2023
Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes
Zahid H, Costello J, Li Y, Kimbrough J, Actis M, Rankovic Z, Yan Q, Pomerantz W. Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes. ACS Chemical Biology 2023, 18: 1278-1293. PMID: 37260298, PMCID: PMC10698694, DOI: 10.1021/acschembio.2c00902.Peer-Reviewed Original ResearchConceptsChromatin Remodeling ComplexNon-BET bromodomainsRemodeling complexProtein degradationHeterobifunctional moleculesBET familyProtein targetsPyrimidine base analogsNumber of degradersDegradersOncogenic roleTernary complexExit vectorsWestern blottingProteinFirst exampleClass IChallenging targetComplexesCECR2ChromatinBromodomainsBPTFFamilyNanoBRET
2022
Bromodomains regulate dynamic targeting of the PBAF chromatin-remodeling complex to chromatin hubs
Kenworthy C, Haque N, Liou S, Chandris P, Wong V, Dziuba P, Lavis L, Liu W, Singer R, Coleman R. Bromodomains regulate dynamic targeting of the PBAF chromatin-remodeling complex to chromatin hubs. Biophysical Journal 2022, 121: 1738-1752. PMID: 35364106, PMCID: PMC9117891, DOI: 10.1016/j.bpj.2022.03.027.Peer-Reviewed Original ResearchConceptsChromatin remodelersChromatin statePBAF chromatin-remodeling complexSingle-molecule fluorescence microscopy studiesDifferent chromatin statesChromatin-remodeling complexRNA polymerase IIChromatin hubTranscriptional burstingPolymerase IIAcetylated nucleosomesFluorescence microscopy studiesPBAFBromodomainsNucleosomesChromatin stabilityLive cellsStable engagementRemodelersDynamic targetingDirect roleChromatinImaging revealsTargetingGenome
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