2024
Modern Photon-Based Craniospinal Irradiation in Leptomeningeal Disease
Keit E, Peterson J, Johnstone P, Robinson T, Figura N. Modern Photon-Based Craniospinal Irradiation in Leptomeningeal Disease. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e242. DOI: 10.1016/j.ijrobp.2024.07.542.Peer-Reviewed Original ResearchIntensity modulated radiotherapyCraniospinal irradiationLeptomeningeal diseaseHematologic malignanciesSolid tumorsOverall survivalProton therapyLocal failureAssociated with improved OSDelay systemic therapyG3+ toxicitySymptomatic leptomeningeal diseaseSite of spreadKaplan Meier methodPhoton-based treatmentsPrimary cancer typeAcute gradeG3 fatigueMedian OSModulated radiotherapyNeutropenic feverMedian followPalliative radiotherapyDisseminated diseaseSystemic therapy
2023
Epigenetic markers and therapeutic targets for metastasis
Kravitz C, Yan Q, Nguyen D. Epigenetic markers and therapeutic targets for metastasis. Cancer And Metastasis Reviews 2023, 42: 427-443. PMID: 37286865, PMCID: PMC10595046, DOI: 10.1007/s10555-023-10109-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEpigenomic alterationsLineage integrityTherapeutic targetEpigenetic markersCancer cellsGenetic aberrationsCurrent knowledgeHuman tumorsMalignant cell cloneTumor progressionDNANumber of discoveriesCell clonesDisseminated diseaseCertain organsPrimary tumorTherapeutic responseMetastatic cancerEpigenomeChromatinHistonesLiquid biopsyAlterationsClonesTarget
2022
Early Release - Economic Burden of Reported Lyme Disease in High-Incidence Areas, United States, 2014–2016 - Volume 28, Number 6—June 2022 - Emerging Infectious Diseases journal - CDC
Hook S, Jeon S, Niesobecki S, Hansen A, Meek J, Bjork J, Dorr F, Rutz H, Feldman K, White J, Backenson P, Shankar M, Meltzer M, Hinckley A. Early Release - Economic Burden of Reported Lyme Disease in High-Incidence Areas, United States, 2014–2016 - Volume 28, Number 6—June 2022 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2022, 28: 1170-1179. PMID: 35608612, PMCID: PMC9155891, DOI: 10.3201/eid2806.211335.Peer-Reviewed Original ResearchConceptsTotal societal costsSocietal costsLyme diseasePatient costsInfectious Diseases journal - CDCMean patient costMean societal costLyme disease endemic stateTotal patient costsCost-effectiveness analysisDisseminated diseaseProspective studyEarly diagnosisIncidence areaDiseaseEffective preventionProbable diseaseDemographic factorsPrevention methodsComprehensive economic evaluationEconomic evaluationPatientsVaccineIllnessDiagnosis
2020
Mycobacterium marinum: nodular hand lesions after a fishing expedition
Tuan J, Spichler-Moffarah A, Ogbuagu O. Mycobacterium marinum: nodular hand lesions after a fishing expedition. BMJ Case Reports 2020, 13: e238835. PMID: 33318281, PMCID: PMC7737068, DOI: 10.1136/bcr-2020-238835.Peer-Reviewed Case Reports and Technical NotesConceptsSoft tissue infectionsDeep space infectionsTissue infectionsSpace infectionAcid-fast bacilliTreatment of skinNon-tuberculous mycobacteriaTerms of treatmentDisseminated diseaseOptimal regimenHand lesionsMedical managementExtremity lesionsCombination therapyInfectionLesionsAddition of rifampicinFurther dataSkinTreatmentMycobacteriaOsteomyelitisRegimenPatientsSurgeryExophiala Dermatitidis Isolated From Blood In Patient With Steroid Use
Yurtsever N, Dougherty P, Condon S, Orsini R, Berman M, Berry G, Duong S. Exophiala Dermatitidis Isolated From Blood In Patient With Steroid Use. American Journal Of Clinical Pathology 2020, 154: s154-s155. PMCID: PMC7665285, DOI: 10.1093/ajcp/aqaa161.337.Peer-Reviewed Original ResearchBlood culturesExophiala dermatitidisAsymptomatic patientsSteroid useFollow-upBeta-D-glucan testHistory of chronic obstructive pulmonary diseaseDiagnose asymptomatic patientsSerum cryptococcus antigenUrinary tract infectionChest X-rayChronic obstructive pulmonary diseaseTreated with doxycyclineState public health laboratoriesE. dermatitidisObstructive pulmonary diseaseIsolates of E. dermatitidisCentral nervous systemPublic health laboratoriesCryptococcus antigenDisseminated diseasePulmonary infectionInvasive infectionsSteroid treatmentTract infectionsCurrent Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes
Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA. Current Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes. Seminars In Respiratory And Critical Care Medicine 2020, 41: 013-030. PMID: 32000281, DOI: 10.1055/s-0039-1698429.Peer-Reviewed Original ResearchConceptsDisseminated diseaseCurrent evidence-based approachesProgressive disseminated diseaseCommon clinical presentationCommunity-acquired pneumoniaChronic pulmonary diseaseSelf-limiting diseaseLiposomal amphotericin BManagement of histoplasmosisEvidence-based approachHistoplasmosis syndromeImmunocompetent patientsPulmonary diseaseClinical presentationCrohn's diseasePreferred agentClinical manifestationsCommon conditionMilder casesAmphotericin BHistoplasmosisAmphotericin B.DiseaseEpidemiologyGlobal disease
2018
Results of Phase 1 study on cytoreductive radical prostatectomy in men with newly diagnosed metastatic prostate cancer
Yuh B, Kwon Y, Shinder B, Singer E, Jang T, Kim S, Stein M, Mayer T, Ferrari A, Lee N, Parikh R, Ruel N, Kim W, Horie S, Byun S, Ahlering T, Kim I. Results of Phase 1 study on cytoreductive radical prostatectomy in men with newly diagnosed metastatic prostate cancer. Prostate International 2018, 7: 102-107. PMID: 31485434, PMCID: PMC6713798, DOI: 10.1016/j.prnil.2018.10.002.Peer-Reviewed Original ResearchMetastatic prostate cancerCytoreductive radical prostatectomyPhase 1 studyProstate-specific antigenRadical prostatectomyCytoreductive surgeryProstate cancerSpecific antigenDeath 5 monthsAcute tubular necrosisMajor perioperative complicationsOverall complication rateRapid disease progressionDay of surgerySubset of menPerioperative complicationsPrimary endpointTemporary dialysisComplication rateDisseminated diseaseTubular necrosisMajor complicationsMean ageClinical trialsDisease progressionGenomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma
Pectasides E, Stachler M, Derks S, Liu Y, Maron S, Islam M, Alpert L, Kwak H, Kindler H, Polite B, Sharma M, Allen K, O'Day E, Lomnicki S, Maranto M, Kanteti R, Fitzpatrick C, Weber C, Setia N, Xiao S, Hart J, Nagy R, Kim K, Choi M, Min B, Nason K, O'Keefe L, Watanabe M, Baba H, Lanman R, Agoston A, Oh D, Dunford A, Thorner A, Ducar M, Wollison B, Coleman H, Ji Y, Posner M, Roggin K, Turaga K, Chang P, Hogarth K, Siddiqui U, Gelrud A, Ha G, Freeman S, Rhoades J, Reed S, Gydush G, Rotem D, Davison J, Imamura Y, Adalsteinsson V, Lee J, Bass A, Catenacci D. Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma. Cancer Discovery 2018, 8: cd-17-0395. PMID: 28978556, PMCID: PMC5894850, DOI: 10.1158/2159-8290.cd-17-0395.Peer-Reviewed Original ResearchConceptsCell-free DNAGastroesophageal adenocarcinomaPrimary tumorMetastatic lesionsMetastatic tumorsTargeted therapyGenomic alterationsGenomic biomarkersAnalysis of cell-free DNACell-free DNA profilingSynchronous metastatic lesionsGenomic profiling resultsTargetable genomic alterationsSelection of therapyClinically relevant alterationsGenomic heterogeneityPrecision medicineUntreated metastasesDisseminated diseaseMultiregional sequencingMetastatic tissuesTargetable alterationsBiomarker testingRelevant alterationsTissue profile
2017
Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy – a case report
Huong N, Altibi A, Hoa N, Tuan L, Salman S, Morsy S, Lien N, Truong N, Mai N, Hoa P, Thang N, Trung V. Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy – a case report. BMC Infectious Diseases 2017, 17: 311. PMID: 28446137, PMCID: PMC5406963, DOI: 10.1186/s12879-017-2415-8.Peer-Reviewed Original ResearchConceptsLong-term immunosuppressive therapyImmunosuppressive therapyCutaneous cryptococcosisMyasthenia gravisCutaneous manifestations of cryptococcosisDifferential diagnosis of cutaneous lesionsAssociated with myasthenia gravisDiagnosis of cutaneous lesionsHIV-uninfected individualsManifestation of cryptococcosisChronic immunosuppressive therapyHIV-infected individualsProgressive skin lesionsDevelopment of cryptococcosisMyasthenia gravis patientsCD4 countCryptococcal meningitisDisseminated diseaseCase presentationWeOpportunistic infectionsMonth historyVietnamese male patientMale patientsCutaneous manifestationsDifferential diagnosisCigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies
Præstegaard C, Jensen A, Jensen SM, Nielsen TS, Webb PM, Nagle CM, DeFazio A, Group O, Høgdall E, Rossing M, Doherty J, Wicklund K, Goodman M, Modugno F, Moysich K, Ness R, Edwards R, Matsuo K, Hosono S, Goode E, Winham S, Fridley B, Cramer D, Terry K, Schildkraut J, Berchuck A, Bandera E, Paddock L, Massuger L, Wentzensen N, Pharoah P, Song H, Whittemore A, McGuire V, Sieh W, Rothstein J, Anton‐Culver H, Ziogas A, Menon U, Gayther S, Ramus S, Gentry‐Maharaj A, Wu A, Pearce C, Pike M, Lee A, Sutphen R, Chang‐Claude J, Risch H, Kjaer S, Consortium O. Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies. International Journal Of Cancer 2017, 140: 2422-2435. PMID: 28063166, PMCID: PMC5489656, DOI: 10.1002/ijc.30600.Peer-Reviewed Original ResearchConceptsPooled hazard ratioCigarette smokingOvarian Cancer Association ConsortiumOvarian cancerHazard ratioPooled analysisStudy-specific hazard ratiosLarge pooled analysisMucinous ovarian tumorsOvarian cancer stageEpithelial ovarian cancerOvarian cancer survivalConfidence intervalsOvarian cancer prognosisCase-control studyRandom-effects modelPotential clinical importanceMedian followAdverse survivalCurrent smokingDisseminated diseaseFormer smokersWorse survivalModifiable factorsOvarian tumors
2015
Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management
Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management. Seminars In Respiratory And Critical Care Medicine 2015, 36: 729-745. PMID: 26398539, DOI: 10.1055/s-0035-1562899.BooksConceptsMost patientsPulmonary diseaseAcute pulmonary diseaseChronic cavitary pneumoniaCommon endemic mycosisProgressive disseminated diseaseCommon clinical presentationCommunity-acquired pneumoniaChronic pulmonary diseaseEvaluation of patientsLiposomal amphotericin BDate evidence-based approachGranulomatous inflammatory diseaseDiagnosis of histoplasmosisEvidence-based approachMediastinal manifestationsCavitary pneumoniaDisseminated diseaseClinical presentationCrohn's diseasePreferred agentClinical syndromeAnaerobic infectionsInflammatory diseasesEndemic mycosisPrototheca wickerhamii algaemia: an emerging infection in solid organ transplant recipients
Bandaranayake TD, Mondolfi A, Peaper DR, Malinis MF. Prototheca wickerhamii algaemia: an emerging infection in solid organ transplant recipients. Transplant Infectious Disease 2015, 17: 599-604. PMID: 26040253, DOI: 10.1111/tid.12407.Peer-Reviewed Case Reports and Technical NotesConceptsSolid organ transplant recipientsOrgan transplant recipientsTransplant recipientsRenal transplant recipientsDisseminated diseaseCutaneous lesionsFatal casesEarly diagnosisRecipientsPrevious casesImpact outcomesPrototheca wickerhamiiDiseaseHuman diseasesP. wickerhamiiLesionsVoriconazoleInfectionDiagnosisFlight mass spectrometryMatrix-assisted laser desorption ionization time
2011
Tumor-stroma interactions a trademark for metastasis
Morales M, Planet E, Arnal-Estape A, Pavlovic M, Tarragona M, Gomis R. Tumor-stroma interactions a trademark for metastasis. The Breast 2011, 20: s50-s55. PMID: 22015293, DOI: 10.1016/s0960-9776(11)70294-6.Peer-Reviewed Original ResearchConceptsGenes associated with metastasisTumor-stroma interactionsPrimary tumorRisk of relapseTumor-stroma communicationAssociated with metastasisDisseminated diseaseMetastatic nestsMetastatic developmentImmune infiltrationBone colonizationClinical correlatesSystemic instigationMetastasisTumorCytokine-cytokine receptor interactionReceptor interactionCytokine-cytokine receptor interaction pathwayExpression profiling dataGenesRelapseLungPathway
2010
Combined Classical Carcinoid and Goblet Cell Carcinoid Tumor: A New Morphologic Variant of Carcinoid Tumor of the Appendix
Chetty R, Klimstra D, Henson D, Albores-Saavedra J. Combined Classical Carcinoid and Goblet Cell Carcinoid Tumor: A New Morphologic Variant of Carcinoid Tumor of the Appendix. The American Journal Of Surgical Pathology 2010, 34: 1163-1167. PMID: 20631606, DOI: 10.1097/pas.0b013e3181e52916.Peer-Reviewed Original ResearchConceptsGoblet cell carcinoidCarcinoid tumorsCell carcinoidMIB-1Tumor typesClassical carcinoidMIB-1 proliferation indexGoblet cell carcinoid tumorVariant of carcinoid tumorSignet ring cell carcinomaMIB-1 indexPelvic soft tissuesClassical carcinoid tumoursTreated with right hemicolectomyOvarian metastasisAppendiceal tumorsPelvic massCarcinoid typeDisseminated diseaseGoblet cell typeRight hemicolectomyAcute appendicitisCell carcinomaIndependent primariesNeuroendocrine markersLyme Disease
Murray TS, Shapiro ED. Lyme Disease. Clinics In Laboratory Medicine 2010, 30: 311-328. PMID: 20513553, PMCID: PMC3652387, DOI: 10.1016/j.cll.2010.01.003.Peer-Reviewed Original ResearchConceptsLyme diseaseClinical presentation variesOnly nonspecific symptomsCranial nerve palsyMultiple erythema migransSigns of infectionCommon vector-borne diseaseNerve palsyDisseminated diseaseMost patientsNonspecific symptomsErythema migransSerologic testingAppropriate antimicrobialsEarly diseasePresentation variesLate diseaseObjective signsSpirochete Borrelia burgdorferiDiseaseBorrelia burgdorferiPatientsMigransSymptomsInfection
2009
Prognostic Significance of Localized Extra-appendiceal Mucin Deposition in Appendiceal Mucinous Neoplasms
Yantiss R, Shia J, Klimstra D, Hahn H, Odze R, Misdraji J. Prognostic Significance of Localized Extra-appendiceal Mucin Deposition in Appendiceal Mucinous Neoplasms. The American Journal Of Surgical Pathology 2009, 33: 248-255. PMID: 18852679, DOI: 10.1097/pas.0b013e31817ec31e.Peer-Reviewed Original ResearchConceptsAppendiceal mucinous neoplasmExtra-appendiceal epitheliumDiffuse peritoneal involvementMucinous neoplasmsMucin depositionPeritoneal involvementRecurrent diseaseProgression to disseminated diseaseHistological evaluationExtra-appendiceal mucinMucinous ascitesDisseminated diseasePrognostic significanceNeoplastic epitheliumClinical outcomesTumor cellsFollow-upCellular mucinNeoplasmsPeriappendiceal regionPatientsEpitheliumMicroscopic examinationDiseaseMucin
2008
Bevacizumab suppresses neuroblastoma progression in the setting of minimal disease
Sims T, Williams R, Ng C, Rosati S, Spence Y, Davidoff A. Bevacizumab suppresses neuroblastoma progression in the setting of minimal disease. Surgery 2008, 144: 269-275. PMID: 18656635, PMCID: PMC2525799, DOI: 10.1016/j.surg.2008.04.009.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsAutocrine CommunicationBevacizumabCell Line, TumorCell ProliferationDisease ProgressionFibroblast Growth Factor 2HumansMiceMice, SCIDNeuroblastomaReceptors, Vascular Endothelial Growth FactorSignal TransductionTumor Cells, CulturedVascular Endothelial Growth Factor AConceptsVascular endothelial growth factorLuciferase-expressing tumor cellsAnti-VEGF monoclonal antibodyUpregulation of proangiogenic factorsMaximal antitumor efficacyVEGF signaling inhibitionActivity of bevacizumabDecreased tumor burdenFibroblast growth factor expressionEndothelial growth factorGrowth factor expressionIn vitro studiesCytoreductive therapyIntraperitoneal bevacizumabBevacizumab treatmentTumor burdenDisseminated diseaseDisseminated neuroblastomaMaintenance therapyMinimal diseaseCombination therapyNeuroblastoma cell linesIn vivo studiesProlonged survivalAntitumor efficacy
2005
Current Status of Gastrointestinal Carcinoids
Modlin IM, Kidd M, Latich I, Zikusoka MN, Shapiro MD. Current Status of Gastrointestinal Carcinoids. Gastroenterology 2005, 128: 1717-1751. PMID: 15887161, DOI: 10.1053/j.gastro.2005.03.038.Peer-Reviewed Original ResearchConceptsGastrointestinal carcinoidsSomatostatin analoguesComputerized axial tomography scanEffective symptomatic therapyLocal endoscopic excisionType III/IVAxial tomography scanQuality of lifeCell of originColonic carcinoidsSynaptophysin immunohistochemistryPlasma chromograninPrimary therapyDisseminated diseaseEmergency surgeryHepatic transplantationSymptomatic therapyHepatic metastasesSurgical excisionRectal carcinoidsEndoscopic excisionHormone secretionIncidental detectionRadiofrequency ablationTomography scanClinically Aggressive Solid Pseudopapillary Tumors of the Pancreas
Tang L, Aydin H, Brennan M, Klimstra D. Clinically Aggressive Solid Pseudopapillary Tumors of the Pancreas. The American Journal Of Surgical Pathology 2005, 29: 512-519. PMID: 15767807, DOI: 10.1097/01.pas.0000155159.28530.88.Peer-Reviewed Original ResearchConceptsSolid pseudopapillary tumorCase of solid pseudopapillary tumorLiver metastasesPathological featuresPseudopapillary tumorClinical courseHistological featuresPresence of disseminated diseaseMemorial Sloan-Kettering Cancer CenterSignificant nuclear atypiaUnusual pathological featuresExtensive tumor necrosisAggressive clinical courseDied of diseaseHigh-grade malignant transformationLymph node metastasisDiffuse growth patternImmunohistochemical staining patternsBeta-catenin distributionSarcomatoid carcinomaMetastatic diseaseDisseminated diseaseInitial resectionUnusual neoplasmsTumor necrosis
2004
Transmission of enterotropic mouse hepatitis virus from immunocompetent and immunodeficient mice.
Compton SR, Ball-Goodrich LJ, Paturzo FX, Macy JD. Transmission of enterotropic mouse hepatitis virus from immunocompetent and immunodeficient mice. Comparative Medicine 2004, 54: 29-35. PMID: 15027615.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Outbred StrainsFecesFemaleHepatitis, Viral, AnimalImmunocompetenceImmunocompromised HostInfectious Disease Transmission, VerticalMiceMice, Inbred StrainsMurine hepatitis virusReverse Transcriptase Polymerase Chain ReactionRNA, ViralRodent DiseasesSentinel SurveillanceSpecies SpecificityVirus SheddingConceptsCell-deficient miceEnterotropic mouse hepatitis virusT cell-deficient miceMouse hepatitis virusInfected miceIntestinal infectionsC57BL/6 miceHepatitis virusB cell-deficient miceViral RNABALB/c miceSevere disseminated diseaseNon-infectious RNADisseminated diseaseNaive miceC miceMHV infectionImmunodeficient miceSentinel miceBALB/ cViral transmissionInfectionMiceVirus RNAWeeks
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