2015
Obsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children
Alvarenga PG, Cesar RC, Leckman JF, Moriyama TS, Torres AR, Bloch MH, Coughlin CG, Hoexter MQ, Manfro GG, Polanczyk GV, Miguel EC, do Rosario MC. Obsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children. Journal Of Psychiatric Research 2015, 62: 108-114. PMID: 25702286, DOI: 10.1016/j.jpsychires.2015.01.018.Peer-Reviewed Original ResearchConceptsSchool-aged childrenPsychiatric symptomsFamily History ScreenAdditional clinical factorsSymptom dimensionsCommunity-based sampleObsessive-compulsive symptom dimensionsClinical factorsObsessive-compulsive disorderPsychiatric comorbidityClinical impairmentSchool impairmentCross-sectional sampleAge 6Clinical samplesFamilial aggregationBiological mothersChildrenBiological relativesSymptomsPrevalenceAge distributionImpairmentNon-clinical samplePresent study
2014
Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive–compulsive disorder
Bloch MH, Bartley CA, Zipperer L, Jakubovski E, Landeros-Weisenberger A, Pittenger C, Leckman JF. Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive–compulsive disorder. Molecular Psychiatry 2014, 19: 1025-1030. PMID: 24912494, PMCID: PMC4169729, DOI: 10.1038/mp.2014.50.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTreatment responseOCD patientsOdds ratioFurther treatment researchCase-control studyPoor treatment outcomesDifferential treatment responseSymptoms of OCDPrimary outcomeTreatment modalitiesEligible studiesTreatment outcomesPatientsElectronic searchSymptomsTotal participantsBehavioral therapyOCD treatmentDisordersSymptom dimensionsTreatment researchDSM-5Hoarding symptomsTreatment
2013
LONG‐TERM OUTCOME IN ADULTS WITH OBSESSIVE‐COMPULSIVE DISORDER
Bloch MH, Green C, Kichuk SA, Dombrowski PA, Wasylink S, Billingslea E, Landeros‐Weisenberger A, Kelmendi B, Goodman WK, Leckman JF, Coric V, Pittenger C. LONG‐TERM OUTCOME IN ADULTS WITH OBSESSIVE‐COMPULSIVE DISORDER. Depression And Anxiety 2013, 30: 716-722. PMID: 23532944, PMCID: PMC3932438, DOI: 10.1002/da.22103.Peer-Reviewed Original ResearchConceptsLong-term outcomesObsessive-compulsive disorderEvidence-based treatmentsAdult OCD patientsLong-term clinical outcomesSymptom severitySerotonin reuptake inhibitor medicationsOCD patientsPlacebo-controlled trialSerotonin reuptake inhibitorsReuptake inhibitor medicationsPercent of subjectsInitial responseSymptom dimensionsLater symptom severityOCD symptomsSignificant OCD symptomsOCD symptom dimensionsAdult patientsClinical characteristicsClinical improvementEligible subjectsPartial respondersInhibitor medicationReuptake inhibitors
2009
Dimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder
Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF, Coric V. Dimensional predictors of response to SRI pharmacotherapy in obsessive–compulsive disorder. Journal Of Affective Disorders 2009, 121: 175-179. PMID: 19577308, PMCID: PMC3974618, DOI: 10.1016/j.jad.2009.06.010.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSRI responseSymptom dimensionsOpen-label continuation phaseClinical Global Improvement ScaleGlobal Improvement ScaleCentral serotonin systemInitial positive responseYale-Brown ObsessiveContinuation phaseMinor symptomsOrdinal logistic regressionClinical trialsSerotonin systemTreatment responseSame patientImprovement ScaleSRI treatmentPatientsSignificant associationLogistic regressionCompulsive ScaleOCD patientsOCD subjectsSymptoms
2008
Four-Factor Structure of Obsessive-Compulsive Disorder Symptoms in Children, Adolescents, and Adults
Stewart SE, Rosario MC, Baer L, Carter AS, Brown TA, Scharf JM, Illmann C, Leckman JF, Sukhodolsky D, Katsovich L, Rasmussen S, Goodman W, Delorme R, Leboyer M, Chabane N, Jenike MA, Geller DA, Pauls DL. Four-Factor Structure of Obsessive-Compulsive Disorder Symptoms in Children, Adolescents, and Adults. Journal Of The American Academy Of Child & Adolescent Psychiatry 2008, 47: 763-772. PMID: 18520961, DOI: 10.1097/chi.0b013e318172ef1e.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisAdult age groupsAge groupsAge group samplesAdult groupFour-factor solutionOngoing translational researchSymptom dimensionsPrevious confirmatory factor analysisObsessive-compulsive disorder symptomsMultiple-group confirmatory factor analysisCategory-based modelComparable model fitOCD symptom dimensions
1997
Symptoms of obsessive-compulsive disorder
Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL. Symptoms of obsessive-compulsive disorder. American Journal Of Psychiatry 1997, 154: 911-917. PMID: 9210740, DOI: 10.1176/ajp.154.7.911.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMultiple psychological domainsYale-Brown Obsessive Compulsive Scale Symptom ChecklistTypes of obsessionsCompulsive Scale Symptom ChecklistSocial relatednessPsychological domainSymptom dimensionsPrincipal component factor analysisCorrelational relationshipsSymptom ChecklistDiverse motor behaviorsMotor behaviorFactor analysisExploratory analysisVarimax rotationTreatment response studiesObsessionDisordersIndependent groupsEmotionsCognitionPerceptionSymptomsCompulsion