2016
Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism
Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA. Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism. Scientific Reports 2016, 6: 35054. PMID: 27845765, PMCID: PMC5109935, DOI: 10.1038/srep35054.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderIntranasal oxytocinSocial motivationSocial perceptionSocial-emotional informationFunctional magnetic resonance imagingPlacebo-controlled crossover designBiological motionSocial stimuliAngry voicesSocial deficitsSpectrum disorderOT administrationMesolimbic reward pathwayBehavioral treatmentBrain rewardReduced connectivityBrain regionsReward pathwayCortical sitesRewardPerceptionMotivationOxytocinBrain sites
2015
Oxytocin-augmented labor and risk for autism in males
Weisman O, Agerbo E, Carter CS, Harris JC, Uldbjerg N, Henriksen TB, Thygesen M, Mortensen PB, Leckman JF, Dalsgaard S. Oxytocin-augmented labor and risk for autism in males. Behavioural Brain Research 2015, 284: 207-212. PMID: 25707712, DOI: 10.1016/j.bbr.2015.02.028.Peer-Reviewed Original ResearchConceptsSynthetic oxytocinInfant developmentICD-10 DCRSingleton live birthsAugmentation of laborAutistic disorderDose-dependent effectAugment laborMaternal exposureLive birthsModest associationEpidemiological analysisAdverse effectsOxytocinPlausible associationRiskMalesInconsistent findingsDisordersFuture studiesBirthAssociationAutismFindingsAugmentation
2013
Oxytocin enhances brain function in children with autism
Gordon I, Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSuperior temporal sulcusTemporal sulcusOrbitofrontal cortexLeft superior temporal sulcusMiddle frontal gyrusMedial prefrontal cortexRight orbitofrontal cortexSocial attunementSocial judgmentsMeaningful stimuliFrontal gyrusSpectrum disorderBrain activityPrefrontal cortexRight amygdalaSocial functioningFunctional MRIPremotor cortexHedonic evaluationBrain functionJudgmentsCortexChildrenOxytocin
2012
Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity
Schneiderman I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity. Psychoneuroendocrinology 2012, 37: 1277-1285. PMID: 22281209, PMCID: PMC3936960, DOI: 10.1016/j.psyneuen.2011.12.021.Peer-Reviewed Original ResearchConceptsRomantic attachmentRomantic relationshipsNew loversRole of oxytocinParent-infant bondingBio-behavioral mechanismsHuman imaging studiesPositive affectAffectionate touchDyadic interactionsOxytocinergic systemBrain areasEmotional distressThree monthsDyadic statesImaging studiesRelationship durationOT levelsAdult HealthYoung adultsHigh individual stabilitySocial focusPlasma oxytocinOxytocinMonths
2011
Oxytocin and social motivation
Gordon I, Martin C, Feldman R, Leckman JF. Oxytocin and social motivation. Developmental Cognitive Neuroscience 2011, 1: 471-493. PMID: 21984889, PMCID: PMC3185363, DOI: 10.1016/j.dcn.2011.07.007.Peer-Reviewed Original ResearchConceptsSocial motivationCourse of developmentBiobehavioral systemsRole of oxytocinSocial creaturesSocial partnersSensory inputKey unresolved questionGonadal axisGastrointestinal tractStress response axisMotivationOTR expressionOxytocinReceptor systemBrainSalienceReproductive organsResponse axisDetection pathwaySystem functionExternal environmentPeripheral componentsUnresolved questionsHumans
2008
Oxytocin and cortisol in romantically unattached young adults: Associations with bonding and psychological distress
Gordon I, Zagoory‐Sharon O, Schneiderman I, Leckman JF, Weller A, Feldman R. Oxytocin and cortisol in romantically unattached young adults: Associations with bonding and psychological distress. Psychophysiology 2008, 45: 349-352. PMID: 18266803, DOI: 10.1111/j.1469-8986.2008.00649.x.Peer-Reviewed Original ResearchConceptsPsychological distressHuman social affiliationSelf-report measuresYoung adultsInvolvement of oxytocinAttachment anxietyAdult representationsSocial affiliationOwn parentsSalivary cortisolPlasma oxytocinOT levelsDistressDepressive symptomsAnxietyOxytocinParentsAdultsCognitionRegression analysisLife spanRepresentationAttachmentCortisolExtensive research
1999
Oxytocin, vasopressin, and autism: is there a connection?
Insel T, O’Brien D, Leckman J. Oxytocin, vasopressin, and autism: is there a connection? Biological Psychiatry 1999, 45: 145-157. PMID: 9951561, DOI: 10.1016/s0006-3223(98)00142-5.Peer-Reviewed Original ResearchConceptsVasopressin neurotransmissionAvailable preclinical evidencePreclinical evidenceClinical studiesAnimal studiesRodent brainPeptide receptorFeatures of autismOxytocinVasopressinGenetic disordersCompulsive behaviorsNeurotransmissionNormal expressionDevelopmental disordersSocial impairmentReceptorsCommunication deficitsDisordersSpecies-typical social behaviorsNeurobiological approachAutismEvidenceUnique effectsExpression