Macrophages need two signals to begin healing process
In the immune system, macrophages act not only as soldiers responding to invading pathogens but also help rebuild the injured tissue once the infection is defeated. A new study by Yale School of Medicine researchers published in the journal Science show how they accomplish this seemingly unrelated task.
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
Study: Receptor suppresses the immune response in order to save it
When viruses enter the body, they activate receptors on the surface of cells that allow viruses to invade those cells. A Yale-led team has found that one of the receptors, known as AXL, actually plays an essential role in the immune system’s ability to fight viral infections.
Sex Differences in the Acute Effects of Intravenous (IV) Delta‑9 Tetrahydrocannabinol (THC)
Anahita Bassir Nia, MD, assistant professor of psychiatry, and Mohini Ranganathan, MD, associate professor of psychiatry, are first and senior authors, respectively, of a paper in Psychopharmacology that investigated the sex differences in the acute effects of intravenous (IV) delta 9 tetrahydrocannabinol (THC), the main psychoactive compound of cannabis.Source: Psychopharmacology
Sticky Nanoparticles Fight Skin Cancer
Using bioadhesive nanoparticles from the laboratory of Dr. W. Mark Saltzman, Dr. Michael Girardi and his team collaborated with Dr. Saltzman and loaded them with a one-two punch of chemotherapy plus immunotherapy to study its impact in skin cancer. The results may have significant impact for how skin cancer tumors are treated.
Increased Admissions of Older Adults to Substance Use Treatment Facilities and Associated Changes in Admission Characteristics, 2000–2017
A new study by Yale researchers found the number and proportion of older adults admitted to SUD treatment facilities increased substantially from 2000 to 2017 and were associated with changes in both population numbers and patient characteristics, especially a relative increase among older adults in cocaine/crack and cannabis use and a relative decrease for use of alcohol and opioids.Source: The Journal of Clinical Psychiatry
Mice Study Reveals a New Method to Unlock The Blood-Brain Barrier
The blood-brain barrier acts as a security border for the brain, playing a vital role in protecting the delicate neurons inside. However, its strict admission policy can be a problem when it comes to dispatching drugs to treat brain diseases.Source: ScienceAlert
Imaging the effect of ketamine on synaptic density in the living brain
A new study by lead author Sophie Holmes, PhD, Assistant Professor of Psychiatry, investigated whether ketamine produces rapid and sustained antidepressant effects through restoration of lost synaptic connections.Source: Molecular
Despite Precautions, COVID-19 Pandemic Disproportionately Impacts People From Minoritized Backgrounds
A new study by researchers at Yale School of Medicine has found that people from racial and ethnic minoritized backgrounds have been disproportionately affected by the COVID-19 pandemic despite being more likely to engage in health and safety precautions than their white counterparts.
Public spaces as transformative creative wellness spaces: an evaluation of Musical Intervention
Musical Intervention (MI) is a public space that supports individuals who seek opportunities for creativity and connection with the broader community. A new study by Yale researchers sought to evaluate and understand MI through surveys, qualitative interviews, and ethnographic observations.Source: Social Work in Mental Health