2022
The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy.
Micevic G, Bosenberg M, Yan Q. The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy. Clinical Cancer Research 2022, 29: 1173-1182. PMID: 36449280, PMCID: PMC10073242, DOI: 10.1158/1078-0432.ccr-22-0784.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImmune checkpoint inhibitorsImmune checkpoint therapyT cell exhaustionCheckpoint therapyAntitumor immune responseT cell populationsCell-intrinsic immunityTypes of cancerViral mimicry responseLow response rateCheckpoint inhibitorsCurrent immunotherapiesPancreatic cancerSustained responsePreclinical modelsTreatment outcomesImmune responseEndogenous antigensResponse rateTumor typesMultiple epigenetic regulatorsCritical mediatorLow immunogenicityTherapyCancer
2021
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis
Chen J, Jing H, Martin-Nalda A, Bastard P, Rivière J, Liu Z, Colobran R, Lee D, Tung W, Manry J, Hasek M, Boucherit S, Lorenzo L, Rozenberg F, Aubart M, Abel L, Su H, Palacin P, Casanova J, Zhang S. Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis. Journal Of Experimental Medicine 2021, 218: e20211349. PMID: 34726731, PMCID: PMC8570298, DOI: 10.1084/jem.20211349.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedChild, PreschoolEncephalitis, ViralEnterovirusEnterovirus InfectionsFemaleFibroblastsHumansInfantInterferon alpha-2Interferon-betaInterferon-Induced Helicase, IFIH1Loss of Function MutationMaleMetabolism, Inborn ErrorsPoly I-CRhombencephalonToll-Like Receptor 3Virus ReplicationConceptsIFN-α2bVirus-induced type I IFN productionType I IFN productionLife-threatening infectionsI IFN productionCentral nervous systemPost-infection treatmentCell-intrinsic immunityLater time pointsEnterovirus infectionHuman TLR3IFN productionNervous systemTLR3Unrelated childrenViral phenotypeInborn errorsViral susceptibilityTime pointsIFIH1 variantsInfectionRhombencephalitisCell linesEV30MDA5
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