2024
Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production
Su X, Zhao L, Zhang H, Wang D, Sun J, Shen L. Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production. Frontiers In Immunology 2024, 15: 1402834. PMID: 39253083, PMCID: PMC11381250, DOI: 10.3389/fimmu.2024.1402834.Peer-Reviewed Original ResearchCitrobacter rodentium infectionIL-22 productionSirtuin 6Regulating gut immune responsesNicotinamide adenine dinucleotide (NAD+)-dependent deacetylaseDextran sodium sulfate-induced colitis modelIntestinal epithelial cell differentiationGroup 3 innate lymphoid cellsDextran sodium sulfate-induced colitisEpithelial cell differentiationGut immune responseFlow cytometryEpigenetic regulationIncreased IL-22 productionCell-intrinsic mannerDependent deacetylaseIntestinal ILC3sCell numberIntestinal inflammatory responseLymphoid cell functionGut defenseConditional knockout miceGut immunityIL-22 expressionHost defense
2023
Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
de Miguel F, Gentile C, Feng W, Silva S, Sankar A, Exposito F, Cai W, Melnick M, Robles-Oteiza C, Hinkley M, Tsai J, Hartley A, Wei J, Wurtz A, Li F, Toki M, Rimm D, Homer R, Wilen C, Xiao A, Qi J, Yan Q, Nguyen D, Jänne P, Kadoch C, Politi K. Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer. Cancer Cell 2023, 41: 1516-1534.e9. PMID: 37541244, PMCID: PMC10957226, DOI: 10.1016/j.ccell.2023.07.005.Peer-Reviewed Original ResearchConceptsMammalian SWI/SNF chromatinSWI/SNF chromatinMSWI/SNF complexesGenome-wide localizationGene regulatory signaturesNon-genetic mechanismsEpithelial cell differentiationEGFR-mutant cellsChromatin accessibilitySNF complexCellular programsRegulatory signaturesTKI-resistant lung cancerGene targetsKinase inhibitor resistanceCell differentiationMesenchymal transitionTKI resistancePharmacologic disruptionTyrosine kinase inhibitor resistanceCell proliferationChromatinInhibitor resistanceEGFR-mutant lungKinase inhibitorsIL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans
Mar J, Ota N, Pokorzynski N, Peng Y, Jaochico A, Sangaraju D, Skippington E, Lekkerkerker A, Rothenberg M, Tan M, Yi T, Keir M. IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans. Microbiome 2023, 11: 47. PMID: 36894983, PMCID: PMC9997005, DOI: 10.1186/s40168-023-01486-1.Peer-Reviewed Original ResearchConceptsIL-22 treatmentUC patientsAhR activityIL-22 productionUlcerative colitis patientsGastrointestinal barrier functionMicrobiome compositionGut microbiome compositionAryl hydrocarbon receptorColitis patientsIL-22Gastrointestinal tractHealthy volunteersFunctional capacityMucus secretionAntimicrobial protein productionMicrobiota compositionEpithelial cell differentiationFecal concentrationsReceptor activityGut microbiomePatientsAhR signalingAryl hydrocarbon receptor (AhR) activityBarrier function
2019
Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with Type-2 inflammation
Zhou X, Kinlough CL, Hughey RP, Jin M, Inoue H, Etling E, Modena BD, Kaminski N, Bleecker ER, Meyers DA, Jarjour NN, Trudeau JB, Holguin F, Ray A, Wenzel SE. Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with Type-2 inflammation. JCI Insight 2019, 4 PMID: 30730306, PMCID: PMC6483602, DOI: 10.1172/jci.insight.122475.Peer-Reviewed Original ResearchConceptsHuman airway epithelial cellsEpithelial dysfunctionPrimary human airway epithelial cellsAirway epithelial cell differentiationT2-high asthmaType 2 inflammationAirway epithelial cellsGoblet cell differentiationEpithelial cell proliferationAirway specimensT2 biomarkersAsthmatic patientsSputum supernatantsT2 inflammationIL-13Cell differentiationAsthmaEpithelial cell differentiationSpecific mucinsEpithelial cell fateΒ-galactoside αEpithelial glycoproteinEpithelial cellsPotential targetEpithelial differentiation
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