2019
Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD
Smith SD, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD. Psychiatry Research 2019, 278: 248-257. PMID: 31233935, PMCID: PMC6637759, DOI: 10.1016/j.psychres.2019.06.021.Peer-Reviewed Original ResearchConceptsBehavioral measuresAttentional controlIntegrated brainGo/No-Go taskGo-P3 latencySlower reaction timesSocial interventionsRobust treatment effectAttentional systemADHD groupERP measuresDifference waveP3 latencyBrain activityADHDTAU groupEEG proceduresHealthy controlsHC groupReaction timeReplication purposesERPTreatment effectsChildrenSecondary goal
2017
A double-blind randomized pilot trial comparing computerized cognitive exercises to Tetris in adolescents with attention-deficit/hyperactivity disorder
Bikic A, Christensen TØ, Leckman JF, Bilenberg N, Dalsgaard S. A double-blind randomized pilot trial comparing computerized cognitive exercises to Tetris in adolescents with attention-deficit/hyperactivity disorder. Nordic Journal Of Psychiatry 2017, 71: 455-464. PMID: 28598701, DOI: 10.1080/08039488.2017.1328070.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderComputerized cognitive exercisesCognitive exercisesHyperactivity disorderComputer game TetrisSignificant intra-group changesADHD symptom measuresSignificant group differencesLarge effect sizesDouble-blind randomized pilot trialBrain trainingSustained attentionCognitive testsGame TetrisMotivation questionnaireHome-based interventionGroup differencesSignificant beneficial effectRandomized pilot trialActive placeboIntra-group changesTetrisAdolescentsEffect sizeBeneficial effects
2016
Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism
Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA. Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism. Scientific Reports 2016, 6: 35054. PMID: 27845765, PMCID: PMC5109935, DOI: 10.1038/srep35054.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderIntranasal oxytocinSocial motivationSocial perceptionSocial-emotional informationFunctional magnetic resonance imagingPlacebo-controlled crossover designBiological motionSocial stimuliAngry voicesSocial deficitsSpectrum disorderOT administrationMesolimbic reward pathwayBehavioral treatmentBrain rewardReduced connectivityBrain regionsReward pathwayCortical sitesRewardPerceptionMotivationOxytocinBrain sitesA Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD
Smith SD, Vitulano LA, Katsovich L, Li S, Moore C, Li F, Grantz H, Zheng X, Eicher V, Guloksuz S, Zheng Y, Dong J, Sukhodolsky DG, Leckman JF. A Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD. Journal Of Attention Disorders 2016, 24: 780-794. PMID: 27178060, PMCID: PMC5107355, DOI: 10.1177/1087054716647490.Peer-Reviewed Original ResearchConceptsIntegrated brainComputerized cognitive remediation trainingCognitive remediation trainingSocial interventionsBehavior management strategiesRemediation trainingCognitive trainingMemory taskADHD symptomatologyADHD symptomsNeurocognitive testsTeacher ratingsBlinded clinician ratingGeneralized improvementADHDMultiple group comparisonsClinician ratingsMultiple domainsClinical functioningSignificant treatment effectOutcome measuresGroup comparisonsSecondary outcome measuresChildrenRatings
2014
Editorial commentary: “What does immunology have to do with brain development and neuropsychiatric disorders?”
Leckman JF, Vaccarino FM. Editorial commentary: “What does immunology have to do with brain development and neuropsychiatric disorders?”. Brain Research 2014, 1617: 1-6. PMID: 25283746, DOI: 10.1016/j.brainres.2014.09.052.Commentaries, Editorials and LettersNeural plasticity in fathers of human infants
Kim P, Rigo P, Mayes LC, Feldman R, Leckman JF, Swain JE. Neural plasticity in fathers of human infants. Social Neuroscience 2014, 9: 522-535. PMID: 24958358, PMCID: PMC4144350, DOI: 10.1080/17470919.2014.933713.Peer-Reviewed Original ResearchConceptsFathers' brainsNeural plasticityLateral prefrontal cortexCurrent longitudinal studyPosterior cingulate cortexVoxel-based morphometry analysisGray matter volumeNeural basisCognitive developmentNeural regionsNeural changesOrbitofrontal cortexPrefrontal cortexWeeks postpartumHuman fathersParental motivationCingulate cortexHuman infantsMood symptomsBrain regionsLongitudinal studyPostpartum mood symptomsMatter volumeMorphometry analysisHuman mothersCommentary: What does immunology have to do with brain development and psychopathology? – a commentary on O'Connor et al. (2014)
Leckman JF. Commentary: What does immunology have to do with brain development and psychopathology? – a commentary on O'Connor et al. (2014). Journal Of Child Psychology And Psychiatry 2014, 55: 632-634. PMID: 24840172, DOI: 10.1111/jcpp.12259.Peer-Reviewed Original Research
2013
Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
Zebardast N, Crowley MJ, Bloch MH, Mayes LC, Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings. Psychiatry Research 2013, 214: 33-41. PMID: 23916249, PMCID: PMC3932431, DOI: 10.1016/j.pscychresns.2013.05.009.Peer-Reviewed Original ResearchConceptsTourette syndromeFunctional magnetic resonance imagingHealthy subjectsTic severityWhole-brain functional magnetic resonance imagingYale Global Tic Severity ScaleTactile startle responseCase-control study designTic Severity ScaleCortical-striatal circuitsBrain activityMagnetic resonance imagingMultiple brain regionsLeft middle frontal gyrusMiddle frontal gyrusDegree of PPIPulse-alone stimuliBlock-design fMRI paradigmTic symptomsNeuropathological dataHealthy controlsPrepulse inhibitionDevelopmental neuropsychiatric disordersSensorimotor gatingLeft caudateMore than Two Dozen “Autisms”
Mercadante MT, Leckman JF. More than Two Dozen “Autisms”. Brazilian Journal Of Psychiatry 2013, 35: 3-4. PMID: 23567593, DOI: 10.1016/j.rbp.2013.01.003.Peer-Reviewed Original Research
2011
Variations in Maternal Behavior—Oxytocin and Reward Pathways—Peripheral Measures Matter?!
Leckman JF. Variations in Maternal Behavior—Oxytocin and Reward Pathways—Peripheral Measures Matter?! Neuropsychopharmacology 2011, 36: 2587-2588. PMID: 22071897, PMCID: PMC3230502, DOI: 10.1038/npp.2011.201.Peer-Reviewed Original ResearchOxytocin and social motivation
Gordon I, Martin C, Feldman R, Leckman JF. Oxytocin and social motivation. Developmental Cognitive Neuroscience 2011, 1: 471-493. PMID: 21984889, PMCID: PMC3185363, DOI: 10.1016/j.dcn.2011.07.007.Peer-Reviewed Original ResearchConceptsSocial motivationCourse of developmentBiobehavioral systemsRole of oxytocinSocial creaturesSocial partnersSensory inputKey unresolved questionGonadal axisGastrointestinal tractStress response axisMotivationOTR expressionOxytocinReceptor systemBrainSalienceReproductive organsResponse axisDetection pathwaySystem functionExternal environmentPeripheral componentsUnresolved questionsHumans
2010
The Plasticity of Human Maternal Brain: Longitudinal Changes in Brain Anatomy During the Early Postpartum Period
Kim P, Leckman JF, Mayes LC, Feldman R, Wang X, Swain JE. The Plasticity of Human Maternal Brain: Longitudinal Changes in Brain Anatomy During the Early Postpartum Period. Behavioral Neuroscience 2010, 124: 695-700. PMID: 20939669, PMCID: PMC4318549, DOI: 10.1037/a0020884.Peer-Reviewed Original ResearchConceptsGray matter volumeEarly postpartum periodMatter volumeMaternal brainPostpartum periodParietal lobePrefrontal cortexTime pointsGray matter changesProspective longitudinal studyVoxel-based morphometryMother's brainSubstantia nigraMonths postpartumWeeks postpartumMidbrain areaMatter changesAnimal studiesMaternal motivationBrain regionsLongitudinal changesFirst monthMagnetic resonance imagesHigh-resolution magnetic resonance imagesMaternal behaviorPerceived quality of maternal care in childhood and structure and function of mothers' brain
Kim P, Leckman JF, Mayes LC, Newman M, Feldman R, Swain JE. Perceived quality of maternal care in childhood and structure and function of mothers' brain. Developmental Science 2010, 13: 662-673. PMID: 20590729, PMCID: PMC3974609, DOI: 10.1111/j.1467-7687.2009.00923.x.Peer-Reviewed Original ResearchConceptsMiddle frontal gyrusSuperior temporal gyrusMaternal careTemporal gyrusHuman mothersFrontal gyrusInfant stimuliFusiform gyrusFirst postpartum monthLarger gray matter volumeGray matter volumeMagnetic resonance imagingHigh maternal careLow maternal careMother's brainPostpartum monthsLong-term effectsOrbital gyrusAnimal studiesBrain areasMatter volumeNeglectful motheringResonance imagingBrain regionsHeightened stress reactivityObsessive–compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM‐V
Leckman JF, Denys D, Simpson HB, Mataix‐Cols D, Hollander E, Saxena S, Miguel EC, Rauch SL, Goodman WK, Phillips KA, Stein DJ. Obsessive–compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM‐V. Depression And Anxiety 2010, 27: 507-527. PMID: 20217853, PMCID: PMC3974619, DOI: 10.1002/da.20669.Peer-Reviewed Original Research
2009
Obsessive–compulsive Disorder: Diagnostic and Treatment Issues
Stein DJ, Denys D, Gloster AT, Hollander E, Leckman JF, Rauch SL, Phillips KA. Obsessive–compulsive Disorder: Diagnostic and Treatment Issues. Psychiatric Clinics Of North America 2009, 32: 665-685. PMID: 19716996, DOI: 10.1016/j.psc.2009.05.007.Peer-Reviewed Original Research
2008
Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements
Hampson M, Tokoglu F, King RA, Constable RT, Leckman JF. Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements. Biological Psychiatry 2008, 65: 594-599. PMID: 19111281, PMCID: PMC2679868, DOI: 10.1016/j.biopsych.2008.11.012.Peer-Reviewed Original ResearchConceptsMotor cortexSupplementary motor areaControl subjectsBrain areasMotor ticsTic disordersTic movementsMotor areaTic-like movementsHealthy control subjectsChronic tic disorderNormal control subjectsChronic motor ticsNovel intervention strategiesFunctional neuroimaging studiesTic executionSevere ticsIntentional movementPatient's ticsMotor regionsPremonitory urgesBrain activity patternsAdult subjectsTic generationCortexMaternal brain response to own baby‐cry is affected by cesarean section delivery
Swain JE, Tasgin E, Mayes LC, Feldman R, Constable RT, Leckman JF. Maternal brain response to own baby‐cry is affected by cesarean section delivery. Journal Of Child Psychology And Psychiatry 2008, 49: 1042-1052. PMID: 18771508, PMCID: PMC3246837, DOI: 10.1111/j.1469-7610.2008.01963.x.Peer-Reviewed Original ResearchConceptsCesarean section deliveryMode of deliveryVD mothersSection deliveryMother's brainVaginal deliveryElective cesarean section deliveryMaternal brain responsesImmediate postpartum periodRight lenticular nucleusSuperior frontal cortexMedial fusiform gyrusBeck Depression InventorySuperior frontal gyrusFunctional magnetic resonance imagingMagnetic resonance imagingSuperior parietal lobeMiddle temporal gyrusEarly postpartumPostpartum periodLenticular nucleusPostpartum depressionFrontal cortexSpecific brain activationParietal lobe
2007
An Evolutionary and Developmental Perspective
Leckman JF. An Evolutionary and Developmental Perspective. Biological Psychiatry 2007, 62: 831-832. PMID: 17825798, PMCID: PMC2693705, DOI: 10.1016/j.biopsych.2007.07.006.Peer-Reviewed Original ResearchThe role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder
Sukhodolsky DG, Leckman JF, Rothenberger A, Scahill L. The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry 2007, 16: 51-59. PMID: 17665283, DOI: 10.1007/s00787-007-1007-3.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderTourette syndromeAbnormal neural oscillationsOscillatory activityHyperactivity disorderAbnormal oscillatory activityThalamo-cortical circuitsSymptoms of ADHDNeural oscillationsNeural oscillatory activityBasal gangliaFunctional abnormalitiesNormal brainThalamocortical regionsThalamocortical oscillationsCortical regionsTransient hyperpolarizationPrefrontal cortexNeural activityNeural communicationPathophysiologyMotor controlSyndromeBrainDisorders
2006
Identification of pyruvate kinase as an antigen associated with Tourette syndrome
Kansy JW, Katsovich L, McIver KS, Pick J, Zabriskie JB, Lombroso PJ, Leckman JF, Bibb JA. Identification of pyruvate kinase as an antigen associated with Tourette syndrome. Journal Of Neuroimmunology 2006, 181: 165-176. PMID: 17011640, PMCID: PMC1853370, DOI: 10.1016/j.jneuroim.2006.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmino Acid SequenceAnimalsAntibodies, BacterialAntigensAutoantibodiesBrainChildCross ReactionsHumansImmunohistochemistryLongitudinal StudiesMaleMiceMice, Inbred C57BLMolecular Sequence DataProspective StudiesPyruvate KinaseRatsSeroepidemiologic StudiesStreptococcal InfectionsTicsTourette SyndromeConceptsStreptococcal infectionObsessive-compulsive disorderTourette syndromeAutoimmune targetExacerbated symptomsBeta-hemolytic streptococcal infectionEarly-onset obsessive-compulsive disorderStreptococcal M proteinPediatric populationTic disordersImmune responseSurface antigenInfectious strainsSyndromeInfectionDisordersPyruvate kinaseM proteinPatientsImmunoreactivitySymptomsAntigenAntibodiesGlycolytic enzymesM1 isoform