2025
Cancer Mortality
Hjartåker A, Weiderpass E, Bray F. Cancer Mortality. 2025, 171-182. DOI: 10.1016/b978-0-323-99967-0.00162-9.Peer-Reviewed Original ResearchCancer mortality burdenMortality burdenCancer mortality trendsGlobal cancer controlCancer deathCancer mortality dataHigher-income settingsProportion of deathsMortality trendsMortality dataCause of cancer deathCancer controlColorectal cancerMiddle-income economiesMeasure of progressLiver cancerCancer formsMortality rateColorectalBurdenData sourcesWorld regionsCancerDeathFrequent cause
2024
Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort
Matta K, Viallon V, Botteri E, Peveri G, Dahm C, Nannsen A, Olsen A, Tjønneland A, Elbaz A, Artaud F, Marques C, Kaaks R, Katzke V, Schulze M, Llanaj E, Masala G, Pala V, Panico S, Tumino R, Ricceri F, Derksen J, Nøst T, Sandanger T, Borch K, Quirós J, Castro-Espin C, Sánchez M, Atxega A, Cirera L, Guevara M, Manjer J, Tin Tin S, Heath A, Touvier M, Goldberg M, Weiderpass E, Gunter M, Freisling H, Riboli E, Ferrari P. Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort. BMC Medicine 2024, 22: 210. PMID: 38807179, PMCID: PMC11134634, DOI: 10.1186/s12916-024-03362-7.Peer-Reviewed Original ResearchConceptsHealthy lifestyle indexAssociated with all-causeHealthy lifestyle changesEuropean Prospective InvestigationRisk of deathCancer mortalityFollow-up questionnaireAll-causeLifestyle changesProspective InvestigationRate advancement periodsUnhealthy lifestyle changesRisk of noncommunicable diseasesCancer and NutritionCancer-free adultsBody mass indexBackgroundHealthy lifestylesLifestyle behaviorsNutrition CohortLifestyle indexLifestyle ProfilePhysical activityAssociated with mortalityNoncommunicable diseasesChange scoresAssociation between waterpipe smoking and lung cancer: a multicentre case–control study in Iran
Rashidian H, Hadji M, Ansari-Moghaddam A, Bakhshi M, Nejatizadeh A, Marzban M, Rezaianzadeh A, Seyyedsalehi M, Moradi A, Gholipour M, Alizadeh-Navaei R, Freedman N, Malekzadeh R, Etemadi A, Kamangar F, Weiderpass E, Pukkala E, Boffetta P, Zendehdel K. Association between waterpipe smoking and lung cancer: a multicentre case–control study in Iran. Public Health 2024, 231: 166-172. PMID: 38701659, DOI: 10.1016/j.puhe.2024.03.008.Peer-Reviewed Original ResearchOR of lung cancerWaterpipe smokingWaterpipe smokersLung cancerHigher OROdds of lung cancerOdds ratioIncreased risk of lung cancerRisk of lung cancerMulticentre case-control studyConfidence intervalsMultivariate logistic regression modelExposure to waterpipe smokeLung cancer casesLogistic regression modelsCase-control studyGlobal public health concernPublic health concernSquamous cell carcinomaResidual confoundingLung cancer patientsCancer casesInitiate smokingWaterpipeNever-smokersOccupation and tongue cancer in Nordic countries
Peltonen J, Nikkilä R, Al-Samadi A, Mäkitie A, Martinsen J, Kjaerheim K, Lynge E, Sparen P, Tryggvadottir L, Weiderpass E, Salo T, Pukkala E. Occupation and tongue cancer in Nordic countries. BMC Oral Health 2024, 24: 506. PMID: 38685000, PMCID: PMC11059716, DOI: 10.1186/s12903-024-04172-2.Peer-Reviewed Original ResearchConceptsStandardized incidence ratioNordic Occupational CancerNational incidence ratesTongue cancerBeverage workersConsumption of alcoholEffects of carcinogen exposureSignificant SIRsIncidence ratiosResultsAmong menInactive personsOccupational cancerIncidence rateNordic countriesOccupational categoriesMethodsThe dataArtistic workersRisk variationMale farmersConclusionsThese findingsCarcinogen exposureWorkersForestry workersCancerTobaccoCorrection to: Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort
Stepien M, Duarte-Salles T, Fedirko V, Trichopoulou A, Lagiou P, Bamia C, Overvad K, Tjønneland A, Hansen L, Boutron-Ruault M, Fagherazzi G, Severi G, Kühn T, Kaaks R, Aleksandrova K, Boeing H, Klinaki E, Palli D, Grioni S, Panico S, Tumino R, Naccarati A, Bueno-de-Mesquita H, Peeters P, Skeie G, Weiderpass E, Parr C, Quirós J, Buckland G, Molina-Montes E, Amiano P, Chirlaque M, Ardanaz E, Sonestedt E, Ericson U, Wennberg M, Nilsson L, Khaw K, Wareham N, Bradbury K, Ward H, Romieu I, Jenab M. Correction to: Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort. European Journal Of Nutrition 2024, 63: 1389-1391. PMID: 38630305, DOI: 10.1007/s00394-024-03374-2.Peer-Reviewed Original ResearchImpact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study
Jansana A, Auguste A, Kvaskoff M, Fournier A, Fontvieille E, Peruchet‐Noray L, Biessy C, Cordova R, Petersen K, Tjønneland A, Katzke V, Kaaks R, Ricceri F, Panico S, Contiero P, Sánchez M, Castilla J, Crous‐Bou M, Heath A, Aglago E, Weiderpass E, Gunter M, Ferrari P, Riboli E, Viallon V, Freisling H. Impact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study. Cancer Communications 2024, 44: 593-597. PMID: 38487965, PMCID: PMC11110950, DOI: 10.1002/cac2.12526.Peer-Reviewed Original ResearchDietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case–cohort study
Zheng J, Steur M, Imamura F, Freisling H, Johnson L, van der Schouw Y, Tong T, Weiderpass E, Bajracharya R, Crous-Bou M, Dahm C, Heath A, Ibsen D, Jannasch F, Katzke V, Masala G, Moreno-Iribas C, Sacerdote C, Schulze M, Sieri S, Wareham N, Danesh J, Butterworth A, Forouhi N. Dietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case–cohort study. American Journal Of Clinical Nutrition 2024, 119: 1164-1174. PMID: 38479550, PMCID: PMC11130694, DOI: 10.1016/j.ajcnut.2024.03.006.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseDietary protein intakeProtein intakeCase-cohort studyCardiovascular diseaseIncident cardiovascular diseaseFatal strokeAssociated with lower incidenceIncidence of fatal strokeRisk of cardiovascular diseaseEuropean Prospective InvestigationPrentice-weighted Cox regressionAssociated with incident cardiovascular diseaseOverall CVDIncident CVD casesIntake of plantMacronutrient intakeStroke incidenceProtein consumptionSubcohort membersIsocaloric substitutionDietary patternsDietary intakeNever smokersProspective InvestigationInflammation and gut barrier function-related genes and colorectal cancer risk in western European populations
Mandle H, Jenab M, Gunter M, Tjønneland A, Olsen A, Dahm C, Zhang J, Sugier P, Rothwell J, Severi G, Kaaks R, Katzke V, Schulze M, Masala G, Sieri S, Panico S, Sacerdote C, Bonet C, Sánchez M, Amiano P, Huerta J, Guevara M, Palmqvist R, Löwenmark T, Perez-Cornago A, Weiderpass E, Heath A, Cross A, Vineis P, Hughes D, Fedirko V. Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations. Mutagenesis 2024, geae008. PMID: 38441165, DOI: 10.1093/mutage/geae008.Peer-Reviewed Original ResearchRectal cancer riskColorectal cancer riskCancer riskSingle-nucleotide polymorphismsAssociated with rectal cancer riskColorectal cancerAssociated with rectal cancerIncident CRC casesAssociated with colon cancerEuropean Prospective InvestigationSingle-nucleotide polymorphism levelColon cancerGut barrier functionUnique single-nucleotide polymorphismsNutrition CohortEuropean populationsCRC casesCrohn's diseaseUnadjusted p-valuesProspective InvestigationInvestigate associationsGene levelColorectal cancer developmentBarrier functionGut barrier permeabilityManaging menopause after cancer
Hickey M, Basu P, Sassarini J, Stegmann M, Weiderpass E, Nakawala Chilowa K, Yip C, Partridge A, Brennan D. Managing menopause after cancer. The Lancet 2024, 403: 984-996. PMID: 38458217, DOI: 10.1016/s0140-6736(23)02802-7.Peer-Reviewed Original ResearchConceptsPremature ovarian insufficiencyMenopausal symptomsRisk of chronic conditionsLong-term effects of cancer treatmentHormone therapyOvarian insufficiencyPatient-focused modelModels of careVasomotor symptomsBreast cancerEffects of cancer treatmentCancer treatmentSexual dysfunctionHigh-income countriesMenopausal hormone therapyQuality of lifeTreatment-induced symptomsLow-income countriesNon-hormonal treatmentsNon-hormonal optionsChronic conditionsManaging menopausal symptomsManaging menopauseDiagnose menopauseVaginal estrogenBMI and breast cancer risk around age at menopause
Von Holle A, Adami H, Baglietto L, Berrington de Gonzalez A, Bertrand K, Blot W, Chen Y, DeHart J, Dossus L, Eliassen A, Fournier A, Garcia-Closas M, Giles G, Guevara M, Hankinson S, Heath A, Jones M, Joshu C, Kaaks R, Kirsh V, Kitahara C, Koh W, Linet M, Park H, Masala G, Mellemkjaer L, Milne R, O'Brien K, Palmer J, Riboli E, Rohan T, Shrubsole M, Sund M, Tamimi R, Tin Tin S, Visvanathan K, Vermeulen R, Weiderpass E, Willett W, Yuan J, Zeleniuch-Jacquotte A, Nichols H, Sandler D, Swerdlow A, Schoemaker M, Weinberg C. BMI and breast cancer risk around age at menopause. Cancer Epidemiology 2024, 89: 102545. PMID: 38377945, PMCID: PMC10942753, DOI: 10.1016/j.canep.2024.102545.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskHazard ratioBreast cancer hazard ratioCancer hazard ratioFive-unit incrementNatural menopauseBreast cancer etiologyHigher body mass indexLoss to follow-upAssociated with decreased riskBreast cancer diagnosisMenopausal status groupsBody mass indexYears age rangeMenopausal hormone therapyPrimary time scalePerson-timeCancer etiologyLoss of ovarian functionCancer diagnosisMass indexBMIPositive associationStatus groupsCirculating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
Rinaldi S, Dossus L, Keski‐Rahkonen P, Kiss A, Navionis A, Biessy C, Travis R, Weiderpass E, Romieu I, Eriksen A, Tjonneland A, Kvaskoff M, Canonico M, Truong T, Katzke V, Kaaks R, Catalano A, Panico S, Masala G, Tumino R, Lukic M, Olsen K, Zamora‐Ros R, Santiuste C, Atxega A, Guevara M, Rodriguez‐Barranco M, Sandstrom M, Hennings J, Almquist M, Kouassivi E, Christakoudi S, Gunter M, Franceschi S. Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women. International Journal Of Cancer 2024, 154: 2064-2074. PMID: 38357914, DOI: 10.1002/ijc.34872.Peer-Reviewed Original ResearchConceptsSex hormone binding globulinSex steroid hormonesThyroid cancerRisk of differentiated thyroid carcinomaOdds ratioSex steroidsSex hormone binding globulin concentrationsSteroid hormonesCancer-free controlsPre-menopausal womenRisk of differentiated TCEuropean Prospective InvestigationPost-menopausal womenEndogenous sex steroidsBorderline significant increaseConditional logistic regression modelsSex steroid productionNo significant associationCirculating sex steroidsCirculating sex steroid hormonesPostmenopausal womenConcentrations of testosteroneProgesterone/estradiol ratioThyroid carcinomaBorderline decreaseFemale reproductive histories and the risk of chronic obstructive pulmonary disease
Liang C, Chung H, Dobson A, Sandin S, Weiderpass E, Mishra G. Female reproductive histories and the risk of chronic obstructive pulmonary disease. Thorax 2024, 79: 508-514. PMID: 38350732, DOI: 10.1136/thorax-2023-220388.Peer-Reviewed Original ResearchConceptsRisk of chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseFemale reproductive factorsReproductive factorsObstructive pulmonary diseaseNatural menopauseBirth yearIncreased risk of COPDPulmonary diseaseBody mass indexDevelopment of chronic obstructive pulmonary diseaseEducation levelCox regression modelsMass indexReproductive historyIncreased riskCohort differencesStillbirthRegression modelsFemale reproductive historyMenarcheMedian follow-upWomenFemale hormonal environmentCohortWorld Oncology Forum amplifies its appeal in global fight against cancer
Cavalli F, Mikkelsen B, Weiderpass E, Sullivan R, Jaffray D, Gospodarowicz M. World Oncology Forum amplifies its appeal in global fight against cancer. The Lancet Oncology 2024, 25: 170-174. PMID: 38301688, DOI: 10.1016/s1470-2045(24)00010-x.Peer-Reviewed Original ResearchStrategies to decrease inequalities in cancer therapeutics, care and prevention
Ringborg U, von Braun J, Celis J, Baumann M, Berns A, Eggermont A, Heard E, Heitor M, Chandy M, Chen C, Costa A, De Lorenzo F, De Robertis E, Dubee F, Ernberg I, Gabriel M, Helland Å, Henrique R, Jönsson B, Kallioniemi O, Korbel J, Krause M, Lowy D, Michielin O, Nagy P, Oberst S, Paglia V, Parker M, Ryan K, Sawyers C, Schüz J, Silkaitis K, Solary E, Thomas D, Turkson P, Weiderpass E, Yang H. Strategies to decrease inequalities in cancer therapeutics, care and prevention. Molecular Oncology 2024, 18: 245-279. PMID: 38135904, PMCID: PMC10850793, DOI: 10.1002/1878-0261.13575.Peer-Reviewed Original ResearchConceptsComprehensive cancer centreEuropean Academy of Cancer SciencesEurope's Beating Cancer PlanHealthcare systemCancer research continuumPrevention modalitiesCost-effective healthcareCancer research infrastructureCancer PlanCancer incidencePatient needsPatient careResearch continuumPrevention opportunitiesPrevention programsCancer preventionCancer centreOutcomes researchHealthcareEconomic statusPontifical Academy of SciencesDecreasing inequalityState-of-the-art patient careCancer scienceResearch portfolioBreast cancer incidence trends in Golestan, Iran: An age-period-cohort analysis by ethnic region, 2004-2018
Ghasemi-Kebria F, Fazel A, Semnani S, Etemadi A, Naeimi-Tabiei M, Hasanpour-Heidari S, Salamat F, Jafari-Delouie N, Sedaghat S, Sadeghzadeh H, Akbari M, Mehrjerdian M, Weiderpass E, Roshandel G, Bray F, Malekzadeh R. Breast cancer incidence trends in Golestan, Iran: An age-period-cohort analysis by ethnic region, 2004-2018. Cancer Epidemiology 2024, 89: 102525. PMID: 38228040, DOI: 10.1016/j.canep.2024.102525.Peer-Reviewed Original ResearchAge-standardized incidence rateAge-period-cohortIncidence rate ratiosAge-period-cohort analysisIncidence trendsCalculated age-standardized incidence ratesBreast cancer incidence trendsTrends of breast cancerCohort effectsNon-linear cohort effectsIncidence rateFemale breast cancer casesCancer incidence trendsBreast cancer incidenceAnnual percentage changeIncreased IRRsRural areasBreast cancer casesBreast cancerCancer incidenceDiagnosis yearReproductive factorsBirth cohortCancer casesRate ratiosPre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study
Pham T, Nimptsch K, Aleksandrova K, Jenab M, Fedirko V, Wu K, Eriksen A, Tjønneland A, Severi G, Rothwell J, Kaaks R, Katzke V, Catalano A, Agnoli C, Masala G, De Magistris M, Tumino R, Vermeulen R, Aizpurua A, Trobajo‐Sanmartín C, Chirlaque M, Sánchez M, San Moon Lu S, Cross A, Christakoudi S, Weiderpass E, Pischon T. Pre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study. International Journal Of Cancer 2024, 154: 1596-1606. PMID: 38200695, DOI: 10.1002/ijc.34830.Peer-Reviewed Original ResearchColorectal cancer diagnosisCRC-specific mortalityEuropean Prospective InvestigationAll-cause mortalityCox proportional hazards modelsProportional hazards modelColorectal cancerCRC-specificAssociated with CRC-specific mortalityPre-diagnosticResistin concentrationsProspective InvestigationHazards modelHazard ratioIncident CRC casesFine-Gray proportional subdistribution hazards modelCause-specific Cox proportional hazards modelsSubgroup analysisBody mass indexNutrition CohortProportional subdistribution hazards modelMedian follow-upAssociated with increased mortalitySubdistribution hazard modelCRC casesUnveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran
Hadji M, Rashidian H, Marzban M, Rezaianzadeh A, Ansari-Moghaddam A, Bakhshi M, Nejatizadeh A, Seyyedsalehi M, Naghibzadeh-Tahami A, Haghdoost A, Mohebbi E, Freedman N, Malekzadeh R, Etemadi A, Kamangar F, Weiderpass E, Pukkala E, Boffetta P, Zendehdel K. Unveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 509-515. PMID: 38180357, PMCID: PMC10988205, DOI: 10.1158/1055-9965.epi-23-0773.Peer-Reviewed Original ResearchWaterpipe smokingIncreased risk of bladder cancerRisk of bladder cancerBladder cancer riskStatistically significant elevated riskCigarette smokingSignificantly elevated riskBladder cancerMulticenter case-control studyCase-control studyMultivariate logistic regressionGlobal public health concernPublic health concernCancer riskTobacco productsEx-smokersWaterpipeWaterpipe smokersOpium useElevated riskLogistic regressionSmokingUrothelial bladder cancerConfounding factorsHealth concernLifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition
Botteri E, Peveri G, Berstad P, Bagnardi V, Hoff G, Heath A, Cross A, Vineis P, Dossus L, Johansson M, Freisling H, Matta K, Huybrechts I, Chen S, B. Borch K, Sandanger T, H. Nøst T, Dahm C, Antoniussen C, Tin Tin S, Fournier A, Marques C, Artaud F, Sánchez M, Guevara M, Santiuste C, Agudo A, Bajracharya R, Katzke V, Ricceri F, Agnoli C, Bergmann M, Schulze M, Panico S, Masala G, Tjønneland A, Olsen A, Stocks T, Manjer J, Aizpurua-Atxega A, Weiderpass E, Riboli E, Gunter M, Ferrari P. Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition. European Journal Of Epidemiology 2024, 39: 147-159. PMID: 38180593, DOI: 10.1007/s10654-023-01059-4.Peer-Reviewed Original ResearchHealthy lifestyle indexLifestyle-related cancersFollow-up questionnaireCancer riskHealthy lifestyle index scoreLifestyle changesHazard ratioConfidence intervalsEuropean Prospective InvestigationFollow-upMiddle-aged participantsBody mass indexLifestyle indexPhysical activityBottom thirdLifestyle questionnaireLifestyle habitsEPIC cohortProspective InvestigationAlcohol consumptionCox regression modelsMass indexCigarette smokingLifestyleQuestionnaire
2023
Association of hormonal and reproductive factors with differentiated thyroid cancer risk in women: a pooled prospective cohort analysis
O’Grady T, Rinaldi S, Michels K, Adami H, Buring J, Chen Y, Clendenen T, D’Aloisio A, DeHart J, Franceschi S, Freedman N, Gierach G, Giles G, Lacey J, Lee I, Liao L, Linet M, McCullough M, Patel A, Prizment A, Robien K, Sandler D, Stolzenberg-Solomon R, Weiderpass E, White E, Wolk A, Zheng W, de Gonzalez A, Kitahara C. Association of hormonal and reproductive factors with differentiated thyroid cancer risk in women: a pooled prospective cohort analysis. International Journal Of Epidemiology 2023, 53: dyad172. PMID: 38110618, PMCID: PMC10859160, DOI: 10.1093/ije/dyad172.Peer-Reviewed Original ResearchConceptsThyroid cancer riskRisk of DTCDTC riskCancer riskMultivariable-adjusted Cox proportional hazards modelsMenopausal hormone therapy useHazard ratioFactors associated with higher riskEstimate hazard ratiosHormonal factorsOral contraceptivesHormone therapy useFactor associated with lower riskCox proportional hazards modelsProspective cohort analysisIncidence of differentiated thyroid cancerPost-menopausal statusMenopausal hormone therapyProportional hazards modelExposure misclassificationReproductive factorsPre-diagnosticTherapy useEvaluate associationsSex steroid hormonesInternational Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts
Timmins I, Jones M, O'Brien K, Adami H, Aune D, Baglietto L, Bertrand K, Brantley K, Chen Y, DeHart J, Clendenen T, Dossus L, Eliassen A, Fletcher O, Fournier A, Håkansson N, Hankinson S, Houlston R, Joshu C, Kirsh V, Kitahara C, Koh W, Linet M, Park H, Lynch B, May A, Mellemkjær L, Milne R, Palmer J, Ricceri F, Rohan T, Ruddy K, Sánchez M, Shu X, Smith-Byrne K, Steindorf K, Sund M, Vachon C, Vatten L, Visvanathan K, Weiderpass E, Willett W, Wolk A, Yuan J, Zheng W, Nichols H, Sandler D, Swerdlow A, Schoemaker M. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts. Journal Of Clinical Oncology 2023, 42: 927-939. PMID: 38079601, PMCID: PMC10927335, DOI: 10.1200/jco.23.01101.Peer-Reviewed Original ResearchLeisure-time physical activityLevels of leisure-time physical activityBreast cancer riskPremenopausal breast cancerBreast cancer risk factorsPhysical activityCancer risk factorsCancer riskHazard ratioHigher levels of leisure-time physical activityAssociations of leisure-time physical activityLow levels of leisure-time physical activitySelf-reported leisure-time physical activityIncident cases of breast cancerAssociation of physical activityPostmenopausal breast cancer riskPremenopausal breast cancer riskBreast cancerPooled analysis of cohort studiesPooled individual-level dataCohort studyAnalysis of cohort studiesBreast cancer incidenceCases of breast cancerEstimate hazard ratios