2024
Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort
Matta K, Viallon V, Botteri E, Peveri G, Dahm C, Nannsen A, Olsen A, Tjønneland A, Elbaz A, Artaud F, Marques C, Kaaks R, Katzke V, Schulze M, Llanaj E, Masala G, Pala V, Panico S, Tumino R, Ricceri F, Derksen J, Nøst T, Sandanger T, Borch K, Quirós J, Castro-Espin C, Sánchez M, Atxega A, Cirera L, Guevara M, Manjer J, Tin Tin S, Heath A, Touvier M, Goldberg M, Weiderpass E, Gunter M, Freisling H, Riboli E, Ferrari P. Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort. BMC Medicine 2024, 22: 210. PMID: 38807179, PMCID: PMC11134634, DOI: 10.1186/s12916-024-03362-7.Peer-Reviewed Original ResearchConceptsHealthy lifestyle indexAssociated with all-causeHealthy lifestyle changesEuropean Prospective InvestigationRisk of deathCancer mortalityFollow-up questionnaireAll-causeLifestyle changesProspective InvestigationRate advancement periodsUnhealthy lifestyle changesRisk of noncommunicable diseasesCancer and NutritionCancer-free adultsBody mass indexBackgroundHealthy lifestylesLifestyle behaviorsNutrition CohortLifestyle indexLifestyle ProfilePhysical activityAssociated with mortalityNoncommunicable diseasesChange scoresInflammation and gut barrier function-related genes and colorectal cancer risk in western European populations
Mandle H, Jenab M, Gunter M, Tjønneland A, Olsen A, Dahm C, Zhang J, Sugier P, Rothwell J, Severi G, Kaaks R, Katzke V, Schulze M, Masala G, Sieri S, Panico S, Sacerdote C, Bonet C, Sánchez M, Amiano P, Huerta J, Guevara M, Palmqvist R, Löwenmark T, Perez-Cornago A, Weiderpass E, Heath A, Cross A, Vineis P, Hughes D, Fedirko V. Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations. Mutagenesis 2024, geae008. PMID: 38441165, DOI: 10.1093/mutage/geae008.Peer-Reviewed Original ResearchRectal cancer riskColorectal cancer riskCancer riskSingle-nucleotide polymorphismsAssociated with rectal cancer riskColorectal cancerAssociated with rectal cancerIncident CRC casesAssociated with colon cancerEuropean Prospective InvestigationSingle-nucleotide polymorphism levelColon cancerGut barrier functionUnique single-nucleotide polymorphismsNutrition CohortEuropean populationsCRC casesCrohn's diseaseUnadjusted p-valuesProspective InvestigationInvestigate associationsGene levelColorectal cancer developmentBarrier functionGut barrier permeabilityPre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study
Pham T, Nimptsch K, Aleksandrova K, Jenab M, Fedirko V, Wu K, Eriksen A, Tjønneland A, Severi G, Rothwell J, Kaaks R, Katzke V, Catalano A, Agnoli C, Masala G, De Magistris M, Tumino R, Vermeulen R, Aizpurua A, Trobajo‐Sanmartín C, Chirlaque M, Sánchez M, San Moon Lu S, Cross A, Christakoudi S, Weiderpass E, Pischon T. Pre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study. International Journal Of Cancer 2024, 154: 1596-1606. PMID: 38200695, DOI: 10.1002/ijc.34830.Peer-Reviewed Original ResearchColorectal cancer diagnosisCRC-specific mortalityEuropean Prospective InvestigationAll-cause mortalityCox proportional hazards modelsProportional hazards modelColorectal cancerCRC-specificAssociated with CRC-specific mortalityPre-diagnosticResistin concentrationsProspective InvestigationHazards modelHazard ratioIncident CRC casesFine-Gray proportional subdistribution hazards modelCause-specific Cox proportional hazards modelsSubgroup analysisBody mass indexNutrition CohortProportional subdistribution hazards modelMedian follow-upAssociated with increased mortalitySubdistribution hazard modelCRC cases
2023
Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality: EPIC cohort study in 9 European countries
Fiolet T, Nicolas G, Casagrande C, Horvath Z, Frenoy P, Weiderpass E, Gunter M, Manjer J, Sonestedt E, Palli D, Simeon V, Tumino R, Bueno-de-Mesquita B, Huerta J, Rodriguez-Barranco M, Abilleira E, Sacerdote C, Schulze M, Heath A, Rylander C, Skeie G, Nøst T, Tjønneland A, Olsen A, Pala V, Kvaskoff M, Huybrechts I, Mancini F. Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality: EPIC cohort study in 9 European countries. International Journal Of Hygiene And Environmental Health 2023, 255: 114287. PMID: 37989047, DOI: 10.1016/j.ijheh.2023.114287.Peer-Reviewed Original ResearchConceptsDietary intakeCause mortalityCohort studyIntake of dioxinsCancer mortalityGeneral populationEPIC cohort studyMultivariable Cox regressionEuropean Prospective InvestigationCardiovascular-specific mortalityMain exposure sourceNDL-PCBsFood consumption dataFood contamination dataSerum/plasmaNon-linear associationNutrition CohortCardiovascular mortalityHazard ratioCox regressionNon-monotonic dose responsesProspective InvestigationEuropean Food Safety AuthorityMortalityInconsistent associations