2012
Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder
Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder. Biological Psychiatry 2012, 72: 964-970. PMID: 22784486, PMCID: PMC3667652, DOI: 10.1016/j.biopsych.2012.05.028.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderKetamine infusionDepression symptomsLow-dose ketamine infusionTreatment-refractory obsessive-compulsive disorderOCD symptomsPathogenesis of OCDIncomplete symptom reliefTreatment-Refractory ObsessiveOpen-label trialRapid antidepressant effectsAspartate glutamate receptorsEffects of ketaminePotent noncompetitive antagonistGlutamate abnormalitiesAntidepressant effectsAntidepressant responseSymptom reliefKetamine effectsComorbid depressionAcute effectsGlutamate receptorsDepressive symptomsNoncompetitive antagonistInfusion
2006
Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome
Mink JW, Walkup J, Frey KA, Como P, Cath D, DeLong MR, Erenberg G, Jankovic J, Juncos J, Leckman JF, Swerdlow N, Visser‐Vandewalle V, Vitek JL. Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome. Movement Disorders 2006, 21: 1831-1838. PMID: 16991144, DOI: 10.1002/mds.21039.Peer-Reviewed Original ResearchMeSH KeywordsDeep Brain StimulationEvaluation Studies as TopicHealth Planning GuidelinesHumansPatient SelectionTourette SyndromeConceptsDeep brain stimulationTourette syndromeClinical trialsBrain stimulationClinical treatment choiceFuture clinical trialsTourette Syndrome AssociationEarly clinical experiencePotential clinical trialsSurgical candidatesPatient selectionTreatment choiceTic disordersSyndrome AssociationClinical careAlternative treatmentClinical experienceTic severityEarly useSyndromeAssessment recommendationsTrialsRecent publicityStimulationSurgery