2006
A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder
Bloch MH, Landeros-Weisenberger A, Kelmendi B, Coric V, Bracken MB, Leckman JF. A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Molecular Psychiatry 2006, 11: 622-632. PMID: 16585942, DOI: 10.1038/sj.mp.4001823.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntipsychotic AgentsBasal Ganglia DiseasesBenzodiazepinesComorbidityDepressive DisorderDibenzothiazepinesDouble-Blind MethodDrug ResistanceDrug Therapy, CombinationHaloperidolHumansMiddle AgedObsessive-Compulsive DisorderOlanzapinePatient DropoutsQuetiapine FumarateRandomized Controlled Trials as TopicRisperidoneSelective Serotonin Reuptake InhibitorsTic DisordersTreatment OutcomeConceptsSerotonin reuptake inhibitorsAntipsychotic augmentationAbsolute risk differenceObsessive-compulsive disorderComorbid ticsOCD patientsTreatment responseSystematic reviewTreatment-refractory obsessive-compulsive disorderTreatment-refractory OCD patientsRefractory obsessive-compulsive disorderDouble-blind trialEfficacy of quetiapineTreatment-refractory OCDCochrane Central RegisterMeaningful treatment responseProportion of subjectsEfficacy of haloperidolRandomized control trialObsessive-compulsive disorder patientsSRI monotherapyAdequate trialCentral RegisterControlled TrialsReuptake inhibitors
1995
Risperidone addition in fluvoxamine-refractory obsessive-compulsive disorder: three cases.
McDougle CJ, Fleischmann RL, Epperson CN, Wasylink S, Leckman JF, Price LH. Risperidone addition in fluvoxamine-refractory obsessive-compulsive disorder: three cases. The Journal Of Clinical Psychiatry 1995, 56: 526-8. PMID: 7592506.Peer-Reviewed Original ResearchConceptsSerotonin uptake inhibitorObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleY-BOCS scoresRisperidone additionOCD patientsComorbid chronic tic disorderPatients' Y-BOCS scoresRefractory obsessive-compulsive disorderOpen-label mannerLow-dose haloperidolSide effect profileWeeks of treatmentChronic tic disorderEffective treatment strategiesObsessive Compulsive ScaleSUI treatmentEffect profileNeuroleptic treatmentTardive dyskinesiaTypical neurolepticsModerate sedationReceptor antagonistTic disordersTreatment strategies
1994
Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder: A Double-blind, Placebo-Controlled Study in Patients With and Without Tics
McDougle CJ, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH. Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder: A Double-blind, Placebo-Controlled Study in Patients With and Without Tics. JAMA Psychiatry 1994, 51: 302-308. PMID: 8161290, DOI: 10.1001/archpsyc.1994.03950040046006.Peer-Reviewed Original ResearchConceptsComorbid chronic tic disorderChronic tic disorderYale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderTic disordersFluvoxamine treatmentOCD patientsClinical Global Impression ScalePlacebo-treated groupDouble-blind fashionWeeks of treatmentGlobal Impression ScaleTreatment of patientsHaloperidol-treated groupEffective symptom reductionObsessive Compulsive ScaleNeuroleptic therapyBlood levelsImpression ScaleTreatment outcomesTreatment responseAdequate treatmentPatientsPlaceboSymptom reduction
1993
Limited therapeutic effect of addition of buspirone in fluvoxamine- refractory obsessive-compulsive disorder
McDougle CJ, Goodman WK, Leckman JF, Holzer JC, Barr LC, McCance-Katz E, Heninger GR, Price LH. Limited therapeutic effect of addition of buspirone in fluvoxamine- refractory obsessive-compulsive disorder. American Journal Of Psychiatry 1993, 150: 647-649. PMID: 8465885, DOI: 10.1176/ajp.150.4.647.Peer-Reviewed Original Research