Skip to Main Content

Group Members

  • John Slade Ely Professor of Medicine (Pulmonary) and Professor of Pathology; Director, Yale Interstitial Lung Disease (ILD) Center of Excellence, Pulmonary, Critical Care & Sleep Medicine; Associate Dean, Medical Student Research

    My training as a physician scientist motivates me to seek new treatments for chronic lung diseases.  I have spent more than 15 years pursuing this goal by studying the relationship mechanisms of fibrotic remodeling in the adult mammalian lung. My laboratory has had a sustained impact on the field of pulmonary fibrosis and is credited with several seminal discoveries that have been verified and reproduced in laboratories around the world. My early work helped ignite interest in the mechanism(s) through which innate immunity is linked to pulmonary fibrosis. For example, my lab was the first to report that monocytes from patients with Scleroderma associated lung fibrosis adopt profibrotic properties following DAMP stimulation. We reported that the lungs of mice exposed to fibrotic stimuli, and humans with IPF, contain aberrantly activated macrophages that can be repolarized with innate immune agonists to attenuate experimentally induced lung fibrosis. We also are credited with linking intracellular DNA sensors and their ligands with numerous forms of interstitial lung disease. Most recently we reported that a previously unrecognized nerve-lung connection drives mammalian lung fibrosis.  My work has been published in journals such as Science, Science Translational Medicine, Nature Medicine, Cell, Journal of Clinical Investigation, Lancet Respiratory Medicine, and the American Journal of Respiratory and Critical Care Medicine. I have been a continuous recipient of NIH funding since 2005 in the form of K08, R01 and U01 awards, and have been honored by my peers with the Jo Rae Wright Award from the American Thoracic Society and induction into the American Society of Clinical Investigation (ASCI).    My discoveries in these domains have been informed by collaborations with Yale immunologists, neuroscientists, and bioengineers with the goal of developing new ways to improve respiratory health.
  • Associate Professor Adjunct

    Dr. Murphy is a member of the biostatistics staff of the Program on Aging. With twelve years experience in the design and manufacture of clinical instrumentation and advanced training in engineering statistics, he is interested in the application of engineering tools to research on aging. Current areas of investigation include multivariate statistics for characterization of multiple co–morbidity, robust design techniques for assessing the tradeoffs of multiple medication use, and the use of hierarchical models, propensity scores, and Bayesian techniques to enhance the analysis of non-randomized interventional designs such as the fall–related utilization of healthcare services by older persons in the state of Connecticut.
  • Professor of Internal Medicine (Pulmonary, Critical Care & Sleep Medicine)

    Dr. Pisani is a board certified physician who specializes in pulmonary and critical care medicine. As a clinician-investigator with expertise in pulmonary, critical care, sleep medicine and chronic disease epidemiology, Dr. Pisani’s research focuses on improving the care and outcomes of critically ill patients.  She has a special interest in geriatric pulmonary and critical care medicine an outcomes in older patients. She holds an MPH in chronic disease epidemiology and brings this training and her research focus to her role as mentor for fellows and junior faculty doing clinical and translational work in pulmonary, critical care and sleep medicine. In addition, she has extensive experience in conducting longitudinal clinical research studies both in the critical care setting and the outpatient setting. Her current research focuses on sleep in critically ill patients and its impact on delirium and other patient centered outcomes.