2024
The Clinical Trajectory of NYHA Functional Class I Patients With Obstructive Hypertrophic Cardiomyopathy
Ahluwalia M, Liu J, Olivotto I, Parikh V, Ashley E, Michels M, Ingles J, Lampert R, Stendahl J, Colan S, Abrams D, Pereira A, Rossano J, Ryan T, Owens A, Ware J, Saberi S, Helms A, Day S, Claggett B, Ho C, Lakdawala N. The Clinical Trajectory of NYHA Functional Class I Patients With Obstructive Hypertrophic Cardiomyopathy. JACC Heart Failure 2024, 13: 332-343. PMID: 39520446, DOI: 10.1016/j.jchf.2024.09.008.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathyClass I patientsFunctional class II patientsNYHA functional class IClass II patientsFunctional class II patientsII patientsHypertrophic cardiomyopathyFollow-upLeft ventricular outflow tract obstructionVentricular outflow tract obstructionNYHA functional class IILeft ventricular ejection fractionRates of clinical outcomesClass INatural historyRestricted cubic spline modelsSeptal reduction therapyOutflow tract obstructionFunctional class IIVentricular ejection fractionComposite event rateCubic spline modelsCox proportional hazardsClass I Recalls of Cardiovascular Devices Between 2013 and 2022 : A Cross-Sectional Analysis.
See C, Mooghali M, Dhruva S, Ross J, Krumholz H, Kadakia K. Class I Recalls of Cardiovascular Devices Between 2013 and 2022 : A Cross-Sectional Analysis. Annals Of Internal Medicine 2024, 177: 1499-1508. PMID: 39284187, DOI: 10.7326/annals-24-00724.Peer-Reviewed Original ResearchCross-sectional studyCross-sectional analysisAdverse health consequencesPatient safetyClinical testingClass IHealth consequencesClinical evidenceFDA summariesPostapproval studiesDecision summariesFood and Drug AdministrationU.S. Food and Drug AdministrationEnd-point selectionPremarket approvalMultiple class IClinical studiesPostmarketing surveillanceSummaryDrug AdministrationMedical device recall databaseRecallPatientsFDAPostmarketingEnhanced Recovery After Surgery (ERAS) cardiac turnkey order set for perioperative pain management in cardiac surgery: Proceedings from the American Association for Thoracic Surgery (AATS) ERAS Conclave 2023
Gregory A, Arora R, Chatterjee S, Crisafi C, Morton-Bailey V, Rea A, Salenger R, Engelman D, Grant M, Group E, Cangut B, Crotwell S, Lobdell K, McConnell G, Reddy S. Enhanced Recovery After Surgery (ERAS) cardiac turnkey order set for perioperative pain management in cardiac surgery: Proceedings from the American Association for Thoracic Surgery (AATS) ERAS Conclave 2023. JTCVS Open 2024, 22: 14-24. PMID: 39780778, PMCID: PMC11704536, DOI: 10.1016/j.xjon.2024.08.018.Peer-Reviewed Original ResearchPerioperative pain managementCardiac surgeryPain managementOpioid administrationOptimal perioperative pain managementOpioid-related adverse eventsClass IShort-acting synthetic opioidLong-acting opioidsCardiac surgical patientsControl post-operativelyNon-steroidal anti-inflammatory drugsAssociated with delayed recoveryLong-term adverse effectsOpioid-based analgesiaEvidence-based order setsOpioid-sparing medicationsAnti-inflammatory drugsComprehensive multimodal approachExpert consensus documentRate of postoperative recoveryOpioid reductionInadequate analgesiaIntravenous analgesicsPost-operativelyPreoperative medication management turnkey order set for nonemergent adult cardiac surgery
Rea A, Salenger R, Grant M, Yeh J, Damas B, Crisalfi C, Arora R, Gregory A, Morton-Bailey V, Engelman D, Group E, Cangut B, Chatterjee S, Lobdell K, McConnell G, Crotwell S, Reddy S. Preoperative medication management turnkey order set for nonemergent adult cardiac surgery. JTCVS Open 2024, 22: 1-13. PMID: 39780789, PMCID: PMC11704528, DOI: 10.1016/j.xjon.2024.06.009.Peer-Reviewed Original ResearchSodium-glucose co-transporter-2Adult cardiac surgeryPreoperative medical managementGlucagon-like peptide-1Cardiac surgeryConsensus manuscriptNon-emergent cardiac surgeryMedical managementClass ICardiac surgical patientsCardiac surgical proceduresRisk of bleedingExpert consensus documentPreoperative managementPreoperative medicationsAnticoagulant medicationSurgical patientsSurgical proceduresSurgeryAnti-plateletPeptide-1Perioperative careConsensus documentCardiac SocietyManagement of patients' medicationFor Patients Undergoing an Induction of Labor, Does Increased Body Mass Index Necessitate Higher Doses of Misoprostol? [ID 2683640]
Mason-Otey A, Lundsberg L, Culhane J, Merriam A. For Patients Undergoing an Induction of Labor, Does Increased Body Mass Index Necessitate Higher Doses of Misoprostol? [ID 2683640]. Obstetrics And Gynecology 2024, 143: 46s-46s. DOI: 10.1097/01.aog.0001013576.14925.24.Peer-Reviewed Original ResearchInduction of laborBody mass indexBody mass index categoriesDose of misoprostolMisoprostol doseClass IIIMass indexProlonged induction of laborClass IIAssociated with increased BMIClass IIncreased BMIPre-gestational diabetesClass II obesityClass I obesityRetrospective cohort analysisMisoprostol administrationObese patientsII obesityMisoprostolInvestigate safetyHigh dosesPrimary outcomeCohort analysisPatientsEnhanced Recovery After Surgery Cardiac Society turnkey order set for surgical-site infection prevention: Proceedings from the American Association for Thoracic Surgery ERAS Conclave 2023
Crisafi C, Grant M, Rea A, Morton-Bailey V, Gregory A, Arora R, Chatterjee S, Lother S, Cangut B, Engelman D, Group E, Salenger R, Lobdell K, McConnell G, Crotwell S, Reddy S, Lazar H. Enhanced Recovery After Surgery Cardiac Society turnkey order set for surgical-site infection prevention: Proceedings from the American Association for Thoracic Surgery ERAS Conclave 2023. Journal Of Thoracic And Cardiovascular Surgery 2024, 168: 1500-1509. PMID: 38574802, DOI: 10.1016/j.jtcvs.2024.03.027.Peer-Reviewed Original ResearchSurgical site infectionCardiac surgeryManagement of surgical site infectionsHigher risk of surgical site infectionImplementation of evidence-based best practicesCardiac surgery increases morbidityRisk of surgical site infectionClass IConsume healthcare resourcesCardiac surgical populationSurgical site infection reductionEvidence-based best practicesProphylactic intravenous antibioticsManaging surgical site infectionsMultidisciplinary care pathwaySurgical site infection preventionPatients' quality of lifeExpert consensus documentQuality of lifeNasal carriageIntravenous antibioticsBlood glucose levelsPatient engagementSSI riskPreoperative identificationEnhanced Recovery After Surgery Cardiac Society turnkey order set for prevention and management of postoperative atrial fibrillation after cardiac surgery: Proceedings from the American Association for Thoracic Surgery ERAS Conclave 2023
Chatterjee S, Cangut B, Rea A, Salenger R, Arora R, Grant M, Morton-Bailey V, Hirji S, Engelman D, Group E, Gregory A, Lobdell K, Hui D, Puskas J, Gaudino M, Crisafi C, Reddy V. Enhanced Recovery After Surgery Cardiac Society turnkey order set for prevention and management of postoperative atrial fibrillation after cardiac surgery: Proceedings from the American Association for Thoracic Surgery ERAS Conclave 2023. JTCVS Open 2024, 18: 118-122. PMID: 38690434, PMCID: PMC11056439, DOI: 10.1016/j.xjon.2024.02.008.Peer-Reviewed Original ResearchPostoperative atrial fibrillationManagement of postoperative atrial fibrillationCardiac surgeryAtrial fibrillationDevelopment of postoperative atrial fibrillationOccurrence of postoperative atrial fibrillationAssociated with increased adverse eventsAdministration of beta-blockersClass IChronic atrial fibrillationPatient-specific risk profilesInitiate appropriate treatmentIndividual risk stratificationExpert consensus documentMultidisciplinary care pathwayElectrolyte normalizationPosterior pericardiotomyRhythm controlAdoption of evidence-based practicesBeta-blockersSurgical interventionRisk stratificationAdverse eventsAnticoagulation managementConsensus manuscriptPre‐pregnancy BMI, rate of gestational weight gain, and preterm birth among US Pacific Islander individuals
Wu B, Shabanova V, Taylor S, Hawley N. Pre‐pregnancy BMI, rate of gestational weight gain, and preterm birth among US Pacific Islander individuals. Obesity 2024, 32: 798-809. PMID: 38304993, PMCID: PMC10965383, DOI: 10.1002/oby.23979.Peer-Reviewed Original ResearchRate of gestational weight gainGestational weight gainPacific Islander individualsPre-pregnancy BMIIncreased risk of PTBRisk of preterm birthPreterm birthPre-pregnancyIslander individualsObesity classNational Center for Health StatisticsCenter for Health StatisticsIncreased riskObesity class ICox proportional hazards modelsPacific Islander mothersHealthy weightWeight gainProportional hazards modelHealth StatisticsSingleton infantsCongenital anomaliesBMIClass IHazards model
2023
ERAS Cardiac Society turnkey order set for patient blood management: Proceedings from the AATS ERAS Conclave 2023
Salenger R, Hirji S, Rea A, Cangut B, Morton-Bailey V, Gregory A, Arora R, Grant M, Raphael J, Engelman D, Group E, Chatterjee S, Lobdell K, Crisafi C, McConnell G, Crotwell S, Reddy S. ERAS Cardiac Society turnkey order set for patient blood management: Proceedings from the AATS ERAS Conclave 2023. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 890-897.e4. PMID: 37866774, DOI: 10.1016/j.jtcvs.2023.10.034.Peer-Reviewed Original ResearchConceptsPatient blood managementPreoperative anemiaHemoglobin thresholdTransfusion of packed red blood cellsPillars of patient blood managementBlood managementClass IPacked red blood cellsImplementation of patient blood managementDiscontinued dual antiplatelet therapyTreating preoperative anemiaCardiac surgery patientsDual antiplatelet therapyTransfusion algorithmCardiac surgeryBlood lossAntifibrinolytic agentsCell saverIron replacementAntiplatelet therapySurgery patientsRed blood cellsConsensus manuscriptPublished guidelinesRoutine useIntegrated Immunopeptidomics and Proteomics Study of SARS-CoV-2–Infected Calu-3 Cells Reveals Dynamic Changes in Allele-specific HLA Abundance and Antigen Presentation
Chen R, Fulton K, Tran A, Duque D, Kovalchik K, Caron E, Twine S, Li J. Integrated Immunopeptidomics and Proteomics Study of SARS-CoV-2–Infected Calu-3 Cells Reveals Dynamic Changes in Allele-specific HLA Abundance and Antigen Presentation. Molecular & Cellular Proteomics 2023, 22: 100645. PMID: 37709257, PMCID: PMC10580047, DOI: 10.1016/j.mcpro.2023.100645.Peer-Reviewed Original ResearchSARS-CoV-2 infectionHuman leukocyte antigenAdaptive immune systemHLA allelesAntigen presentationAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionImmune systemSyndrome coronavirus 2 infectionCoronavirus disease 2019 (COVID-19) casesHost proteome changesCoronavirus 2 infectionCertain HLA allelesToll-like receptorsDifferent HLA allelesCoronavirus disease 2019Calu-3 cellsHost cellsLeukocyte antigenViral antigensDisease 2019Viral infectionDevelopment of therapeuticsInfectionClass IDesign of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes
Zahid H, Costello J, Li Y, Kimbrough J, Actis M, Rankovic Z, Yan Q, Pomerantz W. Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes. ACS Chemical Biology 2023, 18: 1278-1293. PMID: 37260298, PMCID: PMC10698694, DOI: 10.1021/acschembio.2c00902.Peer-Reviewed Original ResearchConceptsChromatin Remodeling ComplexNon-BET bromodomainsRemodeling complexProtein degradationHeterobifunctional moleculesBET familyProtein targetsPyrimidine base analogsNumber of degradersDegradersOncogenic roleTernary complexExit vectorsWestern blottingProteinFirst exampleClass IChallenging targetComplexesCECR2ChromatinBromodomainsBPTFFamilyNanoBRETCharacterization of US Food and Drug Administration Class I Recalls from 2018 to 2022 for Moderate- and High-Risk Medical Devices: A Cross-Sectional Study
Mooghali M, Ross J, Kadakia K, Dhruva S. Characterization of US Food and Drug Administration Class I Recalls from 2018 to 2022 for Moderate- and High-Risk Medical Devices: A Cross-Sectional Study. Medical Devices Evidence And Research 2023, 16: 111-122. PMID: 37229515, PMCID: PMC10204764, DOI: 10.2147/mder.s412802.Peer-Reviewed Original ResearchCross-sectional studyClass I medical deviceClass IHigh-risk medical devicesSerious adverse eventsSafety concernsAdverse eventsMedian numberUS FoodRecalled deviceTherapeutic useDevice recallsHigh-risk devicesDevice useSerious safety concernsMedical device recallsMultiple recallsLife-sustaining devicesDevice assessment
2022
Impact of Pre-Existing Ischemic Heart Disease on Severe Maternal Morbidity and Mortality During Delivery Hospitalizations
Denoble A, Goldstein S, Wein L, Grotegut C, Federspiel J. Impact of Pre-Existing Ischemic Heart Disease on Severe Maternal Morbidity and Mortality During Delivery Hospitalizations. JACC Advances 2022, 1: 100157. PMID: 36684662, PMCID: PMC9851052, DOI: 10.1016/j.jacadv.2022.100157.Peer-Reviewed Original ResearchSevere maternal morbidityIschemic heart diseaseDelivery hospitalizationsComplex survey methodsCardiac diseaseCardiac diagnosisMaternal morbidityHeart diseasePre-existing ischaemic heart diseasePre-existing ischemic heart diseaseNontransfusion severe maternal morbidityWorld Health Organization classificationClass IAdverse pregnancy outcomesNationwide Readmissions DatabaseRelative risk regressionWorld Health Organization class IPregnancy outcomesPrimary outcomeRetrospective studyAdverse outcomesUnadjusted analysesOrganization classificationRisk regressionWorse outcomesPlacental macrophage responses to viral and bacterial ligands and the influence of fetal sex
Pantazi P, Kaforou M, Tang Z, Abrahams V, McArdle A, Guller S, Holder B. Placental macrophage responses to viral and bacterial ligands and the influence of fetal sex. IScience 2022, 25: 105653. PMID: 36505933, PMCID: PMC9732417, DOI: 10.1016/j.isci.2022.105653.Peer-Reviewed Original ResearchPathogen-associated molecular patternsViral pathogen-associated molecular patternsHofbauer cellsFetal sexMajor histocompatibility complex class IAdverse pregnancy outcomesHistocompatibility complex class IToll-like receptorsComplex class ISex-dependent responseInfectious triggerPregnancy outcomesPlacental macrophagesVertical pathogen transmissionViral infectionLipid metabolismMacrophage responseBacterial ligandsProtein expression changesClass IMolecular patternsPlacentaMacrophagesCytoskeleton organizationQuantitative proteomicsImpact of Obesity on Clinical and Financial Outcomes of Minimally Invasive Hysterectomy for Benign Conditions
Le Neveu M, AlAshqar A, Kohn J, Tambovtseva A, Wang K, Borahay M. Impact of Obesity on Clinical and Financial Outcomes of Minimally Invasive Hysterectomy for Benign Conditions. Journal Of Obstetrics And Gynaecology Canada 2022, 44: 953-959. PMID: 35598864, PMCID: PMC9481667, DOI: 10.1016/j.jogc.2022.04.018.Peer-Reviewed Original ResearchConceptsLength of stayClass III obesityAdverse perioperative eventsEffect of obesityInvasive hysterectomyPerioperative eventsClass IRetrospective cohort studyImpact of obesityOperating room timeCohort studyMean BMIBlood lossBenign hysterectomyClinical outcomesHysterectomy methodsHospital chargesRobotic hysterectomyObesityHysterectomyRoom timePatientsBenign conditionsClass IIIClass IIChapter 7 The avian major histocompatibility complex
Kaufman J. Chapter 7 The avian major histocompatibility complex. 2022, 135-161. DOI: 10.1016/b978-0-12-818708-1.00033-6.Peer-Reviewed Original ResearchRenewing the Call for Reforms to Medical Device Safety—The Case of Penumbra
Kadakia KT, Beckman AL, Ross JS, Krumholz HM. Renewing the Call for Reforms to Medical Device Safety—The Case of Penumbra. JAMA Internal Medicine 2022, 182: 59-65. PMID: 34842892, DOI: 10.1001/jamainternmed.2021.6626.Commentaries, Editorials and LettersConceptsReperfusion catheterClinical evidenceClass IPenumbra reperfusion catheterSingle-arm trialUser Facility Device Experience (MAUDE) databaseAdverse event reportsPostmarket surveillanceHealth policy makersMedical device reportsPenumbra deviceClinical evaluationPatient deathDevice safetyMedicine recommendationsAnimal dataCatheterFDA databaseFDA medical device regulationsClinical literatureSmall sample sizeDevice reportsEvent reportsPublic healthExperience database
2020
Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy
Alashi A, Smedira NG, Hodges K, Popovic ZB, Thamilarasan M, Wierup P, Lever HM, Desai MY. Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy. Journal Of The American Heart Association 2020, 10: e016210. PMID: 33342243, PMCID: PMC7955478, DOI: 10.1161/jaha.120.016210.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresCardiomyopathy, HypertrophicDissectionEarly Medical InterventionEchocardiography, StressExercise TestFemaleHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePatient SelectionPractice Guidelines as TopicSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsVentricular outflow tract gradientObstructive coronary artery diseaseBetter long-term survivalSurgical myectomyOutflow tract gradientObstructive hypertrophic cardiomyopathyCoronary artery diseaseLong-term survivalClass ITract gradientEarly surgeryArtery diseaseHypertrophic cardiomyopathyLeft ventricular outflow tract gradientAppropriate internal defibrillator dischargePrimary composite end pointBasal septal thicknessClass I indicationsPrimary composite eventsHypertrophic obstructive cardiomyopathyComposite end pointLong-term outcomesComposite eventsEarly referralObstructive cardiomyopathyAssociation of Body Mass Index and Age With Morbidity and Mortality in Patients Hospitalized With COVID-19
Hendren NS, de Lemos JA, Ayers C, Das SR, Rao A, Carter S, Rosenblatt A, Walchok J, Omar W, Khera R, Hegde AA, Drazner MH, Neeland IJ, Grodin JL. Association of Body Mass Index and Age With Morbidity and Mortality in Patients Hospitalized With COVID-19. Circulation 2020, 143: 135-144. PMID: 33200947, DOI: 10.1161/circulationaha.120.051936.Peer-Reviewed Original ResearchConceptsBody mass indexClass III obesityHospital deathMechanical ventilationHigh riskVenous thromboembolismObese patientsMass indexObese individualsAmerican Heart Association COVID-19 Cardiovascular Disease RegistryAssociation of BMIMajor adverse cardiac eventsHigher body mass indexCOVID-19Significant body mass indexClass ICardiovascular Disease RegistryGeneralizable patient populationsAdverse cardiac eventsPrimary end pointCOVID-19 prevention strategiesCOVID-19 outcomesCoronavirus disease 2019Public health messagingAdults 51Robustness of the Comparative Observational Evidence Supporting Class I and II Cardiac Surgery Procedures
Gaudino M, Hameed I, Robinson NB, Naik A, Weidenmann V, Ruan Y, Tam D, Girardi LN, Fremes S. Robustness of the Comparative Observational Evidence Supporting Class I and II Cardiac Surgery Procedures. Journal Of The American Heart Association 2020, 9: e016964. PMID: 32815427, PMCID: PMC7660761, DOI: 10.1161/jaha.120.016964.Peer-Reviewed Original ResearchConceptsBilateral internal thoracic arteryValve-sparing root replacementSingle internal thoracic arteryInternal thoracic arteryThoracic arteryBentall procedureRoot replacementMV repairObservational studyClass IEffect estimatesCardiac surgery proceduresImproved clinical outcomesMitral valve repairUnmeasured confoundingEffect sizeObserved effect estimatesMV replacementSurgery guidelinesClinical outcomesValve repairRisk ratioArterySurgery proceduresObserved associations
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