2025
Estimating the Serotype-Specific Association Between the Concentration of Vaccine-Induced Serum Antibodies and Protection Against Pneumococcal Colonization
Wong A, Warren J, Fitch L, Perniciaro S, Dagan R, Weinberger D. Estimating the Serotype-Specific Association Between the Concentration of Vaccine-Induced Serum Antibodies and Protection Against Pneumococcal Colonization. The Journal Of Infectious Diseases 2025, jiaf106. PMID: 40036886, DOI: 10.1093/infdis/jiaf106.Peer-Reviewed Original ResearchHigher-valent PCVsPneumococcal conjugate vaccinePneumococcal colonizationVaccine-induced serum antibodiesRisk of colonizationSerum immunoglobulin GRandomized controlled trialsConjugate vaccinePCV13Clinical trialsSerum IgGImmune responseVaccinated childrenSevere diseaseVaccine effectivenessSerum antibodiesPCV20Serotype-specificImmunoglobulin GSerotypesColonIndirect protectionIgGVaccineTrials
2024
Air Versus Carbon Dioxide Insufflation Versus Water Immersion During Colonoscopy
Pleskow D, Erim T, Ketwaroo G. Air Versus Carbon Dioxide Insufflation Versus Water Immersion During Colonoscopy. 2024, 27-37. DOI: 10.1201/9781003523307-3.Peer-Reviewed Original Research
2022
Ethnic and Racial Inequities in Cancer Screening During the COVID-19 Pandemic: a multi-site observational study in the United States
Idossa D, Borno H, Wang K, Pletcher M, Gresham G, Canchola A, Bell D, Matheny M, Schilling L, Perkins A, Zheng K, Ohno-Machado L, Kim J, Soohoo S, Meeker D, Gomez S. Ethnic and Racial Inequities in Cancer Screening During the COVID-19 Pandemic: a multi-site observational study in the United States. International Journal Of Cancer Care And Delivery 2022, 2 DOI: 10.53876/001c.37412.Peer-Reviewed Original ResearchCancer screeningBlack individualsProstate cancer screeningSARS-CoV2 infectionColon cancer screeningMulti-site observational studyCOVID-19 pandemicRelative reductionSurgical resectionProstate resectionProstate cancerCurrent COVID-19 pandemicObservational studyColon cancerSARS-CoV2Largest relative declineLargest relative reductionInfection rateDiagnostic mammogramsDiagnostic proceduresScreening activitiesBreastStudy periodDiagnostic mammographyColon
2021
Lower Gastrointestinal Functional and Motility Disorders in Children
Arbizu R, Freiberg B, Rodriguez L. Lower Gastrointestinal Functional and Motility Disorders in Children. Pediatric Clinics Of North America 2021, 68: 1255-1271. PMID: 34736588, DOI: 10.1016/j.pcl.2021.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnorectal MalformationsBiopsyChildChild, PreschoolColonic DiseasesConstipationErythromycinFemaleGastrointestinal DiseasesGastrointestinal MotilityHirschsprung DiseaseHumansInfantIntestinal Pseudo-ObstructionIntestine, SmallLower Gastrointestinal TractMaleManometryNutritional StatusQuality of LifeConceptsMotility disordersSignificant morbidityTherapeutic interventionsColorectal disordersPediatric gastroenterologistsClinical presentationSmall bowelGastrointestinal disordersCommon complaintDiagnostic evaluationSmall intestineDisordersMorbidityComplicationsSuch interventionsInterventionSocial stigmaPoor qualityBowelAnorectumGastroenterologistsColonMortalityComplaintsIntestine5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING
Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. 5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING. The EMBO Journal 2021, 40: embj2020106065. PMID: 33615517, PMCID: PMC8013832, DOI: 10.15252/embj.2020106065.Peer-Reviewed Original ResearchConceptsAnti-tumor immunityTumor burdenSubsequent type I interferon productionHigh STING expressionIntratumoral T cellsT-cell depletionType I interferon productionI interferon productionLoss of STINGImmunocompetent hostsColorectal specimensT cellsSTING expressionBetter survivalHigh doseTherapeutic effectivenessHuman colorectal specimensMelanoma tumorsInterferon productionChemotherapeutic drugsMurine colonImmunityEfficacyStingsColon
2020
317 CYTOF ANALYSIS OF HUMAN COLON AND BLOOD REVEALS DISTINCT IMMUNE SIGNATURES OF ULCERATIVE COLITIS AND CROHN'S DISEASE
Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Field M, McCourt C, Toothaker J, Goldsmith J, Kean L, Shalek A, Tseng G, Konnikova L, Snapper S. 317 CYTOF ANALYSIS OF HUMAN COLON AND BLOOD REVEALS DISTINCT IMMUNE SIGNATURES OF ULCERATIVE COLITIS AND CROHN'S DISEASE. Gastroenterology 2020, 158: s-57. DOI: 10.1016/s0016-5085(20)30824-6.Peer-Reviewed Original ResearchIntestinal TMEM16A function as a luminal chloride channel
Kazi M, Saha T, Aoun J, Hayashi M, Sheikh I, Leblanc N, Sarkar P, Ameen N, Woodward O. Intestinal TMEM16A function as a luminal chloride channel. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.06115.Peer-Reviewed Original ResearchMouse intestinal tissueIntestinal tissueHuman colonic tissueColonic tissueLuminal expressionLuminal ClTMEM16A protein expressionIntestinal epithelial tissueAvailable polyclonal antibodyLuminal membraneWestern blot analysisTMEM16A functionSerosal applicationAgonist carbacholDistal colonCarbacholMRNA expressionColonWestern blotMouse intestineT84 cellsHigh expressionHuman colonProtein expressionTMEM16A protein
2018
Defining Early-Onset Colon and Rectal Cancers
Jacobs D, Zhu R, Luo J, Grisotti G, Heller DR, Kurbatov V, Johnson CH, Zhang Y, Khan SA. Defining Early-Onset Colon and Rectal Cancers. Frontiers In Oncology 2018, 8: 504. PMID: 30460196, PMCID: PMC6232522, DOI: 10.3389/fonc.2018.00504.Peer-Reviewed Original ResearchEarly-onset colonRectal cancerCancer incidenceColon cancerEnd Results Program databaseSignet ring cell subtypeColorectal cancer incidenceRectal cancer incidenceColon cancer incidenceAdenocarcinoma histologyRectosigmoid locationBlack populationClinicopathological characteristicsClinicopathological featuresProgram databaseInclusion criteriaPercent changeColonCell subtypesCancerPatientsIncidence increasesIncidenceSimilar riseSuch cohorts
2017
Chapter 19 Animal Models of Inflammatory Bowel Disease
Jamwal S, Kumar P. Chapter 19 Animal Models of Inflammatory Bowel Disease. 2017, 467-477. DOI: 10.1016/b978-0-12-809468-6.00019-x.Peer-Reviewed Original ResearchInflammatory bowel diseaseAnimal modelsBowel diseasePathologic mechanismsHuman inflammatory bowel diseaseImmune system overactivationDifferent animal modelsIntestinal inflammationClinical featuresInflammatory conditionsMucosal barrierClinical studiesGut microbiotaSmall intestineCellular alterationsOxidative stressDisease assessmentDiseaseMolecular assessmentAlterationsDate overviewInflammationDrug discoveryPathophysiologyColon
2016
Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk
Cannioto R, LaMonte M, Risch H, Hong C, Sucheston-Campbell L, Eng K, Szender J, Chang-Claude J, Schmalfeldt B, Klapdor R, Gower E, Minlikeeva A, Zirpoli G, Bandera E, Berchuck A, Cramer D, Doherty J, Edwards R, Fridley B, Goode E, Goodman M, Hogdall E, Hosono S, Jensen A, Jordan S, Kjaer S, Matsuo K, Ness R, Olsen C, Olson S, Pearce C, Pike M, Rossing M, Szamreta E, Thompson P, Tseng C, Vierkant R, Webb P, Wentzensen N, Wicklund K, Winham S, Wu A, Modugno F, Schildkraut J, Terry K, Kelemen L, Moysich K. Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk. Obstetrical & Gynecological Survey 2016, 71: 528-530. DOI: 10.1097/ogx.0000000000000357.Peer-Reviewed Original Research
2015
Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci
Hulur I, Gamazon ER, Skol AD, Xicola RM, Llor X, Onel K, Ellis NA, Kupfer SS. Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC Genomics 2015, 16: 138. PMID: 25766683, PMCID: PMC4351699, DOI: 10.1186/s12864-015-1292-z.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseColorectal cancerBowel diseaseSingle nucleotide polymorphismsBody mass indexType 2 diabetesHealthy African AmericansColorectal cancer risk variantsMass indexTarget genesColonic diseaseColonic samplesDiseaseNovel target geneBackgroundGenome-wide association studiesHuman colonDifferent ethnic groupsRisk variantsAfrican AmericansColonFalse discovery rateGenetic variantsNucleotide polymorphismsBiological differencesFunctional role
2014
Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers
Singh S, Arcaroli J, Thompson DC, Messersmith W, Vasiliou V. Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers. Advances In Experimental Medicine And Biology 2014, 815: 281-294. PMID: 25427913, PMCID: PMC4347404, DOI: 10.1007/978-3-319-09614-8_16.Peer-Reviewed Original ResearchConceptsPancreatic cancerColorectal cancerRetinoic acidChronic alcohol consumptionImportant risk factorCancer-related deathCancer stem cellsProgression of cancerPoor prognosisEventual prognosisRisk factorsAlcohol consumptionCancerImportant mechanistic roleTumor developmentRetinaldehyde dehydrogenasesCancer initiationPrognosisColonTumorsStem cellsProgressionBiomarkersALDH1A1Mechanistic roleMutacin del gen BRAF en pacientes con cnceres de colon y recto con KRAS no mutado
Roa I, Game A, Bizama C, Schalper K. Mutacin del gen BRAF en pacientes con cnceres de colon y recto con KRAS no mutado. Revista Medica De Chile 2014, 142: 55-60. PMID: 24861115, DOI: 10.4067/s0034-98872014000100009.Peer-Reviewed Original ResearchConceptsBRAF V600E mutationV600E mutationColorectal cancerPrimary tumorKRAS mutationsIndependent prognostic factorBRAF gene mutationRestriction fragment length polymorphismColorectal cancer samplesGrowth factor pathwaysLiver metastasesPrognostic factorsMetastatic adenocarcinomaTumor locationBRAF geneFactor pathwayMonoclonal antibodiesCancer samplesMutation casesGene mutationsTissue samplesPatientsDirect sequencingMetastasisColon
2013
Colovesical Fistula Caused by an Ingested Chicken Bone
Clements MB, Hedrick TL, Colen DL, Schenkman NS. Colovesical Fistula Caused by an Ingested Chicken Bone. Urology 2013, 82: e37-e38. PMID: 24295267, DOI: 10.1016/j.urology.2013.08.054.Peer-Reviewed Original ResearchConceptsIngested chicken boneColovesical fistulaSigmoid colonForeign bodyInflammatory bowel diseaseFistulous communicationHospital dischargeBowel diseaseColonic diverticulaIatrogenic injuryUrinary bladderGastrointestinal tractRadiation therapyChicken boneFistulaBladderColonTractDirect visualizationBoneDiverticulitisColonoscopyPatientsNeoplasmsUrethraMutacin del gen KRAS en el cncer de colon y recto
Roa I, Snchez T, Majlis A, Schalper K. Mutacin del gen KRAS en el cncer de colon y recto. Revista Medica De Chile 2013, 141: 1166-1172. PMID: 24522420, DOI: 10.4067/s0034-98872013000900009.Peer-Reviewed Original ResearchConceptsKRAS mutationsPrimary tumorColorectal cancer tissue samplesTissue samplesColo-rectal cancerCancer tissue samplesColorectal cancerMetastatic tumorsTumor locationColorectal carcinogenesisG12C mutationCodon 13KRAS oncogeneCodon 12Tumor samplesTumorsExtraction sitesDirect sequencingCancerDistribution of mutationsMutationsPoint mutationsMetastasisRectumColonIdentification of Functionally Distinct Na-HCO3 Co-Transporters in Colon
Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM. Identification of Functionally Distinct Na-HCO3 Co-Transporters in Colon. PLOS ONE 2013, 8: e62864. PMID: 23690961, PMCID: PMC3653958, DOI: 10.1371/journal.pone.0062864.Peer-Reviewed Original ResearchConceptsNa-HCO3 cotransportDistal colonProximal colonNBC activityNBC isoformsRat colonColonic epithelial cellsCrypt glandsSensitive transporterHCO3- secretionColonHCO3-dependent mechanismEpithelial cellsSaturable processHOE694Isoform 1Basolateral membraneCotransportPCR analysisNorthern blotDIDSMolecular studiesMolecular identityApparent KiCritical role
2012
Internal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex?
Rodriguez L, Siddiqui A, Nurko S. Internal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex? Neurogastroenterology & Motility 2012, 24: 1023-e545. PMID: 22757618, PMCID: PMC3465462, DOI: 10.1111/j.1365-2982.2012.01965.x.Peer-Reviewed Original ResearchConceptsHigh-amplitude peristaltic contractionsInternal anal sphincter relaxationAnal sphincter relaxationIAS relaxationSphincter relaxationAnal residual pressureManometry tracingsDefecation disordersConstipated childrenAnal relaxationHepatic flexureResting pressureDistal colonPeristaltic contractionsColonAbstractTextConstipationContraction propagationReflexChildrenImportant proportionContractionMost casesPatientsBisacodyl
2011
Functional role of NHE4 as a pH regulator in rat and human colonic crypts
Arena EA, Longo WE, Roberts KE, Geibel P, Nateqi J, Brandstetter M, Geibel JP. Functional role of NHE4 as a pH regulator in rat and human colonic crypts. American Journal Of Physiology - Cell Physiology 2011, 302: c412-c418. PMID: 22049213, DOI: 10.1152/ajpcell.00163.2011.Peer-Reviewed Original ResearchConceptsHuman colonic cryptsNHE4 activityColonic cryptsElective colon resectionEffects of aldosteroneSprague-Dawley ratsColon resectionRat modelGastrointestinal tractAldosteroneColonic samplesΜM forskolinFluid homeostasisRatsHuman colonHuman specimensCAMP levelsIntracellular pathwaysCryptsNHE4ColonSignificant changesLittle descriptionFunctional roleRecent studiesJejunal Adaptation in a Prepubertal Boy After Total Ileal Resection and Jejunostomy Placement
Cheng SX, Gathungu G, Pashankar D, Jain D, Husain SZ. Jejunal Adaptation in a Prepubertal Boy After Total Ileal Resection and Jejunostomy Placement. Journal Of Clinical Gastroenterology 2011, 45: 846-849. PMID: 21552141, PMCID: PMC4425287, DOI: 10.1097/mcg.0b013e318214b2d9.Peer-Reviewed Original ResearchEosinophilic Myenteric Ganglionitis
Chander B, Fiedler P, Jain D. Eosinophilic Myenteric Ganglionitis. Journal Of Clinical Gastroenterology 2011, 45: 314-316. PMID: 20921901, DOI: 10.1097/mcg.0b013e3181f5978a.Peer-Reviewed Original ResearchConceptsEosinophilic myenteric ganglionitisMyenteric ganglionitisAuerbach's plexusSigmoid colonFunctional bowel obstructionOnly significant findingBowel dysmotilityFecal disimpactionRecurrent obstipationBowel obstructionClinical improvementHartmann's procedureUnknown etiologyCase reportDisease entityMuscular layerGanglionitisResectionEosinophilsPlexusColonInfiltrationSignificant findingsDysmotilityObstipation
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