Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)
Diseases of the Cardiovascular System
What is the purpose of this trial?
Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.
- Ages35 years - 100 years
- Trial withMayo Clinic Jacksonville Florida
- Start Date07/20/2015
- End Date12/31/2024
- Last Updated12/22/2022
- Study HIC#1501015248