2022
Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
Cai WL, Chen JF, Chen H, Wingrove E, Kurley SJ, Chan LH, Zhang M, Arnal-Estape A, Zhao M, Balabaki A, Li W, Yu X, Krop ED, Dou Y, Liu Y, Jin J, Westbrook TF, Nguyen DX, Yan Q. Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation. ELife 2022, 11: e78163. PMID: 36043466, PMCID: PMC9584608, DOI: 10.7554/elife.78163.Peer-Reviewed Original ResearchConceptsBreast cancer cellsMetastatic breast cancerBreast cancerRibosomal gene expressionCancer cellsKnockdown of WDR5Vivo genetic screenReversible epigenetic mechanismsGenetic screenTranslation regulationTriple-negative breast cancerEpigenetic regulatorsEpigenetic mechanismsBreast cancer growthCancer-related deathTranslation efficiencyWDR5Novel therapeutic strategiesTranslation rateGene expressionCell growthAdvanced diseaseEffective therapyMetastatic capabilityPotent suppression
2017
Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression
Aggarwal A, Feldman D, Feldman B. Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression. The Journal Of Steroid Biochemistry And Molecular Biology 2017, 177: 155-158. PMID: 28710021, PMCID: PMC5764828, DOI: 10.1016/j.jsbmb.2017.07.003.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyBreast cancerD deficiencyPoor outcomeInhibit breast cancer growthAssociated with worse prognosisLow vitamin D levelsAggressive molecular phenotypePrimary tumor growthSerum 25(OH)D concentrationsDevelopment of metastasesVitamin D levelsBreast cancer growthBreast cancer patientsHuman breast cancerVitamin D signalingVitamin D receptorBreast cancer cellsVitamin D actionPrimary tumorWorse prognosisD levelsTumor progressionTumor growthD receptor
2016
Vitamin D mitigates the adverse effects of obesity on breast cancer in mice
Swami S, Krishnan A, Williams J, Aggarwal A, Albertelli M, Horst R, Feldman B, Feldman D. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocrine Related Cancer 2016, 23: 251-264. PMID: 26817629, PMCID: PMC4889430, DOI: 10.1530/erc-15-0557.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdipose TissueAMP-Activated Protein KinasesAnimalsAromataseCalciumCyclooxygenase 2Diet, High-FatDietary SupplementsDinoprostoneEstradiolEstrogensEstroneFemaleHumansLeptinMammary Glands, AnimalMammary Neoplasms, ExperimentalMCF-7 CellsMiceMice, Inbred C57BLObesityOvariectomyRNA, MessengerTumor BurdenVitamin DConceptsAdverse effects of obesityDietary vitamin DEffect of obesityDiet-induced obesityBreast cancer growthVitamin DBreast cancerEstrogen synthesisAdverse effectsObese miceExpression of leptin receptorInsulin resistanceMMTV-Wnt1 transgenic miceIncreased adiponectin receptorsEstrogen receptor-positiveOvariectomized C57BL/6 micePostmenopausal breast cancerVitamin D deficiencyMultiple interrelated pathwaysMammary fat padLocal estrogen synthesisBreast tumor cellsSurrounding adipose tissuePostmenopausal settingVitamin D compounds
2013
Human Vγ2Vδ2 T cells limit breast cancer growth by modulating cell survival‐, apoptosis‐related molecules and microenvironment in tumors
Aggarwal R, Lu J, Kanji S, Das M, Joseph M, Lustberg M, Ray A, Pompili V, Shapiro C, Das H. Human Vγ2Vδ2 T cells limit breast cancer growth by modulating cell survival‐, apoptosis‐related molecules and microenvironment in tumors. International Journal Of Cancer 2013, 133: 2133-2144. PMID: 23595559, PMCID: PMC3939063, DOI: 10.1002/ijc.28217.Peer-Reviewed Original ResearchConceptsΓδ T cellsVγ2Vδ2 T cellsT cellsApoptosis-related moleculesAntineoplastic effectsVγ2Vδ2 T-cell subsetTumor cellsInfiltration of tumorsMICA/BT cell subsetsHuman Vγ2Vδ2 T cellsBreast cancer growthExpression levelsInnate immune systemMolecular signalingBreast tumor cellsMDA-MB-231Resistant cell linesCell subsetsSurface expression levelsCancer growthImmune systemTumor growthMalignant transformationTumor progression
2011
Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer
Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, Imai Y, Rimm DL, Liu XS, Brown M. Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer. Cancer Cell 2011, 20: 119-131. PMID: 21741601, PMCID: PMC3180861, DOI: 10.1016/j.ccr.2011.05.026.Peer-Reviewed Original ResearchMeSH KeywordsAndrogensAnilidesAnimalsbeta CateninBreast NeoplasmsCell Line, TumorCell ProliferationDihydrotestosteroneFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 3-alphaHumansMiceNitrilesReceptor, ErbB-2Receptors, AndrogenReceptors, EstrogenSignal TransductionTosyl CompoundsTranscriptional ActivationUp-RegulationWnt ProteinsXenograft Model Antitumor AssaysConceptsAndrogen receptorBreast cancerEstrogen receptorER-/HER2Estrogen receptor-negative breast cancerReceptor-negative breast cancerBreast cancer growthER- breast tumorsPotential therapeutic approachTumor cell growthAndrogen-regulated gene expressionEndocrine therapyER statusTherapeutic approachesAR cistromeBreast tumorsCancer growthDirect transcriptional inductionCancerHER2Ligand-dependent activationReceptorsSpecific targetingTumorsCell growth
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