Bench to Bedside: Pharmacogenomics, Adverse Drug Interactions, and the Cytochrome P450 System
Sikka R, Magauran B, Ulrich A, Shannon M. Bench to Bedside: Pharmacogenomics, Adverse Drug Interactions, and the Cytochrome P450 System. Academic Emergency Medicine 2005, 12: 1227-1235. PMID: 16282513, DOI: 10.1197/j.aem.2005.06.027.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiotransformationCytochrome P-450 Enzyme SystemDrug InteractionsFemaleGenotypeHumansMaleMiddle AgedPharmacogeneticsPhenotypePolymorphism, GeneticConceptsAdverse drug interactionsDrug interactionsCytochrome P450 familyCytochrome P450 systemPreventable medical errorsClinical effectsTherapeutic implicationsHealth careP450 systemPharmaceutical agentsMedical errorsCytochrome P450P450 familyPharmacogenomicsCYP2C19PopulationBasic biochemistryCYP2E1CYP2C9CYP3A4CYP2D6PhysiciansCYP1A2BedsideCare