1995
Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons.
Shi W, Nathaniel P, Bunney B. Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons. Journal Of Pharmacology And Experimental Therapeutics 1995, 274: 735-40. PMID: 7636736.Peer-Reviewed Original ResearchConceptsEffects of ritanserinBasal firing rateDA autoreceptorsDA neuronsDA agonistsP-chlorophenylalanineSubstantia nigra DA neuronsSingle-unit recording techniquesChloral hydrate-anesthetized ratsFiring rateDA agonist quinpiroleDirect DA agonistsIndirect DA agonistPostsynaptic D2 receptorsExtrapyramidal side effectsD2-like receptorsSignificant therapeutic effectAgonist-induced inhibitionMidbrain dopamine neuronsMidbrain dopamine systemAgonist quinpiroleDA antagonistsMDL 100907Receptor antagonistDopamine neurons
1991
Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex?
Shi W, Bunney B. Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex? Synapse 1991, 9: 157-164. PMID: 1776128, DOI: 10.1002/syn.890090302.Peer-Reviewed Original ResearchConceptsEffects of neurotensinNeurotensin receptorsDopamine neuronsDopamine cellsCell activitySingle-unit recording techniquesFiring rateMidbrain dopamine neuron activityAction of neurotensinBasal firing rateDopamine receptor blockadeDopamine-induced inhibitionDopamine neuron activityMidbrain dopamine neuronsReceptor blockadeDepolarization inactivationExcitatory effectsNative neurotensinBrain slicesNeuron activityNeurotensinNeurotensin analoguesSame receptorRecording techniquesReceptors
1990
Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons
Shi W, Bunney B. Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons. Neuropharmacology 1990, 29: 1095-1097. PMID: 1982340, DOI: 10.1016/0028-3908(90)90119-c.Peer-Reviewed Original ResearchConceptsD2 agonistDA cellsSingle-unit recording techniquesMidbrain DA neuronsCentral DA systemsDopamine D2 agonistMidbrain dopamine neuronsSpecific D2 agonistDA neuronsIntracerebroventricular administrationDopamine neuronsSpontaneous activityDA systemInhibitory effectRecording techniquesAgonistsNeuronsBiochemical studiesCellsQuinpiroleNeurotensinRatsAdministration
1984
The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity
Freeman A, Bunney B. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity. European Journal Of Pharmacology 1984, 104: 287-293. PMID: 6094217, DOI: 10.1016/0014-2999(84)90404-7.Peer-Reviewed Original ResearchConceptsDA neuronsNeuronal activityN-allylnormetazocineMidbrain dopamine neuronal activitySingle-unit recording techniquesSubstantia nigra zona compactaFiring rateA10 DA neuronsDopamine neuronal activitySigma receptor agonistsMidbrain dopamine neuronsBaseline firing rateEffects of phencyclidineWeak inhibitory actionExcitatory effectsZona compactaHaloperidol pretreatmentDopamine neuronsReceptor agonistBiphasic effectInhibitory actionNeuronsRecording techniquesPhencyclidineDrugs
1983
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
Chiodo L, Bunney B. Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. Journal Of Neuroscience 1983, 3: 1607-1619. PMID: 6135762, PMCID: PMC6564520, DOI: 10.1523/jneurosci.03-08-01607.1983.Peer-Reviewed Original ResearchConceptsExtrapyramidal side effectsDepolarization inactivationA10 neuronsAntipsychotic drugsDA neuronsDopaminergic neuronsSide effectsExtracellular single-unit recording techniquesExcitatory amino acid glutamateInhibitory neurotransmitter gamma-aminobutyric acidSingle-unit recording techniquesNeurotransmitter gamma-aminobutyric acidActive DA cellsA10 dopaminergic neuronsMidbrain dopaminergic neuronsGamma-aminobutyric acidActivity of A9Amino acid glutamateChronic administrationMicroiontophoretic applicationNeuroleptic treatmentNeuroleptic administrationAtypical neurolepticsTricyclic antidepressantsDA cells
1981
Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons
Skirboll L, Grace A, Hommer D, Rehfeld J, Goldstein M, Hökfelt T, Bunney B. Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons. Neuroscience 1981, 6: 2111-2124. PMID: 6120481, DOI: 10.1016/0306-4522(81)90002-6.Peer-Reviewed Original ResearchConceptsCholecystokinin-like peptidesVentral tegmental areaDopaminergic neuronsFiring rateSubstantia nigraTegmental areaDopaminergic cellsExtracellular single-unit recording techniquesMidbrain dopamine-containing neuronsSingle-unit recording techniquesDopamine-containing neuronsBrain dopaminergic systemDopamine-rich areasMidbrain dopamine neuronsDepolarization inactivationResponsive neuronsDopamine neuronsDopaminergic systemComparable dosesTyrosine hydroxylaseCholecystokininBursting activityNeuronsImmunocytochemical techniquesRecording techniques
1980
Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways
Hommer D, Bunney B. Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways. Life Sciences 1980, 27: 377-386. PMID: 7412480, DOI: 10.1016/0024-3205(80)90185-x.Peer-Reviewed Original ResearchConceptsStriato-nigral pathwayDopaminergic neuronsReticulata neuronsInhibitory periodSingle-unit recording techniquesNon-dopaminergic neuronsNigro-striatal pathwaySciatic nerve stimulationRat substantia nigraDopaminergic neuron activitySensory stimuliInitial inhibitionStimulation-induced changesActivity of dopaminergicNigral neuronsNerve stimulationSubstantia nigraNeuron activityNeuronsRecording techniquesHaloperidolLesionsInhibitionStimulationPathwayEffects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment
Grace A, Bunney B. Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment. Brain Research Bulletin 1980, 5: 537-543. DOI: 10.1016/0361-9230(80)90087-8.Peer-Reviewed Original ResearchChronic haloperidol treatmentDopaminergic cell activityEffects of baclofenHaloperidol treatmentLow dosesExtracellular single-unit recording techniquesNeuroleptic-induced side effectsRat nigral dopaminergic neuronsCell activitySingle-unit recording techniquesInhibitory effectNigral DA cellsSingle low dosesNigral dopaminergic neuronsTreatment of spasticityAction of baclofenDose-response curveMechanism of actionDepolarization inactivationDopaminergic neuronsHaloperidol pretreatmentDA cellsPossible efficacyNigral inputsBaclofen
1979
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons
Grace A, Bunney B. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. European Journal Of Pharmacology 1979, 59: 211-218. PMID: 527646, DOI: 10.1016/0014-2999(79)90283-8.Peer-Reviewed Original ResearchConceptsZona reticulataGABA agonistsGABAergic inputsZona compactaSubstantia nigraLow dosesCell activitySingle-unit recording techniquesNigral dopaminergic cellsInhibitory GABAergic inputMeans of microiontophoresisPopulations of neuronsCell firing rateGABA excitationExcitatory effectsDopaminergic neuronsDopaminergic cellsInhibitory neuronsSame doseElectrophysiological studiesNeuron activityZR cellsFiring rateNeuronsAgonistsEFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITY
Bunney B, Grace A. EFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITY. 1979, 666-668. DOI: 10.1016/b978-1-4832-8363-0.50202-0.Peer-Reviewed Original ResearchActive DA cellsChronic haloperidol treatmentDA cellsExtracellular single-unit recording techniquesRat nigral dopaminergic neuronsSingle-unit recording techniquesNigral dopaminergic neuronsNeurological side effectsEffects of chronicDepolarization inactivationHaloperidol treatmentDopaminergic neuronsExcitatory inputsSide effectsCell activityRecording techniquesPossible new mechanismSubsequent studiesTreatmentCellsAnimalsNigralChronicNeurons
1975
Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine
Svensson T, Bunney B, Aghajanian G. Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine. Brain Research 1975, 92: 291-306. PMID: 1174954, DOI: 10.1016/0006-8993(75)90276-0.Peer-Reviewed Original ResearchConceptsNE neuronsAgonist clonidineHigh dosesMidbrain dorsal raphe nucleusAlpha-adrenergic agonist clonidineSingle-unit recording techniquesBrain NE neuronsClonidine-induced depressionDorsal raphe nucleusAdrenergic agonist clonidineBrain norepinephrineRaphe neuronsIntravenous clonidineAdrenergic transmissionSerotonergic neuronsDepressant effectDopaminergic neuronsRaphe nucleusSpontaneous firingLocus coeruleusClonidineLow doseL-amphetamineAdrenergic receptorsNeuronsD & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons.
Bunney B, Walters J, Kuhar M, Roth R, Aghajanian G. D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons. Psychopharmacology Communications 1975, 1: 177-90. PMID: 1223998.Peer-Reviewed Original ResearchConceptsNoradrenergic neuronsDopaminergic neuronsD-amphetamineSingle-unit recording techniquesSubstantia nigra zona compactaSubstantia nigra dopamineLocus coeruleus cellsIsomers of amphetamineCentral dopaminergicZona compactaDA cellsDopamine neuronsLocus coeruleusParalyzed ratsCatecholamine systemsLow dosesInterpretation of studiesPharmacological toolsFiring ratePreferential effectComparative potencyNeuronsAmphetamineLethal dosesRecording techniques
1974
A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons
Bunney B, Aghajanian G. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons. Life Sciences 1974, 15: 309-318. PMID: 4549921, DOI: 10.1016/0024-3205(74)90221-5.Peer-Reviewed Original ResearchConceptsChlorpromazine sulfoxideSingle-unit recording techniquesAnti-psychotic propertyCentral dopaminergic neuronsVentral tegmental neuronsPossible clinical importanceEffect of chlorpromazineA10 neuronsDopaminergic neuronsAntipsychotic efficacyPlasma levelsTegmental neuronsAntipsychotic agentsTherapeutic effectAntipsychotic propertiesClinical importanceEquivalent dosesRecording techniquesChlorpromazineNeuronsDepressionPreliminary studyPrevious findingsSulfoxide levelsChlorpromazine metabolites