1988
The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
Bean A, Shepard P, Bunney B, Nestler E, Roth R. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology 1988, 34: 715-8. PMID: 2974120.Peer-Reviewed Original ResearchConceptsPertussis toxin injectionDopamine synthesisToxin injectionDopamine autoreceptorsRat striatumPertussis toxinAutoreceptor-mediated inhibitionDopamine agonist apomorphineG proteinsAgonist apomorphineUnilateral administrationControl ratsSystemic administrationStriatal tissueEffects of activationAutoreceptorsApomorphineStriatumRatsAdministrationInjectionToxinActivationStriataAgonists
1984
The control of firing pattern in nigral dopamine neurons: burst firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: burst firing. Journal Of Neuroscience 1984, 4: 2877-2890. PMID: 6150071, PMCID: PMC6564720, DOI: 10.1523/jneurosci.04-11-02877.1984.Peer-Reviewed Original ResearchConceptsDA cellsIntracellular injectionBase-line firing rateFiring ratePotassium conductanceIntracellular calcium injectionNigral dopamine neuronsStriatal DA releaseVivo intracellular recordingsBurst-firing modeDegree of burstDA releaseDopamine neuronsExtracellular iontophoresisBurst firingIntracellular recordingsCalcium injectionDopamine cellsCalcium influxCalcium involvementBursting patternInjectionCellsConsecutive spikesBlockade
1980
Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence
Grace A, Bunney B. Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence. Science 1980, 210: 654-656. PMID: 7433992, DOI: 10.1126/science.7433992.Peer-Reviewed Original ResearchConceptsL-DOPA injectionIntracellular recordingsAntidromic conduction velocitiesPutative dopaminergic neuronsDopamine-containing neuronsRat substantia nigraAntidromic activationDopaminergic neuronsSubstantia nigraSlow depolarizationBurst firingFluorescence histochemistryConduction velocityFast potentialsNeuronsExtracellular spikesInjectionHistofluorescenceRecordingsNigra