2020
Risk factors for obsessive–compulsive symptoms. Follow-up of a community-based youth cohort
Macul Ferreira de Barros P, do Rosário MC, Szejko N, Polga N, Requena GL, Ravagnani B, Fatori D, Batistuzzo MC, Hoexter MQ, Rohde LA, Polanczyk GV, Leckman JF, Miguel EC, de Alvarenga PG. Risk factors for obsessive–compulsive symptoms. Follow-up of a community-based youth cohort. European Child & Adolescent Psychiatry 2020, 30: 89-104. PMID: 32076869, DOI: 10.1007/s00787-020-01495-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsRisk factorsAbsence of breastfeedingOCS scoresBaseline anxiety disordersPotential risk factorsLarge community cohortLow socioeconomic statusRegression analysisMental health assessmentMaternal stress levelsLower intelligence quotientCommunity cohortChildhood adversityLower ageHigher OCS scoresAnxiety disordersPsychopathological factorsSocioeconomic statusGenetic factorsSignificant predictorsBaselineHealth assessmentScoresAge
2017
The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disordersTemporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study
Leslie DL, Kobre RA, Richmand BJ, Guloksuz S, Leckman JF. Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study. Frontiers In Psychiatry 2017, 8: 3. PMID: 28154539, PMCID: PMC5244035, DOI: 10.3389/fpsyt.2017.00003.Peer-Reviewed Original ResearchObsessive-compulsive disorderAnorexia nervosaNeuropsychiatric disordersPrior vaccinationPilot case-control studyAnxiety disordersConditional logistic regression modelsClear public health benefitsVaccination of childrenCase-control studyChronic tic disorderMajor depressive disorderChildhood infectious diseasesCertain neuropsychiatric disordersAttention deficit hyperactivity disorderPublic health benefitsLogistic regression modelsAntecedent administrationAntecedent infectionAntecedent vaccinationDeficit hyperactivity disorderInfluenza vaccinationVaccination scheduleIncident diagnosisCDC guidelinesOxytocin response to youth–mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior
Lebowitz ER, Silverman WK, Martino AM, Zagoory‐Sharon O, Feldman R, Leckman JF. Oxytocin response to youth–mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior. Depression And Anxiety 2017, 34: 127-136. PMID: 28052452, PMCID: PMC5503301, DOI: 10.1002/da.22585.Peer-Reviewed Original ResearchConceptsSeparation anxiety disorderAnxious youthAnxiety disordersSeparation anxietySalivary oxytocinAffective touchDSM-5 anxiety disordersYouth anxiety symptomsOT responseParticular anxiety disordersAttachment figuresReliable codersMaternal sensitivityDyadic behaviorsChildren's ratingsMaternal intrusivenessAttachment behaviorAnxiety symptomsAnxiety regulationSocial supportPossible intervention strategiesSignificant distressHigher youthYouthIntervention strategiesTics and Tourette Syndrome
Sukhodolsky D, Gladstone T, Kaushal S, Piasecka J, Leckman J. Tics and Tourette Syndrome. Autism And Child Psychopathology Series 2017, 241-256. DOI: 10.1007/978-3-319-71210-9_14.ChaptersHabit reversal trainingTourette syndromeBehavioral interventionsPathophysiology of TSComprehensive clinical careComprehensive Behavioral InterventionCore clinical characteristicsAttention-deficit/hyperactivity disorderModerators of responseCo-occurring conditionsDisruptive behavior disordersClinical characteristicsChronic motorClinical efficacyTic expressionVocal ticsClinical recommendationsCo-occurring psychopathologyClinical careTic severityTreatment approachesPremonitory urgesBehavior disorderAnxiety disordersDiagnostic assessment
2016
Cross-generational influences on childhood anxiety disorders: pathways and mechanisms
Lebowitz ER, Leckman JF, Silverman WK, Feldman R. Cross-generational influences on childhood anxiety disorders: pathways and mechanisms. Journal Of Neural Transmission 2016, 123: 1053-1067. PMID: 27145763, PMCID: PMC5007197, DOI: 10.1007/s00702-016-1565-y.Peer-Reviewed Original ResearchConceptsAnxiety disordersChild anxiety treatment outcomeChild anxiety disordersChildhood anxiety disordersParent-based interventionsAnxiety treatment outcomesCross-generational influencesSocial referencingFamily accommodationChild anxietyParenting stylesVicarious learningOxytocinergic systemChildren's symptomsBehavioral systemsParental responsesParental anxietyMaternal anxietyAnxietyExistence of linksSevere distressDisordersPrenatal environmentTreatment outcomesResearch
2015
Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation
Lebowitz ER, Leckman JF, Feldman R, Zagoory-Sharon O, McDonald N, Silverman WK. Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation. Psychoneuroendocrinology 2015, 65: 35-43. PMID: 26716876, PMCID: PMC4895196, DOI: 10.1016/j.psyneuen.2015.12.007.Peer-Reviewed Original ResearchConceptsSalivary OT levelsFamily accommodationSeparation anxiety disorderYouth anxietyAnxiety disordersAnxious youthInterpersonal behaviorSeparation anxietyOT levelsDSM-5 anxiety disordersSeparation anxiety symptomsTreatment of anxietyNeuropeptide oxytocinSalivary OTClinical anxietyMaternal ratingsSalivary oxytocinAnxiety symptomsOxytocinergic systemRegulation of anxietyAnxious behaviorOwn behaviorAnxiety assessmentAnxietyParental involvement
2013
The Risks and Benefits of Antidepressants to Treat Pediatric-Onset Depression and Anxiety Disorders: A Developmental Perspective
Leckman JF. The Risks and Benefits of Antidepressants to Treat Pediatric-Onset Depression and Anxiety Disorders: A Developmental Perspective. Psychotherapy And Psychosomatics 2013, 82: 129-131. PMID: 23548739, DOI: 10.1159/000345543.Peer-Reviewed Original Research
2012
FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS
Lebowitz ER, Woolston J, Bar‐Haim Y, Calvocoressi L, Dauser C, Warnick E, Scahill L, Chakir AR, Shechner T, Hermes H, Vitulano LA, King RA, Leckman JF. FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS. Depression And Anxiety 2012, 30: 47-54. PMID: 22965863, PMCID: PMC3932435, DOI: 10.1002/da.21998.Peer-Reviewed Original ResearchConceptsChildhood anxiety disordersFamily Accommodation ScaleFamily accommodationAnxiety disordersMeasures of anxietyFamilies of childrenObsessive-compulsive disorderGood internal consistencyTwo-factor solutionAnxious childrenPediatric anxietyAccommodation ScaleSeparation anxietyGreater symptom severityAnxiety symptomsCompulsive disorderDivergent validityFamily routinesAnxietyDiagnostic InterviewPoor treatment outcomesInternal consistencySymptom severityMost parentsFactor analysisTrajectory in obsessive-compulsive disorder comorbidities
de Mathis MA, Diniz JB, Hounie AG, Shavitt RG, Fossaluza V, Ferrão Y, Leckman JF, de Bragança Pereira C, do Rosario MC, Miguel EC. Trajectory in obsessive-compulsive disorder comorbidities. European Neuropsychopharmacology 2012, 23: 594-601. PMID: 22921470, DOI: 10.1016/j.euroneuro.2012.08.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderHigher lifetime frequencyOCD patientsFirst diagnosisTic disordersSeparation anxiety disorderLifetime frequencyObsessive-compulsive disorder (OCD) comorbidityAnxiety disordersOnset of OCDDistribution of comorbiditiesSpecific comorbid diagnosesLifetime psychiatric diagnosesPost-traumatic stress disorderFirst comorbiditySymptom onsetClinical courseClinical presentationPsychiatric comorbidityDisorder comorbidityOCD courseBeck AnxietyComorbid disordersPsychiatric disordersComorbidities
2007
Tourette Syndrome and Tic Disorders: A Decade of Progress
SWAIN JE, SCAHILL L, LOMBROSO PJ, KING RA, LECKMAN JF. Tourette Syndrome and Tic Disorders: A Decade of Progress. Journal Of The American Academy Of Child & Adolescent Psychiatry 2007, 46: 947-968. PMID: 17667475, DOI: 10.1097/chi.0b013e318068fbcc.Peer-Reviewed Original Research
2005
Tourette syndrome and tic disorders: overview and practical guide to diagnosis and treatment.
Swain JE, Leckman JF. Tourette syndrome and tic disorders: overview and practical guide to diagnosis and treatment. Innov Clin Neurosci 2005, 2: 26-36. PMID: 21152158, PMCID: PMC3000195.Peer-Reviewed Original ResearchTourette syndromeObsessive-compulsive disorderNatural historyFirst-line optionCourse of illnessAlpha-adrenergic agentsComputerized literature searchAtypical neurolepticsTic disordersAccurate prognosticationAdrenergic agentsPathophysiological modelProper diagnosisHabit reversalSyndromeLiterature searchAnxiety disordersBehavioral interventionsImproved treatmentDisordersPatientsPractical reviewTreatmentDiagnosisAttention problems
2002
Development and natural history of mood disorders
Costello EJ, Pine DS, Hammen C, March JS, Plotsky PM, Weissman MM, Biederman J, Goldsmith HH, Kaufman J, Lewinsohn PM, Hellander M, Hoagwood K, Koretz DS, Nelson CA, Leckman JF. Development and natural history of mood disorders. Biological Psychiatry 2002, 52: 529-542. PMID: 12361667, DOI: 10.1016/s0006-3223(02)01372-0.Peer-Reviewed Original ResearchConceptsMood disordersMood disorders researchPediatric-onset bipolar disorderBipolar disorderUnipolar depressionNatural historySpecific risk factorsModel of pathogenesisPrecursor of depressionPsychotropic medicationsRisk infantsRisk factorsSuccessful treatmentHigh riskMultidisciplinary workgroupChildhood anxiety disordersJuvenile depressionDisorder researchEarly onsetProtective factorsAnxiety disordersPanel of expertsMental healthDisordersDepression
1985
Depressives with secondary alcoholism: psychiatric disorders in offspring.
Merikangas KR, Weissman MM, Prusoff BA, Pauls DL, Leckman JF. Depressives with secondary alcoholism: psychiatric disorders in offspring. Journal Of Studies On Alcohol And Drugs 1985, 46: 199-204. PMID: 4010295, DOI: 10.15288/jsa.1985.46.199.Peer-Reviewed Original ResearchConceptsOffspring of probandsSecondary alcoholismMajor depressionGreater riskFivefold greater riskThreefold greater riskOffspring of controlsUnderlying illnessPsychiatric illnessPsychiatric disordersDepressed probandsAlcoholismAnxiety disordersDisordersDepressionFamilial aggregationProbandsRiskIllnessOffspringNumber of parentsAdditional increaseDepressive
1983
Anxiety disorders and depression: contradictions between family study data and DSM-III conventions
Leckman JF, Merikangas KR, Pauls DL, Prusoff BA, Weissman MM. Anxiety disorders and depression: contradictions between family study data and DSM-III conventions. American Journal Of Psychiatry 1983, 140: 880-882. PMID: 6859304, DOI: 10.1176/ajp.140.7.880.Peer-Reviewed Original Research