2024
Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations
Mandle H, Jenab M, Gunter M, Tjønneland A, Olsen A, Dahm C, Zhang J, Sugier P, Rothwell J, Severi G, Kaaks R, Katzke V, Schulze M, Masala G, Sieri S, Panico S, Sacerdote C, Bonet C, Sánchez M, Amiano P, Huerta J, Guevara M, Palmqvist R, Löwenmark T, Perez-Cornago A, Weiderpass E, Heath A, Cross A, Vineis P, Hughes D, Fedirko V. Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations. Mutagenesis 2024, geae008. PMID: 38441165, DOI: 10.1093/mutage/geae008.Peer-Reviewed Original ResearchRectal cancer riskColorectal cancer riskCancer riskSingle-nucleotide polymorphismsAssociated with rectal cancer riskColorectal cancerAssociated with rectal cancerIncident CRC casesAssociated with colon cancerEuropean Prospective InvestigationSingle-nucleotide polymorphism levelColon cancerGut barrier functionUnique single-nucleotide polymorphismsNutrition CohortEuropean populationsCRC casesCrohn's diseaseUnadjusted p-valuesProspective InvestigationInvestigate associationsGene levelColorectal cancer developmentBarrier functionGut barrier permeabilityBMI and breast cancer risk around age at menopause
Von Holle A, Adami H, Baglietto L, Berrington de Gonzalez A, Bertrand K, Blot W, Chen Y, DeHart J, Dossus L, Eliassen A, Fournier A, Garcia-Closas M, Giles G, Guevara M, Hankinson S, Heath A, Jones M, Joshu C, Kaaks R, Kirsh V, Kitahara C, Koh W, Linet M, Park H, Masala G, Mellemkjaer L, Milne R, O'Brien K, Palmer J, Riboli E, Rohan T, Shrubsole M, Sund M, Tamimi R, Tin Tin S, Visvanathan K, Vermeulen R, Weiderpass E, Willett W, Yuan J, Zeleniuch-Jacquotte A, Nichols H, Sandler D, Swerdlow A, Schoemaker M, Weinberg C. BMI and breast cancer risk around age at menopause. Cancer Epidemiology 2024, 89: 102545. PMID: 38377945, PMCID: PMC10942753, DOI: 10.1016/j.canep.2024.102545.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskHazard ratioBreast cancer hazard ratioCancer hazard ratioFive-unit incrementNatural menopauseBreast cancer etiologyHigher body mass indexLoss to follow-upAssociated with decreased riskBreast cancer diagnosisMenopausal status groupsBody mass indexYears age rangeMenopausal hormone therapyPrimary time scalePerson-timeCancer etiologyLoss of ovarian functionCancer diagnosisMass indexBMIPositive associationStatus groupsUnveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran
Hadji M, Rashidian H, Marzban M, Rezaianzadeh A, Ansari-Moghaddam A, Bakhshi M, Nejatizadeh A, Seyyedsalehi M, Naghibzadeh-Tahami A, Haghdoost A, Mohebbi E, Freedman N, Malekzadeh R, Etemadi A, Kamangar F, Weiderpass E, Pukkala E, Boffetta P, Zendehdel K. Unveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 509-515. PMID: 38180357, PMCID: PMC10988205, DOI: 10.1158/1055-9965.epi-23-0773.Peer-Reviewed Original ResearchWaterpipe smokingIncreased risk of bladder cancerRisk of bladder cancerBladder cancer riskStatistically significant elevated riskCigarette smokingSignificantly elevated riskBladder cancerMulticenter case-control studyCase-control studyMultivariate logistic regressionGlobal public health concernPublic health concernCancer riskTobacco productsEx-smokersWaterpipeWaterpipe smokersOpium useElevated riskLogistic regressionSmokingUrothelial bladder cancerConfounding factorsHealth concernLifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition
Botteri E, Peveri G, Berstad P, Bagnardi V, Hoff G, Heath A, Cross A, Vineis P, Dossus L, Johansson M, Freisling H, Matta K, Huybrechts I, Chen S, B. Borch K, Sandanger T, H. Nøst T, Dahm C, Antoniussen C, Tin Tin S, Fournier A, Marques C, Artaud F, Sánchez M, Guevara M, Santiuste C, Agudo A, Bajracharya R, Katzke V, Ricceri F, Agnoli C, Bergmann M, Schulze M, Panico S, Masala G, Tjønneland A, Olsen A, Stocks T, Manjer J, Aizpurua-Atxega A, Weiderpass E, Riboli E, Gunter M, Ferrari P. Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition. European Journal Of Epidemiology 2024, 39: 147-159. PMID: 38180593, DOI: 10.1007/s10654-023-01059-4.Peer-Reviewed Original ResearchHealthy lifestyle indexLifestyle-related cancersFollow-up questionnaireCancer riskHealthy lifestyle index scoreLifestyle changesHazard ratioConfidence intervalsEuropean Prospective InvestigationFollow-upMiddle-aged participantsBody mass indexLifestyle indexPhysical activityBottom thirdLifestyle questionnaireLifestyle habitsEPIC cohortProspective InvestigationAlcohol consumptionCox regression modelsMass indexCigarette smokingLifestyleQuestionnaire
2023
Association of hormonal and reproductive factors with differentiated thyroid cancer risk in women: a pooled prospective cohort analysis
O’Grady T, Rinaldi S, Michels K, Adami H, Buring J, Chen Y, Clendenen T, D’Aloisio A, DeHart J, Franceschi S, Freedman N, Gierach G, Giles G, Lacey J, Lee I, Liao L, Linet M, McCullough M, Patel A, Prizment A, Robien K, Sandler D, Stolzenberg-Solomon R, Weiderpass E, White E, Wolk A, Zheng W, de Gonzalez A, Kitahara C. Association of hormonal and reproductive factors with differentiated thyroid cancer risk in women: a pooled prospective cohort analysis. International Journal Of Epidemiology 2023, 53: dyad172. PMID: 38110618, PMCID: PMC10859160, DOI: 10.1093/ije/dyad172.Peer-Reviewed Original ResearchConceptsThyroid cancer riskRisk of DTCDTC riskCancer riskMultivariable-adjusted Cox proportional hazards modelsMenopausal hormone therapy useHazard ratioFactors associated with higher riskEstimate hazard ratiosHormonal factorsOral contraceptivesHormone therapy useFactor associated with lower riskCox proportional hazards modelsProspective cohort analysisIncidence of differentiated thyroid cancerPost-menopausal statusMenopausal hormone therapyProportional hazards modelExposure misclassificationReproductive factorsPre-diagnosticTherapy useEvaluate associationsSex steroid hormonesInternational Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts
Timmins I, Jones M, O'Brien K, Adami H, Aune D, Baglietto L, Bertrand K, Brantley K, Chen Y, DeHart J, Clendenen T, Dossus L, Eliassen A, Fletcher O, Fournier A, Håkansson N, Hankinson S, Houlston R, Joshu C, Kirsh V, Kitahara C, Koh W, Linet M, Park H, Lynch B, May A, Mellemkjær L, Milne R, Palmer J, Ricceri F, Rohan T, Ruddy K, Sánchez M, Shu X, Smith-Byrne K, Steindorf K, Sund M, Vachon C, Vatten L, Visvanathan K, Weiderpass E, Willett W, Wolk A, Yuan J, Zheng W, Nichols H, Sandler D, Swerdlow A, Schoemaker M. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts. Journal Of Clinical Oncology 2023, 42: 927-939. PMID: 38079601, PMCID: PMC10927335, DOI: 10.1200/jco.23.01101.Peer-Reviewed Original ResearchLeisure-time physical activityLevels of leisure-time physical activityBreast cancer riskPremenopausal breast cancerBreast cancer risk factorsPhysical activityCancer risk factorsCancer riskHazard ratioHigher levels of leisure-time physical activityAssociations of leisure-time physical activityLow levels of leisure-time physical activitySelf-reported leisure-time physical activityIncident cases of breast cancerAssociation of physical activityPostmenopausal breast cancer riskPremenopausal breast cancer riskBreast cancerPooled analysis of cohort studiesPooled individual-level dataCohort studyAnalysis of cohort studiesBreast cancer incidenceCases of breast cancerEstimate hazard ratiosBody mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies
Fontvieille E, Viallon V, Recalde M, Cordova R, Jansana A, Peruchet-Noray L, Lennon H, Heath A, Aune D, Christakoudi S, Katzke V, Kaaks R, Inan-Eroglu E, Schulze M, Mellemkjær L, Tjønneland A, Overvad K, Farràs M, Petrova D, Amiano P, Chirlaque M, Moreno-Iribas C, Tin Tin S, Masala G, Sieri S, Ricceri F, Panico S, May A, Monninkhof E, Weiderpass E, Gunter M, Ferrari P, Freisling H. Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies. BMC Medicine 2023, 21: 418. PMID: 37993940, PMCID: PMC10666332, DOI: 10.1186/s12916-023-03114-z.Peer-Reviewed Original ResearchConceptsRisk due to interactionObesity-related cancersRisk of obesity-related cancersBody mass indexHigher body mass indexCardiometabolic diseasesJoint associationsHazard ratioCancer riskIncidence of obesity-related cancersJoint association of body mass indexCardiovascular diseaseConfidence intervalsRisk of overall cancerExcess risk due to interactionAssociation of body mass indexSurrogate measure of adiposityUK Biobank prospective cohortCategories of overweight/obesityUK Biobank (UKBAdditive interactionMass indexCardiometabolic disease statusParticipant data meta-analysisCancer risk reductionPrediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study
Hughes D, Schomburg L, Jenab M, Biessy C, Méplan C, Moskal A, Sun Q, Demircan K, Fedirko V, Weiderpass E, Mukhtar M, Olsen A, Tjønneland A, Overvad K, Schulze M, Nøst T, Skeie G, Olsen K, Ricceri F, Grioni S, Palli D, Masala G, Tumino R, Pasanisi F, Amiano P, Colorado Yohar S, Agudo A, Sánchez M, Ardanaz E, Sund M, Andersson A, Perez-Cornago A, Travis R, Heath A, Dossus L. Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study. Free Radical Biology And Medicine 2023, 209: 381-393. PMID: 37923090, DOI: 10.1016/j.freeradbiomed.2023.10.401.Peer-Reviewed Original ResearchConceptsAssociated with BC riskBC riskCase-control pairsOdds ratioMultivariable-adjusted logistic regression modelsBreast cancer riskInfluence BC riskCancer and NutritionConfidence intervalsEuropean Prospective InvestigationHigher risk of BCPremenopausal BC riskRisk of BCPrevent breast cancerAssociated with lower riskEuropean cohort studiesBreast cancerGenetic variant associationsLogistic regression modelsGlutathione peroxidase 3Multiple testing correctionStatistically significant associationPremenopausal BCCancer riskVariant associationsAlcohol and Cancer: The Epidemiological Evidence
Ferrari P, Rumgay H, Weiderpass E, Soerjomataram I. Alcohol and Cancer: The Epidemiological Evidence. 2023, 1371-1389. DOI: 10.1007/978-3-031-32483-3_74.Peer-Reviewed Original ResearchInternational Agency for Research on CancerCancer riskEpidemiological evidencePopulation attributable fractionAlcoholic beverage consumptionBurden of diseaseCases of cancerConsumption of alcoholic beveragesConsumption of alcoholAttributable fractionImpact of alcoholCancer sitesCancer burdenBeverage consumptionCancer casesMonographs programAlcohol consumptionAlcohol intakeAlcohol useFemale breastScientific evidenceUpper digestive tractAlcoholic beveragesAnatomical sitesCancerProspective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer
Nimptsch K, Aleksandrova K, Pham T, Papadimitriou N, Janke J, Christakoudi S, Heath A, Olsen A, Tjønneland A, Schulze M, Katzke V, Kaaks R, van Guelpen B, Harbs J, Palli D, Macciotta A, Pasanisi F, Yohar S, Guevara M, Amiano P, Grioni S, Jakszyn P, Figueiredo J, Samadder N, Li C, Moreno V, Potter J, Schoen R, Um C, Weiderpass E, Jenab M, Gunter M, Pischon T. Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer. BMC Medicine 2023, 21: 391. PMID: 37833736, PMCID: PMC10576353, DOI: 10.1186/s12916-023-03104-1.Peer-Reviewed Original ResearchConceptsColorectal cancer riskColorectal cancer casesMendelian randomizationColorectal cancerEpidemiology of Colorectal Cancer ConsortiumAssociated with colorectal cancer riskTwo-sample Mendelian randomization studyColon Cancer Family RegistryPublished genome-wide association studiesColorectal Cancer ConsortiumCancer Family RegistryConditional logistic regression modelsMendelian randomization analysisMendelian randomization studiesCancer and NutritionEuropean Prospective InvestigationNested case-control studyGenome-wide association studiesLogistic regression modelsCase-control studyDevelopment of colorectal cancerFamily RegistryStatistically significant associationCancer ConsortiumCancer riskIs the number of ideal cardiovascular health metrics in midlife associated with lower risk of cancer? Evidence from 3 European prospective cohorts
van Sloten T, Climie R, Deraz O, Périer M, Valentin E, Fayosse A, Sabia S, Weiderpass E, Jouven X, Goldberg M, Zins M, Touvier M, Deschasaux-Tanguy M, Fezeu L, Hercberg S, Singh-Manoux A, Empana J. Is the number of ideal cardiovascular health metrics in midlife associated with lower risk of cancer? Evidence from 3 European prospective cohorts. CMAJ Open 2023, 11: e774-e781. PMID: 37607746, PMCID: PMC10449017, DOI: 10.9778/cmajo.20220175.Peer-Reviewed Original ResearchIdeal cardiovascular health metricsCardiovascular health metricsHealth metricsWhitehall IIPrimordial preventionCancer eventsCancer riskAssociated with lower cancer riskHazard ratioPrevention of cardiovascular risk factorsAggregated hazard ratiosRisk factorsCommonality of risk factorsLower cancer riskCardiovascular risk factorsIncident cancerRandom-effects modelPrevention of cancerFollow-upSmoking metricsIdeal metricsOnset of cancerGAZELMidlifeEuropean cohort