2025
Cancer Mortality
Hjartåker A, Weiderpass E, Bray F. Cancer Mortality. 2025, 171-182. DOI: 10.1016/b978-0-323-99967-0.00162-9.Peer-Reviewed Original ResearchCancer mortality burdenMortality burdenCancer mortality trendsGlobal cancer controlCancer deathCancer mortality dataHigher-income settingsProportion of deathsMortality trendsMortality dataCause of cancer deathCancer controlColorectal cancerMiddle-income economiesMeasure of progressLiver cancerCancer formsMortality rateColorectalBurdenData sourcesWorld regionsCancerDeathFrequent cause
2024
Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations
Mandle H, Jenab M, Gunter M, Tjønneland A, Olsen A, Dahm C, Zhang J, Sugier P, Rothwell J, Severi G, Kaaks R, Katzke V, Schulze M, Masala G, Sieri S, Panico S, Sacerdote C, Bonet C, Sánchez M, Amiano P, Huerta J, Guevara M, Palmqvist R, Löwenmark T, Perez-Cornago A, Weiderpass E, Heath A, Cross A, Vineis P, Hughes D, Fedirko V. Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations. Mutagenesis 2024, geae008. PMID: 38441165, DOI: 10.1093/mutage/geae008.Peer-Reviewed Original ResearchRectal cancer riskColorectal cancer riskCancer riskSingle-nucleotide polymorphismsAssociated with rectal cancer riskColorectal cancerAssociated with rectal cancerIncident CRC casesAssociated with colon cancerEuropean Prospective InvestigationSingle-nucleotide polymorphism levelColon cancerGut barrier functionUnique single-nucleotide polymorphismsNutrition CohortEuropean populationsCRC casesCrohn's diseaseUnadjusted p-valuesProspective InvestigationInvestigate associationsGene levelColorectal cancer developmentBarrier functionGut barrier permeabilityPre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study
Pham T, Nimptsch K, Aleksandrova K, Jenab M, Fedirko V, Wu K, Eriksen A, Tjønneland A, Severi G, Rothwell J, Kaaks R, Katzke V, Catalano A, Agnoli C, Masala G, De Magistris M, Tumino R, Vermeulen R, Aizpurua A, Trobajo‐Sanmartín C, Chirlaque M, Sánchez M, San Moon Lu S, Cross A, Christakoudi S, Weiderpass E, Pischon T. Pre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study. International Journal Of Cancer 2024, 154: 1596-1606. PMID: 38200695, DOI: 10.1002/ijc.34830.Peer-Reviewed Original ResearchColorectal cancer diagnosisCRC-specific mortalityEuropean Prospective InvestigationAll-cause mortalityCox proportional hazards modelsProportional hazards modelColorectal cancerCRC-specificAssociated with CRC-specific mortalityPre-diagnosticResistin concentrationsProspective InvestigationHazards modelHazard ratioIncident CRC casesFine-Gray proportional subdistribution hazards modelCause-specific Cox proportional hazards modelsSubgroup analysisBody mass indexNutrition CohortProportional subdistribution hazards modelMedian follow-upAssociated with increased mortalitySubdistribution hazard modelCRC cases
2023
Opium use and risk of colorectal cancer: a multi-center case-referent study in Iran
Hadji M, Marzban M, Rashidian H, Naghibzadeh-Tahami A, Gholipour M, Mohebbi E, Safari-Faramani R, Seyyedsalehi M, Hosseini B, Alizadeh-Navaei R, Rezaianzadeh A, Moradi A, ShahidSales S, Najafi F, Moazed V, Haghdoost A, Rahimi-Movaghar A, Etemadi A, Malekzadeh R, Boffetta P, Weiderpass E, Kamangar F, Zendehdel K, Pukkala E. Opium use and risk of colorectal cancer: a multi-center case-referent study in Iran. Acta Oncologica 2023, 62: 1661-1668. PMID: 37934078, DOI: 10.1080/0284186x.2023.2276326.Peer-Reviewed Original ResearchConceptsRisk of colorectal cancerCase-referent studyOpium useColorectal cancerIncreased risk of CRCOdds ratioMultivariable unconditional logistic regression modelOccupational physical activityUnconditional logistic regression modelsIncreased risk of cancerColorectal cancer casesIncreased riskConsumption of red meatMeasure odds ratiosRisk of cancerInternational Agency for Cancer ResearchLogistic regression modelsPhysical activityTrained interviewersSocioeconomic statusPotential confoundersMarital statusFamily historyRed meatOpium consumptionProspective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer
Nimptsch K, Aleksandrova K, Pham T, Papadimitriou N, Janke J, Christakoudi S, Heath A, Olsen A, Tjønneland A, Schulze M, Katzke V, Kaaks R, van Guelpen B, Harbs J, Palli D, Macciotta A, Pasanisi F, Yohar S, Guevara M, Amiano P, Grioni S, Jakszyn P, Figueiredo J, Samadder N, Li C, Moreno V, Potter J, Schoen R, Um C, Weiderpass E, Jenab M, Gunter M, Pischon T. Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer. BMC Medicine 2023, 21: 391. PMID: 37833736, PMCID: PMC10576353, DOI: 10.1186/s12916-023-03104-1.Peer-Reviewed Original ResearchConceptsColorectal cancer riskColorectal cancer casesMendelian randomizationColorectal cancerEpidemiology of Colorectal Cancer ConsortiumAssociated with colorectal cancer riskTwo-sample Mendelian randomization studyColon Cancer Family RegistryPublished genome-wide association studiesColorectal Cancer ConsortiumCancer Family RegistryConditional logistic regression modelsMendelian randomization analysisMendelian randomization studiesCancer and NutritionEuropean Prospective InvestigationNested case-control studyGenome-wide association studiesLogistic regression modelsCase-control studyDevelopment of colorectal cancerFamily RegistryStatistically significant associationCancer ConsortiumCancer risk