2023
Early adversity changes the economic conditions of mouse structural brain network organization
Carozza S, Holmes J, Vértes P, Bullmore E, Arefin T, Pugliese A, Zhang J, Kaffman A, Akarca D, Astle D. Early adversity changes the economic conditions of mouse structural brain network organization. Developmental Psychobiology 2023, 65: e22405. PMID: 37607894, PMCID: PMC10505050, DOI: 10.1002/dev.22405.Peer-Reviewed Original ResearchConceptsEarly adversityStructural brain network organizationPostnatal stressBrain network organizationMental health outcomesEarly life adversityCognitive abilitiesNeural processesLife adversityConnectome organizationAdversityStructural connectomeConnectomeNetwork organizationGenerative processMouse connectomeHealth outcomesLong-distance connectionsOrganizationEffective responseAdaptive mechanismsAbilityStressWiring cost
2007
Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights
Kaffman A, Meaney MJ. Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights. Journal Of Child Psychology And Psychiatry 2007, 48: 224-244. PMID: 17355397, DOI: 10.1111/j.1469-7610.2007.01730.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArousalBehavior, AnimalBrainCognitionCritical Period, PsychologicalDNA MethylationEmotionsEpigenesis, GeneticFemaleGroomingHumansHypothalamo-Hypophyseal SystemMaleMaternal BehaviorMicePhenotypePrimatesRatsReceptors, NeurotransmitterSensory DeprivationSocial EnvironmentTouchConceptsDNA methylationFrequency of lickingParent-offspring interactionsPostnatal maternal carePromoter elementsGene expressionPostmitotic cellsMolecular insightsParental careBehavioral traitsFunctional consequencesImportant roleMolecular scaffoldsMethylationMaternal careNon-human primatesRecent rodent workBrain developmentExpressionNeurodevelopmental aspectsRodentsMammalsGenesPrimates