Publications

2026

4-1BB immunotherapy reveals the Eomes dependency of exhausted CD4+ T cell lineage maintenance and function in anti-tumor immunity
Agesta A, Ferrand C, Le Dorze AL, Peillex C, Carrié N, Palak A, Joulia E, Esteban L, Bernal T, Barascud R, Peroceschi R, Pichler A, Chaubet A, Zham M, Saoudi A, El-Costa H, Adoue V, Lu BY, Lucca LE, Martinet L, Dejean AS. 2026. Immunity, in press.
Peer-Reviewed Original Research In Press

2025

Uncovering differences in local and systemic immunity in human primary and metastatic brain tumors
Lu B, Yahsi B, Lucca L, DiStasio M, Liu Y, Gu J, Bhata, S, Kasbe M, Coburn J, Arnal-Estape A, Zhao H, Moliterno J, Chiang V, Omuro A, Lee M, Hafler D. Neuro-Oncology, 27;Supp_5, Nov 2025, v222–v223, https://doi.org/10.1093/neuonc/noaf201.0883
Peer-Reviewed Original Research
Phenotypic and functional characterization of tumor-reactive T cells in malignant pleural effusions
Gaiger NS, Coburn J, Lee MN, Zhang L, Chen H, Woodard GA, Kluger HM, Schoenfeld DA, Lu BY. bioRxiv 2025.12.05.692662; doi: https://doi.org/10.64898/2025.12.05.692662
Peer-Reviewed Original Research
NSCLC Brain Metastases Exhibit Reduced HLA-I Antigen Presentation Machinery and Immune Evasion Independent of IFNγ Signaling Defects
Vilariño N, López de Rodas M, Villalba M, Rajendran BK, Hijazo S, Costantini A, Ranjan K, Ramos J, Lu BY, Kravitz C, Nadal E, Goldberg SB, Nguyen DX, Schalper KA. (Molecular Cancer - under review)
Peer-Reviewed Original Research
Tumor reactive T cells may be harvested from malignant pleural effusions
Gaiger NS, Coburn J, Zhang L, Nolan N, Woodard G, Kluger HM, et al. 381 Tumor reactive T cells may be harvested from malignant pleural effusions. Journal for ImmunoTherapy of Cancer. 2025;13:. https://doi.org/10.1136/jitc-2025-SITC2025.0381
Peer-Reviewed Original Research
TIL-Guided Discovery of TCRs Targeting Epitopes Derived from Dark Antigens and Application to Cancer Immunotherapies
Nogueira C, Heer S, Rayon-Estrada V, Brenner J, Mehta N, Drescher T, Dong J, Shambharkar P, Cereghetti-Terraneo N, Loi M, Renoux F, Malia T, Wille M, Carey S, Swain J, Lu B, Kluger H, Hafler D, Pregibon D, Hurwitz A, Kisielow J, Obermair FJ, Coyle A. 2025;13:. https://jitc.bmj.com/content/13/Suppl_2/A1125
Peer-Reviewed Original Research
997 TIL-guided discovery of TCRs targeting epitopes derived from dark antigens and application to cancer immunotherapies
Nogueira C, Heer S, Rayon-Estrada V, Brenner J, Mehta N, Drescher T, Dong J, Shambharkar P, Cereghetti-Terraneo N, Loi M, Renoux F, Malia T, Wille M, Carey S, Swain J, Lu B, Kluger H, Hafler D, Pregibon D, Hurwitz A, Kisielow J, Obermair F, Coyle A. 997 TIL-guided discovery of TCRs targeting epitopes derived from dark antigens and application to cancer immunotherapies. 2025, a1125-a1125. DOI: 10.1136/jitc-2025-sitc2025.0997.
Peer-Reviewed Original Research
Concepts
TRLS-11 UNCOVERING ANTIGEN-SPECIFICITY OF INTRATUMORAL CD8+ T CELLS IN NON-SMALL CELL LUNG CANCER BRAIN METASTASES
Lu B, Yahsi B, Gu J, Coburn J, Kasbe M, Arnal-Estape A, Sohn K, Whitehead K, Mosharraf M, Nguyen D, Zhao H, Lucca L, Schalper K, Chiang V, Hafler D, Lee M. TRLS-11 UNCOVERING ANTIGEN-SPECIFICITY OF INTRATUMORAL CD8+ T CELLS IN NON-SMALL CELL LUNG CANCER BRAIN METASTASES. Neuro-Oncology Advances 2025, 7: ii36-ii36. PMCID: PMC12342607, DOI: 10.1093/noajnl/vdaf123.134.
Peer-Reviewed Original Research
Concepts
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour
Yoshida T, Nguyen M, Zhang L, Lu B, Zhu B, Murray K, Mineur Y, Zhang C, Xu D, Lin E, Luchsinger J, Bhatta S, Waizman D, Coden M, Ma Y, Israni-Winger K, Russo A, Wang H, Song W, Al Souz J, Zhao H, Craft J, Picciotto M, Grutzendler J, Distasio M, Palm N, Hafler D, Wang A. The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour. Nature 2025, 643: 499-508. PMID: 40437096, PMCID: PMC12768464, DOI: 10.1038/s41586-025-09050-7.
Peer-Reviewed Original Research
Concepts

2024

2023

2022

TCR-sequencing in cancer and autoimmunity: barcodes and beyond
Pauken KE, Lagattuta KA, Lu BY, Lucca LE, Daud AI, Hafler DA, Kluger HM, Raychaudhuri S, Sharpe AH. TCR-sequencing in cancer and autoimmunity: barcodes and beyond. Trends In Immunology 2022, 43: 180-194. PMID: 35090787, PMCID: PMC8882139, DOI: 10.1016/j.it.2022.01.002.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords and Concepts

2021

2020

PD-1/PD-L1 Blockers in NSCLC Brain Metastases: Challenging Paradigms and Clinical Practice
Eguren-Santamaria I, Sanmamed MF, Goldberg SB, Kluger HM, Idoate MA, Lu B, Corral J, Schalper KA, Herbst RS, Gil-Bazo I. PD-1/PD-L1 Blockers in NSCLC Brain Metastases: Challenging Paradigms and Clinical Practice. Clinical Cancer Research 2020, 26: 4186-4197. PMID: 32354698, DOI: 10.1158/1078-0432.ccr-20-0798.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2019

Functional profile and clinical significance of major tumor infiltrating lymphocyte subsets in lung cancer-associated brain metastases.
Lu B, Gupta R, Stewart T, Kluger H, Jilaveanu L, Schalper K, Goldberg S. Functional profile and clinical significance of major tumor infiltrating lymphocyte subsets in lung cancer-associated brain metastases. Journal Of Clinical Oncology 2019, 37: 2066-2066. DOI: 10.1200/jco.2019.37.15_suppl.2066.
Peer-Reviewed Original Research
Concepts

See All Publications

Publications

2026

4-1BB immunotherapy reveals the Eomes dependency of exhausted CD4+ T cell lineage maintenance and function in anti-tumor immunity

2025

Uncovering differences in local and systemic immunity in human primary and metastatic brain tumors

Phenotypic and functional characterization of tumor-reactive T cells in malignant pleural effusions

NSCLC Brain Metastases Exhibit Reduced HLA-I Antigen Presentation Machinery and Immune Evasion Independent of IFNγ Signaling Defects

Tumor reactive T cells may be harvested from malignant pleural effusions

TIL-Guided Discovery of TCRs Targeting Epitopes Derived from Dark Antigens and Application to Cancer Immunotherapies

997 TIL-guided discovery of TCRs targeting epitopes derived from dark antigens and application to cancer immunotherapies

TRLS-11 UNCOVERING ANTIGEN-SPECIFICITY OF INTRATUMORAL CD8+ T CELLS IN NON-SMALL CELL LUNG CANCER BRAIN METASTASES

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour

2024

Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma

Decoy-resistant IL-18 reshapes the tumor microenvironment and enhances rejection by anti-CTLA-4 in renal cell carcinoma

HLA class-I antigen presentation machinery (APM) alterations mediate immune evasion in lung cancer brain metastases.

Providing 0.1 Full-Time Equivalent (FTE) Support to Fellowship Core Faculty Improves Faculty Involvement in Fellowship Education and Recruitment

2023

Beyond the Lab and Into the Hospital: An Outlook on the Clinical Utility of Spatial Omics Technologies

Chemoimmunotherapy for Untreated Lung Cancer Brain Metastases: Systemic Before Local Therapy?

BSBM-18 SINGLE-CELL PROFILING TUMOR-INFILTRATING IMMUNE CELLS REVEALS CXCL13+ FOLLICULAR HELPER-LIKE CD4+ T CELLS IN HUMAN BRAIN TUMORS

BSBM-16 HLA CLASS-I ANTIGEN PRESENTATION MACHINERY AND IFN-γ PATHWAY ALTERATIONS IN LUNG CANCER BRAIN METASTASES

The Association Between Civil Legal Needs After Incarceration, Psychosocial Stress, and Cardiovascular Disease Risk Factors

2022

TCR-sequencing in cancer and autoimmunity: barcodes and beyond

2021

Spatially resolved analysis of the T cell immune contexture in lung cancer-associated brain metastases

Intracranial Complications From Immune Checkpoint Therapy in a Patient With NSCLC and Multiple Sclerosis: Case Report

Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells

Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells

2020

PD-1/PD-L1 Blockers in NSCLC Brain Metastases: Challenging Paradigms and Clinical Practice

2019

Functional profile and clinical significance of major tumor infiltrating lymphocyte subsets in lung cancer-associated brain metastases.