2025
Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks
Kurbanov D, Ahangari F, Adams T, De Man R, Tang J, Carlon M, Abu Hussein N, Cortesi E, Zapata M, De Sadelaar L, Wuyts W, Vanaudenaerde B, Kaminski N, McDonough J. Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 328: l456-l462. PMID: 39970931, DOI: 10.1152/ajplung.00171.2024.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisIdiopathic pulmonary fibrosis tissuePulmonary fibrosisLung tissueEpigenetic clocksPotential of DNA methylationDNA methylation levelsDebilitating lung diseaseIllumina MethylationEPIC arrayHuman lung tissueEpigenetic ageDNA methylation clocksBiological ageAffected lung tissueIPF casesClinical prognosisMethylation patternsDNA methylationLung diseaseHealthy controlsAcceleration of biological agingMethylation levelsMethylationEPIC arrayAge accelerationClinical assessmentSymposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida
Rogina B, Anderson R, Lebrasseur N, Curan S, Yousefzadeh M, Ghosh B, Duque G, Howlett S, Austad S, Demuth I, Gerstorf D, Korfhage J, Lombard D, Abadir P, Christensen K, Carey J, Alberts S, Campos F, Palavicini J, Palmer A, Bell J, Basisty N, de Cabo R, Gomes A, Dixit V, Sen P, Baur J, Imai S, Li X, Valdez G, Orr M, Pletcher S, Andersen J, Jones L, Castillo-Azofeida D, Bonaguidi M, Suh Y, Duncan F, Murray A, C W, Burkewitz K, Henne M, Zhou K, Bouhrara M, Benjamini D, Kolind S, Walker K, Reiter D, Dean D, Gorbunova V, Gladyshev V, Palovics R, Niedernhofer L, Fan R, Bueckle A, Hurley J, Esser K, Kapahi P, Sato S, Jiang N, Ashiqueali S, Diaz J, Mishra S, Ralmundo N, Banarjee R, Allsopp R, Reynolds L, Zhang B, Sebastiani P, Monti S, Schork N, Rappaport N. Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida. The Journals Of Gerontology Series A 2025, glaf026. PMID: 39932386, DOI: 10.1093/gerona/glaf026.Peer-Reviewed Original ResearchInter-organelle crosstalkNon-genetic interventionComparative transcriptomicsAging researchSymposia reportsClinical trialsOrganismal levelReproductive ageCircadian clockStem cellsEpigenetic clocksProgressive deteriorationPhysiological functionsSociety of AmericaPromote human healthAgeTranslation studiesInternational expertsMetabolomicsInterventionInflammaging
2024
Potential use of epigenetic clocks to understand factors associated with aging at the population level and in public health
Martínez-Magaña J, Hurtado-Soriano J, Montalvo-Ortiz J, Gomez-Verjan J. Potential use of epigenetic clocks to understand factors associated with aging at the population level and in public health. Gaceta Médica De México 2024, 160: 357-359. PMID: 39602607, DOI: 10.24875/gmm.m24000897.Peer-Reviewed Original ResearchMaternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns
Dye C, Alschuler D, Wu H, Duarte C, Monk C, Belsky D, Lee S, O’Donnell K, Baccarelli A, Scorza P. Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns. JAMA Network Open 2024, 7: e2427063. PMID: 39120899, PMCID: PMC11316241, DOI: 10.1001/jamanetworkopen.2024.27063.Peer-Reviewed Original ResearchConceptsMaternal adverse childhood experiencesAdverse childhood experiencesEdinburgh Postnatal Depression ScaleAccessible Resource for Integrated Epigenomics StudiesEpigenetic age accelerationGestational age accelerationAssociated with epigenetic agingAvon Longitudinal Study of ParentsLongitudinal Study of ParentsPostnatal Depression ScalePrimary outcomeChildhood experiencesAvon Longitudinal StudyEpigenetic ageStudy of ParentsAge accelerationHigher ACE scoresCross-sectional studyEpigenetic clocksMother-offspring dyadsDepression ScaleHealth districtMother-child dyadsDNA methylation–based epigenetic clocksInvestigate depressionTowards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology
Martínez-Magaña J, Hurtado-Soriano J, Rivero-Segura N, Montalvo-Ortiz J, Garcia-delaTorre P, Becerril-Rojas K, Gomez-Verjan J. Towards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology. Archives Of Medical Research 2024, 55: 103033. PMID: 38955096, DOI: 10.1016/j.arcmed.2024.103033.Peer-Reviewed Original ResearchImpact of public health interventionsHealth problems associated with agingPublic health interventionsPublic health strategiesEpigenetic clocksEfficacy of interventionsProblems associated with agingBiological agePublic health concernHealth interventionsHealth strategiesAssociated with ageDNA methylation levelsHuman phenomeHealthy agingHealth concernEpigenetic ageMultiple traitsHealthMethylation levelsInterventionAssociationAgeEpidemiological contextHealth span
2023
Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging
Garg A, Seli E. Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging. Fertility And Sterility 2023, 121: 26-33. PMID: 37979607, DOI: 10.1016/j.fertnstert.2023.11.011.Peer-Reviewed Original ResearchConceptsPoor ovarian responseLeukocyte telomere lengthOvarian reserveTelomere lengthAssisted Reproductive TechnologyOvarian responseFollicular somatic cellsMethylome changesDNA methylomePrevalence of infertilityDiminished ovarian reserveSomatic cellsCellular agingEpigenetic clocksDNA methylation ageReproductive potentialReproductive declineOvarian agingSurrogate biomarkerCommon causeMethylomeART outcomesChronologic ageEmbryo aneuploidyReproductive functionThe Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health
Harvanek Z, Boks M, Vinkers C, Higgins-Chen A. The Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health. Biological Psychiatry 2023, 94: 694-705. PMID: 36764569, PMCID: PMC10409884, DOI: 10.1016/j.biopsych.2023.02.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Within subject cross‐tissue analyzes of epigenetic clocks in substance use disorder postmortem brain and blood
Cabrera‐Mendoza B, Stertz L, Najera K, Selvaraj S, Teixeira A, Meyer T, Fries G, Walss‐Bass C. Within subject cross‐tissue analyzes of epigenetic clocks in substance use disorder postmortem brain and blood. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2022, 192: 13-27. PMID: 36056652, PMCID: PMC9742183, DOI: 10.1002/ajmg.b.32920.Peer-Reviewed Original ResearchConceptsSubstance use disordersStimulant use disorderUse disordersPostmortem brainsAlcohol use disorderBrains of individualsBlood tissueBiological agingSubgroup analysisBrain valuesEpigenetic clocksSUD groupPeripheral measuresAging StudyDisordersBrainPatientsBloodDNA methylation changesSame individualTissueIndividualsMethylation changesOpioidsTissue specificityAging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease
Thrush KL, Bennett DA, Gaiteri C, Horvath S, Dyck CHV, Higgins-Chen AT, Levine ME. Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease. Aging 2022, 14: 5641-5668. PMID: 35907208, PMCID: PMC9365556, DOI: 10.18632/aging.204196.Peer-Reviewed Original ResearchConceptsDisease risk increasesBrain agingAD brain tissueΕ4 carrier statusClinical AD dementiaMultiple brain regionsEpigenetic alterationsReligious Orders StudyAD dementiaTest-retest reliabilityCortical samplesAD riskEpigenetic age accelerationSubcortical regionsPathologic ADAlzheimer's diseaseBrain regionsBrain tissueEpigenetic clocksCarrier statusStrong associationRush MemoryAge accelerationRisk increaseAging ProjectLongitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination
Pang APS, Higgins-Chen AT, Comite F, Raica I, Arboleda C, Went H, Mendez T, Schotsaert M, Dwaraka V, Smith R, Levine ME, Ndhlovu LC, Corley MJ. Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination. Frontiers In Genetics 2022, 13: 819749. PMID: 35719387, PMCID: PMC9203887, DOI: 10.3389/fgene.2022.819749.Peer-Reviewed Original ResearchSevere COVID-19T cellsCOVID-19 diagnosisMRNA vaccinationCOVID-19B cellsCOVID-19 vaccine responsesNon-hospitalized COVID-19MRNA COVID-19 vaccineSARS-CoV-2 infectionHost epigenetic landscapeMedian time frameExhausted T cellsNaïve T cellsCOVID-19 vaccinationCOVID-19 exposureCOVID-19 vaccineEpigenetic clock analysisModerna mRNAVaccine responsesImmune cellsEpigenetic clocksHealthy individualsVaccinationLongitudinal assessmentTick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock
Minteer C, Morselli M, Meer M, Cao J, Higgins‐Chen A, Lang SM, Pellegrini M, Yan Q, Levine ME. Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock. Aging Cell 2022, 21: e13553. PMID: 35104377, PMCID: PMC8844113, DOI: 10.1111/acel.13553.Peer-Reviewed Original ResearchConceptsMouse embryonic fibroblastsDNA methylationEpigenetic agingImportant chromatin regulatorsPolycomb group (PcG) factorsAnti-aging interventionsChromatin regulatorsEmbryonic fibroblastsCellular senescenceTissue agingCellular agingEpigenetic clocksMultiple tissuesMouse tissuesCaloric restrictionMechanistic insightsAging changesKidney fibroblastsReduced representationTime pointsPhysiological agingMouse culturesSuch alterationsTick-TockTissue
2021
Genome-wide DNA methylation profiling in nonagenarians suggests an effect of PM20D1 in late onset Alzheimer’s disease
Coto-Vílchez C, Martínez-Magaña J, Mora-Villalobos L, Valerio D, Genis-Mendoza A, Silverman J, Nicolini H, Raventós H, Chavarria-Soley G. Genome-wide DNA methylation profiling in nonagenarians suggests an effect of PM20D1 in late onset Alzheimer’s disease. CNS Spectrums 2021, 28: 174-182. PMID: 34911598, DOI: 10.1017/s109285292100105x.Peer-Reviewed Original ResearchGenome-wide DNA methylation profilingEpigenetic clocksWhole blood DNA methylation profilesQuantitative loci analysisCell cycle regulationDNA methylation profilesDNA methylation profilingEpigenetic ageMQTL SNPsBlood DNA methylation profilesHorvath's epigenetic clockInfinium MethylationEPIC BeadChipCycle regulationSynthesis of ceramideDifferential methylationMethylation profilingMethylation profilesLocus analysisMethylation levelsAverage methylationGenesMethylation analysisMethylationEPIC BeadChipPM20D1DMRs
2020
Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects
Higgins-Chen AT, Boks MP, Vinkers CH, Kahn RS, Levine ME. Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects. Biological Psychiatry 2020, 88: 224-235. PMID: 32199607, PMCID: PMC7368835, DOI: 10.1016/j.biopsych.2020.01.025.Peer-Reviewed Original ResearchConceptsAge-associated proteinsEpigenetic clocksDNA methylation data setsMethylation data setsEpigenetic ageing biomarkersReduced cancer riskCD8 T cellsBody mass indexLong-term outcomesHorvath's epigenetic clockLower cancer ratesDNA methylationDNA methylation predictorsBiological age differencesMitotic clockMitotic divisionAge clocksCause mortalityNatural killerMass indexEarly mortalityMedication dataSZ casesClozapine's effectIncreased Mortality
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