Jing Cheng
Postdoctoral AssociateDownloadHi-Res Photo
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Postdoctoral Associate
Biography
My Ph.D. research focused on algorithm development and data processing in cryo-electron microscopy (cryo-EM). In the Liu lab at Yale, I am now applying cryo-EM to investigate how bacterial pathogens invade mammalian hosts. My project aims to resolve the high-resolution in-situ structure of bacterial secretion systems, specifically type III (T3SS). Results of this work will reveal how bacteria secrete proteins across the host phospholipid membranes to achieve infection.
Appointments
Molecular Biophysics and Biochemistry
Postdoctoral AssociatePrimary
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Research
Overview
Medical Subject Headings (MeSH)
Biophysics; Cryoelectron Microscopy; Electron Microscope Tomography; Protein Structural Elements
ORCID
0000-0002-3917-3756- View Lab Website
Liu Lab
Research at a Glance
Publications Timeline
A big-picture view of Jing Cheng's research output by year.
Research Interests
Research topics Jing Cheng is interested in exploring.
8Publications
230Citations
Cryoelectron Microscopy
Electron Microscope Tomography
Publications
2024
Author Correction: Determining protein structures in cellular lamella at pseudo-atomic resolution by GisSPA
Cheng J, Liu T, You X, Zhang F, Sui S, Wan X, Zhang X. Author Correction: Determining protein structures in cellular lamella at pseudo-atomic resolution by GisSPA. Nature Communications 2024, 15: 3423. PMID: 38654014, PMCID: PMC11039706, DOI: 10.1038/s41467-024-47528-6.Peer-Reviewed Original ResearchAltmetric
2023
The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis
Yang Q, Wu C, Zhu D, Li J, Cheng J, Zhang X. The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis. Structure 2023, 31: 1275-1281.e4. PMID: 37527655, DOI: 10.1016/j.str.2023.07.002.Peer-Reviewed Original ResearchCitationsAltmetricArchitecture of severe fever with thrombocytopenia syndrome virus
Sun Z, Cheng J, Bai Y, Cao L, Xie D, Deng F, Zhang X, Rao Z, Lou Z. Architecture of severe fever with thrombocytopenia syndrome virus. Protein & Cell 2023, 14: 914-918. PMID: 37038326, PMCID: PMC10691843, DOI: 10.1093/procel/pwad019.Peer-Reviewed Original ResearchCitationsAltmetricIn situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex
You X, Zhang X, Cheng J, Xiao Y, Ma J, Sun S, Zhang X, Wang H, Sui S. In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex. Nature 2023, 616: 199-206. PMID: 36922595, DOI: 10.1038/s41586-023-05831-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPhotosystem IOxygenic photosynthetic organismsSolid structural basisSitu structureLight-harvesting complexRed alga Porphyridium purpureumPhotosynthetic organismsIncomplete proteinStructural basisPhycobilisomesExcitation energy transfer pathwaysMegacomplexesPorphyridium purpureumPSIIPhotosystemsElectron tomographyLight energyAtomic resolutionStructural informationInteraction detailsAssemblyTransfer pathwayEnergy transfer pathwaysUnclear owingOrganismsDetermining protein structures in cellular lamella at pseudo-atomic resolution by GisSPA
Cheng J, Liu T, You X, Zhang F, Sui S, Wan X, Zhang X. Determining protein structures in cellular lamella at pseudo-atomic resolution by GisSPA. Nature Communications 2023, 14: 1282. PMID: 36922493, PMCID: PMC10017804, DOI: 10.1038/s41467-023-36175-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein complexesCellular lamellaTarget protein complexesCryo-electron tomographyProtein structure determinationCryo-electron microscopy imagesHigh-throughput data collectionProtein structureAtomic resolutionStructure determinationComplexesPhycobilisomesComplex structureMajor toolLamellaeHigh-resolution reconstruction
2021
Determining structures in a native environment using single-particle cryoelectron microscopy images
Cheng J, Li B, Si L, Zhang X. Determining structures in a native environment using single-particle cryoelectron microscopy images. The Innovation 2021, 2: 100166. PMID: 34632438, PMCID: PMC8488058, DOI: 10.1016/j.xinn.2021.100166.Peer-Reviewed Original ResearchCitationsAltmetricOptimizing weighting functions for cryo-electron microscopy
Cheng J, Zhang X. Optimizing weighting functions for cryo-electron microscopy. Biophysics Reports 2021, 7: 152-158. PMID: 37288147, PMCID: PMC10235905, DOI: 10.52601/bpr.2021.210001.Peer-Reviewed Original ResearchCitationsAltmetric
2019
High-quality, high-throughput cryo-electron microscopy data collection via beam tilt and astigmatism-free beam-image shift
Wu C, Huang X, Cheng J, Zhu D, Zhang X. High-quality, high-throughput cryo-electron microscopy data collection via beam tilt and astigmatism-free beam-image shift. Journal Of Structural Biology 2019, 208: 107396. PMID: 31562921, DOI: 10.1016/j.jsb.2019.09.013.Peer-Reviewed Original ResearchCitationsAltmetric
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Jun Liu Lab
Yale West Campus, 840 West Campus Drive
West Haven, CT 06516
United States