656-1662. PMID: 32109449, DOI: 10.1016/j.athoracsur.2020.01.021.Peer-Reviewed Original ResearchConceptsSignet ring cell adenocarcinomaNational Cancer DatabaseSRC tumorsACA patientsCancer DatabaseProportional hazards regression modelsCommon histologic variantRole of esophagectomyClinical stage IRole of surgeryHazards regression modelsHigh-grade tumorsSRC histologySRC patientsAdult patientsComplete resectionWorse prognosisCell adenocarcinomaEsophageal cancerEsophageal carcinomaHistologic variantsSuperior survivalEsophageal adenocarcinomaTreatment characteristicsClinical recommendations
2019
Next-generation Sequencing in the Management of Gastric and Esophageal Cancers
Rubinstein JC, Nicolson NG, Ahuja N. Next-generation Sequencing in the Management of Gastric and Esophageal Cancers. Surgical Clinics Of North America 2019, 99: 511-527. PMID: 31047039, DOI: 10.1016/j.suc.2019.02.005.Peer-Reviewed Original ResearchConceptsNext-generation sequencingHigh-throughput sequencing technologyAvailable genomic dataSingle-nucleotide resolutionGenome-wide molecular profilingSpecific oncogenic pathwaysSequencing technologiesGenomic dataOncogenic pathwaysGenomic profilesMolecular profilingSequencingPathwayDifficult disease processManagement of gastricIndividual tumorsOrgan-specific treatmentTumorigenesisAbundanceProfilingCancer careEsophageal malignancyEsophageal cancerImmense potentialDisease process
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