Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex
Woo E, Datta D, Arnsten AFT. Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex. Frontiers In Neuroanatomy 2022, 16: 849937. PMID: 35444520, PMCID: PMC9013768, DOI: 10.3389/fnana.2022.849937.Peer-Reviewed Original ResearchPrelimbic medial prefrontal cortexRat prelimbic medial prefrontal cortexMedial prefrontal cortexLayer IIIPrefrontal cortexDendritic spinesReceptor type 3Dorsolateral prefrontal cortexPrimate dlPFCReceptor subtypesAxon terminalsNeuronal firingPL-mPFCIntervaricose segmentsMGlu3Glial membranesRhesus monkeysPredominant locationType 3GliaCognitive functioningDLPFCCortexSpineCurrent studyUnusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia
Arnsten AFT, Woo E, Yang S, Wang M, Datta D. Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia. Biological Psychiatry 2022, 92: 480-490. PMID: 35305820, PMCID: PMC9372235, DOI: 10.1016/j.biopsych.2022.02.003.Peer-Reviewed Original ResearchConceptsEnvironmental insultsMore superficial layersDorsolateral prefrontal cortexPrimate dlPFCInflammatory mechanismsInflammatory insultKynurenic acidNMDA receptorsReceptor neurotransmissionDendritic spinesLayer IIICAMP/PKAGlutamatergic synapsePrefrontal cortexInsultPotassium channelsNeurotransmissionCalcium signalingSynapsesGenetic insultsSuperficial layersSchizophreniaSpineCortexNeuromodulation