2016
Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
Gaughan T, Buckley A, Hommer R, Grant P, Williams K, Leckman JF, Swedo SE. Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). Journal Of Clinical Sleep Medicine 2016, 12: 1027-32. PMID: 27166296, PMCID: PMC4918985, DOI: 10.5664/jcsm.5942.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeNeuropsychiatric syndromeMotor disinhibitionRapid eye movement (REM) sleep abnormalitiesPeriodic limb movementsPopulation of childrenConsecutive subjectsPediatric neurologistsFull polysomnographyHand stereotypiesPolysomnographic investigationSleep abnormalitiesSleep architectureREM sleepPolysomnographyLimb movementsSyndromeAbnormalitiesChildrenSleepDisinhibitionExcessive movementSubjectsNeurologists
2014
The Modulating Role of Stress in the Onset and Course of Tourette’s Syndrome
Buse J, Kirschbaum C, Leckman JF, Münchau A, Roessner V. The Modulating Role of Stress in the Onset and Course of Tourette’s Syndrome. Behavior Modification 2014, 38: 184-216. PMID: 24516255, DOI: 10.1177/0145445514522056.Peer-Reviewed Original ResearchConceptsTourette syndromePsychosocial stressActivation of HPAAdrenal axis activationExacerbation of ticsNoradrenergic neurotransmissionAxis activationHPA axisTic disordersTic exacerbationAberrant markersSyndromeNeurotransmissionModulating roleExacerbationPatientsUnderlying mechanismStrong activationImmunologyActivationCommon occurrenceSubsequent changesDopaminergicAbnormalitiesPathology
2007
Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis
Yoon DY, Gause CD, Leckman JF, Singer HS. Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis. Journal Of The Neurological Sciences 2007, 255: 50-56. PMID: 17337006, DOI: 10.1016/j.jns.2007.01.069.Peer-Reviewed Original ResearchConceptsTourette syndromeDopamine transporterReceptor densityPathophysiology of TSAlpha-adrenergic receptorsSex-matched controlsD2 receptor densityPostmortem brain tissueFrontal regionsDopaminergic dysfunctionNeurochemical abnormalitiesDopaminergic abnormalitiesNeurochemical markersTS patientsFrontal cortexSemiquantitative immunoblottingFrontal lobeBrain tissueTS subjectsTerminal markersOccipital regionAbnormalitiesVesicular dockingPathophysiologySyndrome
1996
Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test.
Grice DE, Leckman JF, Pauls DL, Kurlan R, Kidd KK, Pakstis AJ, Chang FM, Buxbaum JD, Cohen DJ, Gelernter J. Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test. American Journal Of Human Genetics 1996, 59: 644-52. PMID: 8751866, PMCID: PMC1914894.Peer-Reviewed Original ResearchConceptsTourette syndromeChronic multiple ticsMultiple ticsTransmission disequilibrium test (TDT) methodsDopaminergic abnormalitiesFamily triosTransmission disequilibrium testReceptor locusSyndromeDopamine D4 receptor locusFunctional mutationsFunctional studiesCommon allelesAllelesPathogenesisParticular allelesDifferent binding propertiesAbnormalities