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Scott Strobel, PhD

Provost and Henry Ford II Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry; Howard Hughes Medical Institute Professor
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About

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Provost and Henry Ford II Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry; Howard Hughes Medical Institute Professor

Biography

Scott Strobel is the Henry Ford II Professor of Molecular Biophysics & Biochemistry (MB&B) and University Provost. Scott joined the Yale faculty in 1995 and served as department chair from 2006-09. From 2011-2019 he has served as Vice President for West Campus Planning & Program Development where he has orchestrated the emergence of the West Campus as a research and educational center of the University. In July 2014 he took on additional responsibility as the inaugural Deputy Provost for Teaching & Learning. In this capacity, he oversaw the creation of the Poorvu Center for Teaching and Learning, housed within the York Street wing of Sterling Memorial Library. As a professor of the Howard Hughes Medical Institute (HHMI) Professor he instituted a program to explore microbial and chemical diversity in the world’s rainforests as a means to inspire undergraduate students in the sciences. He chaired the University Science Strategy Committee which was tasked with developing a ten-year strategic plan for the sciences and engineering at Yale. In 2019 as Vice Provost for Science Initiatives, he was charged with implementing that plan. He began as Provost in 2020. He was awarded the Dylan Hixon Prize for Teaching Excellence in the Natural Sciences, the Graduate Mentoring Award in the Sciences and the Yale Science and Engineering Award for Meritorious Service. His research group explores the chemical basis of RNA function and the role of the fluoride ion channel in cellular fluoride detoxification.

Appointments

Education & Training

Postdoctoral Fellow
University of Colorado, Boulder, CO (1995)
PhD
California Institute of Technology (1992)

Research

Overview

Research in the Strobel laboratory focuses on RNA catalysis and biofuel production.

Direct Conversion of Cellulose to Biofuel by a novel fungus.

This is the newest project in the lab and a new research direction for our group closely related to the undergraduate Rainforest Expedition program supported by HHMI. This project involves an emerging biotechnology for the production of hydrocarbons from cellulose-based waste feedstock with a low-carbon footprint that is chemically equivalent to jet fuel. Gliocladium roseum (NRRL 50072) is an endophytic fungus recently isolated from Northern Patagonia that produces and excretes a broad spectrum of straight and branched medium chain-length hydrocarbons, including heptane, octane, undecane, dodecane and hexadecane, when grown in an sealed vessel. G. roseum can also generate and release these products when grown on cellulose, the world's most abundant natural organic compound. This organism has the potential to produce desirable biofuels via a fermentation process that is nearly carbon neutral. It is a basic science observation with clear implications for energy production and utilization.

The goals of this project are to characterize the biosynthetic basis of hydrocarbon production and release by G. roseum, to isolate the enzymes responsible for hydrocarbon synthesis and transport, and to use this information to optimize the yields of biofuel output. Overproduction will be achieved either by biological engineering of keys genes in the pathway, or transfer of the biosynthetic pathway to organisms used in standard fermentation processes. The hydrocarbon products and their derivatives will be subjected to chemical analysis and combustion studies. Realization of these goals will transform this basic science observation into real world applications that could transform the source and long-term availability of petroleum fuels.

We also have several ongoing projects in the area of RNA biochemistry.

Protein Synthesis.

Crystallographic studies reveal that the ribosomal peptidyl transferase center is composed exclusively of rRNA, i.e., that the ribosome is a ribozyme. We aim to determine how this biologically fundamental reaction is catalyzed. We are taking several approaches to understand this enzyme, including: (i) synthesis and characterization of transition state inhibitors; (ii) preparation of modified A-site and P-site tRNA substrates to test for substrate assisted catalysis of peptide bond formation by enzyme kinetic analysis; (iii) purification of mutant ribosomes to assess the role of rRNA functional groups; (iv) investigating the reaction transition state by kinetic isotope effect analysis and by determining the Brønsted coefficient for the ester aminolysis reaction.

Intron Splicing.

The discovery of the RNA self-splicing group I intron provided the first demonstration that not all enzymes are proteins. We recently reported the X-ray crystal structure of a catalytically active group I intron splicing intermediate. This is the first splicing complex of any kind to include a complete intron, both exons and an organized active site occupied with metal ions. The exon ligation is chemically equivalent for pre-mRNA splicing by the spliceosome. As a result, the chemical themes of splice site selection, exon alignment, and catalytic metal ion positioning, which are manifest in this splicing intermediate complex, are likely to find parallels in pre-mRNA splicing. We are now undertaking several additional structural and biochemical studies to characterize the entire RNA splicing pathway. The overriding goals of these studies are to: (i) understand the mechanism of RNA splicing, (ii) explain how RNA tertiary structure is formed and active sites created in the absence of proteins, (iii) reveal how metal ions contribute to RNA catalysis, and (iv) visualize the nature of the transition state of the phosphoryl transfer reaction promoted during exon ligation.

Medical Subject Headings (MeSH)

Biochemistry; Biofuels; Biophysics; Chemicals and Drugs; Chemistry; Endophytes; Ribosomes; Technology, Industry, Agriculture

Research at a Glance

Yale Co-Authors

Frequent collaborators of Scott Strobel's published research.

Publications

2024

2023

2017

2016

2015

2014

2013

Academic Achievements & Community Involvement

  • activity

    Ribosome Collaborations

  • honor

    Schering Plough Research Institute Award

  • honor

    Graduate Mentoring Award

  • honor

    Professor

  • honor

    Dylan Hixon Prize for Teaching Excellence in the Natural Sciences

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